SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4byf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A28_B_STRB2_1
(PROGESTERONE
RECEPTOR)		 4byf UNCONVENTIONAL
MYOSIN-IC
(Homo
sapiens) 		5 / 12 LEU A 314
LEU A 303
LEU A 306
LEU A 346
THR A 538
 None
 1.41A 1a28B-4byfA:
undetectable		 1a28B-4byfA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_A_DVAA8_0
(ACTINOMYCIN D)		 4byf UNCONVENTIONAL
MYOSIN-IC
(Homo
sapiens) 		3 / 3 THR A 650
THR A 647
PRO A 649
 None
 0.79A 1a7yA-4byfA:
undetectable		 1a7yA-4byfA:
1.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_B_DVAB2_0
(ACTINOMYCIN D)		 4byf UNCONVENTIONAL
MYOSIN-IC
(Homo
sapiens) 		3 / 3 THR A 647
PRO A 649
THR A 650
 None
 0.64A 1a7yB-4byfA:
undetectable		 1a7yB-4byfA:
1.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_B_DVAB8_0
(ACTINOMYCIN D)		 4byf UNCONVENTIONAL
MYOSIN-IC
(Homo
sapiens) 		3 / 3 THR A 650
THR A 647
PRO A 649
 None
 0.87A 1a7yB-4byfA:
undetectable		 1a7yB-4byfA:
1.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMY_A_AZMA400_1
(MURINE CARBONIC
ANHYDRASE V)		 4byf UNCONVENTIONAL
MYOSIN-IC
(Homo
sapiens) 		5 / 11 TYR A 229
LEU A 209
LEU A 217
THR A 216
TRP A 249
 None
 1.13A 1dmyA-4byfA:
undetectable		 1dmyA-4byfA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSC_C_DVAC2_0
(ACTINOMYCIN D)		 4byf UNCONVENTIONAL
MYOSIN-IC
(Homo
sapiens) 		3 / 3 THR A 647
PRO A 649
THR A 650
 None
 0.56A 1dscC-4byfA:
undetectable		 1dscC-4byfA:
1.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSC_C_DVAC8_0
(ACTINOMYCIN D)		 4byf UNCONVENTIONAL
MYOSIN-IC
(Homo
sapiens) 		3 / 3 THR A 650
THR A 647
PRO A 649
 None
 0.70A 1dscC-4byfA:
undetectable		 1dscC-4byfA:
1.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FJA_C_DVAC8_0
(ACTINOMYCIN D)		 4byf UNCONVENTIONAL
MYOSIN-IC
(Homo
sapiens) 		3 / 3 THR A 650
THR A 647
PRO A 649
 None
 0.62A 1fjaC-4byfA:
undetectable		 1fjaC-4byfA:
1.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FJA_D_DVAD8_0
(ACTINOMYCIN D)		 4byf UNCONVENTIONAL
MYOSIN-IC
(Homo
sapiens) 		3 / 3 THR A 650
THR A 647
PRO A 649
 None
 0.62A 1fjaD-4byfA:
undetectable		 1fjaD-4byfA:
1.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTB_A_PZQA901_0
(GLUTATHIONE
S-TRANSFERASE)		 4byf UNCONVENTIONAL
MYOSIN-IC
(Homo
sapiens) 		3 / 3 GLN A 610
TYR A  55
ARG A  56
 None
AOV  A1001 ( 4.5A)
None
 0.76A 1gtbA-4byfA:
undetectable		 1gtbA-4byfA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_E_DVAE2_0
(ACTINOMYCIN D)		 4byf UNCONVENTIONAL
MYOSIN-IC
(Homo
sapiens) 		3 / 3 THR A 647
PRO A 649
THR A 650
 None
 0.78A 1i3wE-4byfA:
undetectable		 1i3wE-4byfA:
1.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_E_DVAE8_0
(ACTINOMYCIN D)		 4byf UNCONVENTIONAL
MYOSIN-IC
(Homo
sapiens) 		3 / 3 THR A 650
THR A 647
PRO A 649
 None
 0.79A 1i3wE-4byfA:
undetectable		 1i3wE-4byfA:
1.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_F_DVAF8_0
(ACTINOMYCIN D)		 4byf UNCONVENTIONAL
MYOSIN-IC
(Homo
sapiens) 		3 / 3 THR A 650
THR A 647
PRO A 649
 None
 0.73A 1i3wF-4byfA:
undetectable		 1i3wF-4byfA:
1.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_G_DVAG2_0
(ACTINOMYCIN D)		 4byf UNCONVENTIONAL
MYOSIN-IC
(Homo
sapiens) 		3 / 3 THR A 647
PRO A 649
THR A 650
 None
 0.80A 1i3wG-4byfA:
undetectable		 1i3wG-4byfA:
1.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_G_DVAG8_0
(ACTINOMYCIN D)		 4byf UNCONVENTIONAL
MYOSIN-IC
(Homo
sapiens) 		3 / 3 THR A 650
THR A 647
PRO A 649
 None
 0.70A 1i3wG-4byfA:
undetectable		 1i3wG-4byfA:
1.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_H_DVAH8_0
(ACTINOMYCIN D)		 4byf UNCONVENTIONAL
MYOSIN-IC
(Homo
sapiens) 		3 / 3 THR A 650
THR A 647
PRO A 649
 None
 0.71A 1i3wH-4byfA:
undetectable		 1i3wH-4byfA:
1.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MNV_D_DVAD2_0
(ACTINOMYCIN D)		 4byf UNCONVENTIONAL
MYOSIN-IC
(Homo
sapiens) 		3 / 3 THR A 647
PRO A 649
THR A 650
 None
 0.76A 1mnvD-4byfA:
undetectable		 1mnvD-4byfA:
1.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MNV_D_DVAD8_0
(ACTINOMYCIN D)		 4byf UNCONVENTIONAL
MYOSIN-IC
(Homo
sapiens) 		3 / 3 THR A 650
THR A 647
PRO A 649
 None
 0.72A 1mnvD-4byfA:
undetectable		 1mnvD-4byfA:
1.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_D_THAD4_2
(LIVER
CARBOXYLESTERASE I)		 4byf UNCONVENTIONAL
MYOSIN-IC
(Homo
sapiens) 		3 / 3 PHE A 149
LEU A 269
MET A 547
 None
 0.79A 1mx1D-4byfA:
undetectable		 1mx1D-4byfA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OVF_B_DVAB2_0
(ACTINOMYCIN D)		 4byf UNCONVENTIONAL
MYOSIN-IC
(Homo
sapiens) 		3 / 3 THR A 647
PRO A 649
THR A 650
 None
 0.72A 1ovfB-4byfA:
undetectable		 1ovfB-4byfA:
1.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFI_A_DVAA8_0
(ACTINOMYCIN X2)		 4byf UNCONVENTIONAL
MYOSIN-IC
(Homo
sapiens) 		3 / 3 THR A 650
THR A 647
PRO A 649
 None
 0.78A 1qfiA-4byfA:
undetectable		 1qfiA-4byfA:
1.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_F_DVAF8_0
(7-AMINO-ACTINOMYCIN
D)		 4byf UNCONVENTIONAL
MYOSIN-IC
(Homo
sapiens) 		3 / 3 THR A 650
THR A 647
PRO A 649
 None
 0.79A 1unjF-4byfA:
undetectable		 1unjF-4byfA:
1.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_L_DVAL2_0
(7-AMINO-ACTINOMYCIN
D)		 4byf UNCONVENTIONAL
MYOSIN-IC
(Homo
sapiens) 		3 / 3 THR A 647
PRO A 649
THR A 650
 None
 0.74A 1unjL-4byfA:
undetectable		 1unjL-4byfA:
1.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_L_DVAL8_0
(7-AMINO-ACTINOMYCIN
D)		 4byf UNCONVENTIONAL
MYOSIN-IC
(Homo
sapiens) 		3 / 3 THR A 650
THR A 647
PRO A 649
 None
 0.72A 1unjL-4byfA:
undetectable		 1unjL-4byfA:
1.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_R_DVAR2_0
(7-AMINO-ACTINOMYCIN
D)		 4byf UNCONVENTIONAL
MYOSIN-IC
(Homo
sapiens) 		3 / 3 THR A 647
PRO A 649
THR A 650
 None
 0.75A 1unjR-4byfA:
undetectable		 1unjR-4byfA:
1.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_R_DVAR8_0
(7-AMINO-ACTINOMYCIN
D)		 4byf UNCONVENTIONAL
MYOSIN-IC
(Homo
sapiens) 		3 / 3 THR A 650
THR A 647
PRO A 649
 None
 0.71A 1unjR-4byfA:
undetectable		 1unjR-4byfA:
1.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_W_DVAW8_0
(7-AMINO-ACTINOMYCIN
D)		 4byf UNCONVENTIONAL
MYOSIN-IC
(Homo
sapiens) 		3 / 3 THR A 650
THR A 647
PRO A 649
 None
 0.76A 1unjW-4byfA:
undetectable		 1unjW-4byfA:
1.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_X_DVAX2_0
(7-AMINO-ACTINOMYCIN
D)		 4byf UNCONVENTIONAL
MYOSIN-IC
(Homo
sapiens) 		3 / 3 THR A 647
PRO A 649
THR A 650
 None
 0.74A 1unjX-4byfA:
undetectable		 1unjX-4byfA:
1.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_X_DVAX8_0
(7-AMINO-ACTINOMYCIN
D)		 4byf UNCONVENTIONAL
MYOSIN-IC
(Homo
sapiens) 		3 / 3 THR A 650
THR A 647
PRO A 649
 None
 0.74A 1unjX-4byfA:
undetectable		 1unjX-4byfA:
1.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_E_DVAE2_0
(7-AMINOACTINOMYCIN D)		 4byf UNCONVENTIONAL
MYOSIN-IC
(Homo
sapiens) 		3 / 3 THR A 647
PRO A 649
THR A 650
 None
 0.78A 1unmE-4byfA:
undetectable		 1unmE-4byfA:
1.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_E_DVAE8_0
(7-AMINOACTINOMYCIN D)		 4byf UNCONVENTIONAL
MYOSIN-IC
(Homo
sapiens) 		3 / 3 THR A 650
THR A 647
PRO A 649
 None
 0.73A 1unmE-4byfA:
undetectable		 1unmE-4byfA:
1.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_F_DVAF2_0
(7-AMINOACTINOMYCIN D)		 4byf UNCONVENTIONAL
MYOSIN-IC
(Homo
sapiens) 		3 / 3 THR A 647
PRO A 649
THR A 650
 None
 0.68A 1unmF-4byfA:
undetectable		 1unmF-4byfA:
1.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_F_DVAF8_0
(7-AMINOACTINOMYCIN D)		 4byf UNCONVENTIONAL
MYOSIN-IC
(Homo
sapiens) 		3 / 3 THR A 650
THR A 647
PRO A 649
 None
 0.69A 1unmF-4byfA:
undetectable		 1unmF-4byfA:
1.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
209D_C_DVAC8_0
(N8-ACTINOMYCIN D)		 4byf UNCONVENTIONAL
MYOSIN-IC
(Homo
sapiens) 		3 / 3 THR A 650
THR A 647
PRO A 649
 None
 0.71A 209dC-4byfA:
undetectable		 209dC-4byfA:
1.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOI_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 4byf UNCONVENTIONAL
MYOSIN-IC
(Homo
sapiens) 		4 / 5 GLY A 626
PRO A  47
VAL A  48
ILE A  45
 None
 0.95A 2aoiA-4byfA:
undetectable		 2aoiA-4byfA:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2002_1
(SERUM ALBUMIN)		 4byf UNCONVENTIONAL
MYOSIN-IC
(Homo
sapiens) 		5 / 11 ILE A 204
PHE A 355
TYR A 351
ARG A 191
GLY A 150
 None
 1.22A 2bxmA-4byfA:
2.9		 2bxmA-4byfA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2002_1
(SERUM ALBUMIN)		 4byf UNCONVENTIONAL
MYOSIN-IC
(Homo
sapiens) 		5 / 11 LEU A 208
LEU A 358
PHE A 355
TYR A 351
GLY A 150
 None
 1.01A 2bxmA-4byfA:
2.9		 2bxmA-4byfA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 4byf UNCONVENTIONAL
MYOSIN-IC
(Homo
sapiens) 		5 / 12 SER A 160
GLY A 164
GLY A 150
LEU A 186
LEU A 410
 AOV  A1001 (-3.0A)
None
None
None
None
 1.02A 2nyuB-4byfA:
undetectable		 2nyuB-4byfA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_B_NDRB1000_0
(PROGESTERONE
RECEPTOR)		 4byf UNCONVENTIONAL
MYOSIN-IC
(Homo
sapiens) 		5 / 12 LEU A 300
LEU A 303
LEU A 306
MET A 539
LEU A 318
 None
 1.49A 2w8yB-4byfA:
undetectable		 2w8yB-4byfA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
316D_C_DVAC2_0
(8-FLUORO-ACTINOMYCIN
D)		 4byf UNCONVENTIONAL
MYOSIN-IC
(Homo
sapiens) 		3 / 3 THR A 647
PRO A 649
THR A 650
 None
 0.76A 316dC-4byfA:
undetectable		 316dC-4byfA:
1.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE510_2
(PHOSPHOLIPASE A2)		 4byf UNCONVENTIONAL
MYOSIN-IC
(Homo
sapiens) 		4 / 6 VAL A 240
GLN A 207
GLY A 211
LEU A 217
 None
 1.05A 3bjwE-4byfA:
undetectable		 3bjwE-4byfA:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_A_SAMA300_0
(PUTATIVE RRNA
METHYLASE)		 4byf UNCONVENTIONAL
MYOSIN-IC
(Homo
sapiens) 		5 / 12 ASN A 527
ASP A 525
GLY A 505
LEU A 459
THR A 473
 None
 1.12A 3eeyA-4byfA:
undetectable		 3eeyA-4byfA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_B_SAMB300_0
(PUTATIVE RRNA
METHYLASE)		 4byf UNCONVENTIONAL
MYOSIN-IC
(Homo
sapiens) 		5 / 12 ASN A 527
ASP A 525
GLY A 505
LEU A 459
THR A 473
 None
 1.13A 3eeyB-4byfA:
undetectable		 3eeyB-4byfA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_0
(PUTATIVE RRNA
METHYLASE)		 4byf UNCONVENTIONAL
MYOSIN-IC
(Homo
sapiens) 		5 / 12 ASN A 527
ASP A 525
GLY A 505
LEU A 459
THR A 473
 None
 1.14A 3eeyC-4byfA:
undetectable		 3eeyC-4byfA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_0
(PUTATIVE RRNA
METHYLASE)		 4byf UNCONVENTIONAL
MYOSIN-IC
(Homo
sapiens) 		5 / 12 ASN A 527
ASP A 525
GLY A 505
LEU A 459
THR A 473
 None
 1.15A 3eeyD-4byfA:
undetectable		 3eeyD-4byfA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 4byf UNCONVENTIONAL
MYOSIN-IC
(Homo
sapiens) 		5 / 12 CYH A 540
THR A 538
THR A 313
GLU A 310
LEU A 346
 None
 1.25A 3gwxB-4byfA:
undetectable		 3gwxB-4byfA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUV_A_ASDA126_1
(STEROID
DELTA-ISOMERASE)		 4byf UNCONVENTIONAL
MYOSIN-IC
(Homo
sapiens) 		5 / 12 TYR A 231
LEU A 303
VAL A 294
ALA A 340
PHE A 284
 None
 1.43A 3nuvA-4byfA:
undetectable		 3nuvA-4byfA:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R6W_A_NFZA213_1
(FMN-DEPENDENT
NADH-AZOREDUCTASE 1)		 4byf UNCONVENTIONAL
MYOSIN-IC
(Homo
sapiens) 		5 / 10 ASN A 404
GLY A 105
GLU A 106
VAL A 516
TYR A 613
 None
 1.46A 3r6wA-4byfA:
undetectable
3r6wB-4byfA:
undetectable		 3r6wA-4byfA:
15.56
3r6wB-4byfA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFR_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4byf UNCONVENTIONAL
MYOSIN-IC
(Homo
sapiens) 		4 / 6 ARG A 630
VAL A 622
TRP A 433
GLU A 424
 None
 1.47A 3ufrA-4byfA:
undetectable
3ufrB-4byfA:
undetectable		 3ufrA-4byfA:
20.28
3ufrB-4byfA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_A_MIYA392_1
(TETX2 PROTEIN)		 4byf UNCONVENTIONAL
MYOSIN-IC
(Homo
sapiens) 		5 / 9 LEU A 382
TYR A 122
PHE A 121
SER A  73
VAL A  72
 None
 1.49A 4a99A-4byfA:
0.0
4a99C-4byfA:
0.0		 4a99A-4byfA:
20.82
4a99C-4byfA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		 4byf UNCONVENTIONAL
MYOSIN-IC
(Homo
sapiens) 		6 / 12 LEU A 119
GLY A 164
THR A 115
LEU A 384
ASN A 151
GLY A 150
 None
 1.31A 4dc3B-4byfA:
undetectable		 4dc3B-4byfA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		 4byf UNCONVENTIONAL
MYOSIN-IC
(Homo
sapiens) 		3 / 3 PRO A 593
TYR A  55
GLY A 600
 None
AOV  A1001 ( 4.5A)
None
 0.66A 4g2zA-4byfA:
undetectable		 4g2zA-4byfA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HIV_D_DVAD2_0
(ACTINOMYCIN D)		 4byf UNCONVENTIONAL
MYOSIN-IC
(Homo
sapiens) 		3 / 3 THR A 647
PRO A 649
THR A 650
 None
 0.86A 4hivD-4byfA:
undetectable		 4hivD-4byfA:
1.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6T_A_SAMA201_0
(RNA POLYMERASE
II-ASSOCIATED FACTOR
1 HOMOLOG, LINKER,
RNA
POLYMERASE-ASSOCIATE
D PROTEIN LEO1)		 4byf UNCONVENTIONAL
MYOSIN-IC
(Homo
sapiens) 		4 / 4 ILE A  45
VAL A 588
VAL A  48
ARG A 623
 None
 1.26A 4m6tA-4byfA:
undetectable		 4m6tA-4byfA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_C_RTLC201_0
(RETINOL-BINDING
PROTEIN 2)		 4byf UNCONVENTIONAL
MYOSIN-IC
(Homo
sapiens) 		5 / 12 ALA A 339
VAL A 350
LEU A 535
LEU A 303
LEU A 314
 None
 1.17A 4qzuC-4byfA:
undetectable		 4qzuC-4byfA:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R82_A_ACTA205_0
(OXIDOREDUCTASE)		 4byf UNCONVENTIONAL
MYOSIN-IC
(Homo
sapiens) 		4 / 5 SER A 104
GLY A 105
ARG A 589
PHE A 414
 None
 1.27A 4r82A-4byfA:
undetectable
4r82B-4byfA:
undetectable		 4r82A-4byfA:
13.14
4r82B-4byfA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_0
(HYDG PROTEIN)		 4byf UNCONVENTIONAL
MYOSIN-IC
(Homo
sapiens) 		5 / 12 VAL A  88
LEU A  81
LEU A 119
LEU A 139
PHE A 171
 None
 1.42A 4rtbA-4byfA:
undetectable		 4rtbA-4byfA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_A_DIFA1006_1
(SERUM ALBUMIN)		 4byf UNCONVENTIONAL
MYOSIN-IC
(Homo
sapiens) 		4 / 7 ILE A 444
HIS A 487
LEU A 509
GLY A 514
 None
 1.02A 4z69A-4byfA:
2.7		 4z69A-4byfA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZXI_A_GLYA1402_0
(TYROCIDINE
SYNTHETASE 3)		 4byf UNCONVENTIONAL
MYOSIN-IC
(Homo
sapiens) 		4 / 7 ASP A 386
ILE A 387
GLY A 389
THR A 112
 MG  A1000 ( 4.0A)
None
AOV  A1001 (-3.1A)
MG  A1000 ( 2.6A)
 0.92A 4zxiA-4byfA:
undetectable		 4zxiA-4byfA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_F_MFXF2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 4byf UNCONVENTIONAL
MYOSIN-IC
(Homo
sapiens) 		4 / 6 SER A 242
ARG A 156
GLY A 108
GLU A 106
 None
None
AOV  A1001 (-3.0A)
None
 1.02A 5cdqA-4byfA:
2.8
5cdqC-4byfA:
2.8
5cdqD-4byfA:
undetectable		 5cdqA-4byfA:
22.12
5cdqC-4byfA:
22.12
5cdqD-4byfA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4byf UNCONVENTIONAL
MYOSIN-IC
(Homo
sapiens) 		4 / 6 PHE A 121
ALA A 123
MET A  66
LEU A 119
 None
 1.24A 5dzkB-4byfA:
undetectable
5dzkP-4byfA:
undetectable		 5dzkB-4byfA:
15.66
5dzkP-4byfA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_S_BEZS801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4byf UNCONVENTIONAL
MYOSIN-IC
(Homo
sapiens) 		4 / 6 PHE A 121
MET A  66
LEU A 119
LEU A 118
 None
 1.24A 5dzke-4byfA:
undetectable
5dzks-4byfA:
undetectable		 5dzke-4byfA:
15.66
5dzks-4byfA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_T_BEZT801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4byf UNCONVENTIONAL
MYOSIN-IC
(Homo
sapiens) 		4 / 8 PHE A 121
MET A  66
LEU A 119
LEU A 118
 None
 1.10A 5dzkF-4byfA:
undetectable
5dzkT-4byfA:
undetectable		 5dzkF-4byfA:
15.66
5dzkT-4byfA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_U_BEZU801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4byf UNCONVENTIONAL
MYOSIN-IC
(Homo
sapiens) 		4 / 6 PHE A 121
ALA A 123
MET A  66
LEU A 119
 None
 1.26A 5dzkg-4byfA:
undetectable
5dzku-4byfA:
undetectable		 5dzkg-4byfA:
15.66
5dzku-4byfA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSU_B_SAMB1304_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 4byf UNCONVENTIONAL
MYOSIN-IC
(Homo
sapiens) 		3 / 3 ASN A 407
TYR A 512
CYH A 445
 None
 1.08A 5lsuB-4byfA:
undetectable		 5lsuB-4byfA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_A_SAMA301_1
(METHYLTRANSFERASE)		 4byf UNCONVENTIONAL
MYOSIN-IC
(Homo
sapiens) 		4 / 4 SER A 582
THR A 380
ASP A 172
ASP A 168
 None
 1.46A 5vimA-4byfA:
undetectable		 5vimA-4byfA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_A_P2EA1201_0
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)		 4byf UNCONVENTIONAL
MYOSIN-IC
(Homo
sapiens) 		5 / 12 THR A 304
VAL A 309
THR A 538
LEU A 346
SER A 275
 None
 1.40A 6ak3A-4byfA:
undetectable		 6ak3A-4byfA:
9.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FOS_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4byf UNCONVENTIONAL
MYOSIN-IC
(Homo
sapiens) 		4 / 6 MET A 539
ALA A 342
LEU A 318
ALA A 317
 None
 1.12A 6fosB-4byfA:
undetectable		 6fosB-4byfA:
7.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLO_A_GBQA1501_1
(SUBSTANCE-P
RECEPTOR,GLGA
GLYCOGEN
SYNTHASE,SUBSTANCE-P
RECEPTOR)		 4byf UNCONVENTIONAL
MYOSIN-IC
(Homo
sapiens) 		5 / 9 ASN A 528
ILE A 458
ILE A 456
GLU A 476
ILE A 455
 None
 1.11A 6hloA-4byfA:
undetectable		 6hloA-4byfA:
21.03