SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4bz4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_A_SAMA105_0
(MET REPRESSOR)		 4bz4 COPPER-REPRESSIBLE
POLYPEPTIDE
(Methylomicrobium
album) 		5 / 10 ALA A 207
GLY A 209
HIS A 222
LEU A  90
PRO A  92
 None
 1.37A 1cmcA-4bz4A:
undetectable
1cmcB-4bz4A:
undetectable		 1cmcA-4bz4A:
17.75
1cmcB-4bz4A:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_1
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 4bz4 COPPER-REPRESSIBLE
POLYPEPTIDE
(Methylomicrobium
album) 		4 / 5 PRO A 201
ALA A 198
ASP A 158
ASP A 152
 None
None
None
CA  A1233 (-3.2A)
 1.20A 2nyuB-4bz4A:
undetectable		 2nyuB-4bz4A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VH3_B_DAHB2_1
(RANASMURFIN)		 4bz4 COPPER-REPRESSIBLE
POLYPEPTIDE
(Methylomicrobium
album) 		4 / 8 ALA A 216
ALA A 219
GLY A 209
ALA A  49
 KYN  A  62 ( 3.8A)
None
None
None
 0.85A 2vh3B-4bz4A:
undetectable		 2vh3B-4bz4A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_D_BRLD478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4bz4 COPPER-REPRESSIBLE
POLYPEPTIDE
(Methylomicrobium
album) 		4 / 4 ILE A 147
GLN A 193
ILE A 182
LEU A 108
 None
 1.28A 3dzyD-4bz4A:
undetectable		 3dzyD-4bz4A:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4bz4 COPPER-REPRESSIBLE
POLYPEPTIDE
(Methylomicrobium
album) 		4 / 8 ILE A 122
ASP A 121
VAL A 195
GLN A 118
 None
 0.74A 4acaC-4bz4A:
undetectable		 4acaC-4bz4A:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4bz4 COPPER-REPRESSIBLE
POLYPEPTIDE
(Methylomicrobium
album) 		4 / 8 ILE A 122
ASP A 121
VAL A 195
GLN A 118
 None
 0.81A 4acbC-4bz4A:
undetectable		 4acbC-4bz4A:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_A_PAUA602_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 4bz4 COPPER-REPRESSIBLE
POLYPEPTIDE
(Methylomicrobium
album) 		4 / 7 GLY A 217
SER A 210
GLY A 209
ALA A 219
 None
 0.92A 5e26A-4bz4A:
undetectable
5e26B-4bz4A:
undetectable		 5e26A-4bz4A:
18.97
5e26B-4bz4A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_B_PAUB601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 4bz4 COPPER-REPRESSIBLE
POLYPEPTIDE
(Methylomicrobium
album) 		4 / 7 ALA A 219
GLY A 217
SER A 210
GLY A 209
 None
 0.88A 5e26A-4bz4A:
undetectable
5e26B-4bz4A:
undetectable		 5e26A-4bz4A:
18.97
5e26B-4bz4A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HUA_A_FK5A201_1
(FK506-BINDING
PROTEIN 1)		 4bz4 COPPER-REPRESSIBLE
POLYPEPTIDE
(Methylomicrobium
album) 		5 / 11 TYR A 116
VAL A 196
ILE A  94
PHE A 151
LEU A 169
 KYN  A  62 ( 4.4A)
None
None
None
None
 1.47A 5huaA-4bz4A:
undetectable		 5huaA-4bz4A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGK_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4bz4 COPPER-REPRESSIBLE
POLYPEPTIDE
(Methylomicrobium
album) 		3 / 3 VAL A  96
TYR A 192
GLN A 193
 None
 0.73A 5qgkA-4bz4A:
undetectable		 5qgkA-4bz4A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGR_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4bz4 COPPER-REPRESSIBLE
POLYPEPTIDE
(Methylomicrobium
album) 		3 / 3 VAL A  96
TYR A 192
GLN A 193
 None
 0.74A 5qgrA-4bz4A:
undetectable		 5qgrA-4bz4A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGT_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4bz4 COPPER-REPRESSIBLE
POLYPEPTIDE
(Methylomicrobium
album) 		3 / 3 VAL A  96
TYR A 192
GLN A 193
 None
 0.76A 5qgtA-4bz4A:
undetectable		 5qgtA-4bz4A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X2T_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 4bz4 COPPER-REPRESSIBLE
POLYPEPTIDE
(Methylomicrobium
album) 		4 / 8 PRO A  92
ALA A 221
THR A 223
THR A  85
 None
 1.03A 5x2tI-4bz4A:
undetectable
5x2tJ-4bz4A:
undetectable
5x2tK-4bz4A:
undetectable
5x2tL-4bz4A:
undetectable		 5x2tI-4bz4A:
18.86
5x2tJ-4bz4A:
22.51
5x2tK-4bz4A:
18.86
5x2tL-4bz4A:
22.51