SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4bzi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA205_1
(CARDIAC TROPONIN C)		 4bzi SEC23P
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 288
ILE A 353
PHE A 375
LEU A 361
LEU A 266
 None
 1.19A 1dtlA-4bziA:
1.5		 1dtlA-4bziA:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4001_1
(SERUM ALBUMIN)		 4bzi SAR1P
(Saccharomyces
cerevisiae) 		4 / 5 ARG B 105
ALA B 109
ASP B  32
GLY B  30
 None
 1.19A 1e7bA-4bziB:
undetectable		 1e7bA-4bziB:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_C_PPFC413_1
(PHOSPHONOACETATE
HYDROLASE)		 4bzi SEC23P
(Saccharomyces
cerevisiae) 		4 / 8 PHE A 608
ASP A 363
HIS A 420
ILE A 612
 None
 0.89A 1ei6C-4bziA:
3.1		 1ei6C-4bziA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ESW_A_ACRA652_1
(AMYLOMALTASE)		 4bzi SEC23P
(Saccharomyces
cerevisiae) 		4 / 6 TYR A 162
GLY A 163
GLY A 292
SER A 132
 None
 0.93A 1eswA-4bziA:
undetectable		 1eswA-4bziA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_A_TESA903_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		 4bzi SEC23P
(Saccharomyces
cerevisiae) 		4 / 6 TYR A 583
VAL A 548
ILE A 549
LEU A 759
 None
 1.32A 1j96A-4bziA:
undetectable		 1j96A-4bziA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLB_A_NVPA999_1
(HIV-1 RT A-CHAIN)		 4bzi SAR1P
(Saccharomyces
cerevisiae) 		4 / 8 LEU B 151
VAL B  98
GLY B 131
LEU B 113
 None
 0.96A 1jlbA-4bziB:
undetectable		 1jlbA-4bziB:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1871_0
(FPRA)		 4bzi SEC23P
(Saccharomyces
cerevisiae) 		4 / 7 PHE A 124
PRO A 152
PHE A 400
SER A 496
 None
 1.15A 1lqtA-4bziA:
2.0		 1lqtA-4bziA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_A_ACTA1428_0
(FPRA)		 4bzi SEC23P
(Saccharomyces
cerevisiae) 		4 / 7 PHE A 124
PRO A 152
PHE A 400
SER A 496
 None
 1.15A 1lquA-4bziA:
1.8		 1lquA-4bziA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S1X_A_NVPA999_1
(REVERSE
TRANSCRIPTASE)		 4bzi SAR1P
(Saccharomyces
cerevisiae) 		4 / 8 LEU B 151
VAL B  98
GLY B 131
LEU B 113
 None
 1.01A 1s1xA-4bziB:
undetectable		 1s1xA-4bziB:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDT_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 4bzi SEC23P
(Saccharomyces
cerevisiae) 		5 / 10 LEU A 140
ILE A 157
GLY A 158
ILE A 160
ILE A 144
 None
 0.87A 1sdtA-4bziA:
undetectable		 1sdtA-4bziA:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDU_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 4bzi SEC23P
(Saccharomyces
cerevisiae) 		5 / 11 LEU A 140
ILE A 157
GLY A 158
ILE A 160
ILE A 144
 None
 0.90A 1sduA-4bziA:
undetectable		 1sduA-4bziA:
9.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDV_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 4bzi SEC23P
(Saccharomyces
cerevisiae) 		5 / 10 LEU A 140
ILE A 157
GLY A 158
ILE A 160
ILE A 144
 None
 0.89A 1sdvA-4bziA:
undetectable		 1sdvA-4bziA:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4bzi SEC23P
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 269
ILE A 160
ILE A 284
LEU A 238
ILE A 144
 None
 0.99A 1xozA-4bziA:
undetectable		 1xozA-4bziA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_A_8MOA501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 4bzi SEC23P
(Saccharomyces
cerevisiae) 		5 / 11 PHE A 706
GLY A 367
ILE A 285
LEU A 387
PHE A 346
 None
 0.96A 1z11A-4bziA:
undetectable		 1z11A-4bziA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_B_8MOB501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 4bzi SEC23P
(Saccharomyces
cerevisiae) 		5 / 11 PHE A 706
GLY A 367
ILE A 285
LEU A 387
PHE A 346
 None
 0.92A 1z11B-4bziA:
undetectable		 1z11B-4bziA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 4bzi SEC23P
(Saccharomyces
cerevisiae) 		4 / 8 VAL A 648
THR A 630
TYR A 665
LEU A 724
 None
 0.93A 1z2bB-4bziA:
undetectable		 1z2bB-4bziA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1434_1
(CHITINASE)		 4bzi SEC23P
(Saccharomyces
cerevisiae) 		3 / 3 TRP A 551
THR A 587
TYR A 583
 None
 1.04A 2a3aA-4bziA:
2.2		 2a3aA-4bziA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_B_TEPB2434_1
(CHITINASE)		 4bzi SEC23P
(Saccharomyces
cerevisiae) 		3 / 3 TRP A 551
THR A 587
TYR A 583
 None
 1.04A 2a3aB-4bziA:
2.4		 2a3aB-4bziA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_A_CFFA1434_1
(CHITINASE)		 4bzi SEC23P
(Saccharomyces
cerevisiae) 		3 / 3 TRP A 551
THR A 587
TYR A 583
 None
 1.06A 2a3bA-4bziA:
2.3		 2a3bA-4bziA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 4bzi SEC23P
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 371
ASP A 604
GLY A 292
ALA A 347
 None
 0.94A 2aohA-4bziA:
undetectable		 2aohA-4bziA:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOX_A_THAA400_1
(HISTAMINE
N-METHYLTRANSFERASE)		 4bzi SEC23P
(Saccharomyces
cerevisiae) 		4 / 8 PHE A 661
PHE A 723
GLN A 594
TYR A 609
 None
 1.48A 2aoxA-4bziA:
undetectable		 2aoxA-4bziA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_1
(POL POLYPROTEIN)		 4bzi SEC23P
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 140
ILE A 157
GLY A 158
ILE A 160
ILE A 144
 None
 0.80A 2avvA-4bziA:
undetectable		 2avvA-4bziA:
9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_A_ACTA1117_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 4bzi SEC23P
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 553
ARG A 554
ARG A 550
 None
 1.01A 2j9dA-4bziA:
undetectable
2j9dC-4bziA:
undetectable		 2j9dA-4bziA:
8.82
2j9dC-4bziA:
8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2L8M_A_CAMA415_0
(CAMPHOR
5-MONOOXYGENASE)		 4bzi SEC23P
(Saccharomyces
cerevisiae) 		5 / 9 TYR A 329
THR A 262
LEU A 286
VAL A 343
VAL A 336
 None
 1.48A 2l8mA-4bziA:
undetectable		 2l8mA-4bziA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA501_1
(CYTOCHROME P450 2C8)		 4bzi SEC23P
(Saccharomyces
cerevisiae) 		5 / 11 GLY A 366
SER A 449
ILE A 284
ALA A 269
VAL A 336
 None
 1.13A 2nnhA-4bziA:
undetectable		 2nnhA-4bziA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4K_A_DR7A301_1
(PROTEASE)		 4bzi SEC23P
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 140
ILE A 157
GLY A 158
ILE A 160
ILE A 144
 None
 0.76A 2o4kA-4bziA:
undetectable		 2o4kA-4bziA:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_B_SNLB2001_1
(MINERALOCORTICOID
RECEPTOR)		 4bzi SEC23P
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 272
LEU A 266
ALA A 265
LEU A 159
PHE A 182
 None
 1.09A 2oaxB-4bziA:
undetectable		 2oaxB-4bziA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_1
(MINERALOCORTICOID
RECEPTOR)		 4bzi SEC23P
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 272
LEU A 266
ALA A 265
LEU A 159
PHE A 182
 None
 1.05A 2oaxD-4bziA:
undetectable		 2oaxD-4bziA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_E_SNLE5001_1
(MINERALOCORTICOID
RECEPTOR)		 4bzi SEC23P
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 272
LEU A 266
ALA A 265
LEU A 159
PHE A 182
 None
 1.09A 2oaxE-4bziA:
undetectable		 2oaxE-4bziA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4bzi SEC23P
SAR1P
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 12 LEU B 122
LEU A 304
ILE B  94
LEU A 308
VAL A 300
 None
 1.03A 2pnjA-4bziB:
4.8		 2pnjA-4bziB:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q72_A_IXXA802_1
(TRANSPORTER)		 4bzi SEC23P
(Saccharomyces
cerevisiae) 		4 / 6 ILE A 379
ARG A 386
ILE A 612
PHE A 608
 None
 1.15A 2q72A-4bziA:
undetectable		 2q72A-4bziA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 4bzi SEC23P
SAR1P
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 8 THR B  54
ASP A 351
LEU B  83
SER A 602
 MG  B1191 ( 3.3A)
None
None
None
 1.06A 2zw9A-4bziB:
undetectable		 2zw9A-4bziB:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZM_A_SAMA401_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 4bzi SEC23P
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 124
GLY A 158
ILE A 285
ASP A 344
LEU A 151
 None
 1.06A 2zzmA-4bziA:
undetectable		 2zzmA-4bziA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
316D_C_DVAC2_0
(8-FLUORO-ACTINOMYCIN
D)		 4bzi SEC23P
(Saccharomyces
cerevisiae) 		3 / 3 THR A 628
PRO A 627
THR A 658
 None
 0.91A 316dC-4bziA:
undetectable		 316dC-4bziA:
3.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		 4bzi SAR1P
(Saccharomyces
cerevisiae) 		3 / 3 LEU B 122
VAL B 128
ARG B 164
 None
 0.89A 3b0wB-4bziB:
undetectable		 3b0wB-4bziB:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_A_SVRA508_1
(PHOSPHOLIPASE A2)		 4bzi SEC23P
(Saccharomyces
cerevisiae) 		4 / 5 VAL A 300
GLN A 320
PHE A 328
ARG A 257
 None
 1.18A 3bjwE-4bziA:
undetectable		 3bjwE-4bziA:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_2
(PHOSPHOLIPASE A2)		 4bzi SEC23P
(Saccharomyces
cerevisiae) 		4 / 5 ILE A 462
SER A  21
PRO A  20
PRO A 513
 None
 1.11A 3bjwC-4bziA:
undetectable		 3bjwC-4bziA:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_A_BEZA302_0
(DISULFIDE
INTERCHANGE PROTEIN)		 4bzi SEC23P
SAR1P
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 6 HIS B  56
LEU A 371
ALA A 607
PRO A 603
 None
 1.20A 3gv1A-4bziB:
undetectable
3gv1C-4bziB:
undetectable		 3gv1A-4bziB:
21.46
3gv1C-4bziB:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB301_0
(DISULFIDE
INTERCHANGE PROTEIN)		 4bzi SEC23P
SAR1P
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 6 LEU A 371
ALA A 607
PRO A 603
HIS B  56
 None
 1.19A 3gv1A-4bziA:
undetectable
3gv1B-4bziA:
undetectable		 3gv1A-4bziA:
11.56
3gv1B-4bziA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_2
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 4bzi SEC23P
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 386
THR A 362
THR A 372
 None
 0.61A 3k2hB-4bziA:
undetectable		 3k2hB-4bziA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA802_0
(GLUTAMATE RECEPTOR 2)		 4bzi SEC23P
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 170
ASN A 180
SER A 173
 None
 0.80A 3lslA-4bziA:
undetectable
3lslD-4bziA:
undetectable		 3lslA-4bziA:
16.80
3lslD-4bziA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID802_0
(GLUTAMATE RECEPTOR 2)		 4bzi SEC23P
(Saccharomyces
cerevisiae) 		3 / 3 SER A 173
ASP A 170
ASN A 180
 None
 0.76A 3lslA-4bziA:
undetectable
3lslD-4bziA:
undetectable		 3lslA-4bziA:
16.80
3lslD-4bziA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_D_AICD374_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 4bzi SEC23P
(Saccharomyces
cerevisiae) 		5 / 11 LEU A 197
LEU A 224
GLY A 275
ARG A 186
ASN A 267
 None
 1.11A 3ndvC-4bziA:
undetectable
3ndvD-4bziA:
undetectable		 3ndvC-4bziA:
18.97
3ndvD-4bziA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK2_X_LDPX433_1
(6-HYDROXY-L-NICOTINE
OXIDASE)		 4bzi SEC23P
(Saccharomyces
cerevisiae) 		4 / 7 MET A 756
LEU A 752
LEU A 556
PHE A 574
 None
 1.32A 3nk2X-4bziA:
undetectable		 3nk2X-4bziA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R94_A_FLRA332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 4bzi SEC23P
(Saccharomyces
cerevisiae) 		5 / 12 SER A  28
ASN A  29
TYR A 563
PHE A 514
PRO A  20
 None
 1.16A 3r94A-4bziA:
undetectable		 3r94A-4bziA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3V_A_TOPA193_1
(DIHYDROFOLATE
REDUCTASE)		 4bzi SAR1P
(Saccharomyces
cerevisiae) 		4 / 5 ASP B  73
LEU B  74
ILE B  94
PHE B  96
 MG  B1191 ( 4.2A)
None
None
None
 1.16A 3s3vA-4bziB:
undetectable		 3s3vA-4bziB:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T01_A_PPFA503_1
(PHOSPHONOACETATE
HYDROLASE)		 4bzi SEC23P
(Saccharomyces
cerevisiae) 		5 / 7 PHE A 608
ASP A 363
HIS A 420
ILE A 612
HIS A 611
 None
 1.38A 3t01A-4bziA:
undetectable		 3t01A-4bziA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4bzi SEC23P
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 241
LEU A 245
LEU A 137
SER A 132
THR A 131
 None
 1.17A 4f4dB-4bziA:
3.2		 4f4dB-4bziA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVC_B_HFGB1602_0
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 4bzi SEC23P
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 140
PHE A 126
VAL A 128
PHE A 388
GLY A 367
 None
 1.18A 4hvcB-4bziA:
2.2		 4hvcB-4bziA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4bzi SAR1P
(Saccharomyces
cerevisiae) 		4 / 5 ASP B  99
ASN B 132
ILE B 134
VAL B 174
 None
GNP  B1190 (-3.6A)
None
GNP  B1190 (-3.9A)
 1.39A 4hytA-4bziB:
2.5		 4hytA-4bziB:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QC6_B_KANB201_2
(BIFUNCTIONAL AAC/APH)		 4bzi SAR1P
(Saccharomyces
cerevisiae) 		3 / 3 LEU B  83
ASP B  86
TYR B  87
 None
 0.65A 4qc6B-4bziB:
undetectable		 4qc6B-4bziB:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_B_ACTB201_0
(RETINOL-BINDING
PROTEIN 2)		 4bzi SEC23P
(Saccharomyces
cerevisiae) 		4 / 5 TYR A  37
TYR A 493
GLU A 111
LEU A  40
 None
 1.15A 4qztB-4bziA:
undetectable		 4qztB-4bziA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4bzi SEC23P
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 192
ARG A 335
ALA A 269
ILE A 268
LEU A 224
 None
 0.99A 4r3aA-4bziA:
undetectable		 4r3aA-4bziA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA503_1
(PENTALENIC ACID
SYNTHASE)		 4bzi SEC23P
(Saccharomyces
cerevisiae) 		4 / 7 THR A 487
ALA A 485
LEU A 511
LEU A 512
 None
 0.83A 4ubsA-4bziA:
undetectable		 4ubsA-4bziA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJE_A_TOYA202_1
(AADB)		 4bzi SEC23P
(Saccharomyces
cerevisiae) 		4 / 8 ASP A 363
GLU A 357
ILE A 299
ASP A 604
 None
 0.62A 4xjeA-4bziA:
undetectable		 4xjeA-4bziA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XMF_A_HSMA202_1
(NITROPHORIN-7)		 4bzi SAR1P
(Saccharomyces
cerevisiae) 		3 / 3 ASP B 114
LEU B 151
GLY B 150
 None
 0.56A 4xmfA-4bziB:
undetectable		 4xmfA-4bziB:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 4bzi SEC23P
(Saccharomyces
cerevisiae) 		4 / 6 GLY A 292
GLY A 290
SER A 602
ARG A 309
 None
 0.90A 4z53A-4bziA:
undetectable
4z53B-4bziA:
undetectable		 4z53A-4bziA:
21.28
4z53B-4bziA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_A_DM2A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4bzi SEC23P
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 416
THR A 442
ASN A 431
ILE A 439
PHE A 489
 None
 1.27A 4zvmA-4bziA:
5.0
4zvmB-4bziA:
5.0		 4zvmA-4bziA:
14.50
4zvmB-4bziA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CFS_A_TOYA203_1
(AAD(2''),GENTAMICIN
2''-NUCLEOTIDYLTRANS
FERASE,GENTAMICIN
RESISTANCE PROTEIN)		 4bzi SEC23P
(Saccharomyces
cerevisiae) 		4 / 8 ASP A 363
GLU A 357
ILE A 299
ASP A 604
 None
 0.64A 5cfsA-4bziA:
2.0		 5cfsA-4bziA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4bzi SEC23P
(Saccharomyces
cerevisiae) 		4 / 8 ALA A 564
PRO A 584
LEU A 559
LEU A 556
 None
 1.09A 5dzkd-4bziA:
undetectable
5dzkr-4bziA:
undetectable		 5dzkd-4bziA:
14.32
5dzkr-4bziA:
1.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4bzi SEC23P
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 186
ILE A 268
PHE A 182
 None
 0.75A 5kirA-4bziA:
1.1		 5kirA-4bziA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4bzi SEC23P
(Saccharomyces
cerevisiae) 		4 / 4 LEU A 193
ARG A 186
ILE A 268
PHE A 182
 None
 0.99A 5kirB-4bziA:
undetectable		 5kirB-4bziA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		 4bzi SEC23P
(Saccharomyces
cerevisiae) 		4 / 7 PRO A 709
PHE A 660
SER A 621
ASN A 620
 None
 1.19A 5l1fC-4bziA:
4.2		 5l1fC-4bziA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)		 4bzi SAR1P
SEC23P
(Saccharomyces
cerevisiae) 		5 / 12 LEU B  83
LEU B  74
GLY B  75
GLY B  76
CYH A 349
 None
None
GNP  B1190 ( 4.0A)
GNP  B1190 (-3.2A)
None
 1.05A 5uc1A-4bziB:
undetectable		 5uc1A-4bziB:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)		 4bzi SAR1P
SEC23P
(Saccharomyces
cerevisiae) 		5 / 12 LEU B  83
LEU B  74
GLY B  75
GLY B  76
CYH A 349
 None
None
GNP  B1190 ( 4.0A)
GNP  B1190 (-3.2A)
None
 1.02A 5uc1B-4bziB:
undetectable		 5uc1B-4bziB:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIH_A_8CVA201_1
(DIHYDROFOLATE
REDUCTASE)		 4bzi SEC23P
(Saccharomyces
cerevisiae) 		4 / 8 ILE A 490
LEU A  65
ILE A 502
THR A 506
 None
 0.80A 5uihA-4bziA:
undetectable		 5uihA-4bziA:
8.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_E_D16E402_1
(THYMIDYLATE SYNTHASE)		 4bzi SEC23P
(Saccharomyces
cerevisiae) 		4 / 6 PHE A 182
ILE A 160
ASP A 248
GLY A 163
 None
 1.00A 5x5qE-4bziA:
undetectable		 5x5qE-4bziA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2O_A_8N6A501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4bzi SEC23P
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 346
SER A 147
LEU A 242
PHE A 287
LEU A 385
 None
 1.49A 5y2oA-4bziA:
undetectable		 5y2oA-4bziA:
7.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0C_D_TA1D502_1
(TUBULIN BETA CHAIN)		 4bzi SEC23P
(Saccharomyces
cerevisiae) 		6 / 12 VAL A 127
LEU A 197
LEU A 272
ALA A 269
LEU A 193
GLY A 184
 None
 1.19A 6b0cD-4bziA:
3.9		 6b0cD-4bziA:
7.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B52_A_OAQA302_0
(SULFOTRANSFERASE)		 4bzi SEC23P
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 268
LEU A 272
MET A 196
LEU A 197
THR A 194
 None
 1.16A 6b52A-4bziA:
undetectable		 6b52A-4bziA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CM4_A_8NUA2001_1
(D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA)		 4bzi SEC23P
(Saccharomyces
cerevisiae) 		4 / 4 ASP A 344
ALA A 399
SER A 451
PHE A 388
 None
 1.35A 6cm4A-4bziA:
0.4		 6cm4A-4bziA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F8C_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 4bzi SEC23P
(Saccharomyces
cerevisiae) 		4 / 6 GLY A 718
THR A 714
ILE A 712
PHE A 661
 None
 0.78A 6f8cA-4bziA:
undetectable		 6f8cA-4bziA:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_1
(-)		 4bzi SEC23P
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 507
THR A 516
VAL A  12
CYH A  35
GLY A  34
 None
 1.37A 6gngB-4bziA:
4.9		 6gngB-4bziA:
22.07