SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4bzk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4bzk PROTEIN TRANSPORT
PROTEIN SEC31
(Saccharomyces
cerevisiae) 		5 / 12 ASP A 446
ALA A 638
SER A 640
SER A 631
LEU A 618
 None
 1.34A 1kiaD-4bzkA:
undetectable		 1kiaD-4bzkA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_A_DVAA6_0
(MINI-GRAMICIDIN A)		 4bzk PROTEIN TRANSPORT
PROTEIN SEC31
(Saccharomyces
cerevisiae) 		3 / 3 ALA A 173
VAL A 175
TRP A 217
 None
 0.76A 1kqeA-4bzkA:
undetectable
1kqeE-4bzkA:
undetectable		 1kqeA-4bzkA:
1.09
1kqeE-4bzkA:
1.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_B_DVAB6_0
(MINI-GRAMICIDIN A)		 4bzk PROTEIN TRANSPORT
PROTEIN SEC31
(Saccharomyces
cerevisiae) 		3 / 3 ALA A 173
VAL A 175
TRP A 217
 None
 0.77A 1kqeB-4bzkA:
undetectable
1kqeD-4bzkA:
undetectable		 1kqeB-4bzkA:
1.09
1kqeD-4bzkA:
1.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_D_DVAD6_0
(MINI-GRAMICIDIN A)		 4bzk PROTEIN TRANSPORT
PROTEIN SEC31
(Saccharomyces
cerevisiae) 		3 / 3 TRP A 217
ALA A 173
VAL A 175
 None
 0.77A 1kqeB-4bzkA:
undetectable
1kqeD-4bzkA:
undetectable		 1kqeB-4bzkA:
1.09
1kqeD-4bzkA:
1.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_E_DVAE6_0
(MINI-GRAMICIDIN A)		 4bzk PROTEIN TRANSPORT
PROTEIN SEC31
(Saccharomyces
cerevisiae) 		3 / 3 TRP A 217
ALA A 173
VAL A 175
 None
 0.77A 1kqeA-4bzkA:
undetectable
1kqeE-4bzkA:
undetectable		 1kqeA-4bzkA:
1.09
1kqeE-4bzkA:
1.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LHV_A_NOGA301_1
(SEX HORMONE-BINDING
GLOBULIN)		 4bzk PROTEIN TRANSPORT
PROTEIN SEC31
(Saccharomyces
cerevisiae) 		4 / 8 SER A 126
THR A 142
ASN A 139
LEU A  86
 None
 1.06A 1lhvA-4bzkA:
undetectable		 1lhvA-4bzkA:
10.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MIC_A_DVAA6_0
(GRAMICIDIN A)		 4bzk PROTEIN TRANSPORT
PROTEIN SEC31
(Saccharomyces
cerevisiae) 		3 / 3 ALA A 173
VAL A 175
TRP A 217
 None
 0.85A 1micA-4bzkA:
undetectable
1micB-4bzkA:
undetectable		 1micA-4bzkA:
1.52
1micB-4bzkA:
1.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_D_AG2D7015_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 4bzk PROTEIN TRANSPORT
PROTEIN SEC31
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 632
ARG A 628
LEU A 450
ASP A 446
 None
 0.77A 1n13D-4bzkA:
undetectable
1n13E-4bzkA:
undetectable		 1n13D-4bzkA:
5.98
1n13E-4bzkA:
3.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S8F_B_BEZB1503_0
(RAS-RELATED PROTEIN
RAB-9A)		 4bzk PROTEIN TRANSPORT
PROTEIN SEC31
(Saccharomyces
cerevisiae) 		4 / 6 VAL A 581
GLU A 586
LEU A 584
ARG A 621
 None
 1.08A 1s8fB-4bzkA:
undetectable		 1s8fB-4bzkA:
8.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_2
(THYROID HORMONE
RECEPTOR BETA-1)		 4bzk PROTEIN TRANSPORT
PROTEIN SEC31
(Saccharomyces
cerevisiae) 		4 / 5 ILE A 576
SER A 567
ARG A 571
LEU A 573
 None
 1.13A 1y0xX-4bzkA:
undetectable		 1y0xX-4bzkA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_1
(CYTOCHROME P450 2C8)		 4bzk PROTEIN TRANSPORT
PROTEIN SEC31
(Saccharomyces
cerevisiae) 		5 / 12 SER A  71
VAL A  24
ALA A  14
THR A  12
VAL A 114
 None
 1.21A 2nniA-4bzkA:
undetectable		 2nniA-4bzkA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q9R_A_BEZA203_0
(PROTEIN OF UNKNOWN
FUNCTION)		 4bzk PROTEIN TRANSPORT
PROTEIN SEC31
(Saccharomyces
cerevisiae) 		5 / 5 LEU A 252
GLY A 255
PRO A 235
ILE A 260
ILE A 237
 None
 1.15A 2q9rA-4bzkA:
undetectable		 2q9rA-4bzkA:
9.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W1B_A_DXCA2034_0
(ACRIFLAVIN
RESISTANCE PROTEIN B)		 4bzk PROTEIN TRANSPORT
PROTEIN SEC31
(Saccharomyces
cerevisiae) 		3 / 3 PHE A 595
SER A 575
LEU A 573
 None
 0.83A 2w1bA-4bzkA:
undetectable		 2w1bA-4bzkA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MJR_D_AC2D601_1
(DEOXYCYTIDINE KINASE)		 4bzk PROTEIN TRANSPORT
PROTEIN SEC31
(Saccharomyces
cerevisiae) 		4 / 8 GLU A 651
GLN A 629
ARG A 680
ASP A 446
 None
 1.16A 3mjrD-4bzkA:
undetectable		 3mjrD-4bzkA:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R75_A_BEZA701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 4bzk PROTEIN TRANSPORT
PROTEIN SEC31
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 260
SER A 276
THR A 281
HIS A 256
THR A 306
 None
 1.48A 3r75A-4bzkA:
undetectable		 3r75A-4bzkA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R75_B_BEZB701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 4bzk PROTEIN TRANSPORT
PROTEIN SEC31
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 260
SER A 276
THR A 281
HIS A 256
THR A 306
 None
 1.49A 3r75B-4bzkA:
undetectable		 3r75B-4bzkA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R76_A_BEZA701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 4bzk PROTEIN TRANSPORT
PROTEIN SEC31
(Saccharomyces
cerevisiae) 		5 / 11 ILE A 260
SER A 276
THR A 281
HIS A 256
THR A 306
 None
 1.45A 3r76A-4bzkA:
undetectable		 3r76A-4bzkA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R76_B_BEZB701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 4bzk PROTEIN TRANSPORT
PROTEIN SEC31
(Saccharomyces
cerevisiae) 		5 / 11 ILE A 260
SER A 276
THR A 281
HIS A 256
THR A 306
 None
 1.48A 3r76B-4bzkA:
undetectable		 3r76B-4bzkA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_0
(GLYCINE
N-METHYLTRANSFERASE)		 4bzk PROTEIN TRANSPORT
PROTEIN SEC31
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 172
HIS A 174
THR A 223
ARG A 243
 None
 1.00A 3thrB-4bzkA:
undetectable		 3thrB-4bzkA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_C_ACTC502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4bzk PROTEIN TRANSPORT
PROTEIN SEC31
(Saccharomyces
cerevisiae) 		3 / 3 PRO A  21
ASP A  18
GLU A 311
 None
 0.76A 3v4tC-4bzkA:
undetectable		 3v4tC-4bzkA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AWU_A_4CHA502_0
(OXIDOREDUCTASE,
FMN-BINDING)		 4bzk PROTEIN TRANSPORT
PROTEIN SEC31
(Saccharomyces
cerevisiae) 		4 / 7 THR A 675
TYR A 667
LEU A 412
PHE A 706
 None
 1.38A 4awuA-4bzkA:
undetectable		 4awuA-4bzkA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7N_A_ZMRA601_2
(NEURAMINIDASE)		 4bzk PROTEIN TRANSPORT
PROTEIN SEC31
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 434
ARG A 680
TRP A 447
 None
 1.45A 4b7nA-4bzkA:
8.4		 4b7nA-4bzkA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_C_ZMRC1470_2
(NEURAMINIDASE)		 4bzk PROTEIN TRANSPORT
PROTEIN SEC31
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 434
ARG A 680
TRP A 447
 None
 1.49A 4cpzC-4bzkA:
9.9		 4cpzC-4bzkA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_F_ZMRF1470_2
(NEURAMINIDASE)		 4bzk PROTEIN TRANSPORT
PROTEIN SEC31
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 434
ARG A 680
TRP A 447
 None
 1.46A 4cpzF-4bzkA:
9.6		 4cpzF-4bzkA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_G_ZMRG1471_2
(NEURAMINIDASE)		 4bzk PROTEIN TRANSPORT
PROTEIN SEC31
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 434
ARG A 680
TRP A 447
 None
 1.40A 4cpzG-4bzkA:
8.9		 4cpzG-4bzkA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJE_B_C2FB302_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4bzk PROTEIN TRANSPORT
PROTEIN SEC31
(Saccharomyces
cerevisiae) 		5 / 12 ASP A 322
ASN A 301
ASP A 279
GLY A 277
SER A 262
 None
 1.40A 4djeB-4bzkA:
undetectable		 4djeB-4bzkA:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJE_B_C2FB302_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4bzk PROTEIN TRANSPORT
PROTEIN SEC31
(Saccharomyces
cerevisiae) 		5 / 12 PHE A  13
ASP A 322
ASP A 279
GLY A 277
SER A 262
 None
 1.39A 4djeB-4bzkA:
undetectable		 4djeB-4bzkA:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_B_ADNB401_1
(APH(2'')-ID)		 4bzk PROTEIN TRANSPORT
PROTEIN SEC31
(Saccharomyces
cerevisiae) 		4 / 8 SER A 178
ILE A 133
LEU A 190
ILE A 135
 None
 0.94A 4dtaB-4bzkA:
undetectable		 4dtaB-4bzkA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4bzk PROTEIN TRANSPORT
PROTEIN SEC31
(Saccharomyces
cerevisiae) 		4 / 5 ILE A  56
LEU A  44
ASP A  18
VAL A 327
 None
 1.03A 4nkxB-4bzkA:
undetectable		 4nkxB-4bzkA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCU_A_SAMA603_0
(CYSTATHIONINE
BETA-SYNTHASE)		 4bzk PROTEIN TRANSPORT
PROTEIN SEC31
(Saccharomyces
cerevisiae) 		4 / 7 ASP A 234
GLN A 210
THR A 229
ILE A 237
 None
 1.05A 4pcuA-4bzkA:
undetectable		 4pcuA-4bzkA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RFQ_A_SAMA401_1
(HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG)		 4bzk PROTEIN TRANSPORT
PROTEIN SEC31
(Saccharomyces
cerevisiae) 		4 / 4 THR A 306
GLY A 277
ASP A 279
SER A 262
 None
 0.97A 4rfqA-4bzkA:
undetectable		 4rfqA-4bzkA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_B_ANWB601_0
(RHODOPSIN KINASE)		 4bzk PROTEIN TRANSPORT
PROTEIN SEC31
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 551
ALA A 543
ILE A 542
LEU A 531
 None
 0.73A 4wboB-4bzkA:
undetectable		 4wboB-4bzkA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESH_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4bzk PROTEIN TRANSPORT
PROTEIN SEC31
(Saccharomyces
cerevisiae) 		5 / 12 ALA A   5
LEU A  47
ILE A  76
GLY A  79
LEU A  42
 None
 1.23A 5eshA-4bzkA:
undetectable		 5eshA-4bzkA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 4bzk PROTEIN TRANSPORT
PROTEIN SEC31
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 740
GLU A 736
LEU A 422
LEU A 718
LEU A 726
 None
 1.11A 5nd7B-4bzkA:
undetectable		 5nd7B-4bzkA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_A_ACTA701_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 4bzk PROTEIN TRANSPORT
PROTEIN SEC31
(Saccharomyces
cerevisiae) 		3 / 3 LYS A 556
LYS A 578
SER A 577
 None
 1.49A 5odiA-4bzkA:
undetectable		 5odiA-4bzkA:
18.13