SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4bzx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_A_SAMA105_0
(PROTEIN (MET
REPRESSOR))		 4bzx BIFUNCTIONAL ENZYME
CYSN/CYSC
(Mycobacterium
tuberculosis) 		4 / 8 GLU A 499
ARG A 502
ARG A 503
LEU A 490
 None
EDO  A1618 (-3.8A)
None
None
 0.83A 1cmaA-4bzxA:
undetectable
1cmaB-4bzxA:
undetectable		 1cmaA-4bzxA:
21.93
1cmaB-4bzxA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_1
(TRANSTHYRETIN)		 4bzx BIFUNCTIONAL ENZYME
CYSN/CYSC
(Mycobacterium
tuberculosis) 		4 / 6 LEU A 501
GLU A 528
ALA A 533
LEU A 504
 ADX  A1613 (-4.3A)
None
None
None
 1.16A 1sn5A-4bzxA:
undetectable		 1sn5A-4bzxA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CIZ_A_ACTA1321_0
(CHLOROPEROXIDASE)		 4bzx BIFUNCTIONAL ENZYME
CYSN/CYSC
(Mycobacterium
tuberculosis) 		4 / 5 LEU A 501
ASN A 500
VAL A 520
ALA A 522
 ADX  A1613 (-4.3A)
ADX  A1613 (-3.5A)
None
ADX  A1613 (-3.6A)
 0.95A 2cizA-4bzxA:
undetectable		 2cizA-4bzxA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_A_AERA602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 4bzx BIFUNCTIONAL ENZYME
CYSN/CYSC
(Mycobacterium
tuberculosis) 		4 / 8 ALA A 460
ASN A 500
GLY A 479
SER A 454
 None
ADX  A1613 (-3.5A)
ADX  A1613 ( 3.7A)
ANP  A1614 (-3.4A)
 0.81A 4r20A-4bzxA:
1.3		 4r20A-4bzxA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4bzx BIFUNCTIONAL ENZYME
CYSN/CYSC
(Mycobacterium
tuberculosis) 		4 / 7 ARG A 530
ARG A 592
ASP A 550
TYR A 583
 CIT  A1623 (-3.9A)
None
EDO  A1615 ( 4.0A)
EDO  A1615 ( 4.9A)
 1.28A 5a06A-4bzxA:
2.4		 5a06A-4bzxA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4bzx BIFUNCTIONAL ENZYME
CYSN/CYSC
(Mycobacterium
tuberculosis) 		4 / 7 ARG A 530
ARG A 592
ASP A 550
TYR A 583
 CIT  A1623 (-3.9A)
None
EDO  A1615 ( 4.0A)
EDO  A1615 ( 4.9A)
 1.29A 5a06B-4bzxA:
undetectable		 5a06B-4bzxA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_C_SORC1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4bzx BIFUNCTIONAL ENZYME
CYSN/CYSC
(Mycobacterium
tuberculosis) 		4 / 7 ARG A 530
ARG A 592
ASP A 550
TYR A 583
 CIT  A1623 (-3.9A)
None
EDO  A1615 ( 4.0A)
EDO  A1615 ( 4.9A)
 1.29A 5a06C-4bzxA:
2.5		 5a06C-4bzxA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4bzx BIFUNCTIONAL ENZYME
CYSN/CYSC
(Mycobacterium
tuberculosis) 		4 / 7 ARG A 530
ARG A 592
ASP A 550
TYR A 583
 CIT  A1623 (-3.9A)
None
EDO  A1615 ( 4.0A)
EDO  A1615 ( 4.9A)
 1.29A 5a06D-4bzxA:
2.2		 5a06D-4bzxA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_E_SORE1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4bzx BIFUNCTIONAL ENZYME
CYSN/CYSC
(Mycobacterium
tuberculosis) 		4 / 7 ARG A 530
ARG A 592
ASP A 550
TYR A 583
 CIT  A1623 (-3.9A)
None
EDO  A1615 ( 4.0A)
EDO  A1615 ( 4.9A)
 1.28A 5a06E-4bzxA:
2.6		 5a06E-4bzxA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_F_SORF1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4bzx BIFUNCTIONAL ENZYME
CYSN/CYSC
(Mycobacterium
tuberculosis) 		4 / 7 ARG A 530
ARG A 592
ASP A 550
TYR A 583
 CIT  A1623 (-3.9A)
None
EDO  A1615 ( 4.0A)
EDO  A1615 ( 4.9A)
 1.28A 5a06F-4bzxA:
2.4		 5a06F-4bzxA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWK_D_EVPD102_1
(DNA TOPOISOMERASE
2-ALPHA)		 4bzx BIFUNCTIONAL ENZYME
CYSN/CYSC
(Mycobacterium
tuberculosis) 		4 / 4 GLY A 563
ASP A 560
ARG A 569
MET A 494
 None
None
None
EDO  A1620 (-4.6A)
 1.33A 5gwkB-4bzxA:
2.6		 5gwkB-4bzxA:
12.47