SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4c00'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JR1_A_MOAA1332_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 4c00 TRANSLOCATION AND
ASSEMBLY MODULE TAMA
(Escherichia
coli) 		5 / 11 ASP A 473
SER A 475
ARG A 477
GLY A 449
THR A 450
 None
None
None
MC3  A 603 (-2.7A)
None
 1.46A 1jr1A-4c00A:
undetectable		 1jr1A-4c00A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JR1_A_MOAA1332_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 4c00 TRANSLOCATION AND
ASSEMBLY MODULE TAMA
(Escherichia
coli) 		5 / 11 ASP A 473
SER A 475
ARG A 477
GLY A 502
THR A 450
 None
None
None
MC3  A 603 ( 3.2A)
None
 1.46A 1jr1A-4c00A:
undetectable		 1jr1A-4c00A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT2_A_SAMA301_1
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)		 4c00 TRANSLOCATION AND
ASSEMBLY MODULE TAMA
(Escherichia
coli) 		3 / 3 THR A 536
GLU A 524
ASP A 528
 MC3  A 603 (-3.2A)
None
None
 0.54A 1nt2A-4c00A:
undetectable		 1nt2A-4c00A:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_A_SAMA301_0
(HEMK PROTEIN)		 4c00 TRANSLOCATION AND
ASSEMBLY MODULE TAMA
(Escherichia
coli) 		5 / 12 PRO A 464
ILE A 484
GLY A 495
VAL A 526
SER A 527
 None
 0.97A 1sg9A-4c00A:
undetectable		 1sg9A-4c00A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_0
(HEMK PROTEIN)		 4c00 TRANSLOCATION AND
ASSEMBLY MODULE TAMA
(Escherichia
coli) 		5 / 12 PRO A 464
ILE A 484
GLY A 495
VAL A 526
SER A 527
 None
 0.96A 1sg9B-4c00A:
undetectable		 1sg9B-4c00A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_C_SAMC303_0
(HEMK PROTEIN)		 4c00 TRANSLOCATION AND
ASSEMBLY MODULE TAMA
(Escherichia
coli) 		5 / 12 PRO A 464
ILE A 484
GLY A 495
VAL A 526
SER A 527
 None
 0.95A 1sg9C-4c00A:
undetectable		 1sg9C-4c00A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN)		 4c00 TRANSLOCATION AND
ASSEMBLY MODULE TAMA
(Escherichia
coli) 		5 / 12 LEU A 499
LEU A 451
ALA A 470
ILE A 484
ILE A 529
 None
MC3  A 603 ( 3.5A)
None
None
None
 1.14A 1tw4A-4c00A:
2.1		 1tw4A-4c00A:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4c00 TRANSLOCATION AND
ASSEMBLY MODULE TAMA
(Escherichia
coli) 		4 / 8 ILE A  79
PHE A  81
ARG A  60
LEU A  43
 None
 0.93A 2eijN-4c00A:
undetectable
2eijW-4c00A:
undetectable		 2eijN-4c00A:
20.17
2eijW-4c00A:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4c00 TRANSLOCATION AND
ASSEMBLY MODULE TAMA
(Escherichia
coli) 		4 / 8 ILE A  79
PHE A  81
ARG A  60
LEU A  43
 None
 0.92A 2eikN-4c00A:
undetectable
2eikW-4c00A:
undetectable		 2eikN-4c00A:
20.17
2eikW-4c00A:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		 4c00 TRANSLOCATION AND
ASSEMBLY MODULE TAMA
(Escherichia
coli) 		4 / 8 LEU A 127
LEU A 113
ASP A 120
ASP A 122
 None
 1.10A 2j2pA-4c00A:
undetectable
2j2pB-4c00A:
undetectable		 2j2pA-4c00A:
19.29
2j2pB-4c00A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_W_CHDW1059_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 4c00 TRANSLOCATION AND
ASSEMBLY MODULE TAMA
(Escherichia
coli) 		4 / 8 ILE A  79
PHE A  81
ARG A  60
LEU A  43
 None
 0.95A 3asnN-4c00A:
undetectable
3asnW-4c00A:
undetectable		 3asnN-4c00A:
20.17
3asnW-4c00A:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHN_A_ACTA108_0
(PROTEIN P-30)		 4c00 TRANSLOCATION AND
ASSEMBLY MODULE TAMA
(Escherichia
coli) 		3 / 3 THR A 348
SER A 370
ARG A 368
 None
None
CL  A 803 (-4.1A)
 0.51A 3phnA-4c00A:
undetectable		 3phnA-4c00A:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_C_SUEC1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 4c00 TRANSLOCATION AND
ASSEMBLY MODULE TAMA
(Escherichia
coli) 		4 / 4 PHE A 429
TYR A 415
LEU A 499
LYS A 498
 None
 1.25A 3sudC-4c00A:
0.0		 3sudC-4c00A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_D_SUED1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 4c00 TRANSLOCATION AND
ASSEMBLY MODULE TAMA
(Escherichia
coli) 		4 / 5 PHE A 429
TYR A 415
LEU A 499
LYS A 498
 None
 1.39A 3sudD-4c00A:
undetectable		 3sudD-4c00A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 4c00 TRANSLOCATION AND
ASSEMBLY MODULE TAMA
(Escherichia
coli) 		4 / 5 PHE A 429
TYR A 415
LEU A 499
LYS A 498
 None
 1.20A 3sueC-4c00A:
undetectable		 3sueC-4c00A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 4c00 TRANSLOCATION AND
ASSEMBLY MODULE TAMA
(Escherichia
coli) 		4 / 5 SER A 522
THR A 536
GLU A 524
ASP A 528
 MC3  A 603 (-2.6A)
MC3  A 603 (-3.2A)
None
None
 1.09A 3tm4A-4c00A:
undetectable		 3tm4A-4c00A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 4c00 TRANSLOCATION AND
ASSEMBLY MODULE TAMA
(Escherichia
coli) 		4 / 5 SER A 522
THR A 536
GLU A 524
ASP A 528
 MC3  A 603 (-2.6A)
MC3  A 603 (-3.2A)
None
None
 1.06A 3tm4B-4c00A:
undetectable		 3tm4B-4c00A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4c00 TRANSLOCATION AND
ASSEMBLY MODULE TAMA
(Escherichia
coli) 		4 / 7 ILE A  79
PHE A  81
ARG A  60
LEU A  43
 None
 0.83A 5b1bN-4c00A:
undetectable
5b1bW-4c00A:
undetectable		 5b1bN-4c00A:
20.17
5b1bW-4c00A:
8.70