SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4c02'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M17_A_AQ4A999_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		7 / 12 ALA A 233
GLU A 248
LEU A 281
THR A 283
GLY A 289
LEU A 343
ASP A 354
 TAK  A1507 (-3.3A)
None
None
TAK  A1507 (-3.6A)
TAK  A1507 (-3.5A)
TAK  A1507 (-4.7A)
TAK  A1507 (-3.5A)
 0.78A 1m17A-4c02A:
26.9		 1m17A-4c02A:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M17_A_AQ4A999_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		7 / 12 ALA A 233
LYS A 235
LEU A 281
THR A 283
GLY A 289
LEU A 343
ASP A 354
 TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
None
TAK  A1507 (-3.6A)
TAK  A1507 (-3.5A)
TAK  A1507 (-4.7A)
TAK  A1507 (-3.5A)
 0.68A 1m17A-4c02A:
26.9		 1m17A-4c02A:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUO_A_ADNA1_1
(AURORA-RELATED
KINASE 1)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		6 / 9 GLY A 215
VAL A 222
ALA A 233
LEU A 263
TYR A 285
LEU A 343
 None
TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
FLC  A1503 ( 4.5A)
TAK  A1507 ( 4.6A)
TAK  A1507 (-4.7A)
 0.88A 1muoA-4c02A:
7.8		 1muoA-4c02A:
26.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFI_B_DVAB8_0
(ACTINOMYCIN X2)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		3 / 3 THR A 466
THR A 468
PRO A 465
 None
 0.87A 1qfiB-4c02A:
undetectable		 1qfiB-4c02A:
3.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_L_DVAL8_0
(7-AMINO-ACTINOMYCIN
D)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		3 / 3 THR A 466
THR A 468
PRO A 465
 None
 0.86A 1unjL-4c02A:
undetectable		 1unjL-4c02A:
3.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_W_DVAW8_0
(7-AMINO-ACTINOMYCIN
D)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		3 / 3 THR A 466
THR A 468
PRO A 465
 None
 0.83A 1unjW-4c02A:
undetectable		 1unjW-4c02A:
3.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_X_DVAX8_0
(7-AMINO-ACTINOMYCIN
D)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		3 / 3 THR A 466
THR A 468
PRO A 465
 None
 0.85A 1unjX-4c02A:
undetectable		 1unjX-4c02A:
3.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_E_DVAE2_0
(7-AMINOACTINOMYCIN D)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		3 / 3 THR A 468
PRO A 465
THR A 466
 None
 0.85A 1unmE-4c02A:
undetectable		 1unmE-4c02A:
3.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_E_DVAE8_0
(7-AMINOACTINOMYCIN D)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		3 / 3 THR A 466
THR A 468
PRO A 465
 None
 0.82A 1unmE-4c02A:
undetectable		 1unmE-4c02A:
3.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_F_DVAF8_0
(7-AMINOACTINOMYCIN D)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		3 / 3 THR A 466
THR A 468
PRO A 465
 None
 0.85A 1unmF-4c02A:
undetectable		 1unmF-4c02A:
3.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		5 / 12 ALA A 233
LEU A 263
THR A 283
LEU A 319
HIS A 334
 TAK  A1507 (-3.3A)
FLC  A1503 ( 4.5A)
TAK  A1507 (-3.6A)
None
None
 0.37A 1uwhA-4c02A:
24.8		 1uwhA-4c02A:
28.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		6 / 12 ALA A 233
LYS A 235
LEU A 263
THR A 283
LEU A 319
HIS A 334
 TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
FLC  A1503 ( 4.5A)
TAK  A1507 (-3.6A)
None
None
 0.58A 1uwhB-4c02A:
24.7		 1uwhB-4c02A:
28.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		6 / 12 VAL A 222
ALA A 233
LEU A 263
THR A 283
LEU A 319
HIS A 334
 TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
FLC  A1503 ( 4.5A)
TAK  A1507 (-3.6A)
None
None
 0.48A 1uwjA-4c02A:
6.9		 1uwjA-4c02A:
27.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		6 / 12 VAL A 222
ALA A 233
LEU A 263
THR A 283
LEU A 319
HIS A 334
 TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
FLC  A1503 ( 4.5A)
TAK  A1507 (-3.6A)
None
None
 0.47A 1uwjB-4c02A:
7.0		 1uwjB-4c02A:
27.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		6 / 12 ALA A 233
THR A 283
GLY A 289
ASP A 293
LEU A 343
ASP A 354
 TAK  A1507 (-3.3A)
TAK  A1507 (-3.6A)
TAK  A1507 (-3.5A)
None
TAK  A1507 (-4.7A)
TAK  A1507 (-3.5A)
 0.73A 1xkkA-4c02A:
19.4		 1xkkA-4c02A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EVA_A_ADNA498_1
(TAK1 KINASE - TAB1
CHIMERA FUSION
PROTEIN)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		7 / 11 GLY A 215
VAL A 222
ALA A 233
TYR A 285
SER A 290
LEU A 343
ASP A 354
 None
TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.6A)
None
TAK  A1507 (-4.7A)
TAK  A1507 (-3.5A)
 0.76A 2evaA-4c02A:
26.1		 2evaA-4c02A:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EVA_A_ADNA498_1
(TAK1 KINASE - TAB1
CHIMERA FUSION
PROTEIN)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		7 / 11 VAL A 214
GLY A 215
VAL A 222
ALA A 233
TYR A 285
SER A 290
LEU A 343
 TAK  A1507 ( 4.3A)
None
TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.6A)
None
TAK  A1507 (-4.7A)
 0.66A 2evaA-4c02A:
26.1		 2evaA-4c02A:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GQG_A_1N1A501_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		7 / 12 ALA A 233
LYS A 235
GLU A 248
THR A 283
GLY A 289
LEU A 343
ALA A 353
 TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
None
TAK  A1507 (-3.6A)
TAK  A1507 (-3.5A)
TAK  A1507 (-4.7A)
TAK  A1507 ( 4.2A)
 0.69A 2gqgA-4c02A:
27.2		 2gqgA-4c02A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITO_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		7 / 12 ALA A 233
LYS A 235
GLU A 248
LEU A 281
GLY A 289
ASP A 293
LEU A 343
 TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
None
None
TAK  A1507 (-3.5A)
None
TAK  A1507 (-4.7A)
 0.92A 2itoA-4c02A:
26.9		 2itoA-4c02A:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITO_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		7 / 12 ALA A 233
LYS A 235
GLU A 248
THR A 283
GLY A 289
ASP A 293
LEU A 343
 TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
None
TAK  A1507 (-3.6A)
TAK  A1507 (-3.5A)
None
TAK  A1507 (-4.7A)
 0.91A 2itoA-4c02A:
26.9		 2itoA-4c02A:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITY_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		9 / 12 GLY A 215
VAL A 222
ALA A 233
LYS A 235
LEU A 281
THR A 283
GLY A 289
LEU A 343
ASP A 354
 None
TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
None
TAK  A1507 (-3.6A)
TAK  A1507 (-3.5A)
TAK  A1507 (-4.7A)
TAK  A1507 (-3.5A)
 0.79A 2ityA-4c02A:
20.8		 2ityA-4c02A:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITZ_A_IREA2021_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		9 / 12 VAL A 222
ALA A 233
LYS A 235
GLU A 248
THR A 283
GLY A 289
ASP A 293
LEU A 343
ASP A 354
 TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
None
TAK  A1507 (-3.6A)
TAK  A1507 (-3.5A)
None
TAK  A1507 (-4.7A)
TAK  A1507 (-3.5A)
 0.92A 2itzA-4c02A:
26.7		 2itzA-4c02A:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q8H_A_TF4A438_1
([PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 1)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		4 / 6 LEU A 257
TYR A 252
ILE A 332
ILE A 262
 None
 0.84A 2q8hA-4c02A:
undetectable		 2q8hA-4c02A:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WGJ_A_VGHA2346_1
(HEPATOCYTE GROWTH
FACTOR RECEPTOR)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		7 / 12 GLY A 215
VAL A 222
ALA A 233
LEU A 263
TYR A 285
GLY A 289
ALA A 353
 None
TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
FLC  A1503 ( 4.5A)
TAK  A1507 ( 4.6A)
TAK  A1507 (-3.5A)
TAK  A1507 ( 4.2A)
 0.77A 2wgjA-4c02A:
24.7		 2wgjA-4c02A:
26.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		3 / 3 TYR A 292
GLU A 413
THR A 378
 None
None
FLC  A1504 ( 3.9A)
 1.04A 2y7hB-4c02A:
undetectable		 2y7hB-4c02A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIA_A_CL9A401_2
(DEOXYCYTIDINE KINASE)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		4 / 4 VAL A 376
ASP A 241
LEU A 281
ARG A 335
 None
 1.18A 2ziaA-4c02A:
undetectable		 2ziaA-4c02A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		6 / 12 VAL A 222
ALA A 233
THR A 283
GLY A 289
LEU A 343
ASP A 354
 TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 (-3.6A)
TAK  A1507 (-3.5A)
TAK  A1507 (-4.7A)
TAK  A1507 (-3.5A)
 0.61A 3bbtB-4c02A:
18.9		 3bbtB-4c02A:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		7 / 12 VAL A 222
ALA A 233
LYS A 235
LEU A 281
GLY A 289
LEU A 343
ASP A 354
 TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
None
TAK  A1507 (-3.5A)
TAK  A1507 (-4.7A)
TAK  A1507 (-3.5A)
 0.84A 3bbtD-4c02A:
19.5		 3bbtD-4c02A:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		7 / 12 VAL A 222
ALA A 233
LYS A 235
THR A 283
GLY A 289
LEU A 343
ASP A 354
 TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
TAK  A1507 (-3.6A)
TAK  A1507 (-3.5A)
TAK  A1507 (-4.7A)
TAK  A1507 (-3.5A)
 0.71A 3bbtD-4c02A:
19.5		 3bbtD-4c02A:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_A_NILA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		6 / 12 ALA A 233
THR A 283
GLY A 289
HIS A 334
LEU A 343
ALA A 353
 TAK  A1507 (-3.3A)
TAK  A1507 (-3.6A)
TAK  A1507 (-3.5A)
None
TAK  A1507 (-4.7A)
TAK  A1507 ( 4.2A)
 0.32A 3cs9A-4c02A:
25.0		 3cs9A-4c02A:
28.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_B_NILB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		5 / 12 ALA A 233
THR A 283
GLY A 289
HIS A 334
ALA A 353
 TAK  A1507 (-3.3A)
TAK  A1507 (-3.6A)
TAK  A1507 (-3.5A)
None
TAK  A1507 ( 4.2A)
 0.33A 3cs9B-4c02A:
25.2		 3cs9B-4c02A:
28.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_D_NILD600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		5 / 12 ALA A 233
THR A 283
GLY A 289
HIS A 334
ALA A 353
 TAK  A1507 (-3.3A)
TAK  A1507 (-3.6A)
TAK  A1507 (-3.5A)
None
TAK  A1507 ( 4.2A)
 0.27A 3cs9D-4c02A:
24.0		 3cs9D-4c02A:
28.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0F_B_B49B9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		6 / 10 VAL A 222
ALA A 233
THR A 283
TYR A 285
GLY A 289
LEU A 343
 TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 (-3.6A)
TAK  A1507 ( 4.6A)
TAK  A1507 (-3.5A)
TAK  A1507 (-4.7A)
 0.82A 3g0fB-4c02A:
24.7		 3g0fB-4c02A:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G5D_A_1N1A1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		7 / 12 VAL A 222
ALA A 233
GLU A 248
THR A 283
TYR A 285
GLY A 289
LEU A 343
 TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
None
TAK  A1507 (-3.6A)
TAK  A1507 ( 4.6A)
TAK  A1507 (-3.5A)
TAK  A1507 (-4.7A)
 0.59A 3g5dA-4c02A:
26.5		 3g5dA-4c02A:
28.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G5D_A_1N1A1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		7 / 12 VAL A 222
ALA A 233
THR A 283
TYR A 285
GLY A 289
LEU A 343
ALA A 353
 TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 (-3.6A)
TAK  A1507 ( 4.6A)
TAK  A1507 (-3.5A)
TAK  A1507 (-4.7A)
TAK  A1507 ( 4.2A)
 0.50A 3g5dA-4c02A:
26.5		 3g5dA-4c02A:
28.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G5D_B_1N1B1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		8 / 12 VAL A 222
ALA A 233
GLU A 248
THR A 283
TYR A 285
GLY A 289
LEU A 343
ALA A 353
 TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
None
TAK  A1507 (-3.6A)
TAK  A1507 ( 4.6A)
TAK  A1507 (-3.5A)
TAK  A1507 (-4.7A)
TAK  A1507 ( 4.2A)
 0.63A 3g5dB-4c02A:
26.4		 3g5dB-4c02A:
28.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G5D_B_1N1B1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		8 / 12 VAL A 222
ALA A 233
LYS A 235
THR A 283
TYR A 285
GLY A 289
LEU A 343
ALA A 353
 TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
TAK  A1507 (-3.6A)
TAK  A1507 ( 4.6A)
TAK  A1507 (-3.5A)
TAK  A1507 (-4.7A)
TAK  A1507 ( 4.2A)
 0.52A 3g5dB-4c02A:
26.4		 3g5dB-4c02A:
28.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEG_A_BAXA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		6 / 12 VAL A 214
VAL A 222
ALA A 233
LYS A 235
GLU A 248
THR A 283
 TAK  A1507 ( 4.3A)
TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
None
TAK  A1507 (-3.6A)
 0.92A 3hegA-4c02A:
16.6		 3hegA-4c02A:
25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K54_A_1N1A1_1
(TYROSINE-PROTEIN
KINASE BTK)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		7 / 12 ALA A 233
LYS A 235
GLU A 248
THR A 283
TYR A 285
GLY A 289
LEU A 343
 TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
None
TAK  A1507 (-3.6A)
TAK  A1507 ( 4.6A)
TAK  A1507 (-3.5A)
TAK  A1507 (-4.7A)
 0.65A 3k54A-4c02A:
25.6		 3k54A-4c02A:
28.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LFA_A_1N1A361_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		4 / 8 VAL A 214
ALA A 233
LYS A 235
THR A 283
 TAK  A1507 ( 4.3A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
TAK  A1507 (-3.6A)
 0.43A 3lfaA-4c02A:
18.8		 3lfaA-4c02A:
26.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OCT_A_1N1A663_1
(TYROSINE-PROTEIN
KINASE BTK)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		7 / 12 VAL A 222
ALA A 233
LYS A 235
THR A 283
TYR A 285
GLY A 289
LEU A 343
 TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
TAK  A1507 (-3.6A)
TAK  A1507 ( 4.6A)
TAK  A1507 (-3.5A)
TAK  A1507 (-4.7A)
 0.54A 3octA-4c02A:
25.4		 3octA-4c02A:
27.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OEZ_A_STIA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		6 / 12 ALA A 233
THR A 283
TYR A 285
GLY A 289
LEU A 343
ALA A 353
 TAK  A1507 (-3.3A)
TAK  A1507 (-3.6A)
TAK  A1507 ( 4.6A)
TAK  A1507 (-3.5A)
TAK  A1507 (-4.7A)
TAK  A1507 ( 4.2A)
 0.45A 3oezA-4c02A:
24.4		 3oezA-4c02A:
28.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OEZ_B_STIB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		7 / 12 VAL A 222
ALA A 233
LYS A 235
THR A 283
TYR A 285
LEU A 343
ALA A 353
 TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
TAK  A1507 (-3.6A)
TAK  A1507 ( 4.6A)
TAK  A1507 (-4.7A)
TAK  A1507 ( 4.2A)
 0.62A 3oezB-4c02A:
24.8		 3oezB-4c02A:
28.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OG7_A_032A1_1
(AKAP9-BRAF FUSION
PROTEIN)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		5 / 12 VAL A 222
ALA A 233
LYS A 235
LEU A 263
GLY A 356
 TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
FLC  A1503 ( 4.5A)
None
 0.73A 3og7A-4c02A:
25.0		 3og7A-4c02A:
28.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OG7_A_032A1_1
(AKAP9-BRAF FUSION
PROTEIN)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		5 / 12 VAL A 222
ALA A 233
LYS A 235
LEU A 263
THR A 283
 TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
FLC  A1503 ( 4.5A)
TAK  A1507 (-3.6A)
 0.32A 3og7A-4c02A:
25.0		 3og7A-4c02A:
28.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_1
(P38A)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		7 / 12 VAL A 214
GLY A 215
VAL A 222
ALA A 233
LYS A 235
THR A 283
LEU A 343
 TAK  A1507 ( 4.3A)
None
TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
TAK  A1507 (-3.6A)
TAK  A1507 (-4.7A)
 0.85A 3ohtA-4c02A:
4.5		 3ohtA-4c02A:
26.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_1
(P38A)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		6 / 12 VAL A 214
VAL A 222
ALA A 233
LYS A 235
THR A 283
ASP A 354
 TAK  A1507 ( 4.3A)
TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
TAK  A1507 (-3.6A)
TAK  A1507 (-3.5A)
 0.83A 3ohtA-4c02A:
4.5		 3ohtA-4c02A:
26.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_1
(P38A)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		6 / 12 GLY A 215
VAL A 222
ALA A 233
LYS A 235
THR A 283
LEU A 343
 None
TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
TAK  A1507 (-3.6A)
TAK  A1507 (-4.7A)
 0.84A 3ohtB-4c02A:
4.5		 3ohtB-4c02A:
26.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QLG_A_1N1A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		8 / 12 VAL A 222
ALA A 233
GLU A 248
THR A 283
TYR A 285
GLY A 289
LEU A 343
ALA A 353
 TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
None
TAK  A1507 (-3.6A)
TAK  A1507 ( 4.6A)
TAK  A1507 (-3.5A)
TAK  A1507 (-4.7A)
TAK  A1507 ( 4.2A)
 0.71A 3qlgA-4c02A:
25.5		 3qlgA-4c02A:
28.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QLG_A_1N1A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		8 / 12 VAL A 222
ALA A 233
LYS A 235
GLU A 248
THR A 283
TYR A 285
GLY A 289
LEU A 343
 TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
None
TAK  A1507 (-3.6A)
TAK  A1507 ( 4.6A)
TAK  A1507 (-3.5A)
TAK  A1507 (-4.7A)
 0.67A 3qlgA-4c02A:
25.5		 3qlgA-4c02A:
28.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QLG_B_1N1B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		9 / 12 VAL A 222
ALA A 233
GLU A 248
THR A 283
TYR A 285
GLY A 289
LEU A 343
ALA A 353
ASP A 354
 TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
None
TAK  A1507 (-3.6A)
TAK  A1507 ( 4.6A)
TAK  A1507 (-3.5A)
TAK  A1507 (-4.7A)
TAK  A1507 ( 4.2A)
TAK  A1507 (-3.5A)
 0.71A 3qlgB-4c02A:
26.5		 3qlgB-4c02A:
28.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UZZ_A_TESA501_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		4 / 7 TYR A 427
TYR A 292
TYR A 381
MET A 444
 None
 1.19A 3uzzA-4c02A:
0.0		 3uzzA-4c02A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_1
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		6 / 12 GLY A 220
VAL A 222
ALA A 233
LYS A 235
LEU A 343
ASP A 354
 None
TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
TAK  A1507 (-4.7A)
TAK  A1507 (-3.5A)
 0.79A 3v5wA-4c02A:
7.5		 3v5wA-4c02A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		7 / 12 ALA A 233
LYS A 235
THR A 283
LEU A 319
HIS A 334
LEU A 343
ALA A 353
 TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
TAK  A1507 (-3.6A)
None
None
TAK  A1507 (-4.7A)
TAK  A1507 ( 4.2A)
 0.76A 3zosA-4c02A:
23.7		 3zosA-4c02A:
28.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_B_0LIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		7 / 12 ALA A 233
LYS A 235
THR A 283
LEU A 319
HIS A 334
LEU A 343
ALA A 353
 TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
TAK  A1507 (-3.6A)
None
None
TAK  A1507 (-4.7A)
TAK  A1507 ( 4.2A)
 0.78A 3zosB-4c02A:
23.9		 3zosB-4c02A:
28.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		6 / 12 LEU A 281
ASP A 336
LYS A 338
ASN A 341
ASP A 354
GLY A 356
 None
None
FLC  A1504 (-2.8A)
None
TAK  A1507 (-3.5A)
None
 1.33A 4an2A-4c02A:
22.5		 4an2A-4c02A:
26.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		5 / 12 LYS A 235
ASP A 336
LYS A 338
ASN A 341
ASP A 354
 TAK  A1507 ( 4.5A)
None
FLC  A1504 (-2.8A)
None
TAK  A1507 (-3.5A)
 0.65A 4an2A-4c02A:
22.5		 4an2A-4c02A:
26.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		7 / 12 ALA A 233
LYS A 235
LEU A 263
THR A 283
HIS A 334
LEU A 343
ALA A 353
 TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
FLC  A1503 ( 4.5A)
TAK  A1507 (-3.6A)
None
TAK  A1507 (-4.7A)
TAK  A1507 ( 4.2A)
 0.52A 4c8bA-4c02A:
24.2		 4c8bA-4c02A:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		4 / 5 VAL A 222
ILE A 262
TYR A 285
ILE A 352
 TAK  A1507 (-4.7A)
None
TAK  A1507 ( 4.6A)
None
 0.76A 4c8bA-4c02A:
24.2		 4c8bA-4c02A:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		8 / 12 ALA A 233
LYS A 235
ILE A 262
LEU A 263
THR A 283
HIS A 334
LEU A 343
ALA A 353
 TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
None
FLC  A1503 ( 4.5A)
TAK  A1507 (-3.6A)
None
TAK  A1507 (-4.7A)
TAK  A1507 ( 4.2A)
 0.69A 4c8bB-4c02A:
24.2		 4c8bB-4c02A:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CKJ_A_ADNA2014_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		6 / 10 GLY A 215
GLY A 217
VAL A 222
ALA A 233
SER A 290
LEU A 343
 None
None
TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
None
TAK  A1507 (-4.7A)
 0.40A 4ckjA-4c02A:
28.4		 4ckjA-4c02A:
25.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HJO_A_AQ4A1001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		7 / 12 VAL A 222
ALA A 233
LYS A 235
THR A 283
GLY A 289
LEU A 343
ASP A 354
 TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
TAK  A1507 (-3.6A)
TAK  A1507 (-3.5A)
TAK  A1507 (-4.7A)
TAK  A1507 (-3.5A)
 0.69A 4hjoA-4c02A:
25.2		 4hjoA-4c02A:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I22_A_IREA9001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		8 / 12 GLY A 215
VAL A 222
ALA A 233
LYS A 235
LEU A 281
ASP A 293
LEU A 343
ASP A 354
 None
TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
None
None
TAK  A1507 (-4.7A)
TAK  A1507 (-3.5A)
 0.78A 4i22A-4c02A:
24.7		 4i22A-4c02A:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I22_A_IREA9001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		8 / 12 GLY A 215
VAL A 222
ALA A 233
LYS A 235
LEU A 281
GLY A 289
ASP A 293
LEU A 343
 None
TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
None
TAK  A1507 (-3.5A)
None
TAK  A1507 (-4.7A)
 0.71A 4i22A-4c02A:
24.7		 4i22A-4c02A:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXO_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		9 / 12 VAL A 222
ALA A 233
LYS A 235
GLU A 248
THR A 283
TYR A 285
GLY A 289
LEU A 343
ASP A 354
 TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
None
TAK  A1507 (-3.6A)
TAK  A1507 ( 4.6A)
TAK  A1507 (-3.5A)
TAK  A1507 (-4.7A)
TAK  A1507 (-3.5A)
 0.99A 4mxoB-4c02A:
26.3		 4mxoB-4c02A:
28.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXX_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		7 / 12 ALA A 233
LYS A 235
GLU A 248
THR A 283
TYR A 285
GLY A 289
LEU A 343
 TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
None
TAK  A1507 (-3.6A)
TAK  A1507 ( 4.6A)
TAK  A1507 (-3.5A)
TAK  A1507 (-4.7A)
 0.57A 4mxxA-4c02A:
26.4		 4mxxA-4c02A:
27.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXX_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		7 / 12 VAL A 222
ALA A 233
LYS A 235
THR A 283
TYR A 285
GLY A 289
LEU A 343
 TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
TAK  A1507 (-3.6A)
TAK  A1507 ( 4.6A)
TAK  A1507 (-3.5A)
TAK  A1507 (-4.7A)
 0.54A 4mxxB-4c02A:
24.7		 4mxxB-4c02A:
27.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0S_A_ADNA500_1
(AURORA KINASE A)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		8 / 11 GLY A 215
VAL A 222
ALA A 233
LYS A 235
LEU A 263
ASN A 341
LEU A 343
ASP A 354
 None
TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
FLC  A1503 ( 4.5A)
None
TAK  A1507 (-4.7A)
TAK  A1507 (-3.5A)
 0.67A 4o0sA-4c02A:
24.9		 4o0sA-4c02A:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0U_A_ADNA501_1
(AURORA KINASE A)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		4 / 6 ALA A 233
LYS A 235
LEU A 263
LEU A 343
 TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
FLC  A1503 ( 4.5A)
TAK  A1507 (-4.7A)
 0.79A 4o0uA-4c02A:
8.0		 4o0uA-4c02A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0U_A_ADNA501_1
(AURORA KINASE A)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		4 / 6 VAL A 222
ALA A 233
LEU A 263
LEU A 343
 TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
FLC  A1503 ( 4.5A)
TAK  A1507 (-4.7A)
 0.42A 4o0uA-4c02A:
8.0		 4o0uA-4c02A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		7 / 12 VAL A 222
LYS A 235
THR A 283
TYR A 285
GLY A 289
LEU A 343
ALA A 353
 TAK  A1507 (-4.7A)
TAK  A1507 ( 4.5A)
TAK  A1507 (-3.6A)
TAK  A1507 ( 4.6A)
TAK  A1507 (-3.5A)
TAK  A1507 (-4.7A)
TAK  A1507 ( 4.2A)
 0.61A 4otwA-4c02A:
19.2		 4otwA-4c02A:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PBH_A_BEZA401_0
(TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT, PUTATIVE)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		5 / 12 ILE A 498
THR A 494
ALA A 313
LEU A 470
LEU A 411
 None
 1.47A 4pbhA-4c02A:
undetectable		 4pbhA-4c02A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		5 / 12 ALA A 233
LYS A 235
LEU A 263
THR A 283
SER A 290
 TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
FLC  A1503 ( 4.5A)
TAK  A1507 (-3.6A)
None
 0.74A 4rzvA-4c02A:
7.3		 4rzvA-4c02A:
29.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		6 / 12 VAL A 222
ALA A 233
LYS A 235
LEU A 263
THR A 283
SER A 290
 TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
FLC  A1503 ( 4.5A)
TAK  A1507 (-3.6A)
None
 0.70A 4rzvB-4c02A:
24.6		 4rzvB-4c02A:
29.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U5J_A_RXTA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		8 / 11 GLY A 217
VAL A 222
ALA A 233
TYR A 285
GLY A 289
ASN A 341
LEU A 343
ALA A 353
 None
TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.6A)
TAK  A1507 (-3.5A)
None
TAK  A1507 (-4.7A)
TAK  A1507 ( 4.2A)
 0.69A 4u5jA-4c02A:
27.6		 4u5jA-4c02A:
28.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UXQ_A_0LIA1752_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		5 / 12 ALA A 233
LEU A 319
HIS A 334
LEU A 343
ALA A 353
 TAK  A1507 (-3.3A)
None
None
TAK  A1507 (-4.7A)
TAK  A1507 ( 4.2A)
 0.33A 4uxqA-4c02A:
25.5		 4uxqA-4c02A:
28.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_B_0LIB1770_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		6 / 9 VAL A 222
LYS A 235
TYR A 285
ARG A 335
LEU A 343
ILE A 352
 TAK  A1507 (-4.7A)
TAK  A1507 ( 4.5A)
TAK  A1507 ( 4.6A)
None
TAK  A1507 (-4.7A)
None
 1.01A 4v01B-4c02A:
24.8		 4v01B-4c02A:
26.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		6 / 11 ALA A 233
THR A 283
GLY A 289
ASN A 341
LEU A 343
ALA A 353
 TAK  A1507 (-3.3A)
TAK  A1507 (-3.6A)
TAK  A1507 (-3.5A)
None
TAK  A1507 (-4.7A)
TAK  A1507 ( 4.2A)
 0.39A 4wa9A-4c02A:
24.0		 4wa9A-4c02A:
27.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		7 / 12 VAL A 222
ALA A 233
THR A 283
GLY A 289
ASN A 341
LEU A 343
ALA A 353
 TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 (-3.6A)
TAK  A1507 (-3.5A)
None
TAK  A1507 (-4.7A)
TAK  A1507 ( 4.2A)
 0.74A 4wa9B-4c02A:
26.0		 4wa9B-4c02A:
27.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WAN_C_ACTC303_0
(BRANCHPOINT-BRIDGING
PROTEIN)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		3 / 3 ASP A 397
ARG A 485
PRO A 482
 EDO  A1509 (-3.7A)
None
EDO  A1509 (-4.0A)
 0.98A 4wanC-4c02A:
undetectable		 4wanC-4c02A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_A_1N1A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		7 / 12 VAL A 222
ALA A 233
LYS A 235
THR A 283
GLY A 289
LEU A 343
ALA A 353
 TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
TAK  A1507 (-3.6A)
TAK  A1507 (-3.5A)
TAK  A1507 (-4.7A)
TAK  A1507 ( 4.2A)
 0.55A 4xeyA-4c02A:
26.7		 4xeyA-4c02A:
25.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_B_1N1B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		7 / 12 VAL A 222
ALA A 233
LYS A 235
THR A 283
GLY A 289
LEU A 343
ALA A 353
 TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
TAK  A1507 (-3.6A)
TAK  A1507 (-3.5A)
TAK  A1507 (-4.7A)
TAK  A1507 ( 4.2A)
 0.54A 4xeyB-4c02A:
26.5		 4xeyB-4c02A:
25.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XLI_A_1N1A601_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		7 / 12 ALA A 233
GLU A 248
THR A 283
TYR A 285
GLY A 289
LEU A 343
ALA A 353
 TAK  A1507 (-3.3A)
None
TAK  A1507 (-3.6A)
TAK  A1507 ( 4.6A)
TAK  A1507 (-3.5A)
TAK  A1507 (-4.7A)
TAK  A1507 ( 4.2A)
 0.64A 4xliA-4c02A:
27.6		 4xliA-4c02A:
27.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XLI_B_1N1B600_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		7 / 12 ALA A 233
GLU A 248
THR A 283
TYR A 285
GLY A 289
LEU A 343
ALA A 353
 TAK  A1507 (-3.3A)
None
TAK  A1507 (-3.6A)
TAK  A1507 ( 4.6A)
TAK  A1507 (-3.5A)
TAK  A1507 (-4.7A)
TAK  A1507 ( 4.2A)
 0.59A 4xliB-4c02A:
27.4		 4xliB-4c02A:
27.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XLI_B_1N1B600_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		7 / 12 ALA A 233
LYS A 235
THR A 283
TYR A 285
GLY A 289
LEU A 343
ALA A 353
 TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
TAK  A1507 (-3.6A)
TAK  A1507 ( 4.6A)
TAK  A1507 (-3.5A)
TAK  A1507 (-4.7A)
TAK  A1507 ( 4.2A)
 0.62A 4xliB-4c02A:
27.4		 4xliB-4c02A:
27.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		5 / 12 VAL A 222
ALA A 233
LYS A 235
LEU A 263
THR A 283
 TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
FLC  A1503 ( 4.5A)
TAK  A1507 (-3.6A)
 0.41A 4xv2A-4c02A:
24.3		 4xv2A-4c02A:
28.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BVW_A_1N1A1009_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		8 / 12 VAL A 222
ALA A 233
LYS A 235
THR A 283
TYR A 285
GLY A 289
LEU A 343
ALA A 353
 TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
TAK  A1507 (-3.6A)
TAK  A1507 ( 4.6A)
TAK  A1507 (-3.5A)
TAK  A1507 (-4.7A)
TAK  A1507 ( 4.2A)
 0.72A 5bvwA-4c02A:
24.2		 5bvwA-4c02A:
27.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		5 / 12 PHE A 237
VAL A 222
ALA A 233
LEU A 263
THR A 283
 None
TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
FLC  A1503 ( 4.5A)
TAK  A1507 (-3.6A)
 0.85A 5cswA-4c02A:
24.3		 5cswA-4c02A:
29.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		5 / 12 VAL A 222
ALA A 233
LYS A 235
LEU A 263
THR A 283
 TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
FLC  A1503 ( 4.5A)
TAK  A1507 (-3.6A)
 0.41A 5cswA-4c02A:
24.3		 5cswA-4c02A:
29.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		5 / 12 PHE A 237
VAL A 222
ALA A 233
LEU A 263
THR A 283
 None
TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
FLC  A1503 ( 4.5A)
TAK  A1507 (-3.6A)
 0.84A 5cswB-4c02A:
24.3		 5cswB-4c02A:
29.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		5 / 12 VAL A 222
ALA A 233
LYS A 235
LEU A 263
THR A 283
 TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
FLC  A1503 ( 4.5A)
TAK  A1507 (-3.6A)
 0.51A 5cswB-4c02A:
24.3		 5cswB-4c02A:
29.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_1
(PROTEIN-TYROSINE
KINASE 6)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		6 / 12 VAL A 222
ALA A 233
LEU A 263
THR A 283
GLY A 289
LEU A 343
 TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
FLC  A1503 ( 4.5A)
TAK  A1507 (-3.6A)
TAK  A1507 (-3.5A)
TAK  A1507 (-4.7A)
 0.71A 5h2uA-4c02A:
24.8		 5h2uA-4c02A:
28.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_B_1N1B501_1
(PROTEIN-TYROSINE
KINASE 6)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		7 / 12 VAL A 222
ALA A 233
LEU A 263
THR A 283
GLY A 289
LEU A 343
ASP A 354
 TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
FLC  A1503 ( 4.5A)
TAK  A1507 (-3.6A)
TAK  A1507 (-3.5A)
TAK  A1507 (-4.7A)
TAK  A1507 (-3.5A)
 0.80A 5h2uB-4c02A:
25.1		 5h2uB-4c02A:
28.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_A_032A401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		4 / 6 LYS A 235
PHE A 265
SER A 290
ASP A 354
 TAK  A1507 ( 4.5A)
None
None
TAK  A1507 (-3.5A)
 1.01A 5hesA-4c02A:
24.5		 5hesA-4c02A:
28.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_B_032B401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		6 / 12 VAL A 222
ALA A 233
LYS A 235
THR A 283
TYR A 285
ASP A 293
 TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
TAK  A1507 (-3.6A)
TAK  A1507 ( 4.6A)
None
 0.78A 5hesB-4c02A:
24.4		 5hesB-4c02A:
28.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HI2_A_BAXA801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		6 / 12 ALA A 233
LYS A 235
LEU A 263
THR A 283
LEU A 319
HIS A 334
 TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
FLC  A1503 ( 4.5A)
TAK  A1507 (-3.6A)
None
None
 0.67A 5hi2A-4c02A:
24.9		 5hi2A-4c02A:
30.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		5 / 12 PHE A 237
VAL A 222
ALA A 233
LEU A 263
THR A 283
 None
TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
FLC  A1503 ( 4.5A)
TAK  A1507 (-3.6A)
 0.77A 5hieA-4c02A:
24.3		 5hieA-4c02A:
28.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		5 / 12 VAL A 222
ALA A 233
LYS A 235
LEU A 263
THR A 283
 TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
FLC  A1503 ( 4.5A)
TAK  A1507 (-3.6A)
 0.37A 5hieA-4c02A:
24.3		 5hieA-4c02A:
28.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		5 / 12 PHE A 237
VAL A 222
ALA A 233
LEU A 263
THR A 283
 None
TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
FLC  A1503 ( 4.5A)
TAK  A1507 (-3.6A)
 0.78A 5hieB-4c02A:
24.2		 5hieB-4c02A:
28.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		5 / 12 VAL A 222
ALA A 233
LYS A 235
LEU A 263
THR A 283
 TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
FLC  A1503 ( 4.5A)
TAK  A1507 (-3.6A)
 0.37A 5hieB-4c02A:
24.2		 5hieB-4c02A:
28.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		6 / 12 GLY A 215
PHE A 237
VAL A 222
ALA A 233
LEU A 263
THR A 283
 None
None
TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
FLC  A1503 ( 4.5A)
TAK  A1507 (-3.6A)
 0.79A 5hieC-4c02A:
5.3		 5hieC-4c02A:
28.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		6 / 12 GLY A 215
VAL A 222
ALA A 233
LYS A 235
LEU A 263
THR A 283
 None
TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
FLC  A1503 ( 4.5A)
TAK  A1507 (-3.6A)
 0.47A 5hieC-4c02A:
5.3		 5hieC-4c02A:
28.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		5 / 12 PHE A 237
VAL A 222
ALA A 233
LEU A 263
THR A 283
 None
TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
FLC  A1503 ( 4.5A)
TAK  A1507 (-3.6A)
 0.77A 5hieD-4c02A:
24.3		 5hieD-4c02A:
28.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		5 / 12 VAL A 222
ALA A 233
LYS A 235
LEU A 263
THR A 283
 TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
FLC  A1503 ( 4.5A)
TAK  A1507 (-3.6A)
 0.36A 5hieD-4c02A:
24.3		 5hieD-4c02A:
28.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9X_A_DB8A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		6 / 12 ALA A 233
GLU A 248
THR A 283
TYR A 285
GLY A 289
LEU A 343
 TAK  A1507 (-3.3A)
None
TAK  A1507 (-3.6A)
TAK  A1507 ( 4.6A)
TAK  A1507 (-3.5A)
TAK  A1507 (-4.7A)
 0.51A 5i9xA-4c02A:
25.3		 5i9xA-4c02A:
27.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9Y_A_1N1A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		6 / 12 ALA A 233
GLU A 248
THR A 283
TYR A 285
GLY A 289
LEU A 343
 TAK  A1507 (-3.3A)
None
TAK  A1507 (-3.6A)
TAK  A1507 ( 4.6A)
TAK  A1507 (-3.5A)
TAK  A1507 (-4.7A)
 0.49A 5i9yA-4c02A:
25.3		 5i9yA-4c02A:
27.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9Y_A_1N1A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		6 / 12 ALA A 233
LYS A 235
THR A 283
TYR A 285
GLY A 289
LEU A 343
 TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
TAK  A1507 (-3.6A)
TAK  A1507 ( 4.6A)
TAK  A1507 (-3.5A)
TAK  A1507 (-4.7A)
 0.49A 5i9yA-4c02A:
25.3		 5i9yA-4c02A:
27.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		4 / 7 GLY A 215
GLY A 217
GLY A 220
VAL A 222
 None
None
None
TAK  A1507 (-4.7A)
 0.29A 5izjB-4c02A:
21.8		 5izjB-4c02A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		4 / 7 GLY A 215
GLY A 217
VAL A 222
LYS A 235
 None
None
TAK  A1507 (-4.7A)
TAK  A1507 ( 4.5A)
 0.34A 5izjA-4c02A:
16.8		 5izjA-4c02A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J4N_B_AG2B501_1
(ARGININE/AGMATINE
ANTIPORTER)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		4 / 6 ILE A 352
GLY A 348
ASN A 347
ILE A 312
 None
None
EDO  A1510 (-4.4A)
None
 0.96A 5j4nB-4c02A:
undetectable		 5j4nB-4c02A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		5 / 7 GLY A 215
GLY A 217
VAL A 222
LYS A 235
ASP A 354
 None
None
TAK  A1507 (-4.7A)
TAK  A1507 ( 4.5A)
TAK  A1507 (-3.5A)
 0.82A 5j5xA-4c02A:
22.9		 5j5xA-4c02A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWV_A_ACAA18_1
(SCRFP-TAG,GP41)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		5 / 12 ASN A 253
GLU A 250
LEU A 251
GLU A 248
LEU A 355
 None
 0.89A 5nwvA-4c02A:
undetectable		 5nwvA-4c02A:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC3_A_DB8A601_1
(WEE1-LIKE PROTEIN
KINASE)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		7 / 12 GLU A 212
GLY A 215
ALA A 233
GLU A 248
TYR A 285
GLY A 289
ASP A 293
 EDO  A1515 (-3.8A)
None
TAK  A1507 (-3.3A)
None
TAK  A1507 ( 4.6A)
TAK  A1507 (-3.5A)
None
 0.77A 5vc3A-4c02A:
24.8		 5vc3A-4c02A:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_C_CHDC401_0
(BILE SALT HYDROLASE)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		4 / 8 LEU A 337
ILE A 262
LEU A 489
ALA A 488
 None
None
FLC  A1505 ( 4.0A)
FLC  A1506 (-3.6A)
 0.69A 5y7pC-4c02A:
undetectable		 5y7pC-4c02A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_A_1E8A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		7 / 12 GLY A 215
VAL A 222
ALA A 233
LYS A 235
LEU A 281
LEU A 343
ASP A 354
 None
TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
None
TAK  A1507 (-4.7A)
TAK  A1507 (-3.5A)
 0.85A 5yu9A-4c02A:
24.7		 5yu9A-4c02A:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_B_1E8B1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		8 / 12 GLY A 215
VAL A 222
ALA A 233
LYS A 235
LEU A 281
ASP A 293
LEU A 343
ASP A 354
 None
TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
None
None
TAK  A1507 (-4.7A)
TAK  A1507 (-3.5A)
 0.87A 5yu9B-4c02A:
25.0		 5yu9B-4c02A:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_C_1E8C1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		7 / 12 VAL A 222
ALA A 233
LYS A 235
LEU A 281
GLY A 289
ASP A 293
ASP A 354
 TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
None
TAK  A1507 (-3.5A)
None
TAK  A1507 (-3.5A)
 0.88A 5yu9C-4c02A:
24.5		 5yu9C-4c02A:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_D_1E8D1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		6 / 12 VAL A 222
ALA A 233
GLY A 289
ASP A 293
LEU A 343
ASP A 354
 TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 (-3.5A)
None
TAK  A1507 (-4.7A)
TAK  A1507 (-3.5A)
 0.51A 5yu9D-4c02A:
24.7		 5yu9D-4c02A:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_D_1E8D1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		6 / 12 VAL A 222
ALA A 233
LYS A 235
GLY A 289
ASP A 293
ASP A 354
 TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
TAK  A1507 (-3.5A)
None
TAK  A1507 (-3.5A)
 0.77A 5yu9D-4c02A:
24.7		 5yu9D-4c02A:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNM_A_1N1A1001_1
(-)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		7 / 12 VAL A 222
ALA A 233
LYS A 235
GLU A 248
THR A 283
GLY A 289
LEU A 343
 TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
None
TAK  A1507 (-3.6A)
TAK  A1507 (-3.5A)
TAK  A1507 (-4.7A)
 0.80A 6fnmA-4c02A:
25.6		 6fnmA-4c02A:
29.06