SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4c0a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT2_A_SAMA301_1
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)		 4c0a IQ MOTIF AND SEC7
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		3 / 3 THR A 433
GLU A 474
ASP A 476
 None
 0.80A 1nt2A-4c0aA:
undetectable		 1nt2A-4c0aA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		 4c0a IQ MOTIF AND SEC7
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		4 / 4 LEU A 663
PRO A 641
ILE A 703
LEU A 705
 None
 1.11A 1ya4B-4c0aA:
undetectable		 1ya4B-4c0aA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4c0a IQ MOTIF AND SEC7
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		4 / 6 ILE A 718
ARG A 728
THR A 732
LEU A 735
 None
 0.93A 2einN-4c0aA:
undetectable
2einW-4c0aA:
undetectable		 2einN-4c0aA:
21.28
2einW-4c0aA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD2_1
(CYTOCHROME P450 2D6)		 4c0a IQ MOTIF AND SEC7
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 9 PHE A 731
LEU A 705
THR A 706
LEU A 637
ILE A 703
 None
 1.16A 3tbgD-4c0aA:
undetectable		 3tbgD-4c0aA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4c0a IQ MOTIF AND SEC7
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		4 / 6 ILE A 718
ARG A 728
THR A 732
LEU A 735
 None
 1.05A 3wg7N-4c0aA:
undetectable
3wg7W-4c0aA:
undetectable		 3wg7N-4c0aA:
21.28
3wg7W-4c0aA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1004_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4c0a IQ MOTIF AND SEC7
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 11 ALA A 508
ILE A 538
VAL A 471
LEU A 468
GLY A 453
 None
 0.95A 3zosA-4c0aA:
undetectable
3zosB-4c0aA:
undetectable		 3zosA-4c0aA:
20.72
3zosB-4c0aA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4c0a IQ MOTIF AND SEC7
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		4 / 7 GLU A 507
GLY A 457
ARG A 504
LYS A 501
 None
 1.02A 4fgzA-4c0aA:
undetectable		 4fgzA-4c0aA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4POO_A_SAMA301_0
(PUTATIVE RNA
METHYLASE)		 4c0a IQ MOTIF AND SEC7
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 12 GLY A 409
HIS A 405
SER A 448
HIS A 596
LEU A 412
 None
 1.20A 4pooA-4c0aA:
undetectable		 4pooA-4c0aA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 4c0a IQ MOTIF AND SEC7
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		4 / 7 PHE A 413
ARG A 449
THR A 592
ILE A 452
 None
 0.98A 5nzyA-4c0aA:
undetectable		 5nzyA-4c0aA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4c0a IQ MOTIF AND SEC7
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		3 / 3 ARG A 629
LEU A 662
PHE A 684
 None
 0.79A 6nknP-4c0aA:
undetectable		 6nknP-4c0aA:
19.90