SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4c0d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A28_A_STRA1_1
(PROGESTERONE
RECEPTOR)
4c0d CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1

(Homo
sapiens)
5 / 12 LEU A2218
LEU A2214
LEU A2184
THR A2224
PHE A2168
None
1.40A 1a28A-4c0dA:
undetectable
1a28A-4c0dA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ6_A_CAMA502_0
(CYTOCHROME P450-CAM)
4c0d CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1

(Homo
sapiens)
4 / 5 PHE A1985
LEU A2026
VAL A1907
ASP A1977
None
1.33A 1dz6A-4c0dA:
undetectable
1dz6A-4c0dA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_D_AG2D7015_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)
4c0d CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1

(Homo
sapiens)
4 / 7 LEU A1901
GLU A1850
ARG A1900
ASP A1844
None
0.66A 1n13D-4c0dA:
undetectable
1n13E-4c0dA:
undetectable
1n13D-4c0dA:
9.33
1n13E-4c0dA:
4.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_A_BEZA502_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)
4c0d CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1

(Homo
sapiens)
4 / 6 ASN A2216
ASN A2272
ARG A2311
ILE A2121
None
1.02A 1oniA-4c0dA:
undetectable
1oniB-4c0dA:
2.0
1oniA-4c0dA:
10.80
1oniB-4c0dA:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_D_BEZD508_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)
4c0d CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1

(Homo
sapiens)
4 / 6 ASN A2216
ASN A2272
ARG A2311
ILE A2121
None
1.07A 1oniD-4c0dA:
undetectable
1oniF-4c0dA:
undetectable
1oniD-4c0dA:
10.80
1oniF-4c0dA:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q13_A_TESA501_1
(PROSTAGLANDIN-E2
9-REDUCTASE)
4c0d CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1
CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 3

(Homo
sapiens)
4 / 6 TYR C 613
HIS A1978
PRO A2087
VAL A2035
None
1.34A 1q13A-4c0dC:
undetectable
1q13A-4c0dC:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_C_CHDC3271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)
4c0d CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1

(Homo
sapiens)
4 / 8 GLN A2252
PHE A2251
LEU A2196
PHE A2192
None
0.84A 1v54C-4c0dA:
2.5
1v54J-4c0dA:
undetectable
1v54C-4c0dA:
14.62
1v54J-4c0dA:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_C_CHDC3271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)
4c0d CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1

(Homo
sapiens)
4 / 8 LEU A1975
GLN A1976
LEU A2026
PHE A2034
None
0.89A 1v54C-4c0dA:
2.5
1v54J-4c0dA:
undetectable
1v54C-4c0dA:
14.62
1v54J-4c0dA:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_C_CHDC3271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)
4c0d CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1

(Homo
sapiens)
4 / 7 GLN A2252
PHE A2251
LEU A2196
PHE A2192
None
0.85A 1v55C-4c0dA:
2.5
1v55J-4c0dA:
undetectable
1v55C-4c0dA:
14.62
1v55J-4c0dA:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_C_CHDC3271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)
4c0d CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1

(Homo
sapiens)
4 / 7 LEU A1975
GLN A1976
LEU A2026
PHE A2034
None
0.96A 1v55C-4c0dA:
2.5
1v55J-4c0dA:
undetectable
1v55C-4c0dA:
14.62
1v55J-4c0dA:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)
4c0d CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1

(Homo
sapiens)
4 / 8 GLN A2252
PHE A2251
LEU A2196
PHE A2192
None
0.82A 2dyrC-4c0dA:
2.5
2dyrJ-4c0dA:
undetectable
2dyrC-4c0dA:
14.62
2dyrJ-4c0dA:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)
4c0d CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1

(Homo
sapiens)
4 / 8 LEU A1975
GLN A1976
LEU A2026
PHE A2034
None
0.89A 2dyrC-4c0dA:
2.5
2dyrJ-4c0dA:
undetectable
2dyrC-4c0dA:
14.62
2dyrJ-4c0dA:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)
4c0d CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1

(Homo
sapiens)
4 / 8 LEU A1975
GLN A1976
LEU A2026
PHE A2034
None
0.92A 2dyrP-4c0dA:
2.6
2dyrW-4c0dA:
undetectable
2dyrP-4c0dA:
14.62
2dyrW-4c0dA:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_C_CHDC310_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)
4c0d CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1

(Homo
sapiens)
4 / 7 GLN A2252
PHE A2251
LEU A2196
PHE A2192
None
0.93A 2dysC-4c0dA:
2.5
2dysJ-4c0dA:
undetectable
2dysC-4c0dA:
14.62
2dysJ-4c0dA:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_C_CHDC310_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)
4c0d CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1

(Homo
sapiens)
4 / 7 LEU A1975
GLN A1976
LEU A2026
PHE A2034
None
0.89A 2dysC-4c0dA:
2.5
2dysJ-4c0dA:
undetectable
2dysC-4c0dA:
14.62
2dysJ-4c0dA:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_P_CHDP310_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)
4c0d CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1

(Homo
sapiens)
4 / 7 LEU A1975
GLN A1976
LEU A2026
PHE A2034
None
0.99A 2dysP-4c0dA:
2.6
2dysW-4c0dA:
undetectable
2dysP-4c0dA:
14.62
2dysW-4c0dA:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)
4c0d CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1

(Homo
sapiens)
4 / 7 GLN A2252
PHE A2251
LEU A2196
PHE A2192
None
0.86A 2eijC-4c0dA:
2.6
2eijJ-4c0dA:
undetectable
2eijC-4c0dA:
14.62
2eijJ-4c0dA:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)
4c0d CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1

(Homo
sapiens)
4 / 7 LEU A1975
GLN A1976
LEU A2026
PHE A2034
None
0.94A 2eijC-4c0dA:
2.6
2eijJ-4c0dA:
undetectable
2eijC-4c0dA:
14.62
2eijJ-4c0dA:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)
4c0d CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1

(Homo
sapiens)
4 / 7 LEU A1975
GLN A1976
LEU A2026
PHE A2034
None
0.97A 2eijP-4c0dA:
2.6
2eijW-4c0dA:
undetectable
2eijP-4c0dA:
14.62
2eijW-4c0dA:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)
4c0d CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1

(Homo
sapiens)
4 / 7 GLN A2252
PHE A2251
LEU A2196
PHE A2192
None
0.87A 2eikC-4c0dA:
2.6
2eikJ-4c0dA:
undetectable
2eikC-4c0dA:
14.62
2eikJ-4c0dA:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)
4c0d CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1

(Homo
sapiens)
4 / 7 LEU A1975
GLN A1976
LEU A2026
PHE A2034
None
0.96A 2eikC-4c0dA:
2.6
2eikJ-4c0dA:
undetectable
2eikC-4c0dA:
14.62
2eikJ-4c0dA:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)
4c0d CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1

(Homo
sapiens)
4 / 8 GLN A2252
PHE A2251
LEU A2196
PHE A2192
None
0.87A 2eilC-4c0dA:
2.6
2eilJ-4c0dA:
undetectable
2eilC-4c0dA:
14.62
2eilJ-4c0dA:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)
4c0d CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1

(Homo
sapiens)
4 / 7 GLN A2252
PHE A2251
LEU A2196
PHE A2192
None
0.89A 2eimC-4c0dA:
3.1
2eimJ-4c0dA:
undetectable
2eimC-4c0dA:
14.62
2eimJ-4c0dA:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)
4c0d CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1

(Homo
sapiens)
4 / 7 LEU A1975
GLN A1976
LEU A2026
PHE A2034
None
0.95A 2eimC-4c0dA:
3.1
2eimJ-4c0dA:
undetectable
2eimC-4c0dA:
14.62
2eimJ-4c0dA:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)
4c0d CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1

(Homo
sapiens)
4 / 7 GLN A2252
PHE A2251
LEU A2196
PHE A2192
None
0.94A 2einC-4c0dA:
3.0
2einJ-4c0dA:
undetectable
2einC-4c0dA:
14.62
2einJ-4c0dA:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)
4c0d CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1

(Homo
sapiens)
4 / 7 LEU A1975
GLN A1976
LEU A2026
PHE A2034
None
0.96A 2einC-4c0dA:
3.0
2einJ-4c0dA:
undetectable
2einC-4c0dA:
14.62
2einJ-4c0dA:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)
4c0d CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1

(Homo
sapiens)
4 / 6 LEU A1975
GLN A1976
LEU A2026
PHE A2034
None
0.88A 2einP-4c0dA:
2.8
2einW-4c0dA:
undetectable
2einP-4c0dA:
14.62
2einW-4c0dA:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDB_A_NPSA1591_1
(SERUM ALBUMIN)
4c0d CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1

(Homo
sapiens)
4 / 8 ILE A2242
PHE A2251
PHE A2284
GLY A2223
None
0.70A 2vdbA-4c0dA:
0.0
2vdbA-4c0dA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_B_FUAB2002_1
(SERUM ALBUMIN)
4c0d CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1

(Homo
sapiens)
4 / 9 ILE A1993
ARG A1992
ALA A1938
VAL A1940
None
0.98A 2vufB-4c0dA:
2.5
2vufB-4c0dA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)
4c0d CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1

(Homo
sapiens)
4 / 7 GLN A2252
PHE A2251
LEU A2196
PHE A2192
None
0.81A 2zxwC-4c0dA:
2.5
2zxwJ-4c0dA:
undetectable
2zxwC-4c0dA:
14.62
2zxwJ-4c0dA:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)
4c0d CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1

(Homo
sapiens)
4 / 7 LEU A1975
GLN A1976
LEU A2026
PHE A2034
None
0.90A 2zxwC-4c0dA:
2.5
2zxwJ-4c0dA:
undetectable
2zxwC-4c0dA:
14.62
2zxwJ-4c0dA:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)
4c0d CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1

(Homo
sapiens)
4 / 6 GLN A2252
PHE A2251
LEU A2196
PHE A2192
None
0.92A 2zxwP-4c0dA:
2.6
2zxwW-4c0dA:
undetectable
2zxwP-4c0dA:
14.62
2zxwW-4c0dA:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)
4c0d CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1

(Homo
sapiens)
4 / 6 LEU A1975
GLN A1976
LEU A2026
PHE A2034
None
0.93A 2zxwP-4c0dA:
2.6
2zxwW-4c0dA:
undetectable
2zxwP-4c0dA:
14.62
2zxwW-4c0dA:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)
4c0d CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1

(Homo
sapiens)
4 / 5 GLN A2252
PHE A2251
LEU A2196
PHE A2192
None
0.93A 3ablC-4c0dA:
4.2
3ablJ-4c0dA:
undetectable
3ablC-4c0dA:
14.62
3ablJ-4c0dA:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)
4c0d CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1

(Homo
sapiens)
4 / 6 GLN A2252
PHE A2251
LEU A2196
PHE A2192
None
1.04A 3ablP-4c0dA:
2.5
3ablW-4c0dA:
undetectable
3ablP-4c0dA:
14.62
3ablW-4c0dA:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)
4c0d CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1

(Homo
sapiens)
4 / 6 GLN A2252
PHE A2251
LEU A2196
PHE A2192
None
0.94A 3ag1C-4c0dA:
3.0
3ag1J-4c0dA:
undetectable
3ag1C-4c0dA:
14.62
3ag1J-4c0dA:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)
4c0d CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1

(Homo
sapiens)
4 / 6 LEU A1975
GLN A1976
LEU A2026
PHE A2034
None
0.85A 3ag1C-4c0dA:
3.0
3ag1J-4c0dA:
undetectable
3ag1C-4c0dA:
14.62
3ag1J-4c0dA:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)
4c0d CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1

(Homo
sapiens)
4 / 8 GLN A2252
PHE A2251
LEU A2196
PHE A2192
None
0.91A 3ag4C-4c0dA:
2.5
3ag4J-4c0dA:
undetectable
3ag4C-4c0dA:
14.62
3ag4J-4c0dA:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)
4c0d CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1

(Homo
sapiens)
4 / 7 GLN A2252
PHE A2251
LEU A2196
PHE A2192
None
0.90A 3asnC-4c0dA:
4.3
3asnJ-4c0dA:
undetectable
3asnC-4c0dA:
14.62
3asnJ-4c0dA:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)
4c0d CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1

(Homo
sapiens)
4 / 7 LEU A1975
GLN A1976
LEU A2026
PHE A2034
None
0.93A 3asnC-4c0dA:
4.3
3asnJ-4c0dA:
undetectable
3asnC-4c0dA:
14.62
3asnJ-4c0dA:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR5_X_PNTX95_0
(PROTEIN S100-B)
4c0d CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1

(Homo
sapiens)
3 / 3 CYH A2020
PHE A2019
PHE A2023
None
0.98A 3cr5X-4c0dA:
undetectable
3cr5X-4c0dA:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B9Z_A_ACRA1818_1
(ALPHA-GLUCOSIDASE,
PUTATIVE, ADG31B)
4c0d CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1

(Homo
sapiens)
5 / 12 ASP A1893
LEU A1894
LEU A1901
ARG A1900
ASP A1843
None
1.13A 4b9zA-4c0dA:
2.7
4b9zA-4c0dA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GRK_A_KTRA713_1
(LACTOTRANSFERRIN)
4c0d CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1
CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 3

(Homo
sapiens)
4 / 5 GLY A2033
VAL A2035
PRO A2032
TYR C 613
None
1.07A 4grkA-4c0dA:
undetectable
4grkA-4c0dA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_ACTA303_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)
4c0d CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1

(Homo
sapiens)
3 / 3 TYR A2276
HIS A2114
ARG A2275
None
0.82A 4htfA-4c0dA:
undetectable
4htfA-4c0dA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKX_A_198A1002_2
(ANDROGEN RECEPTOR)
4c0d CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1

(Homo
sapiens)
4 / 6 LEU A2267
ASN A2268
LEU A2308
ILE A2126
None
1.14A 4okxA-4c0dA:
undetectable
4okxA-4c0dA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_2
(HISTONE DEACETYLASE
8)
4c0d CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1
CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 3

(Homo
sapiens)
3 / 3 PRO C 626
MET C 625
TYR A2036
None
1.11A 4qa0B-4c0dC:
undetectable
4qa0B-4c0dC:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_B_SHHB404_1
(HISTONE DEACETYLASE
8)
4c0d CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1
CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 3

(Homo
sapiens)
3 / 3 PRO C 626
MET C 625
TYR A2036
None
1.09A 4qa0A-4c0dC:
undetectable
4qa0A-4c0dC:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XLD_A_BRLA502_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
4c0d CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1

(Homo
sapiens)
5 / 12 PHE A2023
CYH A2020
PHE A2047
MET A2051
LEU A1967
None
1.27A 4xldA-4c0dA:
undetectable
4xldA-4c0dA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
4c0d CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1

(Homo
sapiens)
4 / 6 GLN A2252
PHE A2251
LEU A2196
PHE A2192
None
1.00A 5b1bC-4c0dA:
2.5
5b1bJ-4c0dA:
undetectable
5b1bC-4c0dA:
14.62
5b1bJ-4c0dA:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
4c0d CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1

(Homo
sapiens)
4 / 7 GLN A2252
PHE A2251
LEU A2196
PHE A2192
None
0.85A 5b1bP-4c0dA:
2.5
5b1bW-4c0dA:
undetectable
5b1bP-4c0dA:
14.62
5b1bW-4c0dA:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
4c0d CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1

(Homo
sapiens)
4 / 7 LEU A1975
GLN A1976
LEU A2026
PHE A2034
None
0.98A 5b1bP-4c0dA:
2.5
5b1bW-4c0dA:
undetectable
5b1bP-4c0dA:
14.62
5b1bW-4c0dA:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DNV_A_BEZA304_0
(SHKAI2IB)
4c0d CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1

(Homo
sapiens)
4 / 5 GLN A1882
HIS A1884
ILE A1888
TYR A1854
None
1.27A 5dnvA-4c0dA:
undetectable
5dnvA-4c0dA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM8_B_L8PB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)
4c0d CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1

(Homo
sapiens)
4 / 8 ASN A2272
ALA A2271
GLN A2273
HIS A2114
None
1.03A 5km8A-4c0dA:
undetectable
5km8B-4c0dA:
undetectable
5km8A-4c0dA:
11.81
5km8B-4c0dA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_A_ACTA803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)
4c0d CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1
CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 3

(Homo
sapiens;
Homo
sapiens)
4 / 4 GLU C 618
PRO A2087
ILE A2090
LEU A2091
None
1.21A 5m45A-4c0dC:
undetectable
5m45A-4c0dC:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_D_ACTD803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)
4c0d CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1
CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 3

(Homo
sapiens;
Homo
sapiens)
4 / 4 GLU C 618
PRO A2087
ILE A2090
LEU A2091
None
1.22A 5m45D-4c0dC:
undetectable
5m45D-4c0dC:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_G_ACTG803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)
4c0d CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1
CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 3

(Homo
sapiens;
Homo
sapiens)
4 / 4 GLU C 618
PRO A2087
ILE A2090
LEU A2091
None
1.21A 5m45G-4c0dC:
undetectable
5m45G-4c0dC:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_J_ACTJ803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)
4c0d CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1
CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 3

(Homo
sapiens;
Homo
sapiens)
4 / 4 GLU C 618
PRO A2087
ILE A2090
LEU A2091
None
1.26A 5m45J-4c0dC:
undetectable
5m45J-4c0dC:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
4c0d CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 3

(Homo
sapiens)
4 / 5 LEU C 671
PHE C 673
LEU C 666
PHE C 662
None
1.13A 5x1fC-4c0dC:
undetectable
5x1fJ-4c0dC:
undetectable
5x1fC-4c0dC:
22.39
5x1fJ-4c0dC:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XOO_B_ADNB503_1
(GLYCOSAMINOGLYCAN
XYLOSYLKINASE)
4c0d CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1
CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 3

(Homo
sapiens)
4 / 5 LEU A2039
VAL A2035
GLU C 618
LEU A2091
None
1.03A 5xooB-4c0dA:
undetectable
5xooB-4c0dA:
6.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2O_A_8N6A501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
4c0d CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1

(Homo
sapiens)
5 / 12 PHE A2023
CYH A2020
PHE A2047
MET A2051
LEU A1967
None
1.22A 5y2oA-4c0dA:
undetectable
5y2oA-4c0dA:
7.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
4c0d CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1

(Homo
sapiens)
4 / 6 GLN A2252
PHE A2251
LEU A2196
PHE A2192
None
1.03A 5z84P-4c0dA:
2.6
5z84W-4c0dA:
undetectable
5z84P-4c0dA:
14.62
5z84W-4c0dA:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
4c0d CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1

(Homo
sapiens)
4 / 7 LEU A1975
GLN A1976
LEU A2026
PHE A2034
None
0.94A 5z85C-4c0dA:
2.5
5z85J-4c0dA:
undetectable
5z85C-4c0dA:
14.62
5z85J-4c0dA:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
4c0d CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1

(Homo
sapiens)
4 / 6 GLN A2252
PHE A2251
LEU A2196
PHE A2192
None
1.04A 5z85P-4c0dA:
2.5
5z85W-4c0dA:
undetectable
5z85P-4c0dA:
14.62
5z85W-4c0dA:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
4c0d CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1

(Homo
sapiens)
4 / 6 GLN A2252
PHE A2251
LEU A2196
PHE A2192
None
1.00A 5z86C-4c0dA:
2.6
5z86J-4c0dA:
undetectable
5z86C-4c0dA:
14.62
5z86J-4c0dA:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
4c0d CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1

(Homo
sapiens)
4 / 6 GLN A2252
PHE A2251
LEU A2196
PHE A2192
None
0.97A 5z86P-4c0dA:
2.6
5z86W-4c0dA:
undetectable
5z86P-4c0dA:
14.62
5z86W-4c0dA:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
4c0d CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1

(Homo
sapiens)
4 / 7 LEU A1975
GLN A1976
LEU A2026
PHE A2034
None
0.93A 5zcoC-4c0dA:
2.5
5zcoJ-4c0dA:
undetectable
5zcoC-4c0dA:
14.62
5zcoJ-4c0dA:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
4c0d CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1

(Homo
sapiens)
4 / 6 GLN A2252
PHE A2251
LEU A2196
PHE A2192
None
1.04A 5zcoP-4c0dA:
4.3
5zcoW-4c0dA:
undetectable
5zcoP-4c0dA:
14.62
5zcoW-4c0dA:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
4c0d CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1

(Homo
sapiens)
4 / 6 GLN A2252
PHE A2251
LEU A2196
PHE A2192
None
1.06A 5zcpC-4c0dA:
2.6
5zcpJ-4c0dA:
undetectable
5zcpC-4c0dA:
14.62
5zcpJ-4c0dA:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
4c0d CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1

(Homo
sapiens)
4 / 6 GLN A2252
PHE A2251
LEU A2196
PHE A2192
None
1.07A 5zcpP-4c0dA:
2.6
5zcpW-4c0dA:
undetectable
5zcpP-4c0dA:
14.62
5zcpW-4c0dA:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
4c0d CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1

(Homo
sapiens)
4 / 7 LEU A1975
GLN A1976
LEU A2026
PHE A2034
None
0.94A 5zcqP-4c0dA:
2.6
5zcqW-4c0dA:
undetectable
5zcqP-4c0dA:
14.62
5zcqW-4c0dA:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HUP_E_DZPE502_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT BETA-3)
4c0d CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1

(Homo
sapiens)
5 / 10 LEU A2016
LEU A1963
THR A2022
ASN A2021
MET A2063
None
1.42A 6hupD-4c0dA:
3.1
6hupE-4c0dA:
2.6
6hupD-4c0dA:
7.98
6hupE-4c0dA:
7.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HUP_E_DZPE502_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT BETA-3)
4c0d CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1

(Homo
sapiens)
5 / 10 LEU A2016
LEU A1963
THR A2022
ASN A2021
PHE A2023
None
1.15A 6hupD-4c0dA:
3.1
6hupE-4c0dA:
2.6
6hupD-4c0dA:
7.98
6hupE-4c0dA:
7.50