SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4c0e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_B_PFLB4001_1
(SERUM ALBUMIN)		 4c0e NOT1
(Chaetomium
thermophilum) 		5 / 9 LEU A2007
LEU A1999
VAL A2016
GLY A2015
LEU A2082
 None
 1.21A 1e7aB-4c0eA:
2.3		 1e7aB-4c0eA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKF_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 4c0e NOT1
(Chaetomium
thermophilum) 		5 / 11 TYR A2111
ASP A2075
ARG A2059
PHE A2069
ILE A2119
 None
 1.08A 1fkfA-4c0eA:
undetectable		 1fkfA-4c0eA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKJ_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 4c0e NOT1
(Chaetomium
thermophilum) 		5 / 11 TYR A2111
ASP A2075
ARG A2059
PHE A2069
ILE A2119
 None
 1.09A 1fkjA-4c0eA:
undetectable		 1fkjA-4c0eA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TCO_C_FK5C509_2
(FK506-BINDING
PROTEIN)		 4c0e NOT1
(Chaetomium
thermophilum) 		5 / 11 TYR A2111
ASP A2075
ARG A2059
PHE A2069
ILE A2119
 None
 1.17A 1tcoC-4c0eA:
undetectable		 1tcoC-4c0eA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAT_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 4c0e NOT1
(Chaetomium
thermophilum) 		5 / 11 TYR A2111
ASP A2075
ARG A2059
PHE A2069
ILE A2119
 None
 1.12A 1yatA-4c0eA:
undetectable		 1yatA-4c0eA:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGY_A_BRLA503_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 4c0e NOT1
(Chaetomium
thermophilum) 		5 / 12 PHE A1892
GLY A1894
CYH A1895
LEU A1908
LEU A1949
 None
 1.38A 1zgyA-4c0eA:
undetectable		 1zgyA-4c0eA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZY_A_CHDA237_0
(PHOSPHOLIPASE A2,
MAJOR ISOENZYME)		 4c0e NOT1
(Chaetomium
thermophilum) 		5 / 11 ILE A1838
MET A1784
ASP A1785
GLY A1791
LEU A1819
 None
 1.22A 2azyA-4c0eA:
undetectable		 2azyA-4c0eA:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FKE_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 4c0e NOT1
(Chaetomium
thermophilum) 		5 / 11 TYR A2111
ASP A2075
ARG A2059
PHE A2069
ILE A2119
 None
 1.11A 2fkeA-4c0eA:
undetectable		 2fkeA-4c0eA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN1_B_FK5B501_1
(70 KDA
PEPTIDYLPROLYL
ISOMERASE)		 4c0e NOT1
(Chaetomium
thermophilum) 		5 / 10 TYR A2111
ASP A2075
ARG A2059
PHE A2069
ILE A2119
 None
 1.16A 2vn1B-4c0eA:
undetectable		 2vn1B-4c0eA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC507_2
(PHOSPHOLIPASE A2)		 4c0e NOT1
(Chaetomium
thermophilum) 		4 / 6 VAL A2048
VAL A2049
PHE A2055
ARG A2103
 None
 1.22A 3bjwF-4c0eA:
undetectable		 3bjwF-4c0eA:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GP0_A_NILA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 4c0e NOT1
(Chaetomium
thermophilum) 		4 / 7 VAL A1766
LEU A1724
LEU A1711
ILE A1763
 None
 0.96A 3gp0A-4c0eA:
undetectable		 3gp0A-4c0eA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHZ_A_FK5A501_1
(70 KDA
PEPTIDYLPROLYL
ISOMERASE, PUTATIVE)		 4c0e NOT1
(Chaetomium
thermophilum) 		5 / 10 TYR A2111
ASP A2075
ARG A2059
PHE A2069
ILE A2119
 None
 1.11A 3ihzA-4c0eA:
undetectable		 3ihzA-4c0eA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NY4_A_SMXA309_1
(BETA-LACTAMASE)		 4c0e NOT1
(Chaetomium
thermophilum) 		4 / 5 ARG A1983
THR A1986
GLU A2101
GLU A2054
 None
 1.47A 3ny4A-4c0eA:
undetectable		 3ny4A-4c0eA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA1_1
(CYTOCHROME P450 2D6)		 4c0e NOT1
(Chaetomium
thermophilum) 		5 / 12 LEU A1758
PHE A1687
GLY A1791
LEU A1793
PHE A1811
 None
 1.29A 3tbgA-4c0eA:
2.9		 3tbgA-4c0eA:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQA_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN SMT3,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 4c0e NOT1
(Chaetomium
thermophilum) 		5 / 10 TYR A2111
ASP A2075
ARG A2059
PHE A2069
ILE A2119
 None
 1.14A 3uqaA-4c0eA:
undetectable		 3uqaA-4c0eA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4c0e NOT1
(Chaetomium
thermophilum) 		3 / 3 LEU A2145
ARG A2143
MET A2098
 None
 0.93A 4m11C-4c0eA:
undetectable		 4m11C-4c0eA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA603_1
(SERUM ALBUMIN)		 4c0e NOT1
(Chaetomium
thermophilum) 		5 / 11 ARG A1849
LEU A1853
TRP A1860
ASP A1847
LEU A1852
 None
 1.33A 4or0A-4c0eA:
undetectable		 4or0A-4c0eA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_C_NOVC2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 4c0e NOT1
(Chaetomium
thermophilum) 		5 / 11 ASN A1960
GLU A1982
ASP A1979
PRO A1985
ILE A1929
 None
 1.47A 4urnC-4c0eA:
undetectable		 4urnC-4c0eA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_3
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 4c0e NOT1
(Chaetomium
thermophilum) 		5 / 12 TYR A2111
ASP A2075
ARG A2059
PHE A2069
ILE A2119
 None
 1.21A 5b8iC-4c0eA:
undetectable		 5b8iC-4c0eA:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HUA_A_FK5A201_1
(FK506-BINDING
PROTEIN 1)		 4c0e NOT1
(Chaetomium
thermophilum) 		5 / 11 TYR A2111
ASP A2075
ARG A2059
PHE A2069
ILE A2119
 None
 1.10A 5huaA-4c0eA:
undetectable		 5huaA-4c0eA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_A_FK5A201_1
(FK506-BINDING
PROTEIN 1)		 4c0e NOT1
(Chaetomium
thermophilum) 		5 / 11 TYR A2111
ASP A2075
ARG A2059
PHE A2069
ILE A2119
 None
 0.96A 5hw8A-4c0eA:
undetectable
5hw8D-4c0eA:
undetectable		 5hw8A-4c0eA:
13.40
5hw8D-4c0eA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_D_FK5D201_1
(FK506-BINDING
PROTEIN 1)		 4c0e NOT1
(Chaetomium
thermophilum) 		5 / 11 TYR A2111
ASP A2075
ARG A2059
PHE A2069
ILE A2119
 None
 1.12A 5hw8D-4c0eA:
undetectable		 5hw8D-4c0eA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_E_FK5E201_1
(FK506-BINDING
PROTEIN 1)		 4c0e NOT1
(Chaetomium
thermophilum) 		5 / 11 TYR A2111
ASP A2075
ARG A2059
PHE A2069
ILE A2119
 None
 0.92A 5hw8E-4c0eA:
undetectable		 5hw8E-4c0eA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWC_A_FK5A201_1
(FK506-BINDING
PROTEIN 1A)		 4c0e NOT1
(Chaetomium
thermophilum) 		5 / 11 TYR A2111
ASP A2075
ARG A2059
PHE A2069
ILE A2119
 None
 1.10A 5hwcA-4c0eA:
undetectable		 5hwcA-4c0eA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 4c0e NOT1
(Chaetomium
thermophilum) 		3 / 3 ASP A2065
ASN A2110
GLN A2114
 None
 0.77A 5k7uA-4c0eA:
undetectable		 5k7uA-4c0eA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WGQ_A_ESTA601_1
(ESTROGEN RECEPTOR)		 4c0e NOT1
(Chaetomium
thermophilum) 		5 / 9 ALA A2050
GLU A2101
ARG A1935
GLY A1992
LEU A1994
 None
 1.43A 5wgqA-4c0eA:
undetectable		 5wgqA-4c0eA:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA604_0
(SERUM ALBUMIN)		 4c0e NOT1
(Chaetomium
thermophilum) 		4 / 8 ALA A1997
GLY A1992
LEU A1993
ALA A2047
 None
 0.71A 6mdqA-4c0eA:
undetectable		 6mdqA-4c0eA:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_A_FK5A201_0
(PEPTIDYLPROLYL
ISOMERASE)		 4c0e NOT1
(Chaetomium
thermophilum) 		5 / 12 TYR A2111
ASP A2075
ARG A2059
PHE A2069
ILE A2119
 None
 1.22A 6mkeA-4c0eA:
undetectable
6mkeD-4c0eA:
undetectable		 6mkeA-4c0eA:
10.42
6mkeD-4c0eA:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_C_FK5C201_1
(PEPTIDYLPROLYL
ISOMERASE)		 4c0e NOT1
(Chaetomium
thermophilum) 		5 / 10 TYR A2111
ASP A2075
ARG A2059
PHE A2069
ILE A2119
 None
 1.04A 6mkeC-4c0eA:
undetectable		 6mkeC-4c0eA:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_D_AM2D301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4c0e NOT1
(Chaetomium
thermophilum) 		4 / 8 ASP A1989
ARG A2051
GLU A2054
GLU A2004
 None
 1.05A 6mn4D-4c0eA:
undetectable		 6mn4D-4c0eA:
20.08