SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4c0h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_B_DVAB8_0
(GRAMICIDIN A)		 4c0h MRNA CLEAVAGE AND
POLYADENYLATION
FACTOR CLP1
(Saccharomyces
cerevisiae) 		3 / 3 TRP A  85
VAL A  27
TRP A  34
 None
 0.99A 1c4dA-4c0hA:
undetectable
1c4dB-4c0hA:
undetectable		 1c4dA-4c0hA:
4.94
1c4dB-4c0hA:
4.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G60_B_SAMB501_0
(ADENINE-SPECIFIC
METHYLTRANSFERASE
MBOIIA)		 4c0h MRNA CLEAVAGE AND
POLYADENYLATION
FACTOR CLP1
(Saccharomyces
cerevisiae) 		5 / 12 ASN A 218
PRO A 165
GLY A 171
THR A 168
TYR A 441
 None
 1.48A 1g60B-4c0hA:
1.8		 1g60B-4c0hA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_B_DX2B271_1
(PTERIDINE REDUCTASE
1)		 4c0h MRNA CLEAVAGE AND
POLYADENYLATION
FACTOR CLP1
(Saccharomyces
cerevisiae) 		4 / 8 ARG A 141
PHE A  73
LEU A 186
PRO A 187
 None
 0.90A 3jq7B-4c0hA:
undetectable		 3jq7B-4c0hA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_A_PFLA319_1
(GLR4197 PROTEIN)		 4c0h MRNA CLEAVAGE AND
POLYADENYLATION
FACTOR CLP1
(Saccharomyces
cerevisiae) 		4 / 7 ILE A  36
LEU A  44
THR A  96
ILE A  95
 None
 0.87A 3p50A-4c0hA:
undetectable		 3p50A-4c0hA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_B_PFLB319_1
(GLR4197 PROTEIN)		 4c0h MRNA CLEAVAGE AND
POLYADENYLATION
FACTOR CLP1
(Saccharomyces
cerevisiae) 		4 / 7 ILE A  36
LEU A  44
THR A  96
ILE A  95
 None
 0.86A 3p50B-4c0hA:
undetectable		 3p50B-4c0hA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_C_PFLC319_1
(GLR4197 PROTEIN)		 4c0h MRNA CLEAVAGE AND
POLYADENYLATION
FACTOR CLP1
(Saccharomyces
cerevisiae) 		4 / 7 ILE A  36
LEU A  44
THR A  96
ILE A  95
 None
 0.85A 3p50C-4c0hA:
undetectable		 3p50C-4c0hA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_D_PFLD320_1
(GLR4197 PROTEIN)		 4c0h MRNA CLEAVAGE AND
POLYADENYLATION
FACTOR CLP1
(Saccharomyces
cerevisiae) 		4 / 7 ILE A  36
LEU A  44
THR A  96
ILE A  95
 None
 0.85A 3p50D-4c0hA:
undetectable		 3p50D-4c0hA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_E_PFLE319_1
(GLR4197 PROTEIN)		 4c0h MRNA CLEAVAGE AND
POLYADENYLATION
FACTOR CLP1
(Saccharomyces
cerevisiae) 		4 / 7 ILE A  36
LEU A  44
THR A  96
ILE A  95
 None
 0.82A 3p50E-4c0hA:
undetectable		 3p50E-4c0hA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9K_A_TYLA2200_1
(CREB-BINDING PROTEIN)		 4c0h MRNA CLEAVAGE AND
POLYADENYLATION
FACTOR CLP1
(Saccharomyces
cerevisiae) 		4 / 6 VAL A 250
LEU A 160
ILE A 268
VAL A 233
 None
 0.94A 4a9kA-4c0hA:
undetectable		 4a9kA-4c0hA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIL_A_RBFA401_2
(MEMBRANE LIPOPROTEIN
TPN38(B))		 4c0h MRNA CLEAVAGE AND
POLYADENYLATION
FACTOR CLP1
(Saccharomyces
cerevisiae) 		4 / 8 VAL A 400
PRO A 358
GLN A 228
ILE A 405
 None
 1.06A 4iilA-4c0hA:
3.6		 4iilA-4c0hA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA505_0
(RNA POLYMERASE
3D-POL)		 4c0h MRNA CLEAVAGE AND
POLYADENYLATION
FACTOR CLP1
(Saccharomyces
cerevisiae) 		3 / 3 CYH A  87
ASN A  21
LYS A  43
 None
 1.43A 4k50A-4c0hA:
undetectable		 4k50A-4c0hA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4H_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 4c0h MRNA CLEAVAGE AND
POLYADENYLATION
FACTOR CLP1
(Saccharomyces
cerevisiae) 		4 / 5 ARG A 135
GLN A 133
ILE A 128
ASP A 251
 None
 1.32A 4z4hA-4c0hA:
2.1		 4z4hA-4c0hA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_F_Z80F401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4c0h MRNA CLEAVAGE AND
POLYADENYLATION
FACTOR CLP1
(Saccharomyces
cerevisiae) 		5 / 10 ILE A 411
VAL A 414
GLU A 351
ASP A 352
ILE A 376
 None
 1.18A 5lg3F-4c0hA:
undetectable		 5lg3F-4c0hA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_G_Z80G401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4c0h MRNA CLEAVAGE AND
POLYADENYLATION
FACTOR CLP1
(Saccharomyces
cerevisiae) 		5 / 10 ILE A 411
VAL A 414
GLU A 351
ASP A 352
ILE A 376
 None
 1.13A 5lg3G-4c0hA:
undetectable		 5lg3G-4c0hA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_J_Z80J401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4c0h MRNA CLEAVAGE AND
POLYADENYLATION
FACTOR CLP1
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 411
VAL A 414
GLU A 351
ASP A 352
ILE A 376
 None
 1.20A 5lg3J-4c0hA:
undetectable		 5lg3J-4c0hA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_A_BEZA301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 4c0h MRNA CLEAVAGE AND
POLYADENYLATION
FACTOR CLP1
(Saccharomyces
cerevisiae) 		4 / 7 ILE A 307
LEU A 109
MET A 112
LEU A 113
 None
 0.99A 5u4sA-4c0hA:
2.4		 5u4sA-4c0hA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_2
(CYTOCHROME P450 3A4)		 4c0h MRNA CLEAVAGE AND
POLYADENYLATION
FACTOR CLP1
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 322
ARG A 326
ARG A 442
 None
 1.01A 5vcgA-4c0hA:
undetectable		 5vcgA-4c0hA:
23.34