SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4c0j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4c0j MITOCHONDRIAL RHO
GTPASE
(Drosophila
melanogaster) 		4 / 8 ARG A 240
ASN A 236
GLN A 248
ASN A 244
 None
 1.34A 1p6kA-4c0jA:
undetectable		 1p6kA-4c0jA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T69_A_SHHA379_1
(HISTONE DEACETYLASE
8)		 4c0j MITOCHONDRIAL RHO
GTPASE
(Drosophila
melanogaster) 		5 / 12 TYR A 409
HIS A 418
GLY A 414
PHE A 334
TYR A 342
 None
 1.38A 1t69A-4c0jA:
undetectable		 1t69A-4c0jA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4c0j MITOCHONDRIAL RHO
GTPASE
(Drosophila
melanogaster) 		4 / 6 ILE A 373
ILE A 427
ILE A 319
ASP A 402
 None
 0.80A 1uwhA-4c0jA:
undetectable		 1uwhA-4c0jA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4c0j MITOCHONDRIAL RHO
GTPASE
(Drosophila
melanogaster) 		4 / 7 ILE A 373
ILE A 427
ILE A 319
ASP A 402
 None
 0.79A 1uwjA-4c0jA:
undetectable		 1uwjA-4c0jA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1217_1
(LIPOPROTEIN LPPX)		 4c0j MITOCHONDRIAL RHO
GTPASE
(Drosophila
melanogaster) 		4 / 4 VAL A 446
LEU A 388
ILE A 336
LEU A 335
 None
 0.97A 2byoA-4c0jA:
undetectable		 2byoA-4c0jA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)		 4c0j MITOCHONDRIAL RHO
GTPASE
(Drosophila
melanogaster) 		3 / 3 SER A 489
THR A 599
PHE A 588
 None
 0.77A 2x91A-4c0jA:
undetectable		 2x91A-4c0jA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_B_HFGB1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 4c0j MITOCHONDRIAL RHO
GTPASE
(Drosophila
melanogaster) 		5 / 12 LEU A 235
VAL A 272
HIS A 418
PHE A 300
THR A 361
 None
 1.42A 5xiqB-4c0jA:
2.1		 5xiqB-4c0jA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_A_9SCA601_1
(SERUM ALBUMIN)		 4c0j MITOCHONDRIAL RHO
GTPASE
(Drosophila
melanogaster) 		4 / 5 ASN A 228
TYR A 342
VAL A 338
LEU A 413
 None
 1.23A 6a7pA-4c0jA:
undetectable		 6a7pA-4c0jA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECF_I_DVAI3010_0
(VLM2
DODECADEPSIPEPTIDE)		 4c0j MITOCHONDRIAL RHO
GTPASE
(Drosophila
melanogaster) 		3 / 3 PHE A 415
ARG A 330
ALA A 337
 None
 0.99A 6ecfB-4c0jA:
4.1		 6ecfB-4c0jA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_C_SAMC301_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 4c0j MITOCHONDRIAL RHO
GTPASE
(Drosophila
melanogaster) 		5 / 12 LEU A 525
PRO A 454
ILE A 452
VAL A 506
ILE A 541
 None
 1.09A 6emuC-4c0jA:
undetectable		 6emuC-4c0jA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBF_A_ACTA507_0
(MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1)		 4c0j MITOCHONDRIAL RHO
GTPASE
(Drosophila
melanogaster) 		3 / 3 LYS A 375
SER A 368
SER A 370
 SO4  A1612 (-2.9A)
None
None
 1.09A 6gbfA-4c0jA:
undetectable		 6gbfA-4c0jA:
21.86