SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4c0w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 4c0w FMN-DEPENDENT
NADH-AZOREDUCTASE 1
(Pseudomonas
putida) 		3 / 3 GLY A 127
GLY A 162
GLY A 165
 None
 0.34A 3bogD-4c0wA:
undetectable		 3bogD-4c0wA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 4c0w FMN-DEPENDENT
NADH-AZOREDUCTASE 1
(Pseudomonas
putida) 		4 / 5 GLN A 103
LEU A  42
SER A   8
ASP A 155
 None
 1.33A 4qtuD-4c0wA:
undetectable		 4qtuD-4c0wA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_A_377A402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4c0w FMN-DEPENDENT
NADH-AZOREDUCTASE 1
(Pseudomonas
putida) 		5 / 9 ALA A  73
SER A  76
ALA A  57
ALA A  53
SER A  51
 None
 1.23A 4twdA-4c0wA:
undetectable
4twdB-4c0wA:
undetectable
4twdC-4c0wA:
undetectable
4twdD-4c0wA:
undetectable
4twdE-4c0wA:
undetectable		 4twdA-4c0wA:
19.24
4twdB-4c0wA:
19.24
4twdC-4c0wA:
19.24
4twdD-4c0wA:
19.24
4twdE-4c0wA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB201_0
(HYDROXYNITRILE LYASE)		 4c0w FMN-DEPENDENT
NADH-AZOREDUCTASE 1
(Pseudomonas
putida) 		5 / 11 VAL A 135
VAL A 172
VAL A 137
TRP A  28
LEU A 199
 None
 1.04A 5e4dB-4c0wA:
undetectable		 5e4dB-4c0wA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHA_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4c0w FMN-DEPENDENT
NADH-AZOREDUCTASE 1
(Pseudomonas
putida) 		3 / 3 VAL A 137
VAL A 172
GLN A 192
 None
 0.68A 5qhaA-4c0wA:
undetectable		 5qhaA-4c0wA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MXT_A_K5YA1401_1
(ENDOLYSIN, BETA-2
ADRENERGIC RECEPTOR
CHIMERA)		 4c0w FMN-DEPENDENT
NADH-AZOREDUCTASE 1
(Pseudomonas
putida) 		3 / 3 ASP A  41
SER A  17
SER A  15
 None
FMN  A1201 (-2.6A)
FMN  A1201 (-2.6A)
 0.83A 6mxtA-4c0wA:
undetectable		 6mxtA-4c0wA:
16.98