SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4c1l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OIP_A_VIVA1278_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4c1l 2-DEHYDRO-3-DEOXYPHO
SPHOHEPTONATE
ALDOLASE
(Pyrococcus
furiosus) 		5 / 12 LEU A 179
ILE A 143
ILE A  27
ILE A 196
VAL A 187
 None
 0.93A 1oipA-4c1lA:
undetectable		 1oipA-4c1lA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_C_URFC2081_1
(URIDINE
PHOSPHORYLASE)		 4c1l 2-DEHYDRO-3-DEOXYPHO
SPHOHEPTONATE
ALDOLASE
(Pyrococcus
furiosus) 		4 / 7 GLY A  29
GLN A 242
ILE A  39
VAL A  42
 None
 1.06A 1rxcC-4c1lA:
undetectable		 1rxcC-4c1lA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_D_URFD2021_1
(URIDINE
PHOSPHORYLASE)		 4c1l 2-DEHYDRO-3-DEOXYPHO
SPHOHEPTONATE
ALDOLASE
(Pyrococcus
furiosus) 		4 / 7 GLY A  29
GLN A 242
ILE A  39
VAL A  42
 None
 1.00A 1rxcD-4c1lA:
undetectable		 1rxcD-4c1lA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_E_URFE2031_1
(URIDINE
PHOSPHORYLASE)		 4c1l 2-DEHYDRO-3-DEOXYPHO
SPHOHEPTONATE
ALDOLASE
(Pyrococcus
furiosus) 		4 / 8 GLY A  29
GLN A 242
ILE A  39
VAL A  42
 None
 0.96A 1rxcE-4c1lA:
undetectable		 1rxcE-4c1lA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_F_URFF2001_1
(URIDINE
PHOSPHORYLASE)		 4c1l 2-DEHYDRO-3-DEOXYPHO
SPHOHEPTONATE
ALDOLASE
(Pyrococcus
furiosus) 		4 / 7 GLY A  29
GLN A 242
ILE A  39
VAL A  42
 None
 0.95A 1rxcF-4c1lA:
undetectable		 1rxcF-4c1lA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_I_URFI2041_1
(URIDINE
PHOSPHORYLASE)		 4c1l 2-DEHYDRO-3-DEOXYPHO
SPHOHEPTONATE
ALDOLASE
(Pyrococcus
furiosus) 		4 / 8 GLY A  29
GLN A 242
ILE A  39
VAL A  42
 None
 0.99A 1rxcI-4c1lA:
undetectable		 1rxcI-4c1lA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_L_URFL2071_1
(URIDINE
PHOSPHORYLASE)		 4c1l 2-DEHYDRO-3-DEOXYPHO
SPHOHEPTONATE
ALDOLASE
(Pyrococcus
furiosus) 		4 / 7 GLY A  29
GLN A 242
ILE A  39
VAL A  42
 None
 0.99A 1rxcL-4c1lA:
undetectable		 1rxcL-4c1lA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UUJ_B_ACTB1077_0
(PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE IB
ALPHA SUBUNIT)		 4c1l 2-DEHYDRO-3-DEOXYPHO
SPHOHEPTONATE
ALDOLASE
(Pyrococcus
furiosus) 		3 / 3 ARG A  77
TYR A 106
LYS A 105
 None
 0.96A 1uujB-4c1lA:
undetectable		 1uujB-4c1lA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_A_BEZA1529_0
(BENZOATE-COENZYME A
LIGASE)		 4c1l 2-DEHYDRO-3-DEOXYPHO
SPHOHEPTONATE
ALDOLASE
(Pyrococcus
furiosus) 		5 / 9 ALA A 213
ALA A 221
GLY A 220
GLY A 223
ILE A 196
 None
 1.25A 2v7bA-4c1lA:
undetectable		 2v7bA-4c1lA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_B_BEZB1529_0
(BENZOATE-COENZYME A
LIGASE)		 4c1l 2-DEHYDRO-3-DEOXYPHO
SPHOHEPTONATE
ALDOLASE
(Pyrococcus
furiosus) 		5 / 9 ALA A 213
ALA A 221
GLY A 220
GLY A 223
ILE A 196
 None
 1.27A 2v7bB-4c1lA:
undetectable		 2v7bB-4c1lA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_K_RBFK200_1
(DODECIN)		 4c1l 2-DEHYDRO-3-DEOXYPHO
SPHOHEPTONATE
ALDOLASE
(Pyrococcus
furiosus) 		4 / 8 HIS A 229
GLN A 242
ARG A  62
TYR A  71
 None
 1.28A 2vxaH-4c1lA:
undetectable
2vxaJ-4c1lA:
undetectable
2vxaK-4c1lA:
undetectable		 2vxaH-4c1lA:
15.56
2vxaJ-4c1lA:
15.56
2vxaK-4c1lA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XNR_A_ACTA1001_0
(NUCLEAR
POLYADENYLATED
RNA-BINDING PROTEIN
3)		 4c1l 2-DEHYDRO-3-DEOXYPHO
SPHOHEPTONATE
ALDOLASE
(Pyrococcus
furiosus) 		3 / 3 SER A 200
ARG A 176
GLN A 241
 None
 0.84A 2xnrA-4c1lA:
undetectable		 2xnrA-4c1lA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_C_486C4_1
(GLUCOCORTICOID
RECEPTOR)		 4c1l 2-DEHYDRO-3-DEOXYPHO
SPHOHEPTONATE
ALDOLASE
(Pyrococcus
furiosus) 		5 / 12 LEU A  46
GLY A  50
TRP A 260
LEU A 249
PHE A  45
 None
 1.36A 3h52C-4c1lA:
undetectable		 3h52C-4c1lA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_A_URFA254_1
(URIDINE
PHOSPHORYLASE)		 4c1l 2-DEHYDRO-3-DEOXYPHO
SPHOHEPTONATE
ALDOLASE
(Pyrococcus
furiosus) 		4 / 6 GLY A  29
GLN A 242
ILE A  39
VAL A  42
 None
 0.97A 3kvvA-4c1lA:
undetectable		 3kvvA-4c1lA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_B_URFB254_1
(URIDINE
PHOSPHORYLASE)		 4c1l 2-DEHYDRO-3-DEOXYPHO
SPHOHEPTONATE
ALDOLASE
(Pyrococcus
furiosus) 		4 / 6 GLY A  29
GLN A 242
ILE A  39
VAL A  42
 None
 1.00A 3kvvB-4c1lA:
undetectable		 3kvvB-4c1lA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_C_URFC254_1
(URIDINE
PHOSPHORYLASE)		 4c1l 2-DEHYDRO-3-DEOXYPHO
SPHOHEPTONATE
ALDOLASE
(Pyrococcus
furiosus) 		4 / 6 GLY A  29
GLN A 242
ILE A  39
VAL A  42
 None
 1.02A 3kvvC-4c1lA:
undetectable		 3kvvC-4c1lA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_D_URFD254_1
(URIDINE
PHOSPHORYLASE)		 4c1l 2-DEHYDRO-3-DEOXYPHO
SPHOHEPTONATE
ALDOLASE
(Pyrococcus
furiosus) 		4 / 6 GLY A  29
GLN A 242
ILE A  39
VAL A  42
 None
 1.01A 3kvvD-4c1lA:
undetectable		 3kvvD-4c1lA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_E_URFE254_1
(URIDINE
PHOSPHORYLASE)		 4c1l 2-DEHYDRO-3-DEOXYPHO
SPHOHEPTONATE
ALDOLASE
(Pyrococcus
furiosus) 		4 / 6 GLY A  29
GLN A 242
ILE A  39
VAL A  42
 None
 1.02A 3kvvE-4c1lA:
undetectable		 3kvvE-4c1lA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_F_URFF254_1
(URIDINE
PHOSPHORYLASE)		 4c1l 2-DEHYDRO-3-DEOXYPHO
SPHOHEPTONATE
ALDOLASE
(Pyrococcus
furiosus) 		4 / 6 GLY A  29
GLN A 242
ILE A  39
VAL A  42
 None
 0.99A 3kvvF-4c1lA:
undetectable		 3kvvF-4c1lA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP1_A_NVPA701_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 4c1l 2-DEHYDRO-3-DEOXYPHO
SPHOHEPTONATE
ALDOLASE
(Pyrococcus
furiosus) 		5 / 10 ASN A 158
VAL A 126
TYR A 152
GLY A 127
LEU A 135
 None
 1.49A 3lp1A-4c1lA:
undetectable		 3lp1A-4c1lA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_B_TPVB100_1
(HIV-1 PROTEASE)		 4c1l 2-DEHYDRO-3-DEOXYPHO
SPHOHEPTONATE
ALDOLASE
(Pyrococcus
furiosus) 		5 / 9 ARG A 206
LEU A 243
ALA A  28
VAL A  42
GLY A  56
 None
 1.33A 3spkA-4c1lA:
undetectable		 3spkA-4c1lA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		 4c1l 2-DEHYDRO-3-DEOXYPHO
SPHOHEPTONATE
ALDOLASE
(Pyrococcus
furiosus) 		5 / 11 ILE A 162
ILE A 153
GLU A  93
PRO A 132
VAL A  91
 None
 1.09A 3tmzA-4c1lA:
undetectable		 3tmzA-4c1lA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_B_URFB1301_1
(URIDINE
PHOSPHORYLASE)		 4c1l 2-DEHYDRO-3-DEOXYPHO
SPHOHEPTONATE
ALDOLASE
(Pyrococcus
furiosus) 		4 / 7 GLY A  29
GLN A 242
ILE A  39
VAL A  42
 None
 1.01A 4e1vB-4c1lA:
undetectable		 4e1vB-4c1lA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_F_URFF1301_1
(URIDINE
PHOSPHORYLASE)		 4c1l 2-DEHYDRO-3-DEOXYPHO
SPHOHEPTONATE
ALDOLASE
(Pyrococcus
furiosus) 		4 / 6 GLY A  29
GLN A 242
ILE A  39
VAL A  42
 None
 0.99A 4e1vF-4c1lA:
undetectable		 4e1vF-4c1lA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_G_URFG1301_1
(URIDINE
PHOSPHORYLASE)		 4c1l 2-DEHYDRO-3-DEOXYPHO
SPHOHEPTONATE
ALDOLASE
(Pyrococcus
furiosus) 		4 / 8 GLY A  29
GLN A 242
ILE A  39
VAL A  42
 None
 0.93A 4e1vG-4c1lA:
undetectable		 4e1vG-4c1lA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_H_URFH1301_1
(URIDINE
PHOSPHORYLASE)		 4c1l 2-DEHYDRO-3-DEOXYPHO
SPHOHEPTONATE
ALDOLASE
(Pyrococcus
furiosus) 		4 / 8 GLY A  29
GLN A 242
ILE A  39
VAL A  42
 None
 0.99A 4e1vH-4c1lA:
undetectable		 4e1vH-4c1lA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_B_STRB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 4c1l 2-DEHYDRO-3-DEOXYPHO
SPHOHEPTONATE
ALDOLASE
(Pyrococcus
furiosus) 		4 / 6 VAL A 226
VAL A 209
ILE A 210
LEU A 252
 None
 0.92A 4l1wB-4c1lA:
11.3		 4l1wB-4c1lA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4c1l 2-DEHYDRO-3-DEOXYPHO
SPHOHEPTONATE
ALDOLASE
(Pyrococcus
furiosus) 		5 / 12 LEU A  46
ILE A 224
VAL A 228
LEU A 243
ILE A 210
 None
 0.96A 5mugA-4c1lA:
undetectable		 5mugA-4c1lA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA605_0
(ALPHA-AMYLASE)		 4c1l 2-DEHYDRO-3-DEOXYPHO
SPHOHEPTONATE
ALDOLASE
(Pyrococcus
furiosus) 		4 / 8 GLY A  57
ILE A  33
HIS A 229
PRO A 230
 None
 0.70A 6ag0A-4c1lA:
7.7		 6ag0A-4c1lA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC605_0
(ALPHA-AMYLASE)		 4c1l 2-DEHYDRO-3-DEOXYPHO
SPHOHEPTONATE
ALDOLASE
(Pyrococcus
furiosus) 		4 / 8 GLY A  57
ILE A  33
HIS A 229
PRO A 230
 None
 0.77A 6ag0C-4c1lA:
5.9		 6ag0C-4c1lA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_A_ACRA602_1
(-)		 4c1l 2-DEHYDRO-3-DEOXYPHO
SPHOHEPTONATE
ALDOLASE
(Pyrococcus
furiosus) 		5 / 12 GLY A  57
GLY A  56
VAL A  91
GLN A 242
GLY A  29
 None
 1.11A 6gneA-4c1lA:
2.1		 6gneA-4c1lA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_1
(-)		 4c1l 2-DEHYDRO-3-DEOXYPHO
SPHOHEPTONATE
ALDOLASE
(Pyrococcus
furiosus) 		5 / 12 GLY A  57
GLY A  56
VAL A  91
GLN A 242
GLY A  29
 None
 1.10A 6gneB-4c1lA:
undetectable		 6gneB-4c1lA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_1
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 4c1l 2-DEHYDRO-3-DEOXYPHO
SPHOHEPTONATE
ALDOLASE
(Pyrococcus
furiosus) 		4 / 7 ILE A  39
GLU A 227
HIS A 229
VAL A  42
 None
MN  A1263 (-2.5A)
None
None
 1.08A 6j20A-4c1lA:
undetectable		 6j20A-4c1lA:
18.82