SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4c1o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A27_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 4c1o BETA-XYLOSIDASE
(Parageobacillus
thermoglucosidas
ius) 		5 / 12 SER A 719
VAL A 717
GLY A 716
VAL A 142
PHE A 375
 None
 1.33A 1a27A-4c1oA:
undetectable		 1a27A-4c1oA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLB_A_NVPA999_1
(HIV-1 RT A-CHAIN)		 4c1o BETA-XYLOSIDASE
(Parageobacillus
thermoglucosidas
ius) 		4 / 8 LEU A 234
VAL A  81
TYR A  67
GLY A  69
 None
 0.91A 1jlbA-4c1oA:
undetectable		 1jlbA-4c1oA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWE_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 4c1o BETA-XYLOSIDASE
(Parageobacillus
thermoglucosidas
ius) 		4 / 7 LEU A 234
VAL A  81
TYR A  67
GLY A  69
 None
 0.86A 1lweA-4c1oA:
undetectable		 1lweA-4c1oA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_F_THAF6_1
(LIVER
CARBOXYLESTERASE I)		 4c1o BETA-XYLOSIDASE
(Parageobacillus
thermoglucosidas
ius) 		5 / 12 GLY A  52
GLY A  53
VAL A 268
LEU A  54
PHE A 136
 None
 1.05A 1mx1F-4c1oA:
undetectable		 1mx1F-4c1oA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RI4_A_SAMA299_0
(MRNA CAPPING ENZYME)		 4c1o BETA-XYLOSIDASE
(Parageobacillus
thermoglucosidas
ius) 		5 / 12 GLY A 598
GLY A 534
ILE A 596
ALA A 595
PHE A 617
 None
 1.04A 1ri4A-4c1oA:
undetectable		 1ri4A-4c1oA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4c1o BETA-XYLOSIDASE
(Parageobacillus
thermoglucosidas
ius) 		4 / 5 GLY A  77
GLN A  75
VAL A 111
SER A  72
 None
 1.38A 1rs6B-4c1oA:
2.2		 1rs6B-4c1oA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4c1o BETA-XYLOSIDASE
(Parageobacillus
thermoglucosidas
ius) 		4 / 5 GLY A  77
GLN A  75
VAL A 111
SER A  72
 None
 1.44A 1zzuA-4c1oA:
undetectable		 1zzuA-4c1oA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4c1o BETA-XYLOSIDASE
(Parageobacillus
thermoglucosidas
ius) 		5 / 12 LEU A 230
LEU A 110
GLY A  69
TYR A  67
ALA A 181
 None
 1.03A 2bm9A-4c1oA:
undetectable		 2bm9A-4c1oA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4c1o BETA-XYLOSIDASE
(Parageobacillus
thermoglucosidas
ius) 		5 / 12 LEU A 230
LEU A 110
GLY A  69
TYR A  67
ALA A 181
 None
 1.07A 2bm9C-4c1oA:
undetectable		 2bm9C-4c1oA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4c1o BETA-XYLOSIDASE
(Parageobacillus
thermoglucosidas
ius) 		5 / 12 LEU A 230
LEU A 110
GLY A  69
TYR A  67
ALA A 181
 None
 1.00A 2br4A-4c1oA:
undetectable		 2br4A-4c1oA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4c1o BETA-XYLOSIDASE
(Parageobacillus
thermoglucosidas
ius) 		5 / 12 LEU A 230
LEU A 110
GLY A  69
TYR A  67
ALA A 181
 None
 1.04A 2br4C-4c1oA:
undetectable		 2br4C-4c1oA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4c1o BETA-XYLOSIDASE
(Parageobacillus
thermoglucosidas
ius) 		5 / 12 LEU A 230
LEU A 110
GLY A  69
TYR A  67
ALA A 181
 None
 1.03A 2br4D-4c1oA:
undetectable		 2br4D-4c1oA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4c1o BETA-XYLOSIDASE
(Parageobacillus
thermoglucosidas
ius) 		5 / 12 LEU A 230
LEU A 110
GLY A  69
TYR A  67
ALA A 181
 None
 1.03A 2br4E-4c1oA:
undetectable		 2br4E-4c1oA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 4c1o BETA-XYLOSIDASE
(Parageobacillus
thermoglucosidas
ius) 		4 / 7 TYR A 339
TYR A 338
GLY A  38
THR A 342
 None
 0.99A 2g70B-4c1oA:
undetectable		 2g70B-4c1oA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_J_ACTJ1116_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 4c1o BETA-XYLOSIDASE
(Parageobacillus
thermoglucosidas
ius) 		4 / 8 GLU A 305
ILE A 304
ILE A 165
GLU A 167
 None
 0.94A 2j9dJ-4c1oA:
undetectable
2j9dK-4c1oA:
undetectable
2j9dL-4c1oA:
undetectable		 2j9dJ-4c1oA:
10.47
2j9dK-4c1oA:
10.47
2j9dL-4c1oA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OK6_H_BEZH2001_0
(AROMATIC AMINE
DEHYDROGENASE, LARGE
SUBUNIT
AROMATIC AMINE
DEHYDROGENASE, SMALL
SUBUNIT)		 4c1o BETA-XYLOSIDASE
(Parageobacillus
thermoglucosidas
ius) 		5 / 10 PHE A 136
LEU A 168
GLY A  69
LEU A  82
PHE A 183
 None
 1.19A 2ok6A-4c1oA:
0.5
2ok6H-4c1oA:
undetectable		 2ok6A-4c1oA:
18.92
2ok6H-4c1oA:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_C_SAMC300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 4c1o BETA-XYLOSIDASE
(Parageobacillus
thermoglucosidas
ius) 		4 / 4 SER A 444
GLY A 441
HIS A 448
ASP A 489
 None
GOL  A1746 ( 3.1A)
None
NA  A1731 (-3.2A)
 1.32A 2oxtC-4c1oA:
undetectable		 2oxtC-4c1oA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1501_1
(CYTOCHROME P450 3A4)		 4c1o BETA-XYLOSIDASE
(Parageobacillus
thermoglucosidas
ius) 		5 / 10 ASP A 371
ARG A 715
ILE A 702
LEU A 721
THR A 718
 None
GOL  A1737 (-3.3A)
None
None
None
 1.21A 2v0mA-4c1oA:
undetectable		 2v0mA-4c1oA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		 4c1o BETA-XYLOSIDASE
(Parageobacillus
thermoglucosidas
ius) 		4 / 8 TYR A 573
SER A 648
THR A 649
THR A 633
 GOL  A1753 (-3.9A)
GOL  A1751 (-2.8A)
GOL  A1751 (-3.9A)
None
 1.21A 2v0zO-4c1oA:
undetectable		 2v0zO-4c1oA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_B_Y00B601_2
(BETA-1 ADRENERGIC
RECEPTOR)		 4c1o BETA-XYLOSIDASE
(Parageobacillus
thermoglucosidas
ius) 		3 / 3 VAL A 142
ASN A 380
TRP A 382
 None
 1.13A 2y00B-4c1oA:
undetectable		 2y00B-4c1oA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YLG_A_ASCA130_0
(CYTOCHROME C')		 4c1o BETA-XYLOSIDASE
(Parageobacillus
thermoglucosidas
ius) 		4 / 5 ALA A 539
GLY A 498
CYH A 566
LYS A 565
 None
 1.44A 2ylgA-4c1oA:
3.0		 2ylgA-4c1oA:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGR_A_T27A556_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H
P51 RT)		 4c1o BETA-XYLOSIDASE
(Parageobacillus
thermoglucosidas
ius) 		5 / 11 LEU A 660
VAL A 370
TYR A 603
LEU A 721
GLU A 597
 None
 1.44A 3bgrA-4c1oA:
undetectable
3bgrB-4c1oA:
0.6		 3bgrA-4c1oA:
21.61
3bgrB-4c1oA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_A_LEIA16_0
(COIL SER L16D-PEN)		 4c1o BETA-XYLOSIDASE
(Parageobacillus
thermoglucosidas
ius) 		4 / 6 GLN A 480
LEU A 482
GLU A 479
LEU A 555
 None
 0.80A 3h5gA-4c1oA:
undetectable
3h5gC-4c1oA:
undetectable		 3h5gA-4c1oA:
3.30
3h5gC-4c1oA:
3.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N61_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE)		 4c1o BETA-XYLOSIDASE
(Parageobacillus
thermoglucosidas
ius) 		4 / 6 VAL A 384
VAL A 370
PHE A 374
GLU A 376
 None
 1.47A 3n61A-4c1oA:
undetectable
3n61B-4c1oA:
undetectable		 3n61A-4c1oA:
20.00
3n61B-4c1oA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UR0_C_SVRC516_1
(RNA-DEPENDENT RNA
POLYMERASE)		 4c1o BETA-XYLOSIDASE
(Parageobacillus
thermoglucosidas
ius) 		5 / 9 PRO A 162
GLY A  38
ALA A  39
ALA A 276
LEU A  56
 None
 1.12A 3ur0C-4c1oA:
1.2		 3ur0C-4c1oA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4c1o BETA-XYLOSIDASE
(Parageobacillus
thermoglucosidas
ius) 		4 / 7 GLU A 376
TYR A 338
HIS A  33
VAL A 124
 None
 1.06A 4a97D-4c1oA:
3.0		 4a97D-4c1oA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC0_A_MIYA1204_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS B FROM
TRANSPOSON TN1 0)		 4c1o BETA-XYLOSIDASE
(Parageobacillus
thermoglucosidas
ius) 		5 / 12 ASN A 588
HIS A 627
PRO A 594
LEU A 523
LEU A 532
 None
 1.04A 4ac0A-4c1oA:
2.2		 4ac0A-4c1oA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGJ_A_1PQA303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4c1o BETA-XYLOSIDASE
(Parageobacillus
thermoglucosidas
ius) 		5 / 9 GLY A  52
GLY A  53
PHE A 136
ILE A 138
PHE A 183
 None
 1.35A 4fgjA-4c1oA:
undetectable
4fgjB-4c1oA:
undetectable		 4fgjA-4c1oA:
15.11
4fgjB-4c1oA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UMJ_A_BFQA1297_1
(GERANYLTRANSTRANSFER
ASE)		 4c1o BETA-XYLOSIDASE
(Parageobacillus
thermoglucosidas
ius) 		4 / 8 LEU A 368
ASP A 367
ARG A 715
GLN A 450
 GOL  A1737 ( 4.9A)
GOL  A1737 (-2.8A)
GOL  A1737 (-3.3A)
None
 1.00A 4umjA-4c1oA:
2.2		 4umjA-4c1oA:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_A_RTZA602_1
(CYTOCHROME P450 2D6)		 4c1o BETA-XYLOSIDASE
(Parageobacillus
thermoglucosidas
ius) 		6 / 12 PHE A 122
GLY A 716
VAL A 355
THR A 342
VAL A 142
PHE A 375
 None
 1.47A 4wnwA-4c1oA:
undetectable		 4wnwA-4c1oA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 4c1o BETA-XYLOSIDASE
(Parageobacillus
thermoglucosidas
ius) 		6 / 12 GLY A 598
ALA A 533
ALA A 595
ILE A 596
LEU A 599
ALA A 542
 None
 1.31A 5bw4B-4c1oA:
undetectable		 5bw4B-4c1oA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS6_A_J3ZA302_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14)		 4c1o BETA-XYLOSIDASE
(Parageobacillus
thermoglucosidas
ius) 		4 / 8 HIS A 684
LEU A 688
LEU A 655
THR A 718
 None
 1.18A 5hs6A-4c1oA:
undetectable		 5hs6A-4c1oA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4c1o BETA-XYLOSIDASE
(Parageobacillus
thermoglucosidas
ius) 		3 / 3 VAL A  37
SER A 314
MET A 331
 None
 0.93A 5ikqA-4c1oA:
undetectable		 5ikqA-4c1oA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLI_A_ASCA202_0
(CYTOCHROME C')		 4c1o BETA-XYLOSIDASE
(Parageobacillus
thermoglucosidas
ius) 		4 / 5 ALA A 539
GLY A 498
CYH A 566
LYS A 565
 None
 1.44A 5jliA-4c1oA:
3.1		 5jliA-4c1oA:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4c1o BETA-XYLOSIDASE
(Parageobacillus
thermoglucosidas
ius) 		4 / 4 LEU A 543
ARG A 548
ILE A 546
PHE A 547
 None
 0.90A 5kirB-4c1oA:
undetectable		 5kirB-4c1oA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OS7_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 4c1o BETA-XYLOSIDASE
(Parageobacillus
thermoglucosidas
ius) 		3 / 3 HIS A 227
SER A 229
LYS A 106
 None
 1.42A 5os7A-4c1oA:
0.5		 5os7A-4c1oA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_A_ACTA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4c1o BETA-XYLOSIDASE
(Parageobacillus
thermoglucosidas
ius) 		4 / 5 GLY A  77
GLN A  75
VAL A 111
SER A  72
 None
 1.32A 5vunA-4c1oA:
undetectable		 5vunA-4c1oA:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_A_SAMA505_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 4c1o BETA-XYLOSIDASE
(Parageobacillus
thermoglucosidas
ius) 		3 / 3 ILE A 580
ASN A 529
CYH A 536
 None
 0.87A 6bp4A-4c1oA:
undetectable		 6bp4A-4c1oA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_A_RFPA502_1
(RIFAMPIN
MONOOXYGENASE)		 4c1o BETA-XYLOSIDASE
(Parageobacillus
thermoglucosidas
ius) 		5 / 12 PHE A  84
VAL A 164
PHE A 270
THR A  44
GLY A  52
 None
 1.44A 6brdA-4c1oA:
undetectable		 6brdA-4c1oA:
8.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F8C_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 4c1o BETA-XYLOSIDASE
(Parageobacillus
thermoglucosidas
ius) 		4 / 6 ALA A 610
GLY A 534
ILE A 664
PHE A 663
 None
 0.80A 6f8cA-4c1oA:
undetectable		 6f8cA-4c1oA:
7.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_D_ZOLD401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4c1o BETA-XYLOSIDASE
(Parageobacillus
thermoglucosidas
ius) 		4 / 7 LEU A 368
ASP A 367
ARG A 715
GLN A 450
 GOL  A1737 ( 4.9A)
GOL  A1737 (-2.8A)
GOL  A1737 (-3.3A)
None
 1.01A 6g31D-4c1oA:
2.7		 6g31D-4c1oA:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_J_ZOLJ401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4c1o BETA-XYLOSIDASE
(Parageobacillus
thermoglucosidas
ius) 		4 / 6 LEU A 368
ASP A 367
ARG A 715
GLN A 450
 GOL  A1737 ( 4.9A)
GOL  A1737 (-2.8A)
GOL  A1737 (-3.3A)
None
 0.92A 6g31J-4c1oA:
undetectable		 6g31J-4c1oA:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GMD_B_ACTB402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 4c1o BETA-XYLOSIDASE
(Parageobacillus
thermoglucosidas
ius) 		3 / 3 HIS A 227
SER A 229
LYS A 106
 None
 1.42A 6gmdB-4c1oA:
0.5		 6gmdB-4c1oA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_N_PCFN606_0
(CYTOCHROME B)		 4c1o BETA-XYLOSIDASE
(Parageobacillus
thermoglucosidas
ius) 		5 / 12 MET A 331
ALA A 334
TYR A 338
TYR A 339
THR A 342
 None
 1.28A 6hu9N-4c1oA:
undetectable		 6hu9N-4c1oA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MHT_D_SAMD328_0
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI)		 4c1o BETA-XYLOSIDASE
(Parageobacillus
thermoglucosidas
ius) 		5 / 12 PHE A 185
GLY A  52
GLY A  49
ASP A  55
ILE A 215
 None
None
EDO  A1735 (-2.9A)
None
None
 1.10A 6mhtA-4c1oA:
undetectable		 6mhtA-4c1oA:
18.47