SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4c1q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_G_BEZG1162_0
(PEROXIREDOXIN 5)
4c1q HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9

(Mus
musculus)
4 / 8 PRO A 244
GLY A 245
LEU A 271
PHE A 273
None
0.80A 1h4oG-4c1qA:
undetectable
1h4oG-4c1qA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N6C_A_SAMA402_0
(SET
DOMAIN-CONTAINING
PROTEIN 7)
4c1q HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9

(Mus
musculus)
5 / 11 ILE A 253
ALA A 256
GLY A 257
ASN A 320
TYR A 357
SAH  A 394 (-4.1A)
SAH  A 394 (-3.6A)
SAH  A 394 ( 3.7A)
SAH  A 394 (-3.4A)
None
0.24A 1n6cA-4c1qA:
7.2
1n6cA-4c1qA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_A_NPSA5_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)
4c1q HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9

(Mus
musculus)
6 / 12 LEU A 354
TYR A 357
LEU A 365
VAL A 319
GLY A 259
SER A 251
None
None
SAH  A 394 ( 4.3A)
None
None
None
1.19A 3nt1A-4c1qA:
undetectable
3nt1A-4c1qA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_B_NPSB4_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)
4c1q HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9

(Mus
musculus)
6 / 12 LEU A 354
TYR A 357
LEU A 365
VAL A 319
GLY A 259
SER A 251
None
None
SAH  A 394 ( 4.3A)
None
None
None
1.20A 3nt1B-4c1qA:
undetectable
3nt1B-4c1qA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_A_SAMA6734_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)
4c1q HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9

(Mus
musculus)
5 / 12 ALA A 256
GLY A 257
TYR A 291
ASN A 320
TYR A 357
SAH  A 394 (-3.6A)
SAH  A 394 ( 3.7A)
SAH  A 394 (-3.9A)
SAH  A 394 (-3.4A)
None
0.77A 3qxyA-4c1qA:
5.7
3qxyA-4c1qA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_B_SAMB6735_0
(N-LYSINE
METHYLTRANSFERASE
SETD6
TRANSCRIPTION FACTOR
P65)
4c1q HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9

(Mus
musculus)
5 / 11 ALA A 256
GLY A 257
TYR A 291
ASN A 320
TYR A 357
SAH  A 394 (-3.6A)
SAH  A 394 ( 3.7A)
SAH  A 394 (-3.9A)
SAH  A 394 (-3.4A)
None
0.78A 3qxyB-4c1qA:
5.5
3qxyQ-4c1qA:
undetectable
3qxyB-4c1qA:
17.94
3qxyQ-4c1qA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_A_SAMA484_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)
4c1q HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9

(Mus
musculus)
5 / 11 ALA A 256
GLY A 257
TYR A 291
ASN A 320
TYR A 357
SAH  A 394 (-3.6A)
SAH  A 394 ( 3.7A)
SAH  A 394 (-3.9A)
SAH  A 394 (-3.4A)
None
0.76A 3rc0A-4c1qA:
5.6
3rc0A-4c1qA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_B_SAMB480_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)
4c1q HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9

(Mus
musculus)
5 / 12 ALA A 256
GLY A 257
TYR A 291
ASN A 320
TYR A 357
SAH  A 394 (-3.6A)
SAH  A 394 ( 3.7A)
SAH  A 394 (-3.9A)
SAH  A 394 (-3.4A)
None
0.75A 3rc0B-4c1qA:
5.4
3rc0B-4c1qA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)
4c1q HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9

(Mus
musculus)
6 / 11 ILE A 253
ALA A 256
GLY A 257
GLY A 290
ASN A 320
TYR A 357
SAH  A 394 (-4.1A)
SAH  A 394 (-3.6A)
SAH  A 394 ( 3.7A)
None
SAH  A 394 (-3.4A)
None
0.37A 4e47A-4c1qA:
10.1
4e47A-4c1qA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_B_SAMB800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)
4c1q HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9

(Mus
musculus)
6 / 11 ILE A 253
ALA A 256
GLY A 257
GLY A 290
ASN A 320
TYR A 357
SAH  A 394 (-4.1A)
SAH  A 394 (-3.6A)
SAH  A 394 ( 3.7A)
None
SAH  A 394 (-3.4A)
None
0.34A 4e47B-4c1qA:
8.9
4e47B-4c1qA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_C_SAMC800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)
4c1q HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9

(Mus
musculus)
6 / 11 ILE A 253
ALA A 256
GLY A 257
GLY A 290
ASN A 320
TYR A 357
SAH  A 394 (-4.1A)
SAH  A 394 (-3.6A)
SAH  A 394 ( 3.7A)
None
SAH  A 394 (-3.4A)
None
0.39A 4e47C-4c1qA:
10.2
4e47C-4c1qA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_D_SAMD800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)
4c1q HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9

(Mus
musculus)
5 / 10 ILE A 253
ALA A 256
GLY A 290
ASN A 320
TYR A 357
SAH  A 394 (-4.1A)
SAH  A 394 (-3.6A)
None
SAH  A 394 (-3.4A)
None
0.39A 4e47D-4c1qA:
10.0
4e47D-4c1qA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J83_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)
4c1q HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9

(Mus
musculus)
5 / 11 ILE A 253
ALA A 256
GLY A 290
ASN A 320
TYR A 357
SAH  A 394 (-4.1A)
SAH  A 394 (-3.6A)
None
SAH  A 394 (-3.4A)
None
0.38A 4j83A-4c1qA:
9.9
4j83A-4c1qA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)
4c1q HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9

(Mus
musculus)
6 / 11 ILE A 253
ALA A 256
GLY A 257
GLY A 290
ASN A 320
TYR A 357
SAH  A 394 (-4.1A)
SAH  A 394 (-3.6A)
SAH  A 394 ( 3.7A)
None
SAH  A 394 (-3.4A)
None
0.32A 4jdsA-4c1qA:
10.2
4jdsA-4c1qA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_B_SAMB401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)
4c1q HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9

(Mus
musculus)
6 / 11 ILE A 253
ALA A 256
GLY A 257
GLY A 290
ASN A 320
TYR A 357
SAH  A 394 (-4.1A)
SAH  A 394 (-3.6A)
SAH  A 394 ( 3.7A)
None
SAH  A 394 (-3.4A)
None
0.36A 4jdsB-4c1qA:
10.3
4jdsB-4c1qA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_C_SAMC401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)
4c1q HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9

(Mus
musculus)
6 / 11 ILE A 253
ALA A 256
GLY A 257
GLY A 290
ASN A 320
TYR A 357
SAH  A 394 (-4.1A)
SAH  A 394 (-3.6A)
SAH  A 394 ( 3.7A)
None
SAH  A 394 (-3.4A)
None
0.39A 4jdsC-4c1qA:
10.1
4jdsC-4c1qA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_D_SAMD401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)
4c1q HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9

(Mus
musculus)
5 / 11 ILE A 253
ALA A 256
GLY A 290
ASN A 320
TYR A 357
SAH  A 394 (-4.1A)
SAH  A 394 (-3.6A)
None
SAH  A 394 (-3.4A)
None
0.37A 4jdsD-4c1qA:
9.8
4jdsD-4c1qA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLG_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)
4c1q HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9

(Mus
musculus)
6 / 12 ILE A 253
ALA A 256
GLY A 257
GLY A 290
ASN A 320
TYR A 357
SAH  A 394 (-4.1A)
SAH  A 394 (-3.6A)
SAH  A 394 ( 3.7A)
None
SAH  A 394 (-3.4A)
None
0.48A 4jlgA-4c1qA:
2.9
4jlgA-4c1qA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLG_B_SAMB401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)
4c1q HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9

(Mus
musculus)
5 / 11 ILE A 253
ALA A 256
GLY A 290
ASN A 320
TYR A 357
SAH  A 394 (-4.1A)
SAH  A 394 (-3.6A)
None
SAH  A 394 (-3.4A)
None
0.48A 4jlgB-4c1qA:
9.9
4jlgB-4c1qA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_C7HA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)
4c1q HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9

(Mus
musculus)
4 / 5 TYR A 276
GLY A 290
TYR A 357
GLY A 358
None
0.58A 5ayfA-4c1qA:
10.2
5ayfA-4c1qA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)
4c1q HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9

(Mus
musculus)
6 / 11 ILE A 253
ALA A 256
GLY A 257
GLY A 290
ASN A 320
TYR A 357
SAH  A 394 (-4.1A)
SAH  A 394 (-3.6A)
SAH  A 394 ( 3.7A)
None
SAH  A 394 (-3.4A)
None
0.40A 5ayfA-4c1qA:
10.2
5ayfA-4c1qA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TQR_B_SAMB8009_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2, POLYCOMB
PROTEIN SUZ12)
4c1q HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9

(Mus
musculus)
5 / 10 GLY A 257
TYR A 291
TYR A 318
ASN A 320
TYR A 357
SAH  A 394 ( 3.7A)
SAH  A 394 (-3.9A)
None
SAH  A 394 (-3.4A)
None
0.42A 5tqrB-4c1qA:
8.9
5tqrB-4c1qA:
10.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V21_A_SAMA1804_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2)
4c1q HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9

(Mus
musculus)
5 / 12 GLY A 257
TYR A 291
ASN A 320
TYR A 357
LEU A 365
SAH  A 394 ( 3.7A)
SAH  A 394 (-3.9A)
SAH  A 394 (-3.4A)
None
SAH  A 394 ( 4.3A)
0.56A 5v21A-4c1qA:
8.7
5v21A-4c1qA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_B_SALB203_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)
4c1q HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9

(Mus
musculus)
4 / 6 PRO A 243
GLY A 245
LEU A 267
VAL A 225
None
0.80A 5x80A-4c1qA:
undetectable
5x80B-4c1qA:
undetectable
5x80A-4c1qA:
18.03
5x80B-4c1qA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CEN_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD3)
4c1q HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9

(Mus
musculus)
5 / 11 GLY A 257
TYR A 291
ASN A 320
TYR A 357
LEU A 365
SAH  A 394 ( 3.7A)
SAH  A 394 (-3.9A)
SAH  A 394 (-3.4A)
None
SAH  A 394 ( 4.3A)
0.23A 6cenA-4c1qA:
9.2
6cenA-4c1qA:
20.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6NM4_A_SAMA402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)
4c1q HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9

(Mus
musculus)
4 / 7 ALA A 256
GLY A 257
ASN A 320
CYH A 321
SAH  A 394 (-3.6A)
SAH  A 394 ( 3.7A)
SAH  A 394 (-3.4A)
None
0.65A 6nm4A-4c1qA:
25.7
6nm4A-4c1qA:
88.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6NM4_A_SAMA402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)
4c1q HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9

(Mus
musculus)
6 / 7 ALA A 256
GLY A 257
LEU A 258
GLY A 290
TYR A 291
ASN A 320
SAH  A 394 (-3.6A)
SAH  A 394 ( 3.7A)
SAH  A 394 (-4.7A)
None
SAH  A 394 (-3.9A)
SAH  A 394 (-3.4A)
0.47A 6nm4A-4c1qA:
25.7
6nm4A-4c1qA:
88.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6NM4_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)
4c1q HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9

(Mus
musculus)
8 / 9 ILE A 253
ALA A 256
GLY A 257
LEU A 258
GLY A 290
TYR A 291
ASN A 320
ARG A 323
SAH  A 394 (-4.1A)
SAH  A 394 (-3.6A)
SAH  A 394 ( 3.7A)
SAH  A 394 (-4.7A)
None
SAH  A 394 (-3.9A)
SAH  A 394 (-3.4A)
None
0.47A 6nm4B-4c1qA:
25.8
6nm4B-4c1qA:
88.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6NM4_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)
4c1q HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9

(Mus
musculus)
7 / 9 ILE A 253
ALA A 256
GLY A 257
TYR A 291
ASN A 320
CYH A 321
ARG A 323
SAH  A 394 (-4.1A)
SAH  A 394 (-3.6A)
SAH  A 394 ( 3.7A)
SAH  A 394 (-3.9A)
SAH  A 394 (-3.4A)
None
None
0.68A 6nm4B-4c1qA:
25.8
6nm4B-4c1qA:
88.00