SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4c1r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XNR_A_ACTA1001_0
(NUCLEAR
POLYADENYLATED
RNA-BINDING PROTEIN
3)		 4c1r MANNOSYL-6-PHOSPHATA
SE
(Bacteroides
thetaiotaomicron) 		3 / 3 SER A 245
ARG A 246
GLN A 203
 None
 0.94A 2xnrA-4c1rA:
undetectable		 2xnrA-4c1rA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_D_TC9D1206_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4c1r MANNOSYL-6-PHOSPHATA
SE
(Bacteroides
thetaiotaomicron) 		4 / 7 TYR A 261
CYH A 224
GLU A 222
TYR A 221
 None
 1.34A 2xytD-4c1rA:
0.0		 2xytD-4c1rA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_D_TFPD201_1
(PROTEIN S100-A4)		 4c1r MANNOSYL-6-PHOSPHATA
SE
(Bacteroides
thetaiotaomicron) 		4 / 8 GLY A 119
PHE A 309
PHE A 147
PHE A 156
 None
 1.06A 3ko0D-4c1rA:
undetectable
3ko0E-4c1rA:
undetectable		 3ko0D-4c1rA:
17.81
3ko0E-4c1rA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL201_1
(PROTEIN S100-A4)		 4c1r MANNOSYL-6-PHOSPHATA
SE
(Bacteroides
thetaiotaomicron) 		4 / 7 GLY A 119
PHE A 309
PHE A 147
PHE A 156
 None
 1.10A 3ko0L-4c1rA:
undetectable
3ko0N-4c1rA:
undetectable		 3ko0L-4c1rA:
17.81
3ko0N-4c1rA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LK0_D_Z80D92_1
(PROTEIN S100-B)		 4c1r MANNOSYL-6-PHOSPHATA
SE
(Bacteroides
thetaiotaomicron) 		3 / 3 HIS A 205
PHE A 211
PHE A 251
 None
 0.70A 3lk0D-4c1rA:
undetectable		 3lk0D-4c1rA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_B_DSFB319_1
(GLR4197 PROTEIN)		 4c1r MANNOSYL-6-PHOSPHATA
SE
(Bacteroides
thetaiotaomicron) 		5 / 9 ILE A  66
ILE A 106
VAL A  29
THR A 196
ILE A 194
 None
 1.24A 3p4wB-4c1rA:
undetectable		 3p4wB-4c1rA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPS_A_CHDA211_0
(CMER)		 4c1r MANNOSYL-6-PHOSPHATA
SE
(Bacteroides
thetaiotaomicron) 		5 / 10 ALA A  30
PHE A  67
GLY A  68
ILE A 106
PHE A 156
 None
 1.46A 3qpsA-4c1rA:
undetectable		 3qpsA-4c1rA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_1
(METHYLTRANSFERASE
NSUN4)		 4c1r MANNOSYL-6-PHOSPHATA
SE
(Bacteroides
thetaiotaomicron) 		3 / 3 ASP A  65
ARG A 109
ASP A 151
 None
 0.88A 4fp9D-4c1rA:
3.0		 4fp9D-4c1rA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAQ_A_2GMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 4c1r MANNOSYL-6-PHOSPHATA
SE
(Bacteroides
thetaiotaomicron) 		4 / 6 ILE A 194
THR A 196
VAL A 308
ASP A 225
 None
 0.74A 4iaqA-4c1rA:
undetectable		 4iaqA-4c1rA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_2
(ANCESTRAL STEROID
RECEPTOR 2)		 4c1r MANNOSYL-6-PHOSPHATA
SE
(Bacteroides
thetaiotaomicron) 		4 / 8 MET A  58
ALA A  56
MET A  80
PHE A 237
 None
 0.99A 4ltwA-4c1rA:
undetectable		 4ltwA-4c1rA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_1_BEZ1801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4c1r MANNOSYL-6-PHOSPHATA
SE
(Bacteroides
thetaiotaomicron) 		3 / 3 LEU A 195
PHE A 158
ILE A 250
 None
 0.76A 5dzk1-4c1rA:
undetectable
5dzkF-4c1rA:
undetectable
5dzkM-4c1rA:
undetectable		 5dzk1-4c1rA:
22.22
5dzkF-4c1rA:
21.93
5dzkM-4c1rA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4c1r MANNOSYL-6-PHOSPHATA
SE
(Bacteroides
thetaiotaomicron) 		5 / 12 GLY A  86
PHE A 256
PHE A 156
THR A 152
THR A 110
 None
 1.22A 5eslA-4c1rA:
undetectable		 5eslA-4c1rA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4c1r MANNOSYL-6-PHOSPHATA
SE
(Bacteroides
thetaiotaomicron) 		4 / 6 ILE A  55
ILE A 250
PHE A  64
HIS A  62
 None
 1.09A 5vkqA-4c1rA:
undetectable
5vkqB-4c1rA:
undetectable		 5vkqA-4c1rA:
9.53
5vkqB-4c1rA:
9.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4c1r MANNOSYL-6-PHOSPHATA
SE
(Bacteroides
thetaiotaomicron) 		4 / 6 ILE A  55
ILE A 250
PHE A  64
HIS A  62
 None
 1.07A 5vkqA-4c1rA:
undetectable
5vkqD-4c1rA:
undetectable		 5vkqA-4c1rA:
9.53
5vkqD-4c1rA:
9.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H0G_B_Y70B502_0
(PROTEIN CEREBLON
ZINC FINGER PROTEIN
692)		 4c1r MANNOSYL-6-PHOSPHATA
SE
(Bacteroides
thetaiotaomicron) 		5 / 11 ASN A 200
HIS A 165
HIS A 162
PHE A 211
GLY A 167
 None
 1.20A 6h0gB-4c1rA:
0.0
6h0gC-4c1rA:
undetectable		 6h0gB-4c1rA:
16.41
6h0gC-4c1rA:
8.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H0G_E_Y70E502_0
(PROTEIN CEREBLON
ZINC FINGER PROTEIN
692)		 4c1r MANNOSYL-6-PHOSPHATA
SE
(Bacteroides
thetaiotaomicron) 		5 / 12 ASN A 200
HIS A 165
HIS A 162
PHE A 211
GLY A 167
 None
 1.17A 6h0gE-4c1rA:
0.0
6h0gF-4c1rA:
undetectable		 6h0gE-4c1rA:
16.41
6h0gF-4c1rA:
8.74