SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4c1s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4001_1
(SERUM ALBUMIN)		 4c1s GLYCOSIDE HYDROLASE
FAMILY 76
MANNOSIDASE
(Bacteroides
thetaiotaomicron) 		4 / 5 ARG A 494
ALA A 439
ASP A 492
GLY A 441
 None
EDO  A1533 (-3.8A)
None
EDO  A1526 (-3.7A)
 0.84A 1e7cA-4c1sA:
undetectable		 1e7cA-4c1sA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HO5_A_ADNA1604_1
(5'-NUCLEOTIDASE)		 4c1s GLYCOSIDE HYDROLASE
FAMILY 76
MANNOSIDASE
(Bacteroides
thetaiotaomicron) 		5 / 11 ILE A 232
SER A 203
GLY A 201
GLY A 199
ASP A 266
 EDO  A1527 (-3.9A)
None
None
None
None
 1.27A 1ho5A-4c1sA:
undetectable		 1ho5A-4c1sA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		 4c1s GLYCOSIDE HYDROLASE
FAMILY 76
MANNOSIDASE
(Bacteroides
thetaiotaomicron) 		4 / 7 ARG A 255
SER A 246
ASN A 253
ASP A 239
 None
 1.32A 1hwiC-4c1sA:
undetectable		 1hwiC-4c1sA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_2
(HMG-COA REDUCTASE)		 4c1s GLYCOSIDE HYDROLASE
FAMILY 76
MANNOSIDASE
(Bacteroides
thetaiotaomicron) 		4 / 7 ARG A 255
SER A 246
ASN A 253
ASP A 239
 None
 1.32A 1hwiD-4c1sA:
undetectable		 1hwiD-4c1sA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_G_SAMG199_0
(METHIONINE REPRESSOR)		 4c1s GLYCOSIDE HYDROLASE
FAMILY 76
MANNOSIDASE
(Bacteroides
thetaiotaomicron) 		5 / 10 GLU A 512
ALA A 509
ALA A 443
PHE A 445
GLY A 441
 None
None
EDO  A1526 (-3.7A)
None
EDO  A1526 (-3.7A)
 1.14A 1mjqG-4c1sA:
undetectable
1mjqH-4c1sA:
undetectable		 1mjqG-4c1sA:
15.24
1mjqH-4c1sA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 4c1s GLYCOSIDE HYDROLASE
FAMILY 76
MANNOSIDASE
(Bacteroides
thetaiotaomicron) 		4 / 6 ASP A 258
ASP A 364
ASN A 365
GLU A 307
 GOL  A1535 (-2.7A)
EDO  A1531 (-2.8A)
None
None
 1.25A 1rjdA-4c1sA:
undetectable		 1rjdA-4c1sA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9W_A_PAUA6002_0
(PANTOTHENATE KINASE)		 4c1s GLYCOSIDE HYDROLASE
FAMILY 76
MANNOSIDASE
(Bacteroides
thetaiotaomicron) 		4 / 8 THR A 212
GLY A 222
ASP A 225
THR A 274
 None
 0.98A 2f9wA-4c1sA:
undetectable
2f9wB-4c1sA:
undetectable		 2f9wA-4c1sA:
21.88
2f9wB-4c1sA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_CCSB417_0
(ESTROGEN RECEPTOR)		 4c1s GLYCOSIDE HYDROLASE
FAMILY 76
MANNOSIDASE
(Bacteroides
thetaiotaomicron) 		3 / 3 GLN A 282
LYS A 284
VAL A 286
 None
 0.89A 2jfaB-4c1sA:
undetectable		 2jfaB-4c1sA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q2H_B_ACTB501_0
(SECRETION CHAPERONE,
PHAGE-DISPLAY
DERIVED PEPTIDE)		 4c1s GLYCOSIDE HYDROLASE
FAMILY 76
MANNOSIDASE
(Bacteroides
thetaiotaomicron) 		3 / 3 ARG A 156
SER A 478
TYR A 514
 None
 1.04A 2q2hA-4c1sA:
undetectable
2q2hB-4c1sA:
undetectable		 2q2hA-4c1sA:
15.00
2q2hB-4c1sA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RK8_A_PPFA3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		 4c1s GLYCOSIDE HYDROLASE
FAMILY 76
MANNOSIDASE
(Bacteroides
thetaiotaomicron) 		4 / 8 LYS A 329
SER A 203
ASP A 269
ARG A 516
 EDO  A1534 (-3.4A)
None
EDO  A1534 (-4.3A)
EDO  A1534 ( 3.7A)
 1.31A 2rk8A-4c1sA:
undetectable		 2rk8A-4c1sA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YLD_A_ASCA130_0
(CYTOCHROME C')		 4c1s GLYCOSIDE HYDROLASE
FAMILY 76
MANNOSIDASE
(Bacteroides
thetaiotaomicron) 		4 / 5 ALA A 395
GLY A 327
CYH A 328
LYS A 329
 None
None
None
EDO  A1534 (-3.4A)
 1.34A 2yldA-4c1sA:
undetectable		 2yldA-4c1sA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDI_A_SAMA601_0
(METHYLTRANSFERASE)		 4c1s GLYCOSIDE HYDROLASE
FAMILY 76
MANNOSIDASE
(Bacteroides
thetaiotaomicron) 		5 / 12 PHE A 454
TYR A 514
ILE A 448
ALA A 443
THR A 447
 EDO  A1530 ( 4.7A)
None
None
EDO  A1526 (-3.7A)
None
 1.31A 3ndiA-4c1sA:
undetectable		 3ndiA-4c1sA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PMZ_E_TUBE220_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4c1s GLYCOSIDE HYDROLASE
FAMILY 76
MANNOSIDASE
(Bacteroides
thetaiotaomicron) 		4 / 6 MET A 424
ILE A 437
SER A 480
SER A 479
 None
 1.24A 3pmzD-4c1sA:
undetectable		 3pmzD-4c1sA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_A_CYZA266_2
(GLUTAMATE RECEPTOR 2)		 4c1s GLYCOSIDE HYDROLASE
FAMILY 76
MANNOSIDASE
(Bacteroides
thetaiotaomicron) 		4 / 5 ILE A 414
PRO A 391
SER A 385
GLY A 389
 None
 1.15A 3tkdB-4c1sA:
undetectable		 3tkdB-4c1sA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_B_CYZB267_1
(GLUTAMATE RECEPTOR 2)		 4c1s GLYCOSIDE HYDROLASE
FAMILY 76
MANNOSIDASE
(Bacteroides
thetaiotaomicron) 		4 / 5 ILE A 414
PRO A 391
SER A 385
GLY A 389
 None
 1.14A 3tkdA-4c1sA:
undetectable		 3tkdA-4c1sA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V7P_A_BEZA430_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 4c1s GLYCOSIDE HYDROLASE
FAMILY 76
MANNOSIDASE
(Bacteroides
thetaiotaomicron) 		4 / 7 GLY A 389
SER A 388
SER A 385
LEU A 361
 None
 0.80A 3v7pA-4c1sA:
undetectable		 3v7pA-4c1sA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZWI_A_ASCA156_0
(CYTOCHROME C')		 4c1s GLYCOSIDE HYDROLASE
FAMILY 76
MANNOSIDASE
(Bacteroides
thetaiotaomicron) 		4 / 5 ALA A 395
GLY A 327
CYH A 328
LYS A 329
 None
None
None
EDO  A1534 (-3.4A)
 1.33A 3zwiA-4c1sA:
undetectable		 3zwiA-4c1sA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_1
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 4c1s GLYCOSIDE HYDROLASE
FAMILY 76
MANNOSIDASE
(Bacteroides
thetaiotaomicron) 		3 / 3 TYR A 407
ASP A 348
ASP A 341
 None
 0.79A 4a6eA-4c1sA:
undetectable		 4a6eA-4c1sA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DA7_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4c1s GLYCOSIDE HYDROLASE
FAMILY 76
MANNOSIDASE
(Bacteroides
thetaiotaomicron) 		5 / 10 ARG A 451
ALA A 515
VAL A 511
GLU A 512
VAL A 164
 None
 1.27A 4da7A-4c1sA:
undetectable		 4da7A-4c1sA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DA7_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4c1s GLYCOSIDE HYDROLASE
FAMILY 76
MANNOSIDASE
(Bacteroides
thetaiotaomicron) 		5 / 10 ARG A 451
GLY A 508
ALA A 515
VAL A 511
GLU A 512
 None
 1.25A 4da7A-4c1sA:
undetectable		 4da7A-4c1sA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_C_SAMC801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 4c1s GLYCOSIDE HYDROLASE
FAMILY 76
MANNOSIDASE
(Bacteroides
thetaiotaomicron) 		5 / 12 GLY A 321
THR A 320
CYH A 346
ALA A 343
LEU A 398
 None
 1.16A 5hw4C-4c1sA:
undetectable		 5hw4C-4c1sA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS5_A_ASCA202_0
(CYTOCHROME C')		 4c1s GLYCOSIDE HYDROLASE
FAMILY 76
MANNOSIDASE
(Bacteroides
thetaiotaomicron) 		3 / 3 CYH A 418
LYS A 420
HIS A 419
 None
 1.25A 5js5A-4c1sA:
undetectable		 5js5A-4c1sA:
18.15