SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4c1t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N6A_A_SAMA402_0
(SET
DOMAIN-CONTAINING
PROTEIN 7)		 4c1t SUGAR TRANSPORTER
SOLUTE-BINDING
PROTEIN
(Bifidobacterium
animalis) 		5 / 10 ALA A 226
GLU A 412
LYS A 233
ASN A 230
GLU A 307
 None
 1.34A 1n6aA-4c1tA:
0.0		 1n6aA-4c1tA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_C_DEXC3999_1
(GLUCOCORTICOID
RECEPTOR)		 4c1t SUGAR TRANSPORTER
SOLUTE-BINDING
PROTEIN
(Bifidobacterium
animalis) 		5 / 12 GLY A 149
ARG A 207
MET A 381
LEU A 375
THR A 352
 None
 1.49A 1p93C-4c1tA:
undetectable		 1p93C-4c1tA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4c1t SUGAR TRANSPORTER
SOLUTE-BINDING
PROTEIN
(Bifidobacterium
animalis) 		3 / 3 MET A 274
ASN A  39
GLN A  71
 None
XYP  A1003 (-3.3A)
None
 1.03A 1xoqB-4c1tA:
undetectable		 1xoqB-4c1tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YVP_B_ACTB2002_0
(60-KDA SS-A/RO
RIBONUCLEOPROTEIN)		 4c1t SUGAR TRANSPORTER
SOLUTE-BINDING
PROTEIN
(Bifidobacterium
animalis) 		4 / 6 TYR A  48
SER A  55
ALA A  53
ASN A 342
 None
 1.13A 1yvpB-4c1tA:
undetectable		 1yvpB-4c1tA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		 4c1t SUGAR TRANSPORTER
SOLUTE-BINDING
PROTEIN
(Bifidobacterium
animalis) 		4 / 8 LEU A 295
SER A 153
LEU A 264
ASP A 155
 None
 0.94A 2j2pA-4c1tA:
undetectable
2j2pB-4c1tA:
undetectable		 2j2pA-4c1tA:
20.44
2j2pB-4c1tA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAV_L_CSCL1383_1
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 4c1t SUGAR TRANSPORTER
SOLUTE-BINDING
PROTEIN
(Bifidobacterium
animalis) 		5 / 12 THR A 318
PHE A 350
HIS A  38
PHE A  36
VAL A  92
 XYP  A1003 ( 4.9A)
XYP  A1004 (-4.8A)
None
None
None
 1.49A 2vavL-4c1tA:
0.0		 2vavL-4c1tA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 4c1t SUGAR TRANSPORTER
SOLUTE-BINDING
PROTEIN
(Bifidobacterium
animalis) 		4 / 8 MET A 150
ALA A 270
ALA A 186
LEU A 238
 None
 0.84A 2wx2B-4c1tA:
undetectable		 2wx2B-4c1tA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_A_X2NA1480_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 4c1t SUGAR TRANSPORTER
SOLUTE-BINDING
PROTEIN
(Bifidobacterium
animalis) 		5 / 12 PHE A 298
PRO A 166
ALA A 167
ALA A 269
THR A 184
 None
 1.31A 2x2nA-4c1tA:
undetectable		 2x2nA-4c1tA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_D_X2ND1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 4c1t SUGAR TRANSPORTER
SOLUTE-BINDING
PROTEIN
(Bifidobacterium
animalis) 		5 / 12 ILE A 393
MET A 150
ALA A 270
ALA A 186
LEU A 238
 None
 1.30A 2x2nD-4c1tA:
undetectable		 2x2nD-4c1tA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_A_VD3A2001_1
(VITAMIN D
HYDROXYLASE)		 4c1t SUGAR TRANSPORTER
SOLUTE-BINDING
PROTEIN
(Bifidobacterium
animalis) 		5 / 12 PRO A 301
MET A 150
ILE A 187
ALA A 188
LEU A 179
 None
 1.18A 3a50A-4c1tA:
undetectable		 3a50A-4c1tA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_D_TPFD490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 4c1t SUGAR TRANSPORTER
SOLUTE-BINDING
PROTEIN
(Bifidobacterium
animalis) 		4 / 8 MET A 150
ALA A 270
ALA A 186
LEU A 238
 None
 1.03A 3l4dD-4c1tA:
undetectable		 3l4dD-4c1tA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNE_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 4c1t SUGAR TRANSPORTER
SOLUTE-BINDING
PROTEIN
(Bifidobacterium
animalis) 		5 / 12 GLY A 149
ARG A 207
MET A 381
LEU A 375
THR A 352
 None
 1.44A 3mneA-4c1tA:
undetectable		 3mneA-4c1tA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK7_A_SAMA770_0
(23S RRNA
METHYLTRANSFERASE)		 4c1t SUGAR TRANSPORTER
SOLUTE-BINDING
PROTEIN
(Bifidobacterium
animalis) 		5 / 12 GLY A 148
GLU A 278
GLY A 149
ILE A 372
SER A 367
 None
 0.96A 3nk7A-4c1tA:
undetectable		 3nk7A-4c1tA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4c1t SUGAR TRANSPORTER
SOLUTE-BINDING
PROTEIN
(Bifidobacterium
animalis) 		5 / 11 ASN A 245
ILE A 187
GLY A 190
ALA A 253
VAL A 281
 None
 1.16A 3rukD-4c1tA:
undetectable		 3rukD-4c1tA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEH_B_DAHB786_1
(PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN)		 4c1t SUGAR TRANSPORTER
SOLUTE-BINDING
PROTEIN
(Bifidobacterium
animalis) 		4 / 7 LEU A 206
GLY A 149
ALA A 299
PHE A 297
 None
 1.01A 3tehB-4c1tA:
undetectable		 3tehB-4c1tA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB1_0
(HEME-BINDING PROTEIN
HUTZ)		 4c1t SUGAR TRANSPORTER
SOLUTE-BINDING
PROTEIN
(Bifidobacterium
animalis) 		4 / 6 TYR A 169
PHE A 300
PRO A 301
LEU A 273
 None
 1.34A 3tgvB-4c1tA:
undetectable		 3tgvB-4c1tA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 4c1t SUGAR TRANSPORTER
SOLUTE-BINDING
PROTEIN
(Bifidobacterium
animalis) 		4 / 8 VAL A 121
VAL A 143
TYR A 319
LEU A 113
 None
 0.93A 3v81C-4c1tA:
1.5		 3v81C-4c1tA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J83_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4c1t SUGAR TRANSPORTER
SOLUTE-BINDING
PROTEIN
(Bifidobacterium
animalis) 		5 / 11 ALA A 226
GLU A 412
LYS A 233
ASN A 230
GLU A 307
 None
 1.48A 4j83A-4c1tA:
undetectable		 4j83A-4c1tA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLG_B_SAMB401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4c1t SUGAR TRANSPORTER
SOLUTE-BINDING
PROTEIN
(Bifidobacterium
animalis) 		5 / 11 ALA A 226
GLU A 412
LYS A 233
ASN A 230
GLU A 307
 None
 1.33A 4jlgB-4c1tA:
undetectable		 4jlgB-4c1tA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0B_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 4c1t SUGAR TRANSPORTER
SOLUTE-BINDING
PROTEIN
(Bifidobacterium
animalis) 		4 / 8 VAL A 121
VAL A 143
TYR A 319
LEU A 113
 None
 1.10A 4q0bA-4c1tA:
undetectable		 4q0bA-4c1tA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UMJ_A_BFQA1297_1
(GERANYLTRANSTRANSFER
ASE)		 4c1t SUGAR TRANSPORTER
SOLUTE-BINDING
PROTEIN
(Bifidobacterium
animalis) 		4 / 8 SER A 153
LEU A 156
ASP A 155
MET A 292
 None
 0.89A 4umjA-4c1tA:
undetectable		 4umjA-4c1tA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZP0_A_DXCA500_0
(MULTIDRUG
TRANSPORTER MDFA)		 4c1t SUGAR TRANSPORTER
SOLUTE-BINDING
PROTEIN
(Bifidobacterium
animalis) 		5 / 10 ASP A 240
MET A 404
LEU A 405
LEU A 235
GLY A 190
 None
 1.47A 4zp0A-4c1tA:
undetectable		 4zp0A-4c1tA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_E_SAME301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 4c1t SUGAR TRANSPORTER
SOLUTE-BINDING
PROTEIN
(Bifidobacterium
animalis) 		5 / 12 GLY A 390
GLY A  98
ALA A 421
ASP A 386
LEU A 397
 None
None
None
XYP  A1002 (-2.8A)
None
 1.19A 5c0oE-4c1tA:
undetectable		 5c0oE-4c1tA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C6P_A_4YHA601_1
(PROTEIN C)		 4c1t SUGAR TRANSPORTER
SOLUTE-BINDING
PROTEIN
(Bifidobacterium
animalis) 		4 / 6 ALA A 261
SER A 260
GLN A  71
ASP A 284
 None
 1.14A 5c6pA-4c1tA:
undetectable		 5c6pA-4c1tA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V5Z_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4c1t SUGAR TRANSPORTER
SOLUTE-BINDING
PROTEIN
(Bifidobacterium
animalis) 		5 / 12 PHE A 134
ILE A 105
GLY A  98
THR A 387
PHE A 320
 None
None
None
XYP  A1002 ( 4.8A)
None
 1.37A 5v5zA-4c1tA:
undetectable		 5v5zA-4c1tA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJI_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 4c1t SUGAR TRANSPORTER
SOLUTE-BINDING
PROTEIN
(Bifidobacterium
animalis) 		5 / 10 GLY A  45
ARG A  46
TRP A  49
ILE A  67
ALA A  69
 XYP  A1004 ( 4.8A)
None
None
None
None
 1.43A 5zjiA-4c1tA:
undetectable
5zjiJ-4c1tA:
undetectable		 5zjiA-4c1tA:
13.88
5zjiJ-4c1tA:
8.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA605_0
(SERUM ALBUMIN)		 4c1t SUGAR TRANSPORTER
SOLUTE-BINDING
PROTEIN
(Bifidobacterium
animalis) 		4 / 8 LYS A 424
GLY A 425
LEU A 389
GLY A 390
 None
 0.62A 6mdqA-4c1tA:
undetectable		 6mdqA-4c1tA:
11.96