SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4c23'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1B2I_A_AMHA84_1
(PROTEIN
(PLASMINOGEN))		 4c23 L-FUCULOSE KINASE
FUCK
(Streptococcus
pneumoniae) 		4 / 7 TYR A 351
ASP A 332
GLU A 334
PHE A 338
 None
 1.41A 1b2iA-4c23A:
undetectable		 1b2iA-4c23A:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GXS_A_BEZA601_0
(P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
A
P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
B)		 4c23 L-FUCULOSE KINASE
FUCK
(Streptococcus
pneumoniae) 		4 / 7 GLY A 281
ASP A 233
SER A 172
HIS A 232
 None
 0.98A 1gxsA-4c23A:
undetectable
1gxsB-4c23A:
undetectable		 1gxsA-4c23A:
18.66
1gxsB-4c23A:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)		 4c23 L-FUCULOSE KINASE
FUCK
(Streptococcus
pneumoniae) 		5 / 12 ILE A 224
PRO A 225
ILE A  69
ALA A  63
ARG A 214
 None
 1.25A 1kijB-4c23A:
undetectable		 1kijB-4c23A:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_A_STIA3_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4c23 L-FUCULOSE KINASE
FUCK
(Streptococcus
pneumoniae) 		4 / 5 TYR A  67
VAL A 211
ILE A  72
MET A  28
 None
 1.43A 1opjA-4c23A:
undetectable		 1opjA-4c23A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4c23 L-FUCULOSE KINASE
FUCK
(Streptococcus
pneumoniae) 		5 / 12 ILE A 298
THR A 333
ILE A 331
LEU A 348
ILE A 297
 None
 0.91A 1ra8A-4c23A:
undetectable		 1ra8A-4c23A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RD7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4c23 L-FUCULOSE KINASE
FUCK
(Streptococcus
pneumoniae) 		5 / 12 ILE A 298
THR A 333
ILE A 331
LEU A 348
ILE A 297
 None
 0.98A 1rd7A-4c23A:
undetectable		 1rd7A-4c23A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RD7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)		 4c23 L-FUCULOSE KINASE
FUCK
(Streptococcus
pneumoniae) 		5 / 12 ILE A 298
THR A 333
ILE A 331
LEU A 348
ILE A 297
 None
 0.96A 1rd7B-4c23A:
undetectable		 1rd7B-4c23A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4c23 L-FUCULOSE KINASE
FUCK
(Streptococcus
pneumoniae) 		5 / 12 ILE A 298
THR A 333
ILE A 331
LEU A 348
ILE A 297
 None
 0.94A 1rx7A-4c23A:
undetectable		 1rx7A-4c23A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN)		 4c23 L-FUCULOSE KINASE
FUCK
(Streptococcus
pneumoniae) 		5 / 11 ASN A 188
ILE A 191
THR A 122
LEU A 118
PHE A 133
 None
 1.44A 1tw4A-4c23A:
undetectable		 1tw4A-4c23A:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		 4c23 L-FUCULOSE KINASE
FUCK
(Streptococcus
pneumoniae) 		4 / 6 ILE A 205
ALA A 174
THR A 176
ALA A 235
 None
 0.92A 1w0gA-4c23A:
0.0		 1w0gA-4c23A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z95_A_198A501_1
(ANDROGEN RECEPTOR)		 4c23 L-FUCULOSE KINASE
FUCK
(Streptococcus
pneumoniae) 		5 / 12 LEU A  83
GLY A  82
VAL A  79
ARG A 101
THR A 169
 None
 1.45A 1z95A-4c23A:
undetectable		 1z95A-4c23A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A8T_B_ADNB252_1
(U8 SNORNA-BINDING
PROTEIN X29)		 4c23 L-FUCULOSE KINASE
FUCK
(Streptococcus
pneumoniae) 		4 / 8 GLY A  19
ILE A  17
ASN A 432
GLN A 436
 None
 0.97A 2a8tB-4c23A:
undetectable		 2a8tB-4c23A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D0K_B_FOLB2161_0
(DIHYDROFOLATE
REDUCTASE)		 4c23 L-FUCULOSE KINASE
FUCK
(Streptococcus
pneumoniae) 		5 / 12 ILE A 298
THR A 333
ILE A 331
LEU A 348
ILE A 297
 None
 0.98A 2d0kB-4c23A:
undetectable		 2d0kB-4c23A:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_A_NCAA1501_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 4c23 L-FUCULOSE KINASE
FUCK
(Streptococcus
pneumoniae) 		4 / 7 ASP A  75
ALA A 429
ARG A  15
ASP A 233
 None
 1.14A 2e5dA-4c23A:
undetectable
2e5dB-4c23A:
undetectable		 2e5dA-4c23A:
24.14
2e5dB-4c23A:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4c23 L-FUCULOSE KINASE
FUCK
(Streptococcus
pneumoniae) 		5 / 12 ILE A  56
LEU A   9
GLY A  73
ASN A 432
ILE A  72
 None
 1.23A 2e7fA-4c23A:
undetectable		 2e7fA-4c23A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4c23 L-FUCULOSE KINASE
FUCK
(Streptococcus
pneumoniae) 		5 / 12 ILE A  56
LEU A   9
GLY A  73
ASN A 432
ILE A  72
 None
 1.21A 2e7fB-4c23A:
undetectable		 2e7fB-4c23A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4c23 L-FUCULOSE KINASE
FUCK
(Streptococcus
pneumoniae) 		4 / 7 LEU A 135
GLN A 134
PHE A 133
LEU A 197
 None
 1.08A 2eijC-4c23A:
undetectable
2eijJ-4c23A:
undetectable		 2eijC-4c23A:
19.10
2eijJ-4c23A:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4c23 L-FUCULOSE KINASE
FUCK
(Streptococcus
pneumoniae) 		4 / 6 LEU A 135
GLN A 134
PHE A 133
LEU A 197
 None
 1.01A 2einP-4c23A:
undetectable
2einW-4c23A:
undetectable		 2einP-4c23A:
19.10
2einW-4c23A:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_A_LDPA501_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 4c23 L-FUCULOSE KINASE
FUCK
(Streptococcus
pneumoniae) 		4 / 7 GLU A 208
GLY A 284
PHE A 180
ILE A 205
 None
 0.98A 2qmzA-4c23A:
undetectable
2qmzB-4c23A:
undetectable		 2qmzA-4c23A:
20.82
2qmzB-4c23A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VH3_B_DAHB2_1
(RANASMURFIN)		 4c23 L-FUCULOSE KINASE
FUCK
(Streptococcus
pneumoniae) 		4 / 8 ALA A 429
GLY A 400
SER A 236
ALA A 237
 None
 0.81A 2vh3B-4c23A:
undetectable		 2vh3B-4c23A:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQY_A_PARA1201_2
(AAC(6')-IB)		 4c23 L-FUCULOSE KINASE
FUCK
(Streptococcus
pneumoniae) 		3 / 3 TRP A  47
GLN A 134
TRP A 255
 None
 0.98A 2vqyA-4c23A:
undetectable		 2vqyA-4c23A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)		 4c23 L-FUCULOSE KINASE
FUCK
(Streptococcus
pneumoniae) 		3 / 3 SER A 231
THR A 428
PHE A 249
 None
 0.72A 2x91A-4c23A:
undetectable		 2x91A-4c23A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YCJ_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4c23 L-FUCULOSE KINASE
FUCK
(Streptococcus
pneumoniae) 		5 / 12 ILE A  56
LEU A   9
GLY A  73
ASN A 432
ILE A  72
 None
 1.25A 2ycjA-4c23A:
undetectable		 2ycjA-4c23A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YHD_A_TESA1920_1
(ANDROGEN RECEPTOR)		 4c23 L-FUCULOSE KINASE
FUCK
(Streptococcus
pneumoniae) 		5 / 12 LEU A 202
LEU A  83
GLY A  82
ARG A 101
THR A 169
 None
 1.38A 2yhdA-4c23A:
undetectable		 2yhdA-4c23A:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AVP_A_MV2A313_1
(PANTOTHENATE KINASE)		 4c23 L-FUCULOSE KINASE
FUCK
(Streptococcus
pneumoniae) 		4 / 7 VAL A 370
LEU A 348
TYR A 371
ILE A 317
 None
 0.94A 3avpA-4c23A:
undetectable		 3avpA-4c23A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DLC_A_SAMA220_0
(PUTATIVE
S-ADENOSYL-L-METHION
INE-DEPENDENT
METHYLTRANSFERASE)		 4c23 L-FUCULOSE KINASE
FUCK
(Streptococcus
pneumoniae) 		5 / 12 GLY A 400
GLY A 402
ASP A 233
HIS A 232
SER A 251
 None
 1.00A 3dlcA-4c23A:
undetectable		 3dlcA-4c23A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FSU_A_C2FA995_0
(5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE)		 4c23 L-FUCULOSE KINASE
FUCK
(Streptococcus
pneumoniae) 		5 / 12 THR A 169
LEU A 197
GLN A 134
THR A 149
LEU A 179
 None
 1.36A 3fsuA-4c23A:
undetectable		 3fsuA-4c23A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 4c23 L-FUCULOSE KINASE
FUCK
(Streptococcus
pneumoniae) 		5 / 12 GLY A 400
ASP A   8
GLY A 431
SER A 240
PHE A 249
 None
 1.22A 3k13C-4c23A:
undetectable		 3k13C-4c23A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		 4c23 L-FUCULOSE KINASE
FUCK
(Streptococcus
pneumoniae) 		4 / 7 ILE A 297
ILE A 331
SER A 342
GLU A 350
 None
 0.86A 3ua5B-4c23A:
undetectable		 3ua5B-4c23A:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 4c23 L-FUCULOSE KINASE
FUCK
(Streptococcus
pneumoniae) 		4 / 4 ASN A 124
SER A 110
LEU A 115
THR A 177
 None
 1.43A 4an2A-4c23A:
undetectable		 4an2A-4c23A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJ1_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4c23 L-FUCULOSE KINASE
FUCK
(Streptococcus
pneumoniae) 		5 / 12 ILE A 298
THR A 333
ILE A 331
LEU A 348
ILE A 297
 None
 0.91A 4ej1A-4c23A:
undetectable		 4ej1A-4c23A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGJ_A_1PQA304_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4c23 L-FUCULOSE KINASE
FUCK
(Streptococcus
pneumoniae) 		4 / 8 PHE A 180
ILE A 173
GLY A 281
GLU A 208
 None
 0.98A 4fgjA-4c23A:
undetectable
4fgjB-4c23A:
undetectable		 4fgjA-4c23A:
20.82
4fgjB-4c23A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FHB_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4c23 L-FUCULOSE KINASE
FUCK
(Streptococcus
pneumoniae) 		5 / 12 ILE A 298
THR A 333
ILE A 331
LEU A 348
ILE A 297
 None
 0.84A 4fhbA-4c23A:
undetectable		 4fhbA-4c23A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FR0_A_SAMA401_0
(ARSENIC
METHYLTRANSFERASE)		 4c23 L-FUCULOSE KINASE
FUCK
(Streptococcus
pneumoniae) 		5 / 12 GLY A 417
ASP A 414
ILE A 250
VAL A 420
LEU A 421
 None
 1.09A 4fr0A-4c23A:
undetectable		 4fr0A-4c23A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I13_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4c23 L-FUCULOSE KINASE
FUCK
(Streptococcus
pneumoniae) 		5 / 12 ILE A 298
THR A 333
ILE A 331
LEU A 348
ILE A 297
 None
 1.00A 4i13A-4c23A:
undetectable		 4i13A-4c23A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4c23 L-FUCULOSE KINASE
FUCK
(Streptococcus
pneumoniae) 		5 / 12 ILE A 298
THR A 333
ILE A 331
LEU A 348
ILE A 297
 None
 0.88A 4kjjA-4c23A:
undetectable		 4kjjA-4c23A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJK_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4c23 L-FUCULOSE KINASE
FUCK
(Streptococcus
pneumoniae) 		5 / 12 ILE A 298
THR A 333
ILE A 331
LEU A 348
ILE A 297
 None
 0.87A 4kjkA-4c23A:
undetectable		 4kjkA-4c23A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJL_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4c23 L-FUCULOSE KINASE
FUCK
(Streptococcus
pneumoniae) 		5 / 12 ILE A 298
THR A 333
ILE A 331
LEU A 348
ILE A 297
 None
 0.92A 4kjlA-4c23A:
undetectable		 4kjlA-4c23A:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJB_A_198A1001_1
(ANDROGEN RECEPTOR)		 4c23 L-FUCULOSE KINASE
FUCK
(Streptococcus
pneumoniae) 		5 / 12 LEU A  83
GLY A  82
VAL A  79
ARG A 101
THR A 169
 None
 1.43A 4ojbA-4c23A:
undetectable		 4ojbA-4c23A:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKX_A_198A1002_1
(ANDROGEN RECEPTOR)		 4c23 L-FUCULOSE KINASE
FUCK
(Streptococcus
pneumoniae) 		5 / 12 LEU A  83
GLY A  82
VAL A  79
ARG A 101
THR A 169
 None
 1.46A 4okxA-4c23A:
undetectable		 4okxA-4c23A:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3Q_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4c23 L-FUCULOSE KINASE
FUCK
(Streptococcus
pneumoniae) 		5 / 12 ILE A 298
THR A 333
ILE A 331
LEU A 348
ILE A 297
 None
 0.88A 4p3qA-4c23A:
undetectable		 4p3qA-4c23A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3R_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4c23 L-FUCULOSE KINASE
FUCK
(Streptococcus
pneumoniae) 		5 / 12 ILE A 298
THR A 333
ILE A 331
LEU A 348
ILE A 297
 None
 0.88A 4p3rA-4c23A:
undetectable		 4p3rA-4c23A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PSS_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4c23 L-FUCULOSE KINASE
FUCK
(Streptococcus
pneumoniae) 		5 / 12 ILE A 298
THR A 333
ILE A 331
LEU A 348
ILE A 297
 None
 0.88A 4pssA-4c23A:
undetectable		 4pssA-4c23A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTH_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4c23 L-FUCULOSE KINASE
FUCK
(Streptococcus
pneumoniae) 		5 / 12 ILE A 298
THR A 333
ILE A 331
LEU A 348
ILE A 297
 None
 0.86A 4pthA-4c23A:
undetectable		 4pthA-4c23A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_A_RBFA201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4c23 L-FUCULOSE KINASE
FUCK
(Streptococcus
pneumoniae) 		5 / 12 ALA A   6
ALA A 427
LEU A  26
MET A  28
GLY A  19
 None
 0.66A 4r38A-4c23A:
undetectable		 4r38A-4c23A:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_C_RBFC201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4c23 L-FUCULOSE KINASE
FUCK
(Streptococcus
pneumoniae) 		5 / 12 ALA A   6
ALA A 427
LEU A  26
MET A  28
GLY A  19
 None
 0.70A 4r38C-4c23A:
undetectable		 4r38C-4c23A:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_D_RBFD201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4c23 L-FUCULOSE KINASE
FUCK
(Streptococcus
pneumoniae) 		5 / 12 ALA A   6
ALA A 427
LEU A  26
MET A  28
GLY A  19
 None
 0.69A 4r38D-4c23A:
undetectable		 4r38D-4c23A:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5G_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4c23 L-FUCULOSE KINASE
FUCK
(Streptococcus
pneumoniae) 		5 / 12 ILE A 298
THR A 333
ILE A 331
LEU A 348
ILE A 297
 None
 0.91A 4x5gB-4c23A:
undetectable		 4x5gB-4c23A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_W_BEZW801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4c23 L-FUCULOSE KINASE
FUCK
(Streptococcus
pneumoniae) 		4 / 5 PHE A 408
ILE A 250
GLY A 294
ILE A 412
 None
 0.81A 5dzkB-4c23A:
undetectable
5dzkI-4c23A:
undetectable
5dzkW-4c23A:
undetectable		 5dzkB-4c23A:
18.49
5dzkI-4c23A:
18.75
5dzkW-4c23A:
3.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4c23 L-FUCULOSE KINASE
FUCK
(Streptococcus
pneumoniae) 		5 / 12 ILE A 298
THR A 333
ILE A 331
LEU A 348
ILE A 297
 None
 0.92A 5eajA-4c23A:
undetectable		 5eajA-4c23A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_A_ADNA501_2
(ADENOSYLHOMOCYSTEINA
SE)		 4c23 L-FUCULOSE KINASE
FUCK
(Streptococcus
pneumoniae) 		4 / 5 GLU A 245
THR A 244
GLU A 261
LEU A 385
 None
 1.19A 5hm8A-4c23A:
undetectable		 5hm8A-4c23A:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_B_ADNB501_2
(ADENOSYLHOMOCYSTEINA
SE)		 4c23 L-FUCULOSE KINASE
FUCK
(Streptococcus
pneumoniae) 		4 / 5 GLU A 245
THR A 244
GLU A 261
LEU A 385
 None
 1.19A 5hm8B-4c23A:
undetectable		 5hm8B-4c23A:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_C_ADNC501_2
(ADENOSYLHOMOCYSTEINA
SE)		 4c23 L-FUCULOSE KINASE
FUCK
(Streptococcus
pneumoniae) 		4 / 5 GLU A 245
THR A 244
GLU A 261
LEU A 385
 None
 1.19A 5hm8C-4c23A:
undetectable		 5hm8C-4c23A:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_D_ADND501_2
(ADENOSYLHOMOCYSTEINA
SE)		 4c23 L-FUCULOSE KINASE
FUCK
(Streptococcus
pneumoniae) 		4 / 5 GLU A 245
THR A 244
GLU A 261
LEU A 385
 None
 1.19A 5hm8D-4c23A:
undetectable		 5hm8D-4c23A:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_E_ADNE501_2
(ADENOSYLHOMOCYSTEINA
SE)		 4c23 L-FUCULOSE KINASE
FUCK
(Streptococcus
pneumoniae) 		4 / 5 GLU A 245
THR A 244
GLU A 261
LEU A 385
 None
 1.19A 5hm8E-4c23A:
undetectable		 5hm8E-4c23A:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_F_ADNF501_2
(ADENOSYLHOMOCYSTEINA
SE)		 4c23 L-FUCULOSE KINASE
FUCK
(Streptococcus
pneumoniae) 		4 / 5 GLU A 245
THR A 244
GLU A 261
LEU A 385
 None
 1.19A 5hm8F-4c23A:
undetectable		 5hm8F-4c23A:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_H_ADNH501_2
(ADENOSYLHOMOCYSTEINA
SE)		 4c23 L-FUCULOSE KINASE
FUCK
(Streptococcus
pneumoniae) 		4 / 5 GLU A 245
THR A 244
GLU A 261
LEU A 385
 None
 1.19A 5hm8H-4c23A:
undetectable		 5hm8H-4c23A:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4c23 L-FUCULOSE KINASE
FUCK
(Streptococcus
pneumoniae) 		5 / 9 SER A 256
ALA A 381
VAL A 258
GLU A 334
ILE A 396
 None
 1.41A 5i3cA-4c23A:
undetectable		 5i3cA-4c23A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UJX_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4c23 L-FUCULOSE KINASE
FUCK
(Streptococcus
pneumoniae) 		5 / 12 ILE A 298
THR A 333
ILE A 331
LEU A 348
ILE A 297
 None
 0.94A 5ujxA-4c23A:
undetectable		 5ujxA-4c23A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_2
(CYTOCHROME P450 3A4)		 4c23 L-FUCULOSE KINASE
FUCK
(Streptococcus
pneumoniae) 		3 / 3 ARG A  98
ARG A  40
ARG A 101
 None
 0.95A 5vcgA-4c23A:
undetectable		 5vcgA-4c23A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_1
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 4c23 L-FUCULOSE KINASE
FUCK
(Streptococcus
pneumoniae) 		4 / 5 THR A 177
ASP A 157
GLU A 170
ASN A 432
 None
 1.41A 5ybbA-4c23A:
undetectable		 5ybbA-4c23A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6J_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4c23 L-FUCULOSE KINASE
FUCK
(Streptococcus
pneumoniae) 		5 / 12 ILE A 298
THR A 333
ILE A 331
LEU A 348
ILE A 297
 None
 0.91A 5z6jA-4c23A:
undetectable		 5z6jA-4c23A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4c23 L-FUCULOSE KINASE
FUCK
(Streptococcus
pneumoniae) 		5 / 12 ILE A 298
THR A 333
ILE A 331
LEU A 348
ILE A 297
 None
 0.92A 5z6kA-4c23A:
undetectable		 5z6kA-4c23A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7DFR_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4c23 L-FUCULOSE KINASE
FUCK
(Streptococcus
pneumoniae) 		5 / 12 ILE A 298
THR A 333
ILE A 331
LEU A 348
ILE A 297
 None
 0.96A 7dfrA-4c23A:
undetectable		 7dfrA-4c23A:
17.27