SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4c25'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_B_ACTB1108_0
(C5A PEPTIDASE)		 4c25 L-FUCULOSE PHOSPHATE
ALDOLASE
(Streptococcus
pneumoniae) 		4 / 6 LEU A  15
HIS A  93
ASN A  27
ILE A  92
 None
ZN  A 301 ( 3.2A)
SO4  A 304 ( 3.8A)
None
 0.85A 1xf1B-4c25A:
undetectable		 1xf1B-4c25A:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTT_E_H4BE1004_1
(HYPOTHETICAL PROTEIN
PH0634)		 4c25 L-FUCULOSE PHOSPHATE
ALDOLASE
(Streptococcus
pneumoniae) 		5 / 11 HIS A 155
HIS A  95
HIS A  93
THR A 130
GLU A  74
 ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.3A)
ZN  A 301 ( 3.2A)
None
13P  A 303 (-4.1A)
 1.10A 2dttD-4c25A:
undetectable
2dttE-4c25A:
undetectable		 2dttD-4c25A:
21.86
2dttE-4c25A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FBX_A_ACTA608_0
(PUTATIVE
PHOSPHOLIPASE B-LIKE
2)		 4c25 L-FUCULOSE PHOSPHATE
ALDOLASE
(Streptococcus
pneumoniae) 		3 / 3 GLU A 173
VAL A 174
CYH A 177
 None
 1.00A 3fbxA-4c25A:
undetectable		 3fbxA-4c25A:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_C_486C4_2
(GLUCOCORTICOID
RECEPTOR)		 4c25 L-FUCULOSE PHOSPHATE
ALDOLASE
(Streptococcus
pneumoniae) 		3 / 3 MET A 198
CYH A 177
PRO A 110
 None
 1.30A 3h52C-4c25A:
undetectable		 3h52C-4c25A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFE_C_TMGC1_1
(SUCCINATE
DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR SUBUNIT,
MITOCHONDRIAL
SUCCINATE
DEHYDROGENASE
CYTOCHROME B560
SUBUNIT,
MITOCHONDRIAL)		 4c25 L-FUCULOSE PHOSPHATE
ALDOLASE
(Streptococcus
pneumoniae) 		4 / 8 HIS A  93
ILE A  91
SER A  29
ILE A  40
 ZN  A 301 ( 3.2A)
None
None
None
 1.04A 3sfeB-4c25A:
undetectable
3sfeC-4c25A:
undetectable		 3sfeB-4c25A:
19.69
3sfeC-4c25A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_1
(WBDD)		 4c25 L-FUCULOSE PHOSPHATE
ALDOLASE
(Streptococcus
pneumoniae) 		4 / 6 GLN A  36
ASP A  89
GLU A   7
LEU A  37
 None
 1.14A 4ax8A-4c25A:
undetectable		 4ax8A-4c25A:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_A_1LDA501_0
(CYTOSINE DEAMINASE)		 4c25 L-FUCULOSE PHOSPHATE
ALDOLASE
(Streptococcus
pneumoniae) 		5 / 12 HIS A  95
HIS A  93
GLU A  74
LEU A 136
SER A  73
 ZN  A 301 ( 3.3A)
ZN  A 301 ( 3.2A)
13P  A 303 (-4.1A)
None
13P  A 303 ( 3.5A)
 1.41A 4r88A-4c25A:
undetectable		 4r88A-4c25A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_2
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		 4c25 L-FUCULOSE PHOSPHATE
ALDOLASE
(Streptococcus
pneumoniae) 		4 / 5 ILE A  45
PRO A  42
HIS A  78
TYR A 131
 None
 1.28A 4s0vA-4c25A:
undetectable		 4s0vA-4c25A:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FUQ_A_ACTA1278_0
(NAD(P)H
DEHYDROGENASE
[QUINONE] 1)		 4c25 L-FUCULOSE PHOSPHATE
ALDOLASE
(Streptococcus
pneumoniae) 		4 / 5 HIS A  78
SER A  29
GLN A  81
ILE A  88
 None
 1.48A 5fuqA-4c25A:
undetectable
5fuqB-4c25A:
undetectable		 5fuqA-4c25A:
21.71
5fuqB-4c25A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA503_1
(CYTOCHROME P450 2C9)		 4c25 L-FUCULOSE PHOSPHATE
ALDOLASE
(Streptococcus
pneumoniae) 		5 / 12 ILE A  92
PRO A  42
THR A  41
LEU A  28
PHE A  47
 None
 1.29A 5xxiA-4c25A:
undetectable		 5xxiA-4c25A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_1
(NS3 PROTEASE)		 4c25 L-FUCULOSE PHOSPHATE
ALDOLASE
(Streptococcus
pneumoniae) 		5 / 9 ASP A  87
ALA A  90
VAL A  30
SER A  29
ASP A  89
 EDO  A 306 ( 3.8A)
None
None
None
None
 1.26A 6c2mB-4c25A:
undetectable		 6c2mB-4c25A:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA502_0
(ADENOSYLHOMOCYSTEINA
SE)		 4c25 L-FUCULOSE PHOSPHATE
ALDOLASE
(Streptococcus
pneumoniae) 		5 / 12 THR A  96
THR A  21
HIS A  78
GLY A 156
HIS A 155
 None
None
None
None
ZN  A 301 ( 3.2A)
 1.39A 6exiA-4c25A:
undetectable		 6exiA-4c25A:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND502_0
(ADENOSYLHOMOCYSTEINA
SE)		 4c25 L-FUCULOSE PHOSPHATE
ALDOLASE
(Streptococcus
pneumoniae) 		5 / 12 THR A  96
THR A  21
HIS A  78
GLY A 156
HIS A 155
 None
None
None
None
ZN  A 301 ( 3.2A)
 1.43A 6exiD-4c25A:
undetectable		 6exiD-4c25A:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_A_ADNA502_1
(-)		 4c25 L-FUCULOSE PHOSPHATE
ALDOLASE
(Streptococcus
pneumoniae) 		5 / 12 THR A  96
HIS A  78
LEU A 158
GLY A 156
HIS A 155
 None
None
None
None
ZN  A 301 ( 3.2A)
 1.37A 6f3mA-4c25A:
undetectable		 6f3mA-4c25A:
19.14