SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4c2f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHI_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4c2f CARBOXY-TERMINAL
PROCESSING PROTEASE
CTPB
(Bacillus
subtilis) 		5 / 12 ALA A 204
LEU A 245
ILE A 263
LEU A 314
ILE A 219
 None
 0.90A 1dhiA-4c2fA:
undetectable		 1dhiA-4c2fA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHI_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 4c2f CARBOXY-TERMINAL
PROCESSING PROTEASE
CTPB
(Bacillus
subtilis) 		5 / 11 ALA A 204
LEU A 245
ILE A 263
LEU A 314
ILE A 219
 None
 0.89A 1dhiB-4c2fA:
undetectable		 1dhiB-4c2fA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHJ_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4c2f CARBOXY-TERMINAL
PROCESSING PROTEASE
CTPB
(Bacillus
subtilis) 		5 / 12 ALA A 204
LEU A 245
ILE A 263
LEU A 314
ILE A 219
 None
 0.92A 1dhjA-4c2fA:
undetectable		 1dhjA-4c2fA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHJ_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 4c2f CARBOXY-TERMINAL
PROCESSING PROTEASE
CTPB
(Bacillus
subtilis) 		5 / 12 ALA A 204
LEU A 245
ILE A 263
LEU A 314
ILE A 219
 None
 0.91A 1dhjB-4c2fA:
undetectable		 1dhjB-4c2fA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRA_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4c2f CARBOXY-TERMINAL
PROCESSING PROTEASE
CTPB
(Bacillus
subtilis) 		5 / 12 ALA A 204
LEU A 245
ILE A 263
LEU A 314
ILE A 219
 None
 0.93A 1draA-4c2fA:
undetectable		 1draA-4c2fA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRA_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 4c2f CARBOXY-TERMINAL
PROCESSING PROTEASE
CTPB
(Bacillus
subtilis) 		5 / 12 ALA A 204
LEU A 245
ILE A 263
LEU A 314
ILE A 219
 None
 0.92A 1draB-4c2fA:
undetectable		 1draB-4c2fA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRB_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4c2f CARBOXY-TERMINAL
PROCESSING PROTEASE
CTPB
(Bacillus
subtilis) 		5 / 12 ALA A 204
LEU A 245
ILE A 263
LEU A 314
ILE A 219
 None
 0.90A 1drbA-4c2fA:
undetectable		 1drbA-4c2fA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRB_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 4c2f CARBOXY-TERMINAL
PROCESSING PROTEASE
CTPB
(Bacillus
subtilis) 		5 / 12 ALA A 204
LEU A 245
ILE A 263
LEU A 314
ILE A 219
 None
 0.89A 1drbB-4c2fA:
undetectable		 1drbB-4c2fA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R9O_A_FLPA501_1
(CYTOCHROME P450 2C9)		 4c2f CARBOXY-TERMINAL
PROCESSING PROTEASE
CTPB
(Bacillus
subtilis) 		5 / 12 VAL A 326
ASN A 362
ILE A 364
GLY A 316
ALA A 315
 None
 1.02A 1r9oA-4c2fA:
undetectable		 1r9oA-4c2fA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4c2f CARBOXY-TERMINAL
PROCESSING PROTEASE
CTPB
(Bacillus
subtilis) 		5 / 12 ALA A 204
LEU A 245
ILE A 263
LEU A 314
ILE A 219
 None
 0.89A 1ra2A-4c2fA:
undetectable		 1ra2A-4c2fA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4c2f CARBOXY-TERMINAL
PROCESSING PROTEASE
CTPB
(Bacillus
subtilis) 		5 / 12 ALA A 204
LEU A 245
ILE A 263
LEU A 314
ILE A 219
 None
 0.94A 1ra3A-4c2fA:
undetectable		 1ra3A-4c2fA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4c2f CARBOXY-TERMINAL
PROCESSING PROTEASE
CTPB
(Bacillus
subtilis) 		5 / 12 ALA A 204
LEU A 245
ILE A 263
LEU A 314
ILE A 219
 None
 0.87A 1ra8A-4c2fA:
undetectable		 1ra8A-4c2fA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4c2f CARBOXY-TERMINAL
PROCESSING PROTEASE
CTPB
(Bacillus
subtilis) 		5 / 12 ALA A 204
LEU A 245
ILE A 263
LEU A 314
ILE A 219
 None
 0.85A 1rb2A-4c2fA:
undetectable		 1rb2A-4c2fA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB3_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 4c2f CARBOXY-TERMINAL
PROCESSING PROTEASE
CTPB
(Bacillus
subtilis) 		5 / 12 ALA A 204
LEU A 245
ILE A 263
LEU A 314
ILE A 219
 None
 0.89A 1rb3B-4c2fA:
undetectable		 1rb3B-4c2fA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RD7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4c2f CARBOXY-TERMINAL
PROCESSING PROTEASE
CTPB
(Bacillus
subtilis) 		6 / 12 ALA A 204
LEU A 245
THR A 226
ILE A 263
LEU A 314
ILE A 219
 None
 1.15A 1rd7A-4c2fA:
undetectable		 1rd7A-4c2fA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RD7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)		 4c2f CARBOXY-TERMINAL
PROCESSING PROTEASE
CTPB
(Bacillus
subtilis) 		5 / 12 ALA A 204
LEU A 245
ILE A 263
LEU A 314
ILE A 219
 None
 0.96A 1rd7B-4c2fA:
undetectable		 1rd7B-4c2fA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4c2f CARBOXY-TERMINAL
PROCESSING PROTEASE
CTPB
(Bacillus
subtilis) 		5 / 12 ALA A 204
LEU A 245
ILE A 263
LEU A 314
ILE A 219
 None
 0.89A 1rx2A-4c2fA:
undetectable		 1rx2A-4c2fA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4c2f CARBOXY-TERMINAL
PROCESSING PROTEASE
CTPB
(Bacillus
subtilis) 		5 / 12 ALA A 204
LEU A 245
ILE A 263
LEU A 314
ILE A 219
 None
 0.96A 2drcA-4c2fA:
undetectable		 2drcA-4c2fA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRC_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 4c2f CARBOXY-TERMINAL
PROCESSING PROTEASE
CTPB
(Bacillus
subtilis) 		5 / 12 ALA A 204
LEU A 245
ILE A 263
LEU A 314
ILE A 219
 None
 0.97A 2drcB-4c2fA:
undetectable		 2drcB-4c2fA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4c2f CARBOXY-TERMINAL
PROCESSING PROTEASE
CTPB
(Bacillus
subtilis) 		5 / 12 ALA A 204
LEU A 245
ILE A 263
LEU A 314
ILE A 219
 None
 0.94A 3drcA-4c2fA:
undetectable		 3drcA-4c2fA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DRC_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 4c2f CARBOXY-TERMINAL
PROCESSING PROTEASE
CTPB
(Bacillus
subtilis) 		5 / 12 ALA A 204
LEU A 245
ILE A 263
LEU A 314
ILE A 219
 None
 0.96A 3drcB-4c2fA:
undetectable		 3drcB-4c2fA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_F_TFPF202_1
(PROTEIN S100-A4)		 4c2f CARBOXY-TERMINAL
PROCESSING PROTEASE
CTPB
(Bacillus
subtilis) 		5 / 11 LEU A 257
ILE A 313
PHE A 332
ASP A  89
SER A  92
 None
 1.49A 3ko0E-4c2fA:
2.8
3ko0F-4c2fA:
2.8
3ko0G-4c2fA:
2.8
3ko0H-4c2fA:
2.8		 3ko0E-4c2fA:
12.44
3ko0F-4c2fA:
12.44
3ko0G-4c2fA:
12.44
3ko0H-4c2fA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_Q_TFPQ202_1
(PROTEIN S100-A4)		 4c2f CARBOXY-TERMINAL
PROCESSING PROTEASE
CTPB
(Bacillus
subtilis) 		5 / 10 ASP A  89
SER A  92
LEU A 257
ILE A 313
PHE A 332
 None
 1.49A 3ko0O-4c2fA:
2.8
3ko0P-4c2fA:
2.8
3ko0Q-4c2fA:
2.9
3ko0R-4c2fA:
2.8		 3ko0O-4c2fA:
12.44
3ko0P-4c2fA:
12.44
3ko0Q-4c2fA:
12.44
3ko0R-4c2fA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PP1_A_ACTA590_0
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 4c2f CARBOXY-TERMINAL
PROCESSING PROTEASE
CTPB
(Bacillus
subtilis) 		4 / 5 GLU A 320
GLN A 272
HIS A 323
GLY A 322
 None
 1.31A 3pp1A-4c2fA:
undetectable		 3pp1A-4c2fA:
25.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQB_A_FOLA2001_0
(DIHYDROFOLATE
REDUCTASE)		 4c2f CARBOXY-TERMINAL
PROCESSING PROTEASE
CTPB
(Bacillus
subtilis) 		5 / 11 ALA A 204
LEU A 245
THR A 226
ILE A 263
LEU A 314
 None
 1.09A 3tqbA-4c2fA:
undetectable		 3tqbA-4c2fA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_B_CLMB221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4c2f CARBOXY-TERMINAL
PROCESSING PROTEASE
CTPB
(Bacillus
subtilis) 		5 / 12 THR A 221
SER A 220
PHE A 203
SER A 223
PHE A 131
 None
 1.28A 3u9fB-4c2fA:
undetectable
3u9fC-4c2fA:
undetectable		 3u9fB-4c2fA:
20.19
3u9fC-4c2fA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_C_CLMC221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4c2f CARBOXY-TERMINAL
PROCESSING PROTEASE
CTPB
(Bacillus
subtilis) 		5 / 11 PHE A 131
THR A 221
SER A 220
PHE A 203
SER A 223
 None
 1.20A 3u9fA-4c2fA:
undetectable
3u9fC-4c2fA:
undetectable		 3u9fA-4c2fA:
20.19
3u9fC-4c2fA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_H_CLMH221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4c2f CARBOXY-TERMINAL
PROCESSING PROTEASE
CTPB
(Bacillus
subtilis) 		5 / 12 THR A 221
SER A 220
PHE A 203
SER A 223
PHE A 131
 None
 1.28A 3u9fH-4c2fA:
undetectable
3u9fI-4c2fA:
undetectable		 3u9fH-4c2fA:
20.19
3u9fI-4c2fA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_L_CLML221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4c2f CARBOXY-TERMINAL
PROCESSING PROTEASE
CTPB
(Bacillus
subtilis) 		5 / 12 PHE A 131
THR A 221
SER A 220
PHE A 203
SER A 223
 None
 1.26A 3u9fJ-4c2fA:
undetectable
3u9fL-4c2fA:
undetectable		 3u9fJ-4c2fA:
20.19
3u9fL-4c2fA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_O_CLMO221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4c2f CARBOXY-TERMINAL
PROCESSING PROTEASE
CTPB
(Bacillus
subtilis) 		5 / 11 PHE A 131
THR A 221
SER A 220
PHE A 203
SER A 223
 None
 1.30A 3u9fM-4c2fA:
undetectable
3u9fO-4c2fA:
undetectable		 3u9fM-4c2fA:
20.19
3u9fO-4c2fA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4c2f CARBOXY-TERMINAL
PROCESSING PROTEASE
CTPB
(Bacillus
subtilis) 		4 / 8 ILE A 147
ILE A 179
PHE A 190
GLY A 140
 None
 0.75A 4acaC-4c2fA:
2.6		 4acaC-4c2fA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFR_B_MTXB162_1
(DIHYDROFOLATE
REDUCTASE)		 4c2f CARBOXY-TERMINAL
PROCESSING PROTEASE
CTPB
(Bacillus
subtilis) 		5 / 12 ALA A 204
LEU A 245
ILE A 263
LEU A 314
ILE A 219
 None
 0.99A 4dfrB-4c2fA:
undetectable		 4dfrB-4c2fA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_A_LNLA701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4c2f CARBOXY-TERMINAL
PROCESSING PROTEASE
CTPB
(Bacillus
subtilis) 		5 / 12 ILE A 263
PHE A 222
GLY A 254
ALA A 308
SER A 311
 None
 0.93A 4e1gA-4c2fA:
undetectable		 4e1gA-4c2fA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4c2f CARBOXY-TERMINAL
PROCESSING PROTEASE
CTPB
(Bacillus
subtilis) 		5 / 12 ILE A 263
PHE A 222
GLY A 254
ALA A 308
SER A 311
 None
 0.95A 4e1gB-4c2fA:
undetectable		 4e1gB-4c2fA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJ1_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4c2f CARBOXY-TERMINAL
PROCESSING PROTEASE
CTPB
(Bacillus
subtilis) 		6 / 12 ALA A 204
LEU A 245
THR A 226
ILE A 263
LEU A 314
ILE A 219
 None
 1.19A 4ej1A-4c2fA:
undetectable		 4ej1A-4c2fA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJ1_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4c2f CARBOXY-TERMINAL
PROCESSING PROTEASE
CTPB
(Bacillus
subtilis) 		5 / 12 ALA A 204
LEU A 245
THR A 226
ILE A 263
LEU A 314
 None
 1.14A 4ej1B-4c2fA:
undetectable		 4ej1B-4c2fA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FHB_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4c2f CARBOXY-TERMINAL
PROCESSING PROTEASE
CTPB
(Bacillus
subtilis) 		6 / 12 ALA A 204
LEU A 245
THR A 226
ILE A 263
LEU A 314
ILE A 219
 None
 1.21A 4fhbA-4c2fA:
undetectable		 4fhbA-4c2fA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4C_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 4c2f CARBOXY-TERMINAL
PROCESSING PROTEASE
CTPB
(Bacillus
subtilis) 		4 / 8 PHE A 230
LEU A 318
VAL A 299
ILE A 217
 None
 0.96A 4l4cB-4c2fA:
undetectable		 4l4cB-4c2fA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NX6_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4c2f CARBOXY-TERMINAL
PROCESSING PROTEASE
CTPB
(Bacillus
subtilis) 		6 / 12 ALA A 204
LEU A 245
THR A 226
ILE A 263
LEU A 314
ILE A 219
 None
 1.23A 4nx6A-4c2fA:
undetectable		 4nx6A-4c2fA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NX7_A_FOLA202_0
(DIHYDROFOLATE
REDUCTASE)		 4c2f CARBOXY-TERMINAL
PROCESSING PROTEASE
CTPB
(Bacillus
subtilis) 		6 / 12 ALA A 204
LEU A 245
THR A 226
ILE A 263
LEU A 314
ILE A 219
 None
 1.25A 4nx7A-4c2fA:
undetectable		 4nx7A-4c2fA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3R_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4c2f CARBOXY-TERMINAL
PROCESSING PROTEASE
CTPB
(Bacillus
subtilis) 		6 / 12 ALA A 204
LEU A 245
THR A 226
ILE A 263
LEU A 314
ILE A 219
 None
 1.27A 4p3rA-4c2fA:
undetectable		 4p3rA-4c2fA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PST_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4c2f CARBOXY-TERMINAL
PROCESSING PROTEASE
CTPB
(Bacillus
subtilis) 		6 / 12 ALA A 204
LEU A 245
THR A 226
ILE A 263
LEU A 314
ILE A 219
 None
 1.24A 4pstA-4c2fA:
undetectable		 4pstA-4c2fA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLE_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4c2f CARBOXY-TERMINAL
PROCESSING PROTEASE
CTPB
(Bacillus
subtilis) 		5 / 12 ALA A 204
LEU A 245
THR A 226
ILE A 263
LEU A 314
 None
 1.12A 4qleA-4c2fA:
undetectable		 4qleA-4c2fA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4c2f CARBOXY-TERMINAL
PROCESSING PROTEASE
CTPB
(Bacillus
subtilis) 		5 / 12 ALA A 204
LEU A 245
THR A 226
ILE A 263
LEU A 314
 None
 1.11A 4x5fA-4c2fA:
undetectable		 4x5fA-4c2fA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5F_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4c2f CARBOXY-TERMINAL
PROCESSING PROTEASE
CTPB
(Bacillus
subtilis) 		5 / 12 ALA A 204
LEU A 245
THR A 226
ILE A 263
LEU A 314
 None
 1.11A 4x5fB-4c2fA:
undetectable		 4x5fB-4c2fA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5G_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4c2f CARBOXY-TERMINAL
PROCESSING PROTEASE
CTPB
(Bacillus
subtilis) 		5 / 12 ALA A 204
LEU A 245
ILE A 263
LEU A 314
ILE A 219
 None
 0.93A 4x5gB-4c2fA:
undetectable		 4x5gB-4c2fA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5H_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4c2f CARBOXY-TERMINAL
PROCESSING PROTEASE
CTPB
(Bacillus
subtilis) 		5 / 12 ALA A 204
LEU A 245
THR A 226
ILE A 263
LEU A 314
 None
 1.14A 4x5hA-4c2fA:
undetectable		 4x5hA-4c2fA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4c2f CARBOXY-TERMINAL
PROCESSING PROTEASE
CTPB
(Bacillus
subtilis) 		6 / 12 ALA A 204
LEU A 245
THR A 226
ILE A 263
LEU A 314
ILE A 219
 None
 1.21A 4x5iA-4c2fA:
undetectable		 4x5iA-4c2fA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4c2f CARBOXY-TERMINAL
PROCESSING PROTEASE
CTPB
(Bacillus
subtilis) 		5 / 12 ALA A 204
LEU A 245
ILE A 263
LEU A 314
ILE A 219
 None
 0.94A 5eajA-4c2fA:
undetectable		 5eajA-4c2fA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UJX_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4c2f CARBOXY-TERMINAL
PROCESSING PROTEASE
CTPB
(Bacillus
subtilis) 		5 / 12 ALA A 204
LEU A 245
ILE A 263
LEU A 314
ILE A 219
 None
 0.96A 5ujxA-4c2fA:
undetectable		 5ujxA-4c2fA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_A_CVIA301_0
(REGULATORY PROTEIN
TETR)		 4c2f CARBOXY-TERMINAL
PROCESSING PROTEASE
CTPB
(Bacillus
subtilis) 		5 / 12 MET A 177
GLU A 137
LEU A 141
ILE A 127
PHE A 131
 None
 1.04A 5vlmA-4c2fA:
undetectable		 5vlmA-4c2fA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_B_SALB203_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 4c2f CARBOXY-TERMINAL
PROCESSING PROTEASE
CTPB
(Bacillus
subtilis) 		4 / 6 GLY A 215
TYR A 216
LEU A 477
VAL A 209
 None
 0.97A 5x80A-4c2fA:
undetectable
5x80B-4c2fA:
undetectable		 5x80A-4c2fA:
16.78
5x80B-4c2fA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6J_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4c2f CARBOXY-TERMINAL
PROCESSING PROTEASE
CTPB
(Bacillus
subtilis) 		5 / 12 ALA A 204
LEU A 245
ILE A 263
LEU A 314
ILE A 219
 None
 0.95A 5z6jA-4c2fA:
undetectable		 5z6jA-4c2fA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4c2f CARBOXY-TERMINAL
PROCESSING PROTEASE
CTPB
(Bacillus
subtilis) 		5 / 12 ALA A 204
LEU A 245
ILE A 263
LEU A 314
ILE A 219
 None
 0.96A 5z6kA-4c2fA:
undetectable		 5z6kA-4c2fA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWT_D_BEZD202_0
(PR 10 PROTEIN)		 4c2f CARBOXY-TERMINAL
PROCESSING PROTEASE
CTPB
(Bacillus
subtilis) 		3 / 3 PHE A 433
ASP A 435
LYS A 438
 None
 0.83A 6awtD-4c2fA:
undetectable		 6awtD-4c2fA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_C_EU7C101_0
(MATRIX PROTEIN 2)		 4c2f CARBOXY-TERMINAL
PROCESSING PROTEASE
CTPB
(Bacillus
subtilis) 		5 / 9 SER A 106
VAL A 164
ALA A 168
VAL A 118
GLY A 113
 None
 1.28A 6bklA-4c2fA:
undetectable
6bklB-4c2fA:
undetectable
6bklC-4c2fA:
undetectable
6bklD-4c2fA:
undetectable		 6bklA-4c2fA:
5.41
6bklB-4c2fA:
5.41
6bklC-4c2fA:
5.41
6bklD-4c2fA:
5.41