SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4c2k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AEG_A_4APA296_1
(CYTOCHROME C
PEROXIDASE)		 4c2k 3-KETOACYL-COA
THIOLASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 GLY A 258
GLY A 256
LEU A 350
ASP A 220
 None
 0.71A 1aegA-4c2kA:
undetectable		 1aegA-4c2kA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AX9_A_EDRA999_1
(ACETYLCHOLINESTERASE)		 4c2k 3-KETOACYL-COA
THIOLASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 GLY A 345
GLU A 318
PHE A 199
HIS A 364
 None
 0.96A 1ax9A-4c2kA:
undetectable		 1ax9A-4c2kA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AX9_A_EDRA999_1
(ACETYLCHOLINESTERASE)		 4c2k 3-KETOACYL-COA
THIOLASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 GLY A 346
GLU A 318
PHE A 199
HIS A 364
 None
 0.93A 1ax9A-4c2kA:
undetectable		 1ax9A-4c2kA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_2
(HIV-1 PROTEASE)		 4c2k 3-KETOACYL-COA
THIOLASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ARG A 130
THR A 153
VAL A 150
 None
EDO  A1397 (-3.5A)
None
 1.01A 1hxbA-4c2kA:
undetectable		 1hxbA-4c2kA:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KXH_A_ACRA598_1
(ALPHA-AMYLASE)		 4c2k 3-KETOACYL-COA
THIOLASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ALA A 299
GLY A 295
ASN A 342
ILE A 348
HIS A 352
 None
 1.22A 1kxhA-4c2kA:
undetectable		 1kxhA-4c2kA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC2199_0
(PROTEIN (METHIONINE
REPRESSOR))		 4c2k 3-KETOACYL-COA
THIOLASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 GLY A 346
GLU A 368
ARG A 371
ARG A 372
LEU A 316
 None
None
DTT  A1400 (-3.1A)
DTT  A1400 (-3.6A)
None
 1.06A 1mj2C-4c2kA:
undetectable
1mj2D-4c2kA:
undetectable		 1mj2C-4c2kA:
13.79
1mj2D-4c2kA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJL_A_SAMA200_0
(METHIONINE REPRESSOR
PROTEIN METJ)		 4c2k 3-KETOACYL-COA
THIOLASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 ALA A 192
GLU A 368
ARG A 371
ARG A 372
LEU A 316
 None
None
DTT  A1400 (-3.1A)
DTT  A1400 (-3.6A)
None
 1.29A 1mjlA-4c2kA:
undetectable
1mjlB-4c2kA:
undetectable		 1mjlA-4c2kA:
13.79
1mjlB-4c2kA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_C_SAMC200_0
(METHIONINE REPRESSOR)		 4c2k 3-KETOACYL-COA
THIOLASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 GLY A 346
GLU A 368
ARG A 371
ARG A 372
LEU A 316
 None
None
DTT  A1400 (-3.1A)
DTT  A1400 (-3.6A)
None
 1.10A 1mjoC-4c2kA:
undetectable
1mjoD-4c2kA:
undetectable		 1mjoC-4c2kA:
13.79
1mjoD-4c2kA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_D_URFD2021_1
(URIDINE
PHOSPHORYLASE)		 4c2k 3-KETOACYL-COA
THIOLASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 GLY A 295
GLN A 326
ILE A 300
VAL A 297
 None
 1.07A 1rxcD-4c2kA:
undetectable		 1rxcD-4c2kA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACK_A_EDRA999_1
(ACETYLCHOLINESTERASE)		 4c2k 3-KETOACYL-COA
THIOLASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 GLY A 345
GLU A 318
PHE A 199
HIS A 364
 None
 0.96A 2ackA-4c2kA:
undetectable		 2ackA-4c2kA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 4c2k 3-KETOACYL-COA
THIOLASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 ASP A 180
GLY A 243
PRO A 325
ALA A 324
 None
 0.91A 2aohA-4c2kA:
undetectable		 2aohA-4c2kA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_1
(HYPOTHETICAL PROTEIN)		 4c2k 3-KETOACYL-COA
THIOLASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 GLY A  18
GLU A 221
ASP A 255
 None
 0.69A 2b25B-4c2kA:
undetectable		 2b25B-4c2kA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_C_SAMC1003_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 4c2k 3-KETOACYL-COA
THIOLASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 TYR A 282
ALA A 299
ALA A 303
ALA A 381
GLY A 295
 None
 1.29A 2igtC-4c2kA:
undetectable		 2igtC-4c2kA:
25.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_A_J01A1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 4c2k 3-KETOACYL-COA
THIOLASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU A 304
SER A 380
ALA A 390
ALA A 303
LEU A 334
 None
 1.17A 2japA-4c2kA:
undetectable		 2japA-4c2kA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_B_J01B1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 4c2k 3-KETOACYL-COA
THIOLASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU A 304
SER A 380
ALA A 390
ALA A 303
LEU A 334
 None
 1.14A 2japB-4c2kA:
undetectable		 2japB-4c2kA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_C_J01C1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 4c2k 3-KETOACYL-COA
THIOLASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU A 304
SER A 380
ALA A 390
ALA A 303
LEU A 334
 None
 1.17A 2japC-4c2kA:
undetectable		 2japC-4c2kA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_D_J01D1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 4c2k 3-KETOACYL-COA
THIOLASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU A 304
SER A 380
ALA A 390
ALA A 303
LEU A 334
 None
 1.14A 2japD-4c2kA:
undetectable		 2japD-4c2kA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA507_0
(CHORISMATE SYNTHASE)		 4c2k 3-KETOACYL-COA
THIOLASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 LEU A 316
ASN A 344
ARG A 372
 None
None
DTT  A1400 (-3.6A)
 0.83A 2qhfA-4c2kA:
undetectable		 2qhfA-4c2kA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_E_SAME1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 4c2k 3-KETOACYL-COA
THIOLASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 GLY A 117
GLY A 258
ALA A  70
PHE A  96
THR A 362
 None
 1.23A 2vdvE-4c2kA:
undetectable		 2vdvE-4c2kA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_F_SAMF1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 4c2k 3-KETOACYL-COA
THIOLASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 GLY A 117
GLY A 258
ALA A  70
PHE A  96
THR A 362
 None
 1.23A 2vdvF-4c2kA:
undetectable		 2vdvF-4c2kA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_B_SAMB400_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)		 4c2k 3-KETOACYL-COA
THIOLASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 9 ALA A  40
GLY A 258
GLY A 117
ILE A 262
ALA A  12
 None
 0.94A 2z0yB-4c2kA:
undetectable		 2z0yB-4c2kA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DHIC8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 4c2k 3-KETOACYL-COA
THIOLASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 SER A 123
GLY A  22
GLY A  18
 None
 0.45A 3bogA-4c2kA:
undetectable
3bogC-4c2kA:
undetectable		 3bogA-4c2kA:
undetectable
3bogC-4c2kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DHIC8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 4c2k 3-KETOACYL-COA
THIOLASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 SER A 359
GLY A 355
GLY A  57
 None
 0.56A 3bogA-4c2kA:
undetectable
3bogC-4c2kA:
undetectable		 3bogA-4c2kA:
undetectable
3bogC-4c2kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC47_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 4c2k 3-KETOACYL-COA
THIOLASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 4 GLY A 355
GLY A  95
GLY A 358
GLY A 118
 None
 0.67A 3bogC-4c2kA:
undetectable		 3bogC-4c2kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKK_A_SAMA301_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 4c2k 3-KETOACYL-COA
THIOLASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 GLY A 293
GLY A 295
ILE A 291
ASN A 167
ALA A 165
 None
 1.12A 3ckkA-4c2kA:
undetectable		 3ckkA-4c2kA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_3
(HIV-1 PROTEASE)		 4c2k 3-KETOACYL-COA
THIOLASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 GLY A 302
ALA A 303
ILE A 389
GLY A 388
VAL A 317
 None
None
None
None
EDO  A1398 (-4.8A)
 0.93A 3cyxB-4c2kA:
undetectable		 3cyxB-4c2kA:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D41_A_FCNA4001_1
(FOMA PROTEIN)		 4c2k 3-KETOACYL-COA
THIOLASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 GLY A 117
GLY A 118
GLY A 355
SER A  98
 None
 0.55A 3d41A-4c2kA:
undetectable		 3d41A-4c2kA:
28.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D41_A_FCNA4001_1
(FOMA PROTEIN)		 4c2k 3-KETOACYL-COA
THIOLASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 GLY A 117
GLY A 118
GLY A 356
SER A  98
 None
 0.70A 3d41A-4c2kA:
undetectable		 3d41A-4c2kA:
28.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4c2k 3-KETOACYL-COA
THIOLASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 TYR A  20
ASP A 255
ASP A  26
 MES  A1401 (-4.7A)
None
None
 0.69A 3ou7B-4c2kA:
undetectable		 3ou7B-4c2kA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHN_A_ACTA108_0
(PROTEIN P-30)		 4c2k 3-KETOACYL-COA
THIOLASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 THR A 396
SER A 395
ARG A 370
 None
 0.82A 3phnA-4c2kA:
undetectable		 3phnA-4c2kA:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_0
(WBDD)		 4c2k 3-KETOACYL-COA
THIOLASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ILE A 262
GLN A 104
ASN A 101
ILE A 279
VAL A 391
 None
 0.94A 4ax8A-4c2kA:
undetectable		 4ax8A-4c2kA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B17_A_SAMA1358_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M)		 4c2k 3-KETOACYL-COA
THIOLASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 GLY A 351
GLY A 346
GLY A 345
TRP A 190
ASP A 220
 None
 1.14A 4b17A-4c2kA:
undetectable		 4b17A-4c2kA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		 4c2k 3-KETOACYL-COA
THIOLASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 8 HIS A 222
GLY A 252
ALA A 347
SER A 251
GLU A 321
 None
MES  A1401 (-3.5A)
None
None
None
 1.49A 4bjcA-4c2kA:
undetectable		 4bjcA-4c2kA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_A_VK3A202_1
(NADPH QUINONE
OXIDOREDUCTASE)		 4c2k 3-KETOACYL-COA
THIOLASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 ARG A 189
TYR A 327
TYR A 182
LEU A 328
 None
 1.42A 4f8yA-4c2kA:
undetectable
4f8yB-4c2kA:
undetectable		 4f8yA-4c2kA:
17.51
4f8yB-4c2kA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_B_VK3B202_1
(NADPH QUINONE
OXIDOREDUCTASE)		 4c2k 3-KETOACYL-COA
THIOLASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 ARG A 189
TYR A 327
TYR A 182
LEU A 328
 None
 1.37A 4f8yA-4c2kA:
undetectable
4f8yB-4c2kA:
undetectable		 4f8yA-4c2kA:
17.51
4f8yB-4c2kA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_C_VK3C202_1
(NADPH QUINONE
OXIDOREDUCTASE)		 4c2k 3-KETOACYL-COA
THIOLASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 ARG A 189
TYR A 327
TYR A 182
LEU A 328
 None
 1.39A 4f8yC-4c2kA:
undetectable
4f8yD-4c2kA:
undetectable		 4f8yC-4c2kA:
17.51
4f8yD-4c2kA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JQ4_B_IMNB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 4c2k 3-KETOACYL-COA
THIOLASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 VAL A 391
ILE A 392
ASN A 342
TYR A 327
LEU A 336
 None
None
None
None
EDO  A1398 (-4.4A)
 1.32A 4jq4B-4c2kA:
undetectable		 4jq4B-4c2kA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_A_SAMA401_0
(METHYLTRANSFERASE
MPPJ)		 4c2k 3-KETOACYL-COA
THIOLASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 GLY A 118
GLY A  57
ALA A  70
ALA A  36
PHE A  96
 None
 1.03A 4kicA-4c2kA:
undetectable		 4kicA-4c2kA:
25.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_A_SAMA900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 4c2k 3-KETOACYL-COA
THIOLASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 GLY A 384
LEU A 152
SER A 151
ARG A  90
CYH A  92
 None
EDO  A1397 (-4.0A)
None
None
None
 1.00A 4krhA-4c2kA:
undetectable		 4krhA-4c2kA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_B_SAMB900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 4c2k 3-KETOACYL-COA
THIOLASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 GLY A 384
LEU A 152
SER A 151
ARG A  90
CYH A  92
 None
EDO  A1397 (-4.0A)
None
None
None
 1.00A 4krhB-4c2kA:
undetectable		 4krhB-4c2kA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UUU_B_SAMB1548_0
(CYSTATHIONINE
BETA-SYNTHASE)		 4c2k 3-KETOACYL-COA
THIOLASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 LEU A  60
GLN A 124
ALA A 125
PRO A 126
ASP A  65
 None
 1.23A 4uuuB-4c2kA:
undetectable		 4uuuB-4c2kA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_A_BEZA1001_0
(BENZOATE-COENZYME A
LIGASE)		 4c2k 3-KETOACYL-COA
THIOLASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 VAL A 208
GLY A  18
ALA A  19
GLY A  22
 None
 0.63A 4zjzA-4c2kA:
undetectable		 4zjzA-4c2kA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_E_SAME301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 4c2k 3-KETOACYL-COA
THIOLASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ALA A 257
GLY A  57
GLY A 118
GLY A 358
ALA A  70
 None
 1.02A 5c0oE-4c2kA:
undetectable		 5c0oE-4c2kA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQY_A_BEZA401_0
(THIOREDOXIN)		 4c2k 3-KETOACYL-COA
THIOLASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 ILE A 262
VAL A   7
GLN A 104
CYH A 107
 None
 0.82A 5dqyA-4c2kA:
undetectable		 5dqyA-4c2kA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQY_A_BEZA401_0
(THIOREDOXIN)		 4c2k 3-KETOACYL-COA
THIOLASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 ILE A 262
VAL A   7
GLN A 104
GLU A 105
 None
 1.03A 5dqyA-4c2kA:
undetectable		 5dqyA-4c2kA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)		 4c2k 3-KETOACYL-COA
THIOLASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 GLY A  95
GLY A  93
ILE A  88
ILE A 361
ASN A 320
 None
 1.16A 5fa8A-4c2kA:
undetectable		 5fa8A-4c2kA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)		 4c2k 3-KETOACYL-COA
THIOLASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 GLY A  95
GLY A 355
ILE A  88
ASN A  89
ASN A 101
 None
 1.06A 5fa8A-4c2kA:
undetectable		 5fa8A-4c2kA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_E_SC2E1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 4c2k 3-KETOACYL-COA
THIOLASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 VAL A   7
GLN A 104
CYH A 107
 None
 0.72A 5icxA-4c2kA:
undetectable
5icxE-4c2kA:
undetectable		 5icxA-4c2kA:
18.57
5icxE-4c2kA:
3.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_F_SC2F1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 4c2k 3-KETOACYL-COA
THIOLASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 VAL A   7
GLN A 104
CYH A 107
 None
 0.80A 5icxC-4c2kA:
undetectable
5icxF-4c2kA:
undetectable		 5icxC-4c2kA:
18.57
5icxF-4c2kA:
3.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUK_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 4c2k 3-KETOACYL-COA
THIOLASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 ALA A  70
VAL A  73
ILE A 261
VAL A  51
ALA A  85
 None
 0.98A 5nukA-4c2kA:
undetectable		 5nukA-4c2kA:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_A_SAMA402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 4c2k 3-KETOACYL-COA
THIOLASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 SER A 186
GLY A 248
ALA A 247
HIS A 352
GLU A 321
 None
 1.35A 5wbvA-4c2kA:
undetectable		 5wbvA-4c2kA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 4c2k 3-KETOACYL-COA
THIOLASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 SER A 186
GLY A 248
ALA A 247
HIS A 352
GLU A 321
 None
 1.34A 5wbvB-4c2kA:
undetectable		 5wbvB-4c2kA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA608_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 4c2k 3-KETOACYL-COA
THIOLASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 GLY A  57
THR A 119
GLU A 120
 None
 0.64A 6b58A-4c2kA:
undetectable		 6b58A-4c2kA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_E_LLLE301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4c2k 3-KETOACYL-COA
THIOLASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 ASP A 220
ARG A 360
GLU A 202
GLU A 318
 None
 1.04A 6mn5E-4c2kA:
undetectable		 6mn5E-4c2kA:
11.06