SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4c2l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBR_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)		 4c2l ENDO-XYLOGALACTURONA
N HYDROLASE A
(Aspergillus
tubingensis) 		5 / 12 PHE A 376
LEU A 388
ALA A 359
ALA A 315
THR A 350
 None
 1.13A 1cbrA-4c2lA:
undetectable		 1cbrA-4c2lA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBR_B_REAB200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)		 4c2l ENDO-XYLOGALACTURONA
N HYDROLASE A
(Aspergillus
tubingensis) 		5 / 12 PHE A 376
LEU A 388
ALA A 359
ALA A 315
THR A 350
 None
 1.13A 1cbrB-4c2lA:
undetectable		 1cbrB-4c2lA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_D_ESTD352_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 4c2l ENDO-XYLOGALACTURONA
N HYDROLASE A
(Aspergillus
tubingensis) 		4 / 6 SER A 254
VAL A 255
GLY A 256
LEU A 258
 None
None
SO4  A1407 (-4.8A)
None
 0.94A 1fduD-4c2lA:
undetectable		 1fduD-4c2lA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		 4c2l ENDO-XYLOGALACTURONA
N HYDROLASE A
(Aspergillus
tubingensis) 		5 / 12 GLY A 256
VAL A 299
SER A 320
LEU A 258
LEU A 338
 SO4  A1407 (-4.8A)
None
None
None
None
 1.06A 1ya4C-4c2lA:
undetectable		 1ya4C-4c2lA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		 4c2l ENDO-XYLOGALACTURONA
N HYDROLASE A
(Aspergillus
tubingensis) 		5 / 12 VAL A 114
ILE A 164
LEU A 191
VAL A 186
PHE A 209
 None
 1.27A 2jn3A-4c2lA:
undetectable		 2jn3A-4c2lA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		 4c2l ENDO-XYLOGALACTURONA
N HYDROLASE A
(Aspergillus
tubingensis) 		4 / 6 ILE A 164
ARG A 123
LEU A 167
LEU A 120
 None
 1.05A 2rlfA-4c2lA:
undetectable
2rlfD-4c2lA:
undetectable		 2rlfA-4c2lA:
7.90
2rlfD-4c2lA:
7.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)		 4c2l ENDO-XYLOGALACTURONA
N HYDROLASE A
(Aspergillus
tubingensis) 		3 / 3 SER A 265
THR A 287
PHE A 316
 None
 0.72A 2x91A-4c2lA:
undetectable		 2x91A-4c2lA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CWK_A_REAA300_1
(CELLULAR RETINOIC
ACID-BINDING PROTEIN
2)		 4c2l ENDO-XYLOGALACTURONA
N HYDROLASE A
(Aspergillus
tubingensis) 		5 / 12 PHE A 376
LEU A 388
ALA A 359
ALA A 315
THR A 350
 None
 1.14A 3cwkA-4c2lA:
undetectable		 3cwkA-4c2lA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_0
(REPRESSOR PROTEIN
MPHR(A))		 4c2l ENDO-XYLOGALACTURONA
N HYDROLASE A
(Aspergillus
tubingensis) 		5 / 12 GLY A  61
LEU A 162
ILE A  53
VAL A 117
ILE A 156
 None
 0.92A 3frqB-4c2lA:
undetectable		 3frqB-4c2lA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4c2l ENDO-XYLOGALACTURONA
N HYDROLASE A
(Aspergillus
tubingensis) 		5 / 12 GLN A 319
ASP A 228
GLY A 284
ALA A 232
SER A 237
 SO4  A1410 ( 4.6A)
SO4  A1410 ( 4.1A)
None
None
None
 1.05A 3sudB-4c2lA:
undetectable		 3sudB-4c2lA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4c2l ENDO-XYLOGALACTURONA
N HYDROLASE A
(Aspergillus
tubingensis) 		5 / 12 GLN A 319
ASP A 228
GLY A 284
ALA A 232
SER A 237
 SO4  A1410 ( 4.6A)
SO4  A1410 ( 4.1A)
None
None
None
 0.98A 3sudD-4c2lA:
undetectable		 3sudD-4c2lA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4c2l ENDO-XYLOGALACTURONA
N HYDROLASE A
(Aspergillus
tubingensis) 		5 / 12 GLN A 319
ASP A 228
GLY A 284
ALA A 232
SER A 237
 SO4  A1410 ( 4.6A)
SO4  A1410 ( 4.1A)
None
None
None
 0.96A 3sueD-4c2lA:
undetectable		 3sueD-4c2lA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 4c2l ENDO-XYLOGALACTURONA
N HYDROLASE A
(Aspergillus
tubingensis) 		3 / 3 TYR A 216
LEU A 122
LYS A 121
 None
 0.67A 3sueD-4c2lA:
undetectable		 3sueD-4c2lA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_A_9PLA501_1
(CYTOCHROME P450 2E1)		 4c2l ENDO-XYLOGALACTURONA
N HYDROLASE A
(Aspergillus
tubingensis) 		4 / 6 PHE A  68
LEU A  82
ALA A  52
LEU A  76
 None
 0.92A 3t3zA-4c2lA:
undetectable		 3t3zA-4c2lA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_B_9PLB501_1
(CYTOCHROME P450 2E1)		 4c2l ENDO-XYLOGALACTURONA
N HYDROLASE A
(Aspergillus
tubingensis) 		4 / 6 PHE A  68
LEU A  82
ALA A  52
LEU A  76
 None
 0.90A 3t3zB-4c2lA:
undetectable		 3t3zB-4c2lA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_D_9PLD501_1
(CYTOCHROME P450 2E1)		 4c2l ENDO-XYLOGALACTURONA
N HYDROLASE A
(Aspergillus
tubingensis) 		4 / 6 PHE A  68
LEU A  82
ALA A  52
LEU A  76
 None
 0.89A 3t3zD-4c2lA:
undetectable		 3t3zD-4c2lA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA301_0
(THAUMATIN-1)		 4c2l ENDO-XYLOGALACTURONA
N HYDROLASE A
(Aspergillus
tubingensis) 		3 / 3 THR A 248
ASN A 278
SER A 279
 NAG  A 411 ( 4.0A)
NAG  A 411 (-1.8A)
None
 0.69A 4tvtA-4c2lA:
undetectable		 4tvtA-4c2lA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4c2l ENDO-XYLOGALACTURONA
N HYDROLASE A
(Aspergillus
tubingensis) 		4 / 8 ASP A  48
THR A  47
TYR A  75
LEU A  76
 None
 1.13A 5b1bA-4c2lA:
undetectable
5b1bC-4c2lA:
undetectable
5b1bP-4c2lA:
undetectable		 5b1bA-4c2lA:
20.85
5b1bC-4c2lA:
19.21
5b1bP-4c2lA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_C_ACTC1740_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGS
FAD-BINDING SUBUNIT)		 4c2l ENDO-XYLOGALACTURONA
N HYDROLASE A
(Aspergillus
tubingensis) 		4 / 4 VAL A  92
GLU A  93
GLY A 129
LEU A 167
 None
 1.11A 5g5gC-4c2lA:
undetectable		 5g5gC-4c2lA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBS_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 4c2l ENDO-XYLOGALACTURONA
N HYDROLASE A
(Aspergillus
tubingensis) 		5 / 12 VAL A 271
ALA A 283
SER A 279
MET A 193
ILE A 245
 None
 1.20A 5hbsA-4c2lA:
undetectable		 5hbsA-4c2lA:
13.62