SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4c2t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4G_B_ZMRB466_2
(NEURAMINIDASE)		 4c2t DNA HELICASE II
(Deinococcus
radiodurans) 		3 / 3 ASP A 312
ARG A 310
ILE A 304
 None
 0.77A 1a4gB-4c2tA:
undetectable		 1a4gB-4c2tA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_CCSA381_0
(ESTROGEN RECEPTOR)		 4c2t DNA HELICASE II
(Deinococcus
radiodurans) 		4 / 5 HIS A  56
GLU A  59
ALA A 221
HIS A 225
 None
 1.30A 1errA-4c2tA:
undetectable
1errB-4c2tA:
undetectable		 1errA-4c2tA:
16.24
1errB-4c2tA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_A_VIBA502_1
(THIAMIN
PYROPHOSPHOKINASE)		 4c2t DNA HELICASE II
(Deinococcus
radiodurans) 		4 / 8 LEU A  49
ASN A 249
GLN A 218
THR A 240
 None
 1.00A 1ig3A-4c2tA:
undetectable
1ig3B-4c2tA:
undetectable		 1ig3A-4c2tA:
16.27
1ig3B-4c2tA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_0
(MODIFICATION
METHYLASE RSRI)		 4c2t DNA HELICASE II
(Deinococcus
radiodurans) 		5 / 12 ASP A 162
PRO A 173
THR A 139
ALA A 178
ALA A 180
 None
 1.22A 1nw5A-4c2tA:
undetectable		 1nw5A-4c2tA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VID_A_SAMA301_0
(CATECHOL
O-METHYLTRANSFERASE)		 4c2t DNA HELICASE II
(Deinococcus
radiodurans) 		5 / 12 VAL A 369
GLU A 336
GLY A 585
TYR A 361
GLN A 588
 None
 1.38A 1vidA-4c2tA:
1.9		 1vidA-4c2tA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 4c2t DNA HELICASE II
(Deinococcus
radiodurans) 		5 / 12 ILE A 417
ALA A 400
ARG A 403
LEU A 430
PHE A 467
 None
 1.44A 1y0xX-4c2tA:
undetectable		 1y0xX-4c2tA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1434_1
(CHITINASE)		 4c2t DNA HELICASE II
(Deinococcus
radiodurans) 		3 / 3 TRP A  88
THR A 102
TYR A 103
 None
 1.12A 2a3aA-4c2tA:
undetectable		 2a3aA-4c2tA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_B_TEPB2434_1
(CHITINASE)		 4c2t DNA HELICASE II
(Deinococcus
radiodurans) 		3 / 3 TRP A  88
THR A 102
TYR A 103
 None
 1.07A 2a3aB-4c2tA:
undetectable		 2a3aB-4c2tA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_A_CFFA1434_1
(CHITINASE)		 4c2t DNA HELICASE II
(Deinococcus
radiodurans) 		3 / 3 TRP A  88
THR A 102
TYR A 103
 None
 1.13A 2a3bA-4c2tA:
undetectable		 2a3bA-4c2tA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4c2t DNA HELICASE II
(Deinococcus
radiodurans) 		3 / 3 LYS A 562
ASP A 550
ASP A 527
 None
 0.70A 2br4A-4c2tA:
undetectable		 2br4A-4c2tA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DM6_A_IMNA1401_1
(NADP-DEPENDENT
LEUKOTRIENE B4
12-HYDROXYDEHYDROGEN
ASE)		 4c2t DNA HELICASE II
(Deinococcus
radiodurans) 		5 / 10 TYR A 116
ILE A 194
ALA A 193
ILE A 148
GLU A 202
 None
 1.01A 2dm6A-4c2tA:
undetectable
2dm6B-4c2tA:
2.0		 2dm6A-4c2tA:
17.53
2dm6B-4c2tA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 4c2t DNA HELICASE II
(Deinococcus
radiodurans) 		3 / 3 ASP A 231
ASP A 267
ASP A 255
 None
 0.75A 2igtA-4c2tA:
2.2		 2igtA-4c2tA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 4c2t DNA HELICASE II
(Deinococcus
radiodurans) 		3 / 3 ASP A 231
ASP A 267
ASP A 255
 None
 0.78A 2igtB-4c2tA:
undetectable		 2igtB-4c2tA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB927_0
(FERROCHELATASE)		 4c2t DNA HELICASE II
(Deinococcus
radiodurans) 		3 / 3 LEU A 172
PRO A 173
ARG A 183
 None
 0.56A 2qd4B-4c2tA:
2.8		 2qd4B-4c2tA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_A_SAMA301_1
(HYPOTHETICAL PROTEIN
TTHA0223)		 4c2t DNA HELICASE II
(Deinococcus
radiodurans) 		4 / 5 GLU A 228
ARG A 617
ASP A 231
ASP A 267
 MG  A1663 (-3.6A)
ANP  A1664 (-2.5A)
None
None
 1.33A 2yqzA-4c2tA:
undetectable		 2yqzA-4c2tA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_B_SAMB401_1
(HYPOTHETICAL PROTEIN
TTHA0223)		 4c2t DNA HELICASE II
(Deinococcus
radiodurans) 		4 / 5 GLU A 228
ARG A 617
ASP A 231
ASP A 267
 MG  A1663 (-3.6A)
ANP  A1664 (-2.5A)
None
None
 1.35A 2yqzB-4c2tA:
undetectable		 2yqzB-4c2tA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZTH_A_SAMA305_0
(CATECHOL
O-METHYLTRANSFERASE)		 4c2t DNA HELICASE II
(Deinococcus
radiodurans) 		5 / 12 VAL A 283
GLY A 254
TYR A 284
SER A 259
ARG A 609
 None
 1.34A 2zthA-4c2tA:
undetectable		 2zthA-4c2tA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWY_A_SAMA301_0
(COMT PROTEIN)		 4c2t DNA HELICASE II
(Deinococcus
radiodurans) 		5 / 12 VAL A 369
GLU A 336
GLY A 585
TYR A 361
GLN A 588
 None
 1.34A 3bwyA-4c2tA:
2.1		 3bwyA-4c2tA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_C_DXCC576_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 4c2t DNA HELICASE II
(Deinococcus
radiodurans) 		4 / 8 PRO A 173
ALA A 177
ALA A 180
THR A 139
 None
 0.76A 3dtuC-4c2tA:
undetectable
3dtuD-4c2tA:
undetectable		 3dtuC-4c2tA:
22.98
3dtuD-4c2tA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_C_TOPC200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4c2t DNA HELICASE II
(Deinococcus
radiodurans) 		5 / 11 ALA A 402
LEU A 487
VAL A 490
ILE A 395
LEU A 514
 None
 1.14A 3fl9C-4c2tA:
undetectable		 3fl9C-4c2tA:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_G_TOPG200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4c2t DNA HELICASE II
(Deinococcus
radiodurans) 		5 / 12 ALA A 402
LEU A 487
VAL A 490
ILE A 395
LEU A 514
 None
 1.15A 3fl9G-4c2tA:
undetectable		 3fl9G-4c2tA:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 4c2t DNA HELICASE II
(Deinococcus
radiodurans) 		5 / 12 ALA A 244
LEU A  61
LYS A 220
ILE A  99
ARG A  98
 None
 1.17A 3ia4A-4c2tA:
undetectable		 3ia4A-4c2tA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_A_BCZA468_1
(NEURAMINIDASE)		 4c2t DNA HELICASE II
(Deinococcus
radiodurans) 		3 / 3 ASP A 118
ARG A 145
ARG A 552
 None
 0.91A 3k37A-4c2tA:
undetectable		 3k37A-4c2tA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU4_B_478B401_1
(PROTEASE)		 4c2t DNA HELICASE II
(Deinococcus
radiodurans) 		5 / 9 ALA A 180
ILE A 125
ILE A 135
VAL A 143
ILE A 144
 None
 1.04A 3nu4A-4c2tA:
undetectable		 3nu4A-4c2tA:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_D_017D200_1
(HIV-1 PROTEASE)		 4c2t DNA HELICASE II
(Deinococcus
radiodurans) 		5 / 10 GLY A  35
ALA A  34
ASP A 257
ILE A 304
VAL A 296
 ANP  A1664 (-3.6A)
ANP  A1664 ( 4.4A)
None
None
None
 1.01A 3oxwC-4c2tA:
undetectable		 3oxwC-4c2tA:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_A_SALA404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 4c2t DNA HELICASE II
(Deinococcus
radiodurans) 		4 / 7 ALA A 151
ARG A 174
ALA A 178
ARG A 182
 None
 1.10A 3twpA-4c2tA:
undetectable		 3twpA-4c2tA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		 4c2t DNA HELICASE II
(Deinococcus
radiodurans) 		4 / 6 ASN A 192
ALA A 193
TYR A 116
ASP A 540
 None
 1.01A 4mdbA-4c2tA:
undetectable		 4mdbA-4c2tA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA603_1
(SERUM ALBUMIN)		 4c2t DNA HELICASE II
(Deinococcus
radiodurans) 		5 / 11 LEU A 100
ARG A 101
ASP A 198
LEU A 199
LEU A 206
 None
 1.36A 4or0A-4c2tA:
undetectable		 4or0A-4c2tA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1Y_A_017A106_2
(ASPARTYL PROTEASE)		 4c2t DNA HELICASE II
(Deinococcus
radiodurans) 		5 / 12 ALA A 180
ILE A 125
ILE A 135
VAL A 143
ILE A 144
 None
 0.99A 4q1yB-4c2tA:
undetectable		 4q1yB-4c2tA:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 4c2t DNA HELICASE II
(Deinococcus
radiodurans) 		5 / 12 GLY A 146
ILE A 169
SER A 170
SER A 153
ALA A 151
 None
 1.05A 4qtuD-4c2tA:
undetectable		 4qtuD-4c2tA:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AOX_F_ACTF1001_0
(ALU JO CONSENSUS RNA
SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN)		 4c2t DNA HELICASE II
(Deinococcus
radiodurans) 		3 / 3 TYR A 237
THR A 232
THR A 240
 None
 0.82A 5aoxE-4c2tA:
undetectable		 5aoxE-4c2tA:
9.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHR_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 4c2t DNA HELICASE II
(Deinococcus
radiodurans) 		5 / 12 VAL A 369
GLU A 336
GLY A 585
TYR A 361
GLN A 588
 None
 1.39A 5fhrA-4c2tA:
2.7		 5fhrA-4c2tA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4c2t DNA HELICASE II
(Deinococcus
radiodurans) 		5 / 12 ALA A 244
ILE A 260
TYR A 261
GLY A 575
PHE A  92
 None
None
None
ANP  A1664 (-3.4A)
None
 1.17A 5jlcA-4c2tA:
undetectable		 5jlcA-4c2tA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSA_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 4c2t DNA HELICASE II
(Deinococcus
radiodurans) 		5 / 12 VAL A 369
GLU A 336
GLY A 585
TYR A 361
GLN A 588
 None
 1.33A 5lsaA-4c2tA:
2.0		 5lsaA-4c2tA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_B_SAMB303_1
(METHYLTRANSFERASE)		 4c2t DNA HELICASE II
(Deinococcus
radiodurans) 		4 / 7 GLY A  96
PHE A  92
SER A  90
ARG A 205
 None
 0.94A 5n5dB-4c2tA:
undetectable		 5n5dB-4c2tA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHA_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4c2t DNA HELICASE II
(Deinococcus
radiodurans) 		3 / 3 VAL A 253
VAL A  30
GLN A  17
 None
None
ANP  A1664 (-3.3A)
 0.66A 5qhaA-4c2tA:
undetectable		 5qhaA-4c2tA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_A_SAMA301_1
(METHYLTRANSFERASE)		 4c2t DNA HELICASE II
(Deinococcus
radiodurans) 		4 / 4 SER A 373
THR A 625
ASP A 641
ASP A 332
 None
 1.45A 5vimA-4c2tA:
undetectable		 5vimA-4c2tA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_A_C2FA3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4c2t DNA HELICASE II
(Deinococcus
radiodurans) 		3 / 3 ASP A 267
ASN A 270
ASP A 277
 None
 0.85A 5vopA-4c2tA:
undetectable		 5vopA-4c2tA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4c2t DNA HELICASE II
(Deinococcus
radiodurans) 		3 / 3 ASP A 267
ASN A 270
ASP A 277
 None
 0.89A 5vopB-4c2tA:
undetectable		 5vopB-4c2tA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB303_1
(BIFUNCTIONAL PROTEIN
FOLD)		 4c2t DNA HELICASE II
(Deinococcus
radiodurans) 		4 / 5 TYR A 361
GLN A 366
GLY A 388
ILE A 383
 None
 1.47A 6debB-4c2tA:
undetectable		 6debB-4c2tA:
7.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DHB_A_BEZA202_0
(HEPATITIS A VIRUS
CELLULAR RECEPTOR 2)		 4c2t DNA HELICASE II
(Deinococcus
radiodurans) 		4 / 6 ARG A 246
ILE A 224
ASN A 249
ASP A 247
 None
 1.42A 6dhbA-4c2tA:
undetectable		 6dhbA-4c2tA:
8.67