SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4c2x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_A_TESA325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 4c2x GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE 2
(Homo
sapiens) 		4 / 7 LEU A 403
TYR A 401
ASN A 246
TYR A 180
 None
None
NHW  A1000 (-4.8A)
NHW  A1000 ( 4.6A)
 1.38A 1afsA-4c2xA:
undetectable		 1afsA-4c2xA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_B_TESB325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 4c2x GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE 2
(Homo
sapiens) 		4 / 7 LEU A 403
TYR A 401
ASN A 246
TYR A 180
 None
None
NHW  A1000 (-4.8A)
NHW  A1000 ( 4.6A)
 1.37A 1afsB-4c2xA:
undetectable		 1afsB-4c2xA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4007_1
(SERUM ALBUMIN)		 4c2x GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE 2
(Homo
sapiens) 		4 / 8 LEU A 474
ASP A 454
LEU A 455
LEU A 453
 None
 0.83A 1e7cA-4c2xA:
undetectable		 1e7cA-4c2xA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPK_A_ACAA80_1
(PLASMINOGEN)		 4c2x GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE 2
(Homo
sapiens) 		4 / 6 ASP A 183
ASN A 186
ASP A 184
TYR A 296
 None
 1.38A 1hpkA-4c2xA:
undetectable		 1hpkA-4c2xA:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_D_ASDD1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 4c2x GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE 2
(Homo
sapiens) 		5 / 9 TYR A 401
LEU A 176
LEU A 197
ALA A 200
PHE A 247
 None
 1.22A 2vcvD-4c2xA:
undetectable		 2vcvD-4c2xA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_I_ASDI1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 4c2x GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE 2
(Homo
sapiens) 		5 / 9 TYR A 401
LEU A 176
LEU A 197
ALA A 200
PHE A 247
 None
 1.17A 2vcvI-4c2xA:
undetectable		 2vcvI-4c2xA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN1_A_FK5A501_2
(70 KDA
PEPTIDYLPROLYL
ISOMERASE)		 4c2x GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE 2
(Homo
sapiens) 		4 / 6 LEU A 493
SER A 227
PHE A 247
GLU A 244
 None
 1.23A 2vn1B-4c2xA:
undetectable		 2vn1B-4c2xA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4c2x GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE 2
(Homo
sapiens) 		4 / 6 ILE A 138
THR A 122
PHE A 119
TYR A 479
 None
None
None
NHW  A1000 ( 4.1A)
 1.27A 3elzB-4c2xA:
undetectable		 3elzB-4c2xA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4c2x GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE 2
(Homo
sapiens) 		4 / 5 ILE A 138
THR A 122
PHE A 119
TYR A 479
 None
None
None
NHW  A1000 ( 4.1A)
 1.33A 3em0A-4c2xA:
undetectable		 3em0A-4c2xA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSK_B_ACTB901_0
(PYRANOSE 2-OXIDASE)		 4c2x GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE 2
(Homo
sapiens) 		4 / 6 SER A 421
PHE A 450
PHE A 461
ASN A 458
 None
 1.27A 3lskB-4c2xA:
0.7		 3lskB-4c2xA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_B_SAMB220_0
(16S RRNA METHYLASE)		 4c2x GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE 2
(Homo
sapiens) 		5 / 12 GLY A 224
GLY A 213
LEU A 248
THR A 174
LEU A 175
 None
None
NHW  A1000 (-4.0A)
None
None
 1.03A 3mteB-4c2xA:
undetectable		 3mteB-4c2xA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_B_SAMB6735_0
(16S RRNA METHYLASE)		 4c2x GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE 2
(Homo
sapiens) 		5 / 12 GLY A 224
GLY A 213
LEU A 248
THR A 174
LEU A 175
 None
None
NHW  A1000 (-4.0A)
None
None
 1.02A 3p2kB-4c2xA:
undetectable		 3p2kB-4c2xA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_D_SUED1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 4c2x GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE 2
(Homo
sapiens) 		4 / 5 PHE A 225
TYR A 192
LEU A 254
ARG A 189
 None
 1.35A 3sudD-4c2xA:
undetectable		 3sudD-4c2xA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_A_ADNA401_2
(ADENOSINE KINASE,
PUTATIVE)		 4c2x GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE 2
(Homo
sapiens) 		4 / 5 ALA A 452
MET A 435
PHE A 467
ASN A 424
 None
 1.44A 3uq6A-4c2xA:
undetectable		 3uq6A-4c2xA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_2
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 4c2x GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE 2
(Homo
sapiens) 		3 / 3 LEU A 441
MET A 435
ASP A 396
 None
 0.86A 3v5wA-4c2xA:
undetectable		 3v5wA-4c2xA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_A_P1BA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 4c2x GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE 2
(Homo
sapiens) 		5 / 12 PRO A 203
TRP A 199
LEU A 495
ILE A 229
TYR A 476
 None
 1.28A 4a79A-4c2xA:
undetectable		 4a79A-4c2xA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_B_P1BB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 4c2x GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE 2
(Homo
sapiens) 		5 / 12 PRO A 203
TRP A 199
LEU A 495
ILE A 229
TYR A 476
 None
 1.26A 4a79B-4c2xA:
undetectable		 4a79B-4c2xA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_B_NCTB501_1
(CYTOCHROME P450 2A13)		 4c2x GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE 2
(Homo
sapiens) 		4 / 8 PHE A 375
PHE A 397
PHE A 422
LEU A 357
 None
 0.85A 4ejgB-4c2xA:
undetectable		 4ejgB-4c2xA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0O_A_URFA303_1
(RRNA N-GLYCOSIDASE)		 4c2x GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE 2
(Homo
sapiens) 		4 / 5 TYR A 356
ASN A 424
TYR A 423
ILE A 353
 None
 1.21A 4o0oA-4c2xA:
undetectable		 4o0oA-4c2xA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_A_ML1A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4c2x GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE 2
(Homo
sapiens) 		4 / 8 PHE A 422
TRP A 199
ASN A 246
ILE A 233
 None
None
NHW  A1000 (-4.8A)
None
 0.85A 4qoiA-4c2xA:
undetectable
4qoiB-4c2xA:
undetectable		 4qoiA-4c2xA:
19.76
4qoiB-4c2xA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_J_377J401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4c2x GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE 2
(Homo
sapiens) 		4 / 6 TYR A 401
TYR A 192
LEU A 197
PHE A 247
 None
 1.07A 4twdI-4c2xA:
undetectable
4twdJ-4c2xA:
undetectable		 4twdI-4c2xA:
21.13
4twdJ-4c2xA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP1_A_LDPA708_1
(DOPAMINE
TRANSPORTER, ISOFORM
B)		 4c2x GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE 2
(Homo
sapiens) 		5 / 10 PHE A 188
VAL A 449
ASP A 448
PHE A 311
SER A 405
 None
 1.07A 4xp1A-4c2xA:
undetectable		 4xp1A-4c2xA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4c2x GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE 2
(Homo
sapiens) 		4 / 7 ALA A 438
ARG A 339
GLY A 337
GLU A 388
 None
 0.93A 5btgA-4c2xA:
undetectable
5btgC-4c2xA:
undetectable
5btgD-4c2xA:
undetectable		 5btgA-4c2xA:
24.23
5btgC-4c2xA:
24.23
5btgD-4c2xA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_1
(CDL2.3A)		 4c2x GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE 2
(Homo
sapiens) 		5 / 12 LEU A 462
PHE A 461
LEU A 398
PHE A 467
ALA A 419
 None
 1.24A 5ieoA-4c2xA:
undetectable		 5ieoA-4c2xA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_1
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4c2x GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE 2
(Homo
sapiens) 		3 / 3 SER A 421
SER A 399
PHE A 461
 None
 0.80A 5mugA-4c2xA:
undetectable		 5mugA-4c2xA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ELI_A_T27A701_1
(REVERSE
TRANSCRIPTASE)		 4c2x GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE 2
(Homo
sapiens) 		5 / 12 LEU A 175
TYR A 180
TYR A 192
PRO A 194
LEU A 172
 None
NHW  A1000 ( 4.6A)
None
None
None
 1.33A 6eliA-4c2xA:
undetectable		 6eliA-4c2xA:
9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_1
(TUBULIN BETA CHAIN)		 4c2x GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE 2
(Homo
sapiens) 		5 / 12 LEU A 329
ALA A 419
PHE A 450
LEU A 439
LEU A 398
 None
 1.12A 6ew0G-4c2xA:
undetectable		 6ew0G-4c2xA:
11.52