SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4c3o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_A_DVAA8_0
(ACTINOMYCIN D)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		3 / 3 THR A 535
THR A 536
PRO A 534
 NFU  A1004 (-3.7A)
None
NFU  A1004 (-3.8A)
 0.76A 1a7yA-4c3oA:
undetectable		 1a7yA-4c3oA:
2.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_B_DVAB8_0
(ACTINOMYCIN D)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		3 / 3 THR A 535
THR A 536
PRO A 534
 NFU  A1004 (-3.7A)
None
NFU  A1004 (-3.8A)
 0.84A 1a7yB-4c3oA:
undetectable		 1a7yB-4c3oA:
2.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_A_NCAA700_0
(EXOTOXIN A)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		4 / 7 GLY A 305
LEU A 302
ALA A 303
TYR A 304
 None
 0.88A 1dmaA-4c3oA:
undetectable		 1dmaA-4c3oA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQU_A_EQIA329_0
(PROTEIN (ESTRADIOL
17
BETA-DEHYDROGENASE
1))		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		5 / 10 VAL A 413
TYR A 551
PRO A 534
HIS A 119
GLU A 461
 None
None
NFU  A1004 (-3.8A)
None
None
 1.42A 1equA-4c3oA:
undetectable		 1equA-4c3oA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_E_DVAE2_0
(ACTINOMYCIN D)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		3 / 3 THR A 536
PRO A 534
THR A 535
 None
NFU  A1004 (-3.8A)
NFU  A1004 (-3.7A)
 0.76A 1i3wE-4c3oA:
undetectable		 1i3wE-4c3oA:
2.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_E_DVAE8_0
(ACTINOMYCIN D)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		3 / 3 THR A 535
THR A 536
PRO A 534
 NFU  A1004 (-3.7A)
None
NFU  A1004 (-3.8A)
 0.80A 1i3wE-4c3oA:
undetectable		 1i3wE-4c3oA:
2.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_F_DVAF8_0
(ACTINOMYCIN D)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		3 / 3 THR A 535
THR A 536
PRO A 534
 NFU  A1004 (-3.7A)
None
NFU  A1004 (-3.8A)
 0.76A 1i3wF-4c3oA:
undetectable		 1i3wF-4c3oA:
2.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_G_DVAG2_0
(ACTINOMYCIN D)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		3 / 3 THR A 536
PRO A 534
THR A 535
 None
NFU  A1004 (-3.8A)
NFU  A1004 (-3.7A)
 0.80A 1i3wG-4c3oA:
undetectable		 1i3wG-4c3oA:
2.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_G_DVAG8_0
(ACTINOMYCIN D)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		3 / 3 THR A 535
THR A 536
PRO A 534
 NFU  A1004 (-3.7A)
None
NFU  A1004 (-3.8A)
 0.82A 1i3wG-4c3oA:
undetectable		 1i3wG-4c3oA:
2.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_H_DVAH8_0
(ACTINOMYCIN D)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		3 / 3 THR A 535
THR A 536
PRO A 534
 NFU  A1004 (-3.7A)
None
NFU  A1004 (-3.8A)
 0.83A 1i3wH-4c3oA:
undetectable		 1i3wH-4c3oA:
2.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_1
(HYPOTHETICAL PROTEIN
RV2118C)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		3 / 3 GLU A 461
HIS A 115
ASP A 577
 None
 0.87A 1i9gA-4c3oA:
undetectable		 1i9gA-4c3oA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MNV_D_DVAD2_0
(ACTINOMYCIN D)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		3 / 3 THR A 536
PRO A 534
THR A 535
 None
NFU  A1004 (-3.8A)
NFU  A1004 (-3.7A)
 0.76A 1mnvD-4c3oA:
undetectable		 1mnvD-4c3oA:
2.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MNV_D_DVAD8_0
(ACTINOMYCIN D)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		3 / 3 THR A 535
THR A 536
PRO A 534
 NFU  A1004 (-3.7A)
None
NFU  A1004 (-3.8A)
 0.76A 1mnvD-4c3oA:
undetectable		 1mnvD-4c3oA:
2.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MOG_A_RBFA200_1
(DODECIN)		 4c3o HYDROGENASE-1 SMALL
SUBUNIT
(Salmonella
enterica) 		3 / 3 PHE B  24
TRP B  11
GLU B  76
 None
None
F4S  B1003 ( 4.8A)
 1.01A 1mogA-4c3oB:
undetectable		 1mogA-4c3oB:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT5_A_DVAA6_0
(GRAMICIDIN A)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		3 / 3 ALA A  94
VAL A 505
TRP A 368
 None
 0.86A 1nt5A-4c3oA:
undetectable		 1nt5A-4c3oA:
3.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT5_B_DVAB6_0
(GRAMICIDIN A)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		3 / 3 ALA A  94
VAL A 505
TRP A 368
 None
 0.86A 1nt5B-4c3oA:
undetectable		 1nt5B-4c3oA:
3.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OVF_B_DVAB2_0
(ACTINOMYCIN D)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		3 / 3 THR A 536
PRO A 534
THR A 535
 None
NFU  A1004 (-3.8A)
NFU  A1004 (-3.7A)
 0.78A 1ovfB-4c3oA:
undetectable		 1ovfB-4c3oA:
2.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFI_A_DVAA8_0
(ACTINOMYCIN X2)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		3 / 3 THR A 535
THR A 536
PRO A 534
 NFU  A1004 (-3.7A)
None
NFU  A1004 (-3.8A)
 0.74A 1qfiA-4c3oA:
undetectable		 1qfiA-4c3oA:
2.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_B_DVAB6_0
(GRAMICIDIN A)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		3 / 3 ALA A 488
VAL A 234
TRP A  69
 None
 0.80A 1tkqB-4c3oA:
undetectable		 1tkqB-4c3oA:
4.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_F_DVAF2_0
(7-AMINO-ACTINOMYCIN
D)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		3 / 3 THR A 536
PRO A 534
THR A 535
 None
NFU  A1004 (-3.8A)
NFU  A1004 (-3.7A)
 0.80A 1unjF-4c3oA:
undetectable		 1unjF-4c3oA:
2.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_F_DVAF8_0
(7-AMINO-ACTINOMYCIN
D)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		3 / 3 THR A 535
THR A 536
PRO A 534
 NFU  A1004 (-3.7A)
None
NFU  A1004 (-3.8A)
 0.76A 1unjF-4c3oA:
undetectable		 1unjF-4c3oA:
2.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_L_DVAL2_0
(7-AMINO-ACTINOMYCIN
D)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		3 / 3 THR A 536
PRO A 534
THR A 535
 None
NFU  A1004 (-3.8A)
NFU  A1004 (-3.7A)
 0.87A 1unjL-4c3oA:
undetectable		 1unjL-4c3oA:
2.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_L_DVAL8_0
(7-AMINO-ACTINOMYCIN
D)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		3 / 3 THR A 535
THR A 536
PRO A 534
 NFU  A1004 (-3.7A)
None
NFU  A1004 (-3.8A)
 0.85A 1unjL-4c3oA:
undetectable		 1unjL-4c3oA:
2.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_R_DVAR2_0
(7-AMINO-ACTINOMYCIN
D)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		3 / 3 THR A 536
PRO A 534
THR A 535
 None
NFU  A1004 (-3.8A)
NFU  A1004 (-3.7A)
 0.86A 1unjR-4c3oA:
undetectable		 1unjR-4c3oA:
2.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_R_DVAR8_0
(7-AMINO-ACTINOMYCIN
D)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		3 / 3 THR A 535
THR A 536
PRO A 534
 NFU  A1004 (-3.7A)
None
NFU  A1004 (-3.8A)
 0.83A 1unjR-4c3oA:
undetectable		 1unjR-4c3oA:
2.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_X_DVAX2_0
(7-AMINO-ACTINOMYCIN
D)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		3 / 3 THR A 536
PRO A 534
THR A 535
 None
NFU  A1004 (-3.8A)
NFU  A1004 (-3.7A)
 0.87A 1unjX-4c3oA:
undetectable		 1unjX-4c3oA:
2.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_X_DVAX8_0
(7-AMINO-ACTINOMYCIN
D)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		3 / 3 THR A 535
THR A 536
PRO A 534
 NFU  A1004 (-3.7A)
None
NFU  A1004 (-3.8A)
 0.85A 1unjX-4c3oA:
undetectable		 1unjX-4c3oA:
2.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2887_1
(AMINOMETHYLTRANSFERA
SE)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		3 / 3 ASP A 118
GLU A  73
ARG A  89
 None
 0.73A 1wopA-4c3oA:
undetectable		 1wopA-4c3oA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_B_ACTB294_0
(GLYCINE
N-METHYLTRANSFERASE)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		4 / 6 ALA A 447
GLU A 446
TYR A 423
LEU A 438
 None
 0.80A 1xvaA-4c3oA:
undetectable
1xvaB-4c3oA:
undetectable		 1xvaA-4c3oA:
18.66
1xvaB-4c3oA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YNN_C_RFPC1120_1
(DNA-DIRECTED RNA
POLYMERASE BETA
CHAIN)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		5 / 12 ARG A 405
SER A 583
LEU A 580
PRO A 541
ILE A 401
 None
 1.47A 1ynnC-4c3oA:
undetectable		 1ynnC-4c3oA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JST_A_HLTA101_1
(FOUR-ALPHA-HELIX
BUNDLE)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
HYDROGENASE-1 SMALL
SUBUNIT
(Salmonella
enterica) 		4 / 5 TRP A 187
ALA B  51
LEU A 179
ALA B  50
 None
 0.99A 2jstA-4c3oA:
undetectable
2jstB-4c3oA:
undetectable		 2jstA-4c3oA:
7.85
2jstB-4c3oA:
7.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_B_REAB1445_1
(PUTATIVE CYTOCHROME
P450 120)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		5 / 12 ALA A 417
THR A 535
GLY A 549
GLN A   8
PRO A 404
 None
NFU  A1004 (-3.7A)
None
None
None
 1.17A 2ve3B-4c3oA:
undetectable		 2ve3B-4c3oA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1356_1
(PROSTAGLANDIN
REDUCTASE 2)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		4 / 8 TYR A 206
PHE A 182
LEU A 166
LEU A 170
 None
 0.89A 2w98B-4c3oA:
undetectable		 2w98B-4c3oA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
HYDROGENASE-1 SMALL
SUBUNIT
(Salmonella
enterica) 		5 / 12 THR B  18
GLU B  16
LEU A 126
ILE A  27
HIS A 117
 None
 1.46A 3gwxB-4c3oB:
undetectable		 3gwxB-4c3oB:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
HYDROGENASE-1 SMALL
SUBUNIT
(Salmonella
enterica) 		5 / 12 THR B  47
THR B  18
GLU B  76
ILE B  25
LEU A 580
 None
None
F4S  B1003 ( 4.8A)
None
None
 1.45A 3gwxB-4c3oB:
undetectable		 3gwxB-4c3oB:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		5 / 12 ALA A 136
LYS A 193
THR A 145
ILE A 148
LEU A 281
 None
 1.13A 3hj3B-4c3oA:
undetectable		 3hj3B-4c3oA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB0_A_DIFA701_1
(LACTOTRANSFERRIN)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		4 / 4 PRO A 541
TYR A 398
GLY A  50
THR A  51
 None
 1.14A 3ib0A-4c3oA:
undetectable		 3ib0A-4c3oA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEO_B_LLTB261_1
(DEOXYCYTIDINE KINASE)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		4 / 7 LEU A 210
TYR A 206
PHE A 173
LEU A 170
 None
 0.96A 3qeoB-4c3oA:
undetectable		 3qeoB-4c3oA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_A_IL2A901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		5 / 12 LEU A 114
THR A 535
THR A 536
ILE A 401
ILE A  75
 None
NFU  A1004 (-3.7A)
None
None
None
 1.04A 3sp9A-4c3oA:
undetectable		 3sp9A-4c3oA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_A_IL2A901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		5 / 12 LEU A 114
THR A 535
THR A 536
ILE A 401
VAL A  78
 None
NFU  A1004 (-3.7A)
None
None
None
 1.13A 3sp9A-4c3oA:
undetectable		 3sp9A-4c3oA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_B_IL2B901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		5 / 12 LEU A 114
THR A 535
THR A 536
ILE A 401
VAL A  78
 None
NFU  A1004 (-3.7A)
None
None
None
 1.14A 3sp9B-4c3oA:
undetectable		 3sp9B-4c3oA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VM4_A_IZPA1_1
(FATTY ACID
ALPHA-HYDROXYLASE)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		4 / 5 LEU A 321
ARG A 418
PRO A 415
ALA A 417
 None
 1.40A 3vm4A-4c3oA:
undetectable		 3vm4A-4c3oA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FJP_A_NPSA711_1
(LACTOTRANSFERRIN)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		4 / 6 GLY A 549
PRO A 541
TYR A 398
GLY A  50
 None
 0.87A 4fjpA-4c3oA:
undetectable		 4fjpA-4c3oA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HIV_D_DVAD2_0
(ACTINOMYCIN D)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		3 / 3 THR A 536
PRO A 534
THR A 535
 None
NFU  A1004 (-3.8A)
NFU  A1004 (-3.7A)
 0.81A 4hivD-4c3oA:
undetectable		 4hivD-4c3oA:
2.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMM_A_CHDA503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		4 / 7 ARG A  18
PRO A 541
SER A 403
VAL A  47
 None
 1.40A 4kmmA-4c3oA:
undetectable		 4kmmA-4c3oA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMU_C_RFPC1401_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		5 / 12 SER A 583
LEU A 580
PRO A 541
ILE A 401
ARG A 405
 None
 1.42A 4kmuC-4c3oA:
1.2		 4kmuC-4c3oA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A202_2
(PROTEASE)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
HYDROGENASE-1 SMALL
SUBUNIT
(Salmonella
enterica) 		5 / 9 ARG A 183
VAL B  73
GLY B  69
PRO B   8
ILE B  10
 None
 1.17A 4ll3B-4c3oA:
undetectable		 4ll3B-4c3oA:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2R_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		4 / 4 HIS A 122
GLU A 461
HIS A 115
LEU A 515
 None
None
None
NFU  A1004 (-3.7A)
 1.08A 4m2rA-4c3oA:
undetectable		 4m2rA-4c3oA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		5 / 12 GLY A 293
GLY A 295
THR A 572
ILE A 569
LEU A 560
 None
 0.97A 4n49A-4c3oA:
undetectable		 4n49A-4c3oA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
HYDROGENASE-1 SMALL
SUBUNIT
(Salmonella
enterica) 		4 / 6 GLU B  22
THR B  18
THR A 535
LEU A 126
 None
None
NFU  A1004 (-3.7A)
None
 0.96A 4pgfA-4c3oB:
3.3		 4pgfA-4c3oB:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		5 / 11 HIS A 585
THR A 535
THR A 536
GLY A  29
ALA A 581
 MG  A1005 (-3.7A)
NFU  A1004 (-3.7A)
None
None
None
 1.24A 4qvlV-4c3oA:
undetectable
4qvlb-4c3oA:
undetectable		 4qvlV-4c3oA:
18.17
4qvlb-4c3oA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		5 / 11 HIS A 585
THR A 535
THR A 536
GLY A  29
ALA A 581
 MG  A1005 (-3.7A)
NFU  A1004 (-3.7A)
None
None
None
 1.24A 4qvlH-4c3oA:
undetectable
4qvlN-4c3oA:
undetectable		 4qvlH-4c3oA:
18.17
4qvlN-4c3oA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		5 / 11 HIS A 585
THR A 535
THR A 536
GLY A  29
ALA A 581
 MG  A1005 (-3.7A)
NFU  A1004 (-3.7A)
None
None
None
 1.25A 4qvmV-4c3oA:
undetectable
4qvmb-4c3oA:
undetectable		 4qvmV-4c3oA:
18.17
4qvmb-4c3oA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		5 / 11 HIS A 585
THR A 535
THR A 536
GLY A  29
ALA A 581
 MG  A1005 (-3.7A)
NFU  A1004 (-3.7A)
None
None
None
 1.24A 4qvmH-4c3oA:
undetectable
4qvmN-4c3oA:
undetectable		 4qvmH-4c3oA:
18.17
4qvmN-4c3oA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		5 / 11 HIS A 585
THR A 535
THR A 536
GLY A  29
ALA A 581
 MG  A1005 (-3.7A)
NFU  A1004 (-3.7A)
None
None
None
 1.27A 4qvpV-4c3oA:
undetectable
4qvpb-4c3oA:
undetectable		 4qvpV-4c3oA:
18.17
4qvpb-4c3oA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		5 / 11 HIS A 585
THR A 535
THR A 536
GLY A  29
ALA A 581
 MG  A1005 (-3.7A)
NFU  A1004 (-3.7A)
None
None
None
 1.27A 4qvpH-4c3oA:
undetectable
4qvpN-4c3oA:
undetectable		 4qvpH-4c3oA:
18.17
4qvpN-4c3oA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		5 / 11 HIS A 585
THR A 535
THR A 536
GLY A  29
ALA A 581
 MG  A1005 (-3.7A)
NFU  A1004 (-3.7A)
None
None
None
 1.25A 4qvqV-4c3oA:
undetectable
4qvqb-4c3oA:
undetectable		 4qvqV-4c3oA:
18.17
4qvqb-4c3oA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		5 / 11 HIS A 585
THR A 535
THR A 536
GLY A  29
ALA A 581
 MG  A1005 (-3.7A)
NFU  A1004 (-3.7A)
None
None
None
 1.26A 4qvqH-4c3oA:
undetectable
4qvqN-4c3oA:
undetectable		 4qvqH-4c3oA:
18.17
4qvqN-4c3oA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		5 / 11 HIS A 585
THR A 535
THR A 536
GLY A  29
ALA A 581
 MG  A1005 (-3.7A)
NFU  A1004 (-3.7A)
None
None
None
 1.26A 4qvwV-4c3oA:
undetectable
4qvwb-4c3oA:
undetectable		 4qvwV-4c3oA:
18.17
4qvwb-4c3oA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		5 / 11 HIS A 585
THR A 535
THR A 536
GLY A  29
ALA A 581
 MG  A1005 (-3.7A)
NFU  A1004 (-3.7A)
None
None
None
 1.25A 4qvwH-4c3oA:
undetectable
4qvwN-4c3oA:
undetectable		 4qvwH-4c3oA:
18.17
4qvwN-4c3oA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		5 / 11 HIS A 585
THR A 535
THR A 536
GLY A  29
ALA A 581
 MG  A1005 (-3.7A)
NFU  A1004 (-3.7A)
None
None
None
 1.24A 4qw0V-4c3oA:
undetectable
4qw0b-4c3oA:
undetectable		 4qw0V-4c3oA:
18.17
4qw0b-4c3oA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		5 / 11 HIS A 585
THR A 535
THR A 536
GLY A  29
ALA A 581
 MG  A1005 (-3.7A)
NFU  A1004 (-3.7A)
None
None
None
 1.23A 4qw0H-4c3oA:
undetectable
4qw0N-4c3oA:
undetectable		 4qw0H-4c3oA:
18.17
4qw0N-4c3oA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		5 / 11 HIS A 585
THR A 535
THR A 536
GLY A  29
ALA A 581
 MG  A1005 (-3.7A)
NFU  A1004 (-3.7A)
None
None
None
 1.25A 4qw1V-4c3oA:
undetectable
4qw1b-4c3oA:
undetectable		 4qw1V-4c3oA:
18.17
4qw1b-4c3oA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		5 / 11 HIS A 585
THR A 535
THR A 536
GLY A  29
ALA A 581
 MG  A1005 (-3.7A)
NFU  A1004 (-3.7A)
None
None
None
 1.24A 4qw1H-4c3oA:
undetectable
4qw1N-4c3oA:
undetectable		 4qw1H-4c3oA:
18.17
4qw1N-4c3oA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		5 / 11 HIS A 585
THR A 535
THR A 536
GLY A  29
ALA A 581
 MG  A1005 (-3.7A)
NFU  A1004 (-3.7A)
None
None
None
 1.24A 4qw3V-4c3oA:
undetectable
4qw3b-4c3oA:
undetectable		 4qw3V-4c3oA:
18.17
4qw3b-4c3oA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		5 / 11 HIS A 585
THR A 535
THR A 536
GLY A  29
ALA A 581
 MG  A1005 (-3.7A)
NFU  A1004 (-3.7A)
None
None
None
 1.25A 4qw3H-4c3oA:
undetectable
4qw3N-4c3oA:
undetectable		 4qw3H-4c3oA:
18.17
4qw3N-4c3oA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_H_SPMH202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		4 / 6 ASN A  45
MET A 556
GLU A 552
GLU A  34
 None
 1.50A 4r87H-4c3oA:
undetectable		 4r87H-4c3oA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		4 / 4 ASN A  14
VAL A  47
THR A  44
ILE A  43
 None
 0.95A 4retA-4c3oA:
undetectable		 4retA-4c3oA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		4 / 4 ASN A  14
VAL A  47
THR A  44
ILE A  43
 None
 0.94A 4retC-4c3oA:
undetectable		 4retC-4c3oA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_DIFA601_1
(SERUM ALBUMIN)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
HYDROGENASE-1 SMALL
SUBUNIT
(Salmonella
enterica) 		5 / 9 LEU B 250
ASP A  67
ALA A  70
VAL A  72
ARG A  74
 F3S  B1002 (-4.0A)
None
None
None
None
 1.32A 4zbrA-4c3oB:
undetectable		 4zbrA-4c3oB:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_F_SORF1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		4 / 4 ARG A  89
HIS A 115
ALA A 112
GLU A 306
 None
 1.15A 5a06A-4c3oA:
0.0
5a06F-4c3oA:
0.0		 5a06A-4c3oA:
21.12
5a06F-4c3oA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		5 / 11 HIS A 585
THR A 535
THR A 536
GLY A  29
ALA A 581
 MG  A1005 (-3.7A)
NFU  A1004 (-3.7A)
None
None
None
 1.21A 5bxnV-4c3oA:
undetectable
5bxnb-4c3oA:
undetectable		 5bxnV-4c3oA:
18.34
5bxnb-4c3oA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		5 / 11 HIS A 585
THR A 535
THR A 536
GLY A  29
ALA A 581
 MG  A1005 (-3.7A)
NFU  A1004 (-3.7A)
None
None
None
 1.23A 5bxnH-4c3oA:
undetectable
5bxnN-4c3oA:
undetectable		 5bxnH-4c3oA:
18.34
5bxnN-4c3oA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		3 / 3 GLU A 461
HIS A 115
ASP A 577
 None
 0.81A 5c0oG-4c3oA:
undetectable		 5c0oG-4c3oA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZ7_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		5 / 11 HIS A 585
THR A 535
THR A 536
GLY A  29
ALA A 581
 MG  A1005 (-3.7A)
NFU  A1004 (-3.7A)
None
None
None
 1.26A 5cz7H-4c3oA:
undetectable
5cz7N-4c3oA:
undetectable		 5cz7H-4c3oA:
18.17
5cz7N-4c3oA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		5 / 11 HIS A 585
THR A 535
THR A 536
GLY A  29
ALA A 581
 MG  A1005 (-3.7A)
NFU  A1004 (-3.7A)
None
None
None
 1.23A 5d0xV-4c3oA:
undetectable
5d0xb-4c3oA:
undetectable		 5d0xV-4c3oA:
18.17
5d0xb-4c3oA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		5 / 11 HIS A 585
THR A 535
THR A 536
GLY A  29
ALA A 581
 MG  A1005 (-3.7A)
NFU  A1004 (-3.7A)
None
None
None
 1.24A 5d0xH-4c3oA:
undetectable
5d0xN-4c3oA:
undetectable		 5d0xH-4c3oA:
18.17
5d0xN-4c3oA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_DIFA601_1
(SERUM ALBUMIN)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
HYDROGENASE-1 SMALL
SUBUNIT
(Salmonella
enterica) 		5 / 9 LEU B 250
ASP A  67
ALA A  70
VAL A  72
ARG A  74
 F3S  B1002 (-4.0A)
None
None
None
None
 1.28A 5dbyA-4c3oB:
undetectable		 5dbyA-4c3oB:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_B_0HKB1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		3 / 3 ASP A  38
ASN A  45
PHE A  10
 None
 0.54A 5dsgB-4c3oA:
undetectable		 5dsgB-4c3oA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXG_B_ESTB601_1
(ESTROGEN RECEPTOR)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
HYDROGENASE-1 SMALL
SUBUNIT
(Salmonella
enterica) 		5 / 11 LEU B  31
ALA B  32
LEU A 210
LEU A 207
LEU B  42
 None
 1.23A 5dxgB-4c3oB:
undetectable		 5dxgB-4c3oB:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		4 / 8 ILE A 263
ALA A 112
THR A 113
VAL A 116
 None
 0.85A 5ecnD-4c3oA:
undetectable		 5ecnD-4c3oA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_A_REAA602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
HYDROGENASE-1 SMALL
SUBUNIT
(Salmonella
enterica) 		5 / 12 ILE A  88
GLY A 235
ASN A 231
LEU A 233
TRP B 205
 None
 1.49A 5fhzA-4c3oA:
undetectable		 5fhzA-4c3oA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_2
(CDL2.2)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
HYDROGENASE-1 SMALL
SUBUNIT
(Salmonella
enterica) 		5 / 12 LEU A 555
VAL A  21
LEU A 580
ILE A  27
GLY B  53
 None
 0.88A 5ienA-4c3oA:
undetectable		 5ienA-4c3oA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_2
(CDL2.3B)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		5 / 9 PRO A 534
VAL A 337
LEU A 339
ILE A 345
LEU A  85
 NFU  A1004 (-3.8A)
None
CL  A1587 ( 4.5A)
None
None
 1.37A 5iepA-4c3oA:
undetectable		 5iepA-4c3oA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH614_0
(NADH DEHYDROGENASE,
PUTATIVE)		 4c3o HYDROGENASE-1 SMALL
SUBUNIT
(Salmonella
enterica) 		4 / 6 ILE B 160
VAL B 146
VAL B 159
TRP B 112
 None
 0.98A 5jwaH-4c3oB:
2.7		 5jwaH-4c3oB:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		5 / 12 HIS A 585
THR A 535
THR A 536
GLY A  29
ALA A 581
 MG  A1005 (-3.7A)
NFU  A1004 (-3.7A)
None
None
None
 1.22A 5l5zV-4c3oA:
undetectable
5l5zb-4c3oA:
undetectable		 5l5zV-4c3oA:
18.17
5l5zb-4c3oA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		5 / 12 HIS A 585
THR A 535
THR A 536
GLY A  29
ALA A 581
 MG  A1005 (-3.7A)
NFU  A1004 (-3.7A)
None
None
None
 1.22A 5l5zH-4c3oA:
undetectable
5l5zN-4c3oA:
undetectable		 5l5zH-4c3oA:
18.17
5l5zN-4c3oA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		5 / 11 HIS A 585
THR A 535
THR A 536
GLY A  29
ALA A 581
 MG  A1005 (-3.7A)
NFU  A1004 (-3.7A)
None
None
None
 1.23A 5l66V-4c3oA:
undetectable
5l66b-4c3oA:
undetectable		 5l66V-4c3oA:
18.17
5l66b-4c3oA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		5 / 11 HIS A 585
THR A 535
THR A 536
GLY A  29
ALA A 581
 MG  A1005 (-3.7A)
NFU  A1004 (-3.7A)
None
None
None
 1.22A 5l66H-4c3oA:
undetectable
5l66N-4c3oA:
undetectable		 5l66H-4c3oA:
18.17
5l66N-4c3oA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_D_CCSD14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2
PROGRAMMED CELL
DEATH 1 LIGAND 1)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		5 / 12 ARG A  74
GLY A  77
GLU A  73
GLY A  81
THR A  82
 None
None
None
None
NFU  A1004 (-4.0A)
 1.24A 5o4yD-4c3oA:
undetectable
5o4yE-4c3oA:
undetectable		 5o4yD-4c3oA:
2.22
5o4yE-4c3oA:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGJ_A_ACTA307_0
(CARBONIC ANHYDRASE
13)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		4 / 6 HIS A 127
LEU A 452
THR A 451
TRP A 289
 None
 1.10A 5ogjA-4c3oA:
undetectable		 5ogjA-4c3oA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGJ_B_ACTB305_0
(CARBONIC ANHYDRASE
13)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		4 / 6 HIS A 127
LEU A 452
THR A 451
TRP A 289
 None
 1.08A 5ogjB-4c3oA:
undetectable		 5ogjB-4c3oA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OHH_B_ACTB311_0
(CARBONIC ANHYDRASE
13)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		4 / 6 HIS A 127
LEU A 452
THR A 451
TRP A 289
 None
 1.09A 5ohhB-4c3oA:
undetectable		 5ohhB-4c3oA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXQ_A_NIZA808_1
(CATALASE-PEROXIDASE)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		4 / 8 GLU A 272
GLY A 466
GLN A 470
LEU A 469
 None
 0.99A 5sxqA-4c3oA:
undetectable		 5sxqA-4c3oA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXT_A_NIZA807_1
(CATALASE-PEROXIDASE)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		5 / 8 GLU A 272
GLY A 466
GLN A 470
LEU A 469
THR A 468
 None
 1.21A 5sxtA-4c3oA:
undetectable		 5sxtA-4c3oA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXT_B_NIZB808_1
(CATALASE-PEROXIDASE)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		5 / 8 GLU A 272
GLY A 466
GLN A 470
LEU A 469
THR A 468
 None
 1.20A 5sxtB-4c3oA:
0.2		 5sxtB-4c3oA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_B_NIZB809_1
(CATALASE-PEROXIDASE)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		5 / 8 GLU A 272
GLY A 466
GLN A 470
LEU A 469
THR A 468
 None
 1.28A 5syjB-4c3oA:
undetectable		 5syjB-4c3oA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VYH_A_FOLA409_0
(S PROTEIN)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		5 / 10 HIS A 127
ALA A 539
GLY A  50
THR A  51
ILE A 401
 None
 1.03A 5vyhA-4c3oA:
undetectable		 5vyhA-4c3oA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AY4_A_TPFA506_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		5 / 10 TYR A 529
ALA A  70
ALA A  84
THR A  82
LEU A 515
 None
None
None
NFU  A1004 (-4.0A)
NFU  A1004 (-3.7A)
 1.45A 6ay4A-4c3oA:
undetectable		 6ay4A-4c3oA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BC9_A_ETSA302_2
(CARBONIC ANHYDRASE 2)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		4 / 5 HIS A 122
GLU A 461
HIS A 115
LEU A 515
 None
None
None
NFU  A1004 (-3.7A)
 1.09A 6bc9A-4c3oA:
undetectable		 6bc9A-4c3oA:
8.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_A_ACTA816_0
(UNCHARACTERIZED
PROTEIN)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		3 / 3 ARG A 458
ARG A 512
ASP A 577
 None
NFU  A1004 (-4.6A)
None
 0.97A 6d8pA-4c3oA:
undetectable		 6d8pA-4c3oA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_B_BO2B201_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-2)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		5 / 12 HIS A 585
THR A 535
THR A 536
GLY A  29
ALA A 581
 MG  A1005 (-3.7A)
NFU  A1004 (-3.7A)
None
None
None
 1.22A 6hwdV-4c3oA:
undetectable
6hwdb-4c3oA:
undetectable		 6hwdV-4c3oA:
10.17
6hwdb-4c3oA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_N_BO2N201_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-2)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		5 / 12 HIS A 585
THR A 535
THR A 536
GLY A  29
ALA A 581
 MG  A1005 (-3.7A)
NFU  A1004 (-3.7A)
None
None
None
 1.23A 6hwdH-4c3oA:
undetectable
6hwdN-4c3oA:
undetectable		 6hwdH-4c3oA:
10.17
6hwdN-4c3oA:
11.19