SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4c3s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4c3s ALDEHYDE
DEHYDROGENASE
(Lachnoclostridiu
m
phytofermentans) 		3 / 3 VAL A 173
ALA A 172
HIS A  95
 None
 0.70A 1q23C-4c3sA:
undetectable		 1q23C-4c3sA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_G_FUAG708_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4c3s ALDEHYDE
DEHYDROGENASE
(Lachnoclostridiu
m
phytofermentans) 		3 / 3 VAL A 173
ALA A 172
HIS A  95
 None
 0.65A 1q23H-4c3sA:
undetectable		 1q23H-4c3sA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4c3s ALDEHYDE
DEHYDROGENASE
(Lachnoclostridiu
m
phytofermentans) 		3 / 3 VAL A 173
ALA A 172
HIS A  95
 None
 0.72A 1q23G-4c3sA:
0.9		 1q23G-4c3sA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4c3s ALDEHYDE
DEHYDROGENASE
(Lachnoclostridiu
m
phytofermentans) 		3 / 3 VAL A 173
ALA A 172
HIS A  95
 None
 0.78A 1q23L-4c3sA:
undetectable		 1q23L-4c3sA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4c3s ALDEHYDE
DEHYDROGENASE
(Lachnoclostridiu
m
phytofermentans) 		3 / 3 VAL A 173
ALA A 172
HIS A  95
 None
 0.64A 1q23J-4c3sA:
0.9		 1q23J-4c3sA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q6I_B_FK5B401_1
(FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKPA)		 4c3s ALDEHYDE
DEHYDROGENASE
(Lachnoclostridiu
m
phytofermentans) 		5 / 10 LEU A 363
VAL A 244
ILE A 391
TYR A 402
ILE A 406
 None
 1.43A 1q6iB-4c3sA:
undetectable		 1q6iB-4c3sA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4c3s ALDEHYDE
DEHYDROGENASE
(Lachnoclostridiu
m
phytofermentans) 		5 / 12 GLU A 346
ILE A 257
GLY A 364
GLN A 303
ILE A 365
 None
 1.31A 2ogyA-4c3sA:
undetectable		 2ogyA-4c3sA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_B_ACTB653_0
(ACETYL-COENZYME A
SYNTHETASE)		 4c3s ALDEHYDE
DEHYDROGENASE
(Lachnoclostridiu
m
phytofermentans) 		4 / 4 VAL A 157
THR A 156
VAL A  49
GLY A 154
 None
 1.19A 2p2fB-4c3sA:
3.7		 2p2fB-4c3sA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_B_VD3B2001_1
(VITAMIN D
HYDROXYLASE)		 4c3s ALDEHYDE
DEHYDROGENASE
(Lachnoclostridiu
m
phytofermentans) 		5 / 11 ILE A 343
LEU A 309
ASN A 319
LEU A 329
ILE A 332
 None
 1.08A 3a50B-4c3sA:
undetectable		 3a50B-4c3sA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_C_VD3C2001_1
(VITAMIN D
HYDROXYLASE)		 4c3s ALDEHYDE
DEHYDROGENASE
(Lachnoclostridiu
m
phytofermentans) 		5 / 11 ILE A 343
LEU A 309
ASN A 319
LEU A 329
ILE A 332
 None
 1.14A 3a50C-4c3sA:
undetectable		 3a50C-4c3sA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_E_VD3E2001_1
(VITAMIN D
HYDROXYLASE)		 4c3s ALDEHYDE
DEHYDROGENASE
(Lachnoclostridiu
m
phytofermentans) 		5 / 12 THR A 327
MET A 331
ILE A 332
ASN A 265
LEU A 353
 None
 1.27A 3a50E-4c3sA:
undetectable		 3a50E-4c3sA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CV9_A_VDXA501_1
(CYTOCHROME P450-SU1)		 4c3s ALDEHYDE
DEHYDROGENASE
(Lachnoclostridiu
m
phytofermentans) 		5 / 9 VAL A 242
LEU A 363
SER A 417
ILE A 258
ILE A 281
 None
 1.23A 3cv9A-4c3sA:
undetectable		 3cv9A-4c3sA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDY_A_RBFA187_1
(LUMAZINE PROTEIN)		 4c3s ALDEHYDE
DEHYDROGENASE
(Lachnoclostridiu
m
phytofermentans) 		5 / 12 ILE A 406
ASP A 407
ALA A 403
THR A 400
ILE A 399
 None
 1.19A 3ddyA-4c3sA:
undetectable		 3ddyA-4c3sA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PRS_A_RITA1001_1
(ENDOTHIAPEPSIN)		 4c3s ALDEHYDE
DEHYDROGENASE
(Lachnoclostridiu
m
phytofermentans) 		5 / 10 ILE A 250
ALA A 248
ILE A 406
TYR A 402
THR A 408
 SO4  A1467 (-4.2A)
None
None
None
None
 1.00A 3prsA-4c3sA:
undetectable		 3prsA-4c3sA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_B_QELB1_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 4c3s ALDEHYDE
DEHYDROGENASE
(Lachnoclostridiu
m
phytofermentans) 		5 / 11 ALA A  99
PHE A 423
THR A 105
PRO A 103
GLU A  58
 None
 1.35A 3qelA-4c3sA:
undetectable
3qelB-4c3sA:
2.9		 3qelA-4c3sA:
22.66
3qelB-4c3sA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SG9_B_KANB305_1
(APH(2'')-ID)		 4c3s ALDEHYDE
DEHYDROGENASE
(Lachnoclostridiu
m
phytofermentans) 		4 / 8 ASN A 138
SER A 388
HIS A 387
GLU A 272
 NAD  A1468 ( 3.9A)
None
NAD  A1468 (-4.0A)
None
 1.02A 3sg9B-4c3sA:
undetectable		 3sg9B-4c3sA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4c3s ALDEHYDE
DEHYDROGENASE
(Lachnoclostridiu
m
phytofermentans) 		3 / 3 SER A 140
ASP A 264
ASP A 324
 None
 0.92A 3uj7A-4c3sA:
4.2		 3uj7A-4c3sA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1478_0
(MJ0495-LIKE PROTEIN)		 4c3s ALDEHYDE
DEHYDROGENASE
(Lachnoclostridiu
m
phytofermentans) 		4 / 7 GLY A 438
THR A 437
SER A 443
PHE A 447
 None
 1.00A 4ac9C-4c3sA:
2.4		 4ac9C-4c3sA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_A_ADNA401_1
(APH(2'')-ID)		 4c3s ALDEHYDE
DEHYDROGENASE
(Lachnoclostridiu
m
phytofermentans) 		5 / 10 ILE A 148
ILE A 176
HIS A  95
LEU A 175
ILE A 144
 None
 1.28A 4dtaA-4c3sA:
undetectable		 4dtaA-4c3sA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J14_A_X2NA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 4c3s ALDEHYDE
DEHYDROGENASE
(Lachnoclostridiu
m
phytofermentans) 		5 / 10 PHE A 447
VAL A 157
ALA A 132
THR A 134
THR A 142
 None
 1.11A 4j14A-4c3sA:
undetectable		 4j14A-4c3sA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6C_B_STRB503_1
(CYTOCHROME P450
MONOOXYGENASE)		 4c3s ALDEHYDE
DEHYDROGENASE
(Lachnoclostridiu
m
phytofermentans) 		5 / 10 GLN A  37
ALA A  38
ALA A  41
ALA A  42
THR A 156
 None
 1.18A 4j6cB-4c3sA:
undetectable		 4j6cB-4c3sA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_2
(TUBULIN BETA-2B
CHAIN)		 4c3s ALDEHYDE
DEHYDROGENASE
(Lachnoclostridiu
m
phytofermentans) 		5 / 12 ALA A  99
THR A 168
ALA A 172
ILE A 176
ILE A 143
 None
 1.11A 4o2bB-4c3sA:
undetectable		 4o2bB-4c3sA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Z_BEZZ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 4c3s ALDEHYDE
DEHYDROGENASE
(Lachnoclostridiu
m
phytofermentans) 		4 / 4 ILE A 343
GLY A 364
ILE A 298
LEU A 363
 None
 0.89A 5dzkl-4c3sA:
undetectable
5dzkz-4c3sA:
undetectable		 5dzkl-4c3sA:
21.43
5dzkz-4c3sA:
0.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWJ_D_QELD503_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 4c3s ALDEHYDE
DEHYDROGENASE
(Lachnoclostridiu
m
phytofermentans) 		5 / 12 ALA A  99
PHE A 423
THR A 105
PRO A 103
GLU A  58
 None
 1.34A 5ewjC-4c3sA:
4.0
5ewjD-4c3sA:
3.8		 5ewjC-4c3sA:
23.32
5ewjD-4c3sA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FUK_A_SNPA1236_1
(MROUPO)		 4c3s ALDEHYDE
DEHYDROGENASE
(Lachnoclostridiu
m
phytofermentans) 		4 / 7 ILE A 365
ILE A 362
ILE A 298
LEU A 353
 None
 0.76A 5fukA-4c3sA:
undetectable
5fukB-4c3sA:
undetectable		 5fukA-4c3sA:
20.99
5fukB-4c3sA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_C_FK5C201_1
(FK506-BINDING
PROTEIN 1)		 4c3s ALDEHYDE
DEHYDROGENASE
(Lachnoclostridiu
m
phytofermentans) 		5 / 10 VAL A 244
ILE A 391
TYR A 402
LEU A 411
ILE A 354
 None
 1.14A 5hw8C-4c3sA:
undetectable
5hw8H-4c3sA:
undetectable		 5hw8C-4c3sA:
15.27
5hw8H-4c3sA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA413_0
(AROMATIC
PEROXYGENASE)		 4c3s ALDEHYDE
DEHYDROGENASE
(Lachnoclostridiu
m
phytofermentans) 		4 / 7 GLY A 347
PHE A 345
GLY A 364
VAL A 366
 None
 0.86A 6ekzA-4c3sA:
undetectable		 6ekzA-4c3sA:
11.57