SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4c3z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JFF_B_TA1B601_1
(TUBULIN BETA CHAIN)		 4c3z MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1
(Homo
sapiens) 		5 / 12 VAL A 837
ASP A 836
LEU A 688
LEU A 691
GLY A 671
 None
 0.97A 1jffB-4c3zA:
undetectable		 1jffB-4c3zA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB504_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4c3z MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1
(Homo
sapiens) 		4 / 7 LEU A 661
ILE A 664
ALA A 690
ILE A 823
 None
 0.92A 1oniB-4c3zA:
undetectable
1oniC-4c3zA:
undetectable		 1oniB-4c3zA:
23.02
1oniC-4c3zA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_C_ADNC1503_1
(CLASS B ACID
PHOSPHATASE)		 4c3z MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1
(Homo
sapiens) 		4 / 8 TYR A 852
LEU A 856
GLY A 860
ASP A 859
 None
 0.99A 1rmtC-4c3zA:
undetectable		 1rmtC-4c3zA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HXF_B_TA1B601_1
(TUBULIN BETA CHAIN)		 4c3z MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1
(Homo
sapiens) 		5 / 12 VAL A 837
ASP A 836
LEU A 688
LEU A 691
GLY A 671
 None
 0.97A 2hxfB-4c3zA:
undetectable		 2hxfB-4c3zA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HXH_B_TA1B601_1
(TUBULIN BETA CHAIN)		 4c3z MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1
(Homo
sapiens) 		5 / 12 VAL A 837
ASP A 836
LEU A 688
LEU A 691
GLY A 671
 None
 0.97A 2hxhB-4c3zA:
undetectable		 2hxhB-4c3zA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P4N_B_TA1B601_1
(TUBULIN BETA CHAIN)		 4c3z MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1
(Homo
sapiens) 		5 / 12 VAL A 837
ASP A 836
LEU A 688
LEU A 691
GLY A 671
 None
 0.96A 2p4nB-4c3zA:
undetectable		 2p4nB-4c3zA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WBE_B_TA1B1439_1
(TUBULIN BETA-2B
CHAIN)		 4c3z MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1
(Homo
sapiens) 		5 / 12 VAL A 837
ASP A 836
LEU A 688
LEU A 691
GLY A 671
 None
 0.97A 2wbeB-4c3zA:
undetectable		 2wbeB-4c3zA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCO_B_TA1B601_1
(BOVINE BETA TUBULIN)		 4c3z MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1
(Homo
sapiens) 		5 / 12 VAL A 837
ASP A 836
LEU A 688
LEU A 691
GLY A 671
 None
 0.97A 3dcoB-4c3zA:
undetectable		 3dcoB-4c3zA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EDL_B_TA1B601_1
(BETA TUBULIN)		 4c3z MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1
(Homo
sapiens) 		5 / 12 VAL A 837
ASP A 836
LEU A 688
LEU A 691
GLY A 671
 None
 0.96A 3edlB-4c3zA:
undetectable		 3edlB-4c3zA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4c3z MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1
(Homo
sapiens) 		4 / 5 PRO A 735
VAL A 810
GLY A 815
LYS A 818
 None
 1.13A 3elzA-4c3zA:
undetectable		 3elzA-4c3zA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IZ0_B_TA1B820_1
(BETA TUBULIN, CHAIN
B FROM PDB 1JFF)		 4c3z MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1
(Homo
sapiens) 		5 / 12 VAL A 837
ASP A 836
LEU A 688
LEU A 691
GLY A 671
 None
 0.96A 3iz0B-4c3zA:
undetectable		 3iz0B-4c3zA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SM2_A_478A126_2
(GAG-PRO-POL
POLYPROTEIN)		 4c3z MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1
(Homo
sapiens) 		5 / 11 ALA A 675
VAL A 840
GLY A 678
LEU A 855
LEU A 832
 None
 0.99A 3sm2B-4c3zA:
undetectable		 3sm2B-4c3zA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZPH_A_PRLA501_0
(ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
ENDOTHELIAL PAS
DOMAIN-CONTAINING
PROTEIN 1)		 4c3z MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1
(Homo
sapiens) 		4 / 7 VAL A 776
LEU A 722
SER A 721
GLU A 724
 None
 0.96A 4zphA-4c3zA:
undetectable
4zphB-4c3zA:
undetectable		 4zphA-4c3zA:
22.39
4zphB-4c3zA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_E_SC2E1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 4c3z MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1
(Homo
sapiens) 		3 / 3 VAL A 782
GLN A 742
CYH A 744
 None
 0.83A 5icxA-4c3zA:
undetectable
5icxE-4c3zA:
undetectable		 5icxA-4c3zA:
20.59
5icxE-4c3zA:
4.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_F_SC2F1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 4c3z MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1
(Homo
sapiens) 		3 / 3 VAL A 782
GLN A 742
CYH A 744
 None
 0.90A 5icxC-4c3zA:
undetectable
5icxF-4c3zA:
undetectable		 5icxC-4c3zA:
20.59
5icxF-4c3zA:
4.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA608_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 4c3z MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1
(Homo
sapiens) 		3 / 3 GLY A 663
THR A 650
GLU A 699
 None
 0.55A 6b58A-4c3zA:
undetectable		 6b58A-4c3zA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_C_DAHC123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 4c3z MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1
(Homo
sapiens) 		5 / 10 PHE A 862
LEU A 856
SER A 851
GLY A 850
ILE A 838
 None
 1.15A 6ebpC-4c3zA:
undetectable		 6ebpC-4c3zA:
15.95