SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4c4a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BRP_A_RTLA183_0
(RETINOL BINDING
PROTEIN)		 4c4a PROTEIN ARGININE
N-METHYLTRANSFERASE
7
(Mus
musculus) 		5 / 12 LEU A 486
PHE A 651
ALA A 561
PHE A 524
LEU A 517
 None
 1.34A 1brpA-4c4aA:
undetectable		 1brpA-4c4aA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3002_1
(SERUM ALBUMIN)		 4c4a PROTEIN ARGININE
N-METHYLTRANSFERASE
7
(Mus
musculus) 		4 / 8 GLN A 425
LEU A 476
LEU A 399
SER A 473
 None
 1.09A 1hk3A-4c4aA:
undetectable		 1hk3A-4c4aA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		 4c4a PROTEIN ARGININE
N-METHYLTRANSFERASE
7
(Mus
musculus) 		4 / 8 ARG A 177
SER A 249
ASP A 251
LYS A 254
 None
 1.18A 1hwiB-4c4aA:
undetectable		 1hwiB-4c4aA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		 4c4a PROTEIN ARGININE
N-METHYLTRANSFERASE
7
(Mus
musculus) 		4 / 7 ARG A 177
SER A 249
ASP A 251
LYS A 254
 None
 1.16A 1hwiC-4c4aA:
undetectable		 1hwiC-4c4aA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_2
(HMG-COA REDUCTASE)		 4c4a PROTEIN ARGININE
N-METHYLTRANSFERASE
7
(Mus
musculus) 		4 / 7 ARG A 177
SER A 249
ASP A 251
LYS A 254
 None
 1.16A 1hwiD-4c4aA:
undetectable		 1hwiD-4c4aA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_A_117A2_1
(HMG-COA REDUCTASE)		 4c4a PROTEIN ARGININE
N-METHYLTRANSFERASE
7
(Mus
musculus) 		4 / 8 ARG A 177
SER A 249
ASP A 251
LYS A 254
 None
 1.19A 1hwkA-4c4aA:
undetectable		 1hwkA-4c4aA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_C_117C4_1
(HMG-COA REDUCTASE)		 4c4a PROTEIN ARGININE
N-METHYLTRANSFERASE
7
(Mus
musculus) 		4 / 8 ARG A 177
SER A 249
ASP A 251
LYS A 254
 None
 1.20A 1hwkC-4c4aA:
undetectable		 1hwkC-4c4aA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_D_117D3_2
(HMG-COA REDUCTASE)		 4c4a PROTEIN ARGININE
N-METHYLTRANSFERASE
7
(Mus
musculus) 		4 / 8 ARG A 177
SER A 249
ASP A 251
LYS A 254
 None
 1.20A 1hwkD-4c4aA:
undetectable		 1hwkD-4c4aA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_B_NIOB602_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4c4a PROTEIN ARGININE
N-METHYLTRANSFERASE
7
(Mus
musculus) 		4 / 5 GLU A 478
GLY A 477
SER A 412
PHE A 481
 None
 1.34A 1icrA-4c4aA:
undetectable
1icrB-4c4aA:
undetectable		 1icrA-4c4aA:
15.46
1icrB-4c4aA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_A_NIOA704_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4c4a PROTEIN ARGININE
N-METHYLTRANSFERASE
7
(Mus
musculus) 		4 / 4 SER A 412
PHE A 481
GLU A 478
GLY A 477
 None
 1.38A 1icvA-4c4aA:
undetectable
1icvB-4c4aA:
undetectable		 1icvA-4c4aA:
15.46
1icvB-4c4aA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW3_A_SAMA500_0
(HISTONE
METHYLTRANSFERASE
DOT1L)		 4c4a PROTEIN ARGININE
N-METHYLTRANSFERASE
7
(Mus
musculus) 		5 / 12 GLU A 684
GLY A 610
VAL A 668
PHE A 524
LEU A 527
 None
 1.31A 1nw3A-4c4aA:
0.0		 1nw3A-4c4aA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RI4_A_SAMA299_0
(MRNA CAPPING ENZYME)		 4c4a PROTEIN ARGININE
N-METHYLTRANSFERASE
7
(Mus
musculus) 		5 / 12 GLY A  72
ILE A 119
ALA A  92
ASP A 133
PHE A  96
 SAH  A1689 (-3.0A)
None
None
None
None
 1.17A 1ri4A-4c4aA:
8.9		 1ri4A-4c4aA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_B_PXLB1005_1
(PYRIDOXINE KINASE)		 4c4a PROTEIN ARGININE
N-METHYLTRANSFERASE
7
(Mus
musculus) 		4 / 7 LEU A 406
THR A 428
GLY A 411
ASP A 410
 None
 1.04A 2ddwB-4c4aA:
undetectable		 2ddwB-4c4aA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_A_SC2A1290_1
(FICOLIN-2)		 4c4a PROTEIN ARGININE
N-METHYLTRANSFERASE
7
(Mus
musculus) 		4 / 5 ASP A  70
LEU A  77
GLY A  76
ARG A  44
 SAH  A1689 ( 4.4A)
SAH  A1689 ( 4.5A)
None
SAH  A1689 (-2.7A)
 1.20A 2j2pA-4c4aA:
undetectable
2j2pB-4c4aA:
undetectable		 2j2pA-4c4aA:
15.20
2j2pB-4c4aA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1291_1
(FICOLIN-2)		 4c4a PROTEIN ARGININE
N-METHYLTRANSFERASE
7
(Mus
musculus) 		4 / 4 ASP A  70
LEU A  77
GLY A  76
ARG A  44
 SAH  A1689 ( 4.4A)
SAH  A1689 ( 4.5A)
None
SAH  A1689 (-2.7A)
 1.18A 2j2pD-4c4aA:
undetectable
2j2pE-4c4aA:
undetectable		 2j2pD-4c4aA:
15.20
2j2pE-4c4aA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1289_1
(FICOLIN-2)		 4c4a PROTEIN ARGININE
N-METHYLTRANSFERASE
7
(Mus
musculus) 		4 / 6 ARG A  44
ASP A  70
LEU A  77
GLY A  76
 SAH  A1689 (-2.7A)
SAH  A1689 ( 4.4A)
SAH  A1689 ( 4.5A)
None
 0.98A 2j2pD-4c4aA:
undetectable
2j2pF-4c4aA:
undetectable		 2j2pD-4c4aA:
15.20
2j2pF-4c4aA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 4c4a PROTEIN ARGININE
N-METHYLTRANSFERASE
7
(Mus
musculus) 		5 / 12 ASP A  70
GLY A  72
GLY A  74
LEU A  78
LEU A 145
 SAH  A1689 ( 4.4A)
SAH  A1689 (-3.0A)
SAH  A1689 ( 3.7A)
SAH  A1689 (-4.5A)
SAH  A1689 (-4.4A)
 0.33A 2nxeB-4c4aA:
9.8		 2nxeB-4c4aA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4c4a PROTEIN ARGININE
N-METHYLTRANSFERASE
7
(Mus
musculus) 		4 / 8 PHE A 674
ILE A 681
PHE A 583
TRP A 494
 None
 0.89A 2qwxA-4c4aA:
undetectable
2qwxB-4c4aA:
undetectable		 2qwxA-4c4aA:
15.85
2qwxB-4c4aA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4c4a PROTEIN ARGININE
N-METHYLTRANSFERASE
7
(Mus
musculus) 		4 / 8 PHE A 674
ILE A 681
PHE A 583
TRP A 494
 None
 0.90A 2qx4A-4c4aA:
undetectable
2qx4B-4c4aA:
undetectable		 2qx4A-4c4aA:
15.72
2qx4B-4c4aA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBP_A_SAMA300_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 4c4a PROTEIN ARGININE
N-METHYLTRANSFERASE
7
(Mus
musculus) 		5 / 12 GLY A  72
GLY A  74
LEU A  78
SER A 123
LEU A 145
 SAH  A1689 (-3.0A)
SAH  A1689 ( 3.7A)
SAH  A1689 (-4.5A)
SAH  A1689 (-3.0A)
SAH  A1689 (-4.4A)
 0.49A 2zbpA-4c4aA:
9.5		 2zbpA-4c4aA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_C_SAMC302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 4c4a PROTEIN ARGININE
N-METHYLTRANSFERASE
7
(Mus
musculus) 		5 / 12 ASP A  70
GLY A  72
LEU A  78
SER A 123
LEU A 145
 SAH  A1689 ( 4.4A)
SAH  A1689 (-3.0A)
SAH  A1689 (-4.5A)
SAH  A1689 (-3.0A)
SAH  A1689 (-4.4A)
 0.51A 3cjtC-4c4aA:
10.0		 3cjtC-4c4aA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DXY_A_SAMA1_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 4c4a PROTEIN ARGININE
N-METHYLTRANSFERASE
7
(Mus
musculus) 		5 / 11 GLY A  72
GLY A  74
ILE A  93
GLU A  94
VAL A  95
 SAH  A1689 (-3.0A)
SAH  A1689 ( 3.7A)
SAH  A1689 ( 4.8A)
SAH  A1689 (-2.6A)
SAH  A1689 (-4.0A)
 0.62A 3dxyA-4c4aA:
7.2		 3dxyA-4c4aA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_H_DHIH3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 4c4a PROTEIN ARGININE
N-METHYLTRANSFERASE
7
(Mus
musculus) 		3 / 3 LEU A 517
TRP A 614
GLY A 628
 None
 0.75A 3l35A-4c4aA:
undetectable
3l35H-4c4aA:
undetectable		 3l35A-4c4aA:
5.64
3l35H-4c4aA:
2.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_A_ACTA207_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 4c4a PROTEIN ARGININE
N-METHYLTRANSFERASE
7
(Mus
musculus) 		4 / 7 GLU A 562
LEU A 553
ARG A  32
ALA A  31
 None
 1.30A 3mbgA-4c4aA:
undetectable
3mbgB-4c4aA:
undetectable		 3mbgA-4c4aA:
12.02
3mbgB-4c4aA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		 4c4a PROTEIN ARGININE
N-METHYLTRANSFERASE
7
(Mus
musculus) 		3 / 3 SER A 257
SER A 258
HIS A 163
 None
 0.84A 3mzeA-4c4aA:
undetectable		 3mzeA-4c4aA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_B_RITB600_1
(CYTOCHROME P450 3A4)		 4c4a PROTEIN ARGININE
N-METHYLTRANSFERASE
7
(Mus
musculus) 		5 / 12 PHE A 112
LEU A  77
PHE A 540
ILE A 140
ALA A  66
 None
SAH  A1689 ( 4.5A)
None
None
None
 1.18A 3nxuB-4c4aA:
undetectable		 3nxuB-4c4aA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA270_0
(PROTEIN SSM1)		 4c4a PROTEIN ARGININE
N-METHYLTRANSFERASE
7
(Mus
musculus) 		4 / 5 SER A 573
ARG A 604
LEU A 629
PRO A 632
 None
 1.16A 3onnA-4c4aA:
2.8		 3onnA-4c4aA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZU_A_X89A411_1
(FLAVOHEMOPROTEIN)		 4c4a PROTEIN ARGININE
N-METHYLTRANSFERASE
7
(Mus
musculus) 		5 / 12 ILE A 455
PHE A 427
LEU A 462
VAL A 500
ALA A 508
 None
 0.71A 3ozuA-4c4aA:
4.5		 3ozuA-4c4aA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_1
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 4c4a PROTEIN ARGININE
N-METHYLTRANSFERASE
7
(Mus
musculus) 		5 / 6 GLY A  74
THR A  75
LEU A  77
GLU A  94
ASP A  70
 SAH  A1689 ( 3.7A)
SAH  A1689 ( 4.7A)
SAH  A1689 ( 4.5A)
SAH  A1689 (-2.6A)
SAH  A1689 ( 4.4A)
 1.18A 3ps9A-4c4aA:
6.2		 3ps9A-4c4aA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_1
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 4c4a PROTEIN ARGININE
N-METHYLTRANSFERASE
7
(Mus
musculus) 		5 / 6 TYR A  35
GLY A  74
THR A  75
LEU A  77
GLU A  94
 SAH  A1689 (-4.5A)
SAH  A1689 ( 3.7A)
SAH  A1689 ( 4.7A)
SAH  A1689 ( 4.5A)
SAH  A1689 (-2.6A)
 0.82A 3ps9A-4c4aA:
6.2		 3ps9A-4c4aA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QJ7_A_SPMA264_1
(THYMIDYLATE SYNTHASE)		 4c4a PROTEIN ARGININE
N-METHYLTRANSFERASE
7
(Mus
musculus) 		4 / 8 ARG A 556
ALA A 561
LEU A 613
ASP A 680
 None
 0.93A 3qj7A-4c4aA:
undetectable
3qj7D-4c4aA:
undetectable		 3qj7A-4c4aA:
17.77
3qj7D-4c4aA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 4c4a PROTEIN ARGININE
N-METHYLTRANSFERASE
7
(Mus
musculus) 		4 / 5 HIS A 313
THR A 148
GLU A 144
ASP A  70
 None
None
SAH  A1689 (-4.4A)
SAH  A1689 ( 4.4A)
 1.39A 3tm4A-4c4aA:
9.8		 3tm4A-4c4aA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 4c4a PROTEIN ARGININE
N-METHYLTRANSFERASE
7
(Mus
musculus) 		4 / 5 HIS A 313
THR A 148
GLU A 144
ASP A  70
 None
None
SAH  A1689 (-4.4A)
SAH  A1689 ( 4.4A)
 1.43A 3tm4B-4c4aA:
9.7		 3tm4B-4c4aA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1001_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 4c4a PROTEIN ARGININE
N-METHYLTRANSFERASE
7
(Mus
musculus) 		3 / 3 ASP A  43
LYS A  42
ASP A  41
 None
 0.55A 4a7tA-4c4aA:
undetectable		 4a7tA-4c4aA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A84_A_DXCA1160_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 4c4a PROTEIN ARGININE
N-METHYLTRANSFERASE
7
(Mus
musculus) 		5 / 12 ILE A 382
VAL A 199
ASN A 446
MET A 439
LEU A 438
 None
 1.20A 4a84A-4c4aA:
undetectable		 4a84A-4c4aA:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9K_B_TYLB2198_1
(CREB-BINDING PROTEIN)		 4c4a PROTEIN ARGININE
N-METHYLTRANSFERASE
7
(Mus
musculus) 		4 / 5 VAL A 233
LEU A 230
ILE A 228
VAL A 277
 None
 0.97A 4a9kB-4c4aA:
undetectable		 4a9kB-4c4aA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_A_IMNA701_1
(CYCLOOXYGENASE-2)		 4c4a PROTEIN ARGININE
N-METHYLTRANSFERASE
7
(Mus
musculus) 		5 / 12 VAL A 278
SER A 280
LEU A 270
VAL A 244
LEU A 335
 None
 1.14A 4coxA-4c4aA:
undetectable		 4coxA-4c4aA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_B_IMNB701_1
(CYCLOOXYGENASE-2)		 4c4a PROTEIN ARGININE
N-METHYLTRANSFERASE
7
(Mus
musculus) 		5 / 12 VAL A 278
SER A 280
LEU A 270
VAL A 244
LEU A 335
 None
 1.15A 4coxB-4c4aA:
undetectable		 4coxB-4c4aA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_C_IMNC701_1
(CYCLOOXYGENASE-2)		 4c4a PROTEIN ARGININE
N-METHYLTRANSFERASE
7
(Mus
musculus) 		5 / 12 VAL A 278
LEU A 279
SER A 280
VAL A 244
LEU A 335
 None
 1.05A 4coxC-4c4aA:
undetectable		 4coxC-4c4aA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_D_IMND701_1
(CYCLOOXYGENASE-2)		 4c4a PROTEIN ARGININE
N-METHYLTRANSFERASE
7
(Mus
musculus) 		5 / 12 VAL A 278
SER A 280
LEU A 270
VAL A 244
LEU A 335
 None
 1.15A 4coxD-4c4aA:
undetectable		 4coxD-4c4aA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)		 4c4a PROTEIN ARGININE
N-METHYLTRANSFERASE
7
(Mus
musculus) 		4 / 6 PHE A 685
ALA A 611
ALA A 561
LEU A 613
 None
 1.02A 4dtzA-4c4aA:
undetectable		 4dtzA-4c4aA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_1
(METHYLTRANSFERASE
NSUN4)		 4c4a PROTEIN ARGININE
N-METHYLTRANSFERASE
7
(Mus
musculus) 		3 / 3 ASP A 554
ARG A 559
ASP A 547
 None
 0.75A 4fp9A-4c4aA:
7.0		 4fp9A-4c4aA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_1
(METHYLTRANSFERASE
NSUN4)		 4c4a PROTEIN ARGININE
N-METHYLTRANSFERASE
7
(Mus
musculus) 		3 / 3 ASP A 554
ARG A 559
ASP A 547
 None
 0.75A 4fp9C-4c4aA:
6.9		 4fp9C-4c4aA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_1
(METHYLTRANSFERASE
NSUN4)		 4c4a PROTEIN ARGININE
N-METHYLTRANSFERASE
7
(Mus
musculus) 		3 / 3 ASP A 554
ARG A 559
ASP A 547
 None
 0.72A 4fp9F-4c4aA:
6.9		 4fp9F-4c4aA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G5J_A_0WMA1102_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4c4a PROTEIN ARGININE
N-METHYLTRANSFERASE
7
(Mus
musculus) 		4 / 7 PHE A 252
TYR A 159
ILE A  71
PRO A 175
 None
 1.16A 4g5jA-4c4aA:
undetectable		 4g5jA-4c4aA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_E_ACTE502_0
(RNA POLYMERASE
3D-POL)		 4c4a PROTEIN ARGININE
N-METHYLTRANSFERASE
7
(Mus
musculus) 		3 / 3 ARG A 441
LYS A 440
LYS A 444
 None
 1.16A 4k50E-4c4aA:
undetectable		 4k50E-4c4aA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI506_0
(RNA POLYMERASE
3D-POL)		 4c4a PROTEIN ARGININE
N-METHYLTRANSFERASE
7
(Mus
musculus) 		3 / 3 ARG A 441
LYS A 440
LYS A 444
 None
 1.24A 4k50I-4c4aA:
undetectable		 4k50I-4c4aA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKT_A_198A1001_1
(ANDROGEN RECEPTOR)		 4c4a PROTEIN ARGININE
N-METHYLTRANSFERASE
7
(Mus
musculus) 		5 / 12 LEU A  78
LEU A  77
GLY A  76
VAL A  83
ILE A  93
 SAH  A1689 (-4.5A)
SAH  A1689 ( 4.5A)
None
None
SAH  A1689 ( 4.8A)
 1.38A 4oktA-4c4aA:
undetectable		 4oktA-4c4aA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_A_ML1A302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4c4a PROTEIN ARGININE
N-METHYLTRANSFERASE
7
(Mus
musculus) 		4 / 8 PHE A 674
ILE A 681
PHE A 583
TRP A 494
 None
 0.91A 4qogA-4c4aA:
undetectable
4qogB-4c4aA:
undetectable		 4qogA-4c4aA:
15.85
4qogB-4c4aA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVD_A_SAMA502_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 4c4a PROTEIN ARGININE
N-METHYLTRANSFERASE
7
(Mus
musculus) 		5 / 12 TYR A  48
GLY A  51
HIS A 176
VAL A 174
ILE A 142
 None
 1.01A 4rvdA-4c4aA:
6.1		 4rvdA-4c4aA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V32_A_EF2A151_1
(CEREBLON ISOFORM 4)		 4c4a PROTEIN ARGININE
N-METHYLTRANSFERASE
7
(Mus
musculus) 		4 / 7 ASN A 490
PRO A 479
PHE A 493
PHE A 674
 None
 1.45A 4v32A-4c4aA:
undetectable		 4v32A-4c4aA:
10.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V32_B_EF2B151_1
(CEREBLON ISOFORM 4)		 4c4a PROTEIN ARGININE
N-METHYLTRANSFERASE
7
(Mus
musculus) 		4 / 7 ASN A 490
PRO A 479
PHE A 493
PHE A 674
 None
 1.42A 4v32B-4c4aA:
undetectable		 4v32B-4c4aA:
10.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X61_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 4c4a PROTEIN ARGININE
N-METHYLTRANSFERASE
7
(Mus
musculus) 		5 / 12 GLY A  72
GLY A  74
LEU A  78
GLU A 144
LEU A 145
 SAH  A1689 (-3.0A)
SAH  A1689 ( 3.7A)
SAH  A1689 (-4.5A)
SAH  A1689 (-4.4A)
SAH  A1689 (-4.4A)
 0.49A 4x61A-4c4aA:
18.1		 4x61A-4c4aA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_D_ACTD403_0
(PROTON-GATED ION
CHANNEL)		 4c4a PROTEIN ARGININE
N-METHYLTRANSFERASE
7
(Mus
musculus) 		4 / 4 ILE A 625
ARG A 378
TYR A 391
GLU A 478
 None
 1.46A 4zzbD-4c4aA:
undetectable		 4zzbD-4c4aA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_E_ACTE403_0
(PROTON-GATED ION
CHANNEL)		 4c4a PROTEIN ARGININE
N-METHYLTRANSFERASE
7
(Mus
musculus) 		3 / 3 ARG A 458
TYR A 495
GLU A 460
 DMX  A2690 (-3.1A)
DMX  A2690 ( 4.4A)
None
 0.71A 4zzbE-4c4aA:
undetectable		 4zzbE-4c4aA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB201_0
(HYDROXYNITRILE LYASE)		 4c4a PROTEIN ARGININE
N-METHYLTRANSFERASE
7
(Mus
musculus) 		5 / 11 VAL A 522
VAL A 612
VAL A 520
ILE A 630
LEU A 566
 None
 1.11A 5e4dB-4c4aA:
undetectable		 5e4dB-4c4aA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB5_B_010B607_0
(HNL ISOENZYME 5)		 4c4a PROTEIN ARGININE
N-METHYLTRANSFERASE
7
(Mus
musculus) 		5 / 10 ALA A 301
VAL A 240
LEU A 230
VAL A 185
TRP A 281
 None
 1.45A 5eb5B-4c4aA:
undetectable		 5eb5B-4c4aA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K50_A_ACTA1403_0
(L-THREONINE
3-DEHYDROGENASE)		 4c4a PROTEIN ARGININE
N-METHYLTRANSFERASE
7
(Mus
musculus) 		4 / 5 SER A  57
VAL A  56
GLY A  86
ALA A  85
 None
 0.91A 5k50A-4c4aA:
2.8		 5k50A-4c4aA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MSD_A_BEZA1202_0
(CARBOXYLIC ACID
REDUCTASE)		 4c4a PROTEIN ARGININE
N-METHYLTRANSFERASE
7
(Mus
musculus) 		4 / 5 HIS A 339
ILE A 151
SER A 257
ALA A 155
 None
 1.22A 5msdA-4c4aA:
3.3		 5msdA-4c4aA:
20.91