SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4c4o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T03_P_TFOP822_1
(POL POLYPROTEIN
SYNTHETIC
OLIGONUCLEOTIDE
PRIMER)		 4c4o CARBONYL REDUCTASE
CPCR2
(Candida
parapsilosis) 		4 / 7 TYR A  61
MET A  63
ASP A 122
HIS A  27
 None
 1.15A 1t03A-4c4oA:
undetectable		 1t03A-4c4oA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPO_H_TESH1010_1
(ANTI-TESTOSTERONE
(HEAVY CHAIN)
ANTI-TESTOSTERONE
(LIGHT CHAIN))		 4c4o CARBONYL REDUCTASE
CPCR2
(Candida
parapsilosis) 		5 / 12 GLY A 178
LEU A 176
PHE A 237
VAL A 156
PRO A 159
 NAD  A1000 (-3.6A)
None
None
None
None
 1.13A 1vpoH-4c4oA:
undetectable
1vpoL-4c4oA:
undetectable		 1vpoH-4c4oA:
21.07
1vpoL-4c4oA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_C_X2NC1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 4c4o CARBONYL REDUCTASE
CPCR2
(Candida
parapsilosis) 		5 / 12 PHE A 237
PRO A 159
VAL A 260
ALA A 206
ALA A 210
 None
None
None
NAD  A1000 (-3.6A)
None
 1.35A 2x2nC-4c4oA:
undetectable		 2x2nC-4c4oA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_C_X2NC1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 4c4o CARBONYL REDUCTASE
CPCR2
(Candida
parapsilosis) 		5 / 12 PHE A 237
PRO A 159
VAL A 260
ALA A 210
ALA A 215
 None
 1.28A 2x2nC-4c4oA:
undetectable		 2x2nC-4c4oA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_Q_TRPQ1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4c4o CARBONYL REDUCTASE
CPCR2
(Candida
parapsilosis) 		4 / 8 GLY A 214
GLN A 188
VAL A 218
VAL A 199
 None
 0.75A 3fi0Q-4c4oA:
undetectable		 3fi0Q-4c4oA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QFX_A_CP6A602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4c4o CARBONYL REDUCTASE
CPCR2
(Candida
parapsilosis) 		5 / 12 VAL A  41
ALA A 146
ILE A 140
LEU A 137
ILE A  67
 None
 1.18A 3qfxA-4c4oA:
undetectable		 3qfxA-4c4oA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QFX_B_CP6B702_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4c4o CARBONYL REDUCTASE
CPCR2
(Candida
parapsilosis) 		5 / 12 VAL A  41
ALA A 146
ILE A 140
LEU A 137
ILE A  67
 None
 1.20A 3qfxB-4c4oA:
undetectable		 3qfxB-4c4oA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4c4o CARBONYL REDUCTASE
CPCR2
(Candida
parapsilosis) 		5 / 9 THR A 153
ALA A 149
ILE A  67
GLY A  42
ALA A  40
 None
 1.10A 4qvqK-4c4oA:
undetectable
4qvqL-4c4oA:
undetectable		 4qvqK-4c4oA:
22.32
4qvqL-4c4oA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4c4o CARBONYL REDUCTASE
CPCR2
(Candida
parapsilosis) 		5 / 9 THR A 153
ALA A 149
ILE A  67
GLY A  42
ALA A  40
 None
 1.10A 4qvqY-4c4oA:
undetectable
4qvqZ-4c4oA:
undetectable		 4qvqY-4c4oA:
22.32
4qvqZ-4c4oA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_B_IMNB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4c4o CARBONYL REDUCTASE
CPCR2
(Candida
parapsilosis) 		5 / 11 GLY A 194
ALA A 215
ILE A 187
LEU A 176
LEU A 175
 None
 1.16A 4xumB-4c4oA:
undetectable		 4xumB-4c4oA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_0
(TUBULIN BETA-2B
CHAIN)		 4c4o CARBONYL REDUCTASE
CPCR2
(Candida
parapsilosis) 		5 / 11 ASN A 290
VAL A  87
SER A 138
TYR A  81
LEU A  34
 None
 1.20A 5jh7B-4c4oA:
undetectable		 5jh7B-4c4oA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_D_6K9D502_0
(TUBULIN BETA-2B
CHAIN)		 4c4o CARBONYL REDUCTASE
CPCR2
(Candida
parapsilosis) 		5 / 11 ASN A 290
VAL A  87
SER A 138
TYR A  81
LEU A  34
 None
 1.19A 5jh7D-4c4oA:
undetectable		 5jh7D-4c4oA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4c4o CARBONYL REDUCTASE
CPCR2
(Candida
parapsilosis) 		5 / 12 ILE A 163
VAL A 256
ILE A 187
ALA A 186
VAL A 197
 None
 1.15A 5n0sB-4c4oA:
2.2		 5n0sB-4c4oA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4c4o CARBONYL REDUCTASE
CPCR2
(Candida
parapsilosis) 		5 / 12 ILE A 163
VAL A 256
ILE A 187
ALA A 186
VAL A 197
 None
 1.08A 5n0tA-4c4oA:
2.3		 5n0tA-4c4oA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_A_SAMA301_0
(METHYLTRANSFERASE)		 4c4o CARBONYL REDUCTASE
CPCR2
(Candida
parapsilosis) 		5 / 12 GLY A  58
GLY A  64
GLY A 120
VAL A  41
PHE A 334
 None
 0.96A 5vimA-4c4oA:
3.4		 5vimA-4c4oA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_B_SAMB301_0
(METHYLTRANSFERASE)		 4c4o CARBONYL REDUCTASE
CPCR2
(Candida
parapsilosis) 		5 / 12 GLY A  58
GLY A  64
GLY A 120
VAL A  41
PHE A 334
 None
 0.97A 5vimB-4c4oA:
3.1		 5vimB-4c4oA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_A_SUEA1202_1
(NS3 PROTEASE)		 4c4o CARBONYL REDUCTASE
CPCR2
(Candida
parapsilosis) 		5 / 9 VAL A 333
ASP A 147
ALA A  88
VAL A  87
SER A 138
 None
 1.35A 6c2mA-4c4oA:
undetectable		 6c2mA-4c4oA:
12.30