SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4c4v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_A_URFA1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 4c4v OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
(Escherichia
coli) 		4 / 6 ASN A 606
ASN A 506
SER A 508
THR A 567
 None
 1.04A 1h7xA-4c4vA:
undetectable		 1h7xA-4c4vA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_B_URFB1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 4c4v OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
(Escherichia
coli) 		4 / 6 ASN A 606
ASN A 506
SER A 508
THR A 567
 None
 1.03A 1h7xB-4c4vA:
undetectable		 1h7xB-4c4vA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_C_URFC1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 4c4v OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
(Escherichia
coli) 		4 / 6 ASN A 606
ASN A 506
SER A 508
THR A 567
 None
 1.03A 1h7xC-4c4vA:
undetectable		 1h7xC-4c4vA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_D_URFD1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 4c4v OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
(Escherichia
coli) 		4 / 6 ASN A 606
ASN A 506
SER A 508
THR A 567
 None
 1.03A 1h7xD-4c4vA:
undetectable		 1h7xD-4c4vA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 4c4v OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
(Escherichia
coli) 		5 / 12 GLY A 655
GLY A 656
GLY A 662
ASP A 740
SER A 658
 None
 1.15A 1wg8B-4c4vA:
undetectable		 1wg8B-4c4vA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_0
(HYPOTHETICAL PROTEIN)		 4c4v OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
(Escherichia
coli) 		5 / 12 THR A 612
GLY A 636
GLY A 638
VAL A 713
ILE A 668
 None
 1.17A 2b25B-4c4vA:
undetectable		 2b25B-4c4vA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 4c4v OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
(Escherichia
coli) 		3 / 3 ASP A 500
ASP A 503
ASP A 464
 None
 0.74A 2igtB-4c4vA:
undetectable		 2igtB-4c4vA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 4c4v OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
(Escherichia
coli) 		4 / 6 THR A 743
ARG A 767
ASP A 746
ASN A 748
 None
 1.18A 2okcA-4c4vA:
undetectable		 2okcA-4c4vA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_A_RABA602_2
(ADENOSYLHOMOCYSTEINA
SE)		 4c4v OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
(Escherichia
coli) 		4 / 5 GLN A 446
THR A 423
GLU A 396
THR A 397
 None
 1.41A 3glqA-4c4vA:
undetectable		 3glqA-4c4vA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_B_RABB602_2
(ADENOSYLHOMOCYSTEINA
SE)		 4c4v OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
(Escherichia
coli) 		4 / 5 GLN A 446
THR A 423
GLU A 396
THR A 397
 None
 1.44A 3glqB-4c4vA:
undetectable		 3glqB-4c4vA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HII_A_PNTA901_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 4c4v OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
(Escherichia
coli) 		5 / 12 ASP A 746
GLY A 707
VAL A 744
TYR A 653
TYR A 637
 None
 1.45A 3hiiA-4c4vA:
1.5		 3hiiA-4c4vA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HII_B_PNTB901_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 4c4v OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
(Escherichia
coli) 		5 / 12 ASP A 746
GLY A 707
VAL A 744
TYR A 653
TYR A 637
 None
 1.45A 3hiiB-4c4vA:
undetectable		 3hiiB-4c4vA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_A_ADNA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 4c4v OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
(Escherichia
coli) 		4 / 5 GLN A 446
THR A 423
GLU A 396
THR A 397
 None
 1.44A 3n58A-4c4vA:
undetectable		 3n58A-4c4vA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1479_0
(MJ0495-LIKE PROTEIN)		 4c4v OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
(Escherichia
coli) 		4 / 5 THR A 720
ILE A 719
GLU A 717
PHE A 586
 None
 1.18A 4ac9C-4c4vA:
undetectable		 4ac9C-4c4vA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4c4v OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
(Escherichia
coli) 		4 / 5 THR A 720
ILE A 719
GLU A 717
PHE A 586
 None
 1.19A 4acaC-4c4vA:
undetectable		 4acaC-4c4vA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4c4v OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
(Escherichia
coli) 		4 / 5 THR A 720
ILE A 719
GLU A 717
PHE A 586
 None
 1.17A 4acbC-4c4vA:
undetectable		 4acbC-4c4vA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_A_ADNA401_2
(SUGAR KINASE)		 4c4v OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
(Escherichia
coli) 		3 / 3 SER A 591
TYR A 578
PRO A 587
 None
 0.91A 4k8cA-4c4vA:
undetectable		 4k8cA-4c4vA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4c4v OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
(Escherichia
coli) 		3 / 3 SER A 591
TYR A 578
PRO A 587
 None
 0.90A 4kahA-4c4vA:
undetectable		 4kahA-4c4vA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_B_ADNB502_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4c4v OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
(Escherichia
coli) 		3 / 3 SER A 591
TYR A 578
PRO A 587
 None
 0.90A 4kahB-4c4vA:
undetectable		 4kahB-4c4vA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4c4v OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
(Escherichia
coli) 		3 / 3 SER A 591
TYR A 578
PRO A 587
 None
 0.91A 4kanA-4c4vA:
undetectable		 4kanA-4c4vA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4c4v OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
(Escherichia
coli) 		3 / 3 SER A 591
TYR A 578
PRO A 587
 None
 0.90A 4kanB-4c4vA:
undetectable		 4kanB-4c4vA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4c4v OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
(Escherichia
coli) 		3 / 3 SER A 591
TYR A 578
PRO A 587
 None
 0.89A 4kbeA-4c4vA:
undetectable		 4kbeA-4c4vA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4c4v OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
(Escherichia
coli) 		3 / 3 SER A 591
TYR A 578
PRO A 587
 None
 0.91A 4kbeB-4c4vA:
undetectable		 4kbeB-4c4vA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4c4v OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
(Escherichia
coli) 		3 / 3 SER A 591
TYR A 578
PRO A 587
 None
 0.89A 4lbgA-4c4vA:
undetectable		 4lbgA-4c4vA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4c4v OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
(Escherichia
coli) 		3 / 3 SER A 591
TYR A 578
PRO A 587
 None
 0.90A 4lbgB-4c4vA:
undetectable		 4lbgB-4c4vA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_B_SAMB601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 4c4v OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
(Escherichia
coli) 		5 / 12 ALA A 654
GLY A 655
GLY A 656
ASP A 740
GLY A 707
 None
 0.98A 4obwB-4c4vA:
undetectable		 4obwB-4c4vA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA301_0
(THAUMATIN-1)		 4c4v OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
(Escherichia
coli) 		3 / 3 THR A 567
ASN A 534
SER A 535
 None
 0.74A 4tvtA-4c4vA:
undetectable		 4tvtA-4c4vA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GSN_A_MMZA503_1
(FLAVIN-CONTAINING
MONOOXYGENASE)		 4c4v OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
(Escherichia
coli) 		3 / 3 ASN A 805
SER A 657
SER A 658
 None
 0.58A 5gsnA-4c4vA:
undetectable		 5gsnA-4c4vA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)		 4c4v OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
(Escherichia
coli) 		5 / 12 PHE A 652
GLY A 669
GLY A 707
ASP A 762
ALA A 654
 None
 1.17A 5kpcB-4c4vA:
undetectable		 5kpcB-4c4vA:
20.59