SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4c5f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_2
(TRANSTHYRETIN)		 4c5f MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE C
(Escherichia
coli) 		4 / 8 LEU A 277
THR A 240
LEU A 274
VAL A 237
 None
 0.99A 1sn5C-4c5fA:
undetectable		 1sn5C-4c5fA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_B_9CRB130_1
(TRANSTHYRETIN)		 4c5f MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE C
(Escherichia
coli) 		4 / 7 LEU A 277
THR A 240
LEU A 274
VAL A 237
 None
 0.92A 1tyrB-4c5fA:
undetectable		 1tyrB-4c5fA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_A_ADNA401_1
(APH(2'')-ID)		 4c5f MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE C
(Escherichia
coli) 		5 / 11 SER A 152
GLY A 149
ALA A 151
ILE A 104
ILE A 127
 None
 1.02A 4dt8A-4c5fA:
undetectable		 4dt8A-4c5fA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_B_ADNB401_1
(APH(2'')-ID)		 4c5f MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE C
(Escherichia
coli) 		5 / 10 SER A 152
GLY A 149
ALA A 151
ILE A 104
ILE A 127
 None
 1.00A 4dt8B-4c5fA:
undetectable		 4dt8B-4c5fA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK6_B_LURB201_1
(TRANSTHYRETIN)		 4c5f MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE C
(Escherichia
coli) 		4 / 8 LEU A 277
THR A 240
LEU A 274
VAL A 237
 None
 0.89A 4ik6B-4c5fA:
undetectable		 4ik6B-4c5fA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_1
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 4c5f MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE C
(Escherichia
coli) 		3 / 3 SER A  76
TYR A  65
ASP A 123
 None
 0.89A 4rp8C-4c5fA:
undetectable		 4rp8C-4c5fA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 4c5f MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE C
(Escherichia
coli) 		4 / 7 ASN A 278
TYR A 299
TYR A 345
LEU A 346
 None
 1.16A 4yv5A-4c5fA:
undetectable		 4yv5A-4c5fA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 4c5f MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE C
(Escherichia
coli) 		4 / 7 ASN A 278
TYR A 299
TYR A 345
LEU A 346
 None
 1.13A 4yv5B-4c5fA:
undetectable		 4yv5B-4c5fA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 4c5f MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE C
(Escherichia
coli) 		3 / 3 LYS A 348
LEU A 185
ASP A  81
 None
 0.79A 5zv2A-4c5fA:
undetectable		 5zv2A-4c5fA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA817_0
(GEPHYRIN)		 4c5f MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE C
(Escherichia
coli) 		3 / 3 THR A 216
ALA A 352
LYS A 354
 None
 0.76A 6fgdA-4c5fA:
undetectable		 6fgdA-4c5fA:
23.39