SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4c5n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OHR_A_1UNA201_1
(ASPARTYLPROTEASE)		 4c5n PHOSPHOMETHYLPYRIMID
INE KINASE
(Staphylococcus
aureus) 		6 / 11 ASP A 188
GLY A 177
GLY A 213
THR A 220
VAL A 234
ILE A 174
 ACP  A 500 (-2.7A)
None
ACP  A 500 (-3.3A)
None
None
None
 1.33A 1ohrA-4c5nA:
undetectable		 1ohrA-4c5nA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_A_BEZA1222_0
(PEROXIREDOXIN 6)		 4c5n PHOSPHOMETHYLPYRIMID
INE KINASE
(Staphylococcus
aureus) 		5 / 8 THR A 137
PRO A 138
VAL A 173
ALA A 133
PRO A 106
 None
 1.43A 2v32A-4c5nA:
undetectable
2v32B-4c5nA:
undetectable		 2v32A-4c5nA:
23.69
2v32B-4c5nA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_B_BEZB1220_0
(PEROXIREDOXIN 6)		 4c5n PHOSPHOMETHYLPYRIMID
INE KINASE
(Staphylococcus
aureus) 		5 / 8 PRO A 106
THR A 137
PRO A 138
VAL A 173
ALA A 133
 None
 1.39A 2v32A-4c5nA:
undetectable
2v32B-4c5nA:
undetectable		 2v32A-4c5nA:
23.69
2v32B-4c5nA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_A_BEZA1222_0
(PEROXIREDOXIN 6.)		 4c5n PHOSPHOMETHYLPYRIMID
INE KINASE
(Staphylococcus
aureus) 		5 / 9 THR A 137
PRO A 138
VAL A 173
ALA A 133
PRO A 106
 None
 1.43A 2v41A-4c5nA:
undetectable
2v41B-4c5nA:
undetectable		 2v41A-4c5nA:
23.69
2v41B-4c5nA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_B_BEZB1222_0
(PEROXIREDOXIN 6.)		 4c5n PHOSPHOMETHYLPYRIMID
INE KINASE
(Staphylococcus
aureus) 		5 / 9 PRO A 106
THR A 137
PRO A 138
VAL A 173
ALA A 133
 None
 1.42A 2v41A-4c5nA:
undetectable
2v41B-4c5nA:
undetectable		 2v41A-4c5nA:
23.69
2v41B-4c5nA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_B_ASDB1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 4c5n PHOSPHOMETHYLPYRIMID
INE KINASE
(Staphylococcus
aureus) 		4 / 6 PHE A 102
LEU A  81
LEU A 130
ALA A 133
 None
 0.90A 2vcvB-4c5nA:
undetectable		 2vcvB-4c5nA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_K_ASDK1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 4c5n PHOSPHOMETHYLPYRIMID
INE KINASE
(Staphylococcus
aureus) 		4 / 6 PHE A 102
LEU A  81
LEU A 130
ALA A 133
 None
 0.91A 2vcvK-4c5nA:
1.4		 2vcvK-4c5nA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW3_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 4c5n PHOSPHOMETHYLPYRIMID
INE KINASE
(Staphylococcus
aureus) 		5 / 9 ALA A 124
LEU A 129
ILE A   9
LEU A  65
ILE A  86
 None
 0.96A 3jw3B-4c5nA:
undetectable		 3jw3B-4c5nA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4c5n PHOSPHOMETHYLPYRIMID
INE KINASE
(Staphylococcus
aureus) 		5 / 11 ALA A  40
ILE A  87
GLY A  79
ALA A  10
THR A   8
 None
 1.19A 3rukD-4c5nA:
undetectable		 3rukD-4c5nA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE506_1
(HEMOLYTIC LECTIN
CEL-III)		 4c5n PHOSPHOMETHYLPYRIMID
INE KINASE
(Staphylococcus
aureus) 		4 / 6 CYH A 214
THR A 215
GLY A  19
ASP A  23
 PXL  A 300 ( 2.9A)
None
PXL  A 300 (-3.6A)
None
 1.20A 3w9tE-4c5nA:
undetectable		 3w9tE-4c5nA:
20.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C5L_A_UEGA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4c5n PHOSPHOMETHYLPYRIMID
INE KINASE
(Staphylococcus
aureus) 		9 / 11 GLY A  11
ASP A  13
ALA A  18
GLY A  19
VAL A  42
MET A  80
VAL A 107
HIS A 210
CYH A 214
 PXL  A 300 (-3.9A)
PXL  A 300 (-4.3A)
PXL  A 300 ( 4.0A)
PXL  A 300 (-3.6A)
PXL  A 300 ( 4.5A)
PXL  A 300 ( 4.2A)
None
ACP  A 500 (-4.3A)
PXL  A 300 ( 2.9A)
 0.26A 4c5lA-4c5nA:
46.2		 4c5lA-4c5nA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C5L_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4c5n PHOSPHOMETHYLPYRIMID
INE KINASE
(Staphylococcus
aureus) 		5 / 9 GLY A  11
ALA A  22
GLY A  19
HIS A 260
CYH A 214
 PXL  A 300 (-3.9A)
None
PXL  A 300 (-3.6A)
None
PXL  A 300 ( 2.9A)
 1.38A 4c5lB-4c5nA:
48.2		 4c5lB-4c5nA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C5L_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4c5n PHOSPHOMETHYLPYRIMID
INE KINASE
(Staphylococcus
aureus) 		9 / 9 GLY A  11
ASP A  13
ALA A  18
GLY A  19
VAL A  42
MET A  80
VAL A 107
HIS A 210
CYH A 214
 PXL  A 300 (-3.9A)
PXL  A 300 (-4.3A)
PXL  A 300 ( 4.0A)
PXL  A 300 (-3.6A)
PXL  A 300 ( 4.5A)
PXL  A 300 ( 4.2A)
None
ACP  A 500 (-4.3A)
PXL  A 300 ( 2.9A)
 0.17A 4c5lB-4c5nA:
48.2		 4c5lB-4c5nA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C5L_C_UEGC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4c5n PHOSPHOMETHYLPYRIMID
INE KINASE
(Staphylococcus
aureus) 		9 / 10 GLY A  11
ASP A  13
ALA A  18
GLY A  19
VAL A  42
MET A  80
VAL A 107
HIS A 210
CYH A 214
 PXL  A 300 (-3.9A)
PXL  A 300 (-4.3A)
PXL  A 300 ( 4.0A)
PXL  A 300 (-3.6A)
PXL  A 300 ( 4.5A)
PXL  A 300 ( 4.2A)
None
ACP  A 500 (-4.3A)
PXL  A 300 ( 2.9A)
 0.26A 4c5lC-4c5nA:
48.1		 4c5lC-4c5nA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C5L_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4c5n PHOSPHOMETHYLPYRIMID
INE KINASE
(Staphylococcus
aureus) 		9 / 10 GLY A  11
ASP A  13
ALA A  18
GLY A  19
VAL A  42
MET A  80
VAL A 107
HIS A 210
CYH A 214
 PXL  A 300 (-3.9A)
PXL  A 300 (-4.3A)
PXL  A 300 ( 4.0A)
PXL  A 300 (-3.6A)
PXL  A 300 ( 4.5A)
PXL  A 300 ( 4.2A)
None
ACP  A 500 (-4.3A)
PXL  A 300 ( 2.9A)
 0.21A 4c5lD-4c5nA:
47.8		 4c5lD-4c5nA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4c5n PHOSPHOMETHYLPYRIMID
INE KINASE
(Staphylococcus
aureus) 		5 / 11 VAL A 104
ALA A 217
PHE A 141
LEU A 146
VAL A 136
 None
 1.44A 4eilA-4c5nA:
undetectable		 4eilA-4c5nA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4c5n PHOSPHOMETHYLPYRIMID
INE KINASE
(Staphylococcus
aureus) 		5 / 10 VAL A 104
ALA A 217
PHE A 141
LEU A 146
VAL A 136
 None
 1.36A 4eilB-4c5nA:
undetectable		 4eilB-4c5nA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4c5n PHOSPHOMETHYLPYRIMID
INE KINASE
(Staphylococcus
aureus) 		5 / 11 VAL A 104
ALA A 217
PHE A 141
LEU A 146
VAL A 136
 None
 1.43A 4eilC-4c5nA:
undetectable		 4eilC-4c5nA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4c5n PHOSPHOMETHYLPYRIMID
INE KINASE
(Staphylococcus
aureus) 		5 / 11 VAL A 104
ALA A 217
PHE A 141
LEU A 146
VAL A 136
 None
 1.45A 4eilE-4c5nA:
undetectable		 4eilE-4c5nA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVC_B_HFGB1602_0
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 4c5n PHOSPHOMETHYLPYRIMID
INE KINASE
(Staphylococcus
aureus) 		5 / 12 LEU A 146
VAL A 136
PRO A 106
THR A  39
GLY A  11
 None
None
None
None
PXL  A 300 (-3.9A)
 1.31A 4hvcB-4c5nA:
3.1		 4hvcB-4c5nA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4c5n PHOSPHOMETHYLPYRIMID
INE KINASE
(Staphylococcus
aureus) 		5 / 10 VAL A 104
ALA A 217
PHE A 141
LEU A 146
VAL A 136
 None
 1.44A 4kyaC-4c5nA:
undetectable		 4kyaC-4c5nA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MUB_A_OAQA302_0
(SULFOTRANSFERASE)		 4c5n PHOSPHOMETHYLPYRIMID
INE KINASE
(Staphylococcus
aureus) 		5 / 12 LEU A 224
VAL A 103
GLY A  19
ASP A  23
PHE A  27
 None
None
PXL  A 300 (-3.6A)
None
None
 1.42A 4mubA-4c5nA:
1.8		 4mubA-4c5nA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVD_A_SAMA502_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 4c5n PHOSPHOMETHYLPYRIMID
INE KINASE
(Staphylococcus
aureus) 		5 / 12 ILE A 165
PRO A 106
HIS A 172
VAL A 173
ILE A 175
 None
 1.02A 4rvdA-4c5nA:
undetectable		 4rvdA-4c5nA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP6_A_B40A601_1
(TRANSPORTER)		 4c5n PHOSPHOMETHYLPYRIMID
INE KINASE
(Staphylococcus
aureus) 		4 / 5 ASP A  13
VAL A 107
ASP A 105
GLY A 213
 PXL  A 300 (-4.3A)
None
None
ACP  A 500 (-3.3A)
 0.86A 4xp6A-4c5nA:
undetectable		 4xp6A-4c5nA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		 4c5n PHOSPHOMETHYLPYRIMID
INE KINASE
(Staphylococcus
aureus) 		3 / 3 ASP A 105
ASP A  13
ASN A 252
 None
PXL  A 300 (-4.3A)
None
 0.86A 6gngB-4c5nA:
undetectable		 6gngB-4c5nA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN8_A_HFGA603_0
(UNCHARACTERIZED
PROTEIN)		 4c5n PHOSPHOMETHYLPYRIMID
INE KINASE
(Staphylococcus
aureus) 		5 / 12 LEU A 146
VAL A 136
PRO A 106
THR A  39
GLY A  11
 None
None
None
None
PXL  A 300 (-3.9A)
 1.29A 6mn8A-4c5nA:
undetectable		 6mn8A-4c5nA:
19.14