SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4c6s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_D_ACTD37_0
(GCN4 LEUCINE ZIPPER)		 4c6s PROBABLE WRKY
TRANSCRIPTION FACTOR
52
(Arabidopsis
thaliana) 		3 / 3 LYS A  34
ARG A 140
VAL A 139
 None
 1.02A 2r2vC-4c6sA:
undetectable
2r2vD-4c6sA:
undetectable		 2r2vC-4c6sA:
12.23
2r2vD-4c6sA:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 4c6s PROBABLE WRKY
TRANSCRIPTION FACTOR
52
(Arabidopsis
thaliana) 		3 / 3 HIS A 146
GLU A   9
ASN A  91
 None
 0.98A 4bupB-4c6sA:
undetectable		 4bupB-4c6sA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4c6s PROBABLE WRKY
TRANSCRIPTION FACTOR
52
(Arabidopsis
thaliana) 		5 / 12 GLN A  88
GLU A  86
GLY A 118
LEU A  67
ILE A 122
 None
 1.16A 4hytA-4c6sA:
3.5		 4hytA-4c6sA:
9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_C_OBNC2004_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4c6s PROBABLE WRKY
TRANSCRIPTION FACTOR
52
(Arabidopsis
thaliana) 		5 / 12 GLN A  88
GLU A  86
GLY A 118
LEU A  67
ILE A 122
 None
 1.15A 4hytC-4c6sA:
undetectable		 4hytC-4c6sA:
9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M51_A_BEZA501_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 4c6s PROBABLE WRKY
TRANSCRIPTION FACTOR
52
(Arabidopsis
thaliana) 		4 / 6 ILE A 138
ILE A 133
SER A 130
PHE A  23
 None
 0.96A 4m51A-4c6sA:
undetectable		 4m51A-4c6sA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UVM_B_ADNB207_1
(HISTIDINE TRIAD
(HIT) PROTEIN)		 4c6s PROBABLE WRKY
TRANSCRIPTION FACTOR
52
(Arabidopsis
thaliana) 		5 / 12 VAL A  11
ILE A  36
ASP A 141
ILE A 138
HIS A 146
 None
 0.98A 5uvmB-4c6sA:
undetectable		 5uvmB-4c6sA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_A_SAMA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 4c6s PROBABLE WRKY
TRANSCRIPTION FACTOR
52
(Arabidopsis
thaliana) 		3 / 3 HIS A 146
GLU A   9
ASN A  91
 None
 0.91A 5wbvA-4c6sA:
undetectable		 5wbvA-4c6sA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 4c6s PROBABLE WRKY
TRANSCRIPTION FACTOR
52
(Arabidopsis
thaliana) 		3 / 3 HIS A 146
GLU A   9
ASN A  91
 None
 0.91A 5wbvB-4c6sA:
undetectable		 5wbvB-4c6sA:
21.51