SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4c75'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1GHM_A_CEDA1_1
(BETA-LACTAMASE)		 4c75 BETA-LACTAMASE
(synthetic
construct) 		7 / 12 SER A  70
LYS A  73
SER A 130
ASN A 132
LYS A 234
GLY A 236
ARG A 244
 NA  A 294 ( 2.5A)
SO4  A 291 ( 4.6A)
SO4  A 291 (-2.8A)
None
SO4  A 291 (-3.4A)
NA  A 294 ( 3.2A)
SO4  A 291 (-4.1A)
 0.37A 1ghmA-4c75A:
37.2		 1ghmA-4c75A:
41.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I2W_A_CFXA1300_1
(BETA-LACTAMASE)		 4c75 BETA-LACTAMASE
(synthetic
construct) 		8 / 12 SER A  70
LYS A  73
SER A 130
ASN A 132
GLU A 166
THR A 216
LYS A 234
GLY A 236
 NA  A 294 ( 2.5A)
SO4  A 291 ( 4.6A)
SO4  A 291 (-2.8A)
None
None
SO4  A 291 ( 4.1A)
SO4  A 291 (-3.4A)
NA  A 294 ( 3.2A)
 0.36A 1i2wA-4c75A:
41.1		 1i2wA-4c75A:
54.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I2W_A_CFXA1300_2
(BETA-LACTAMASE)		 4c75 BETA-LACTAMASE
(synthetic
construct) 		5 / 5 TYR A 105
PRO A 167
LEU A 169
THR A 235
ARG A 244
 None
None
None
SO4  A 291 (-3.8A)
SO4  A 291 (-4.1A)
 0.75A 1i2wA-4c75A:
41.1		 1i2wA-4c75A:
54.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		 4c75 BETA-LACTAMASE
(synthetic
construct) 		8 / 12 SER A  70
LYS A  73
SER A 130
ASN A 132
GLU A 166
THR A 216
GLY A 236
ARG A 244
 NA  A 294 ( 2.5A)
SO4  A 291 ( 4.6A)
SO4  A 291 (-2.8A)
None
None
SO4  A 291 ( 4.1A)
NA  A 294 ( 3.2A)
SO4  A 291 (-4.1A)
 0.40A 1i2wB-4c75A:
41.3		 1i2wB-4c75A:
54.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YMX_A_CFXA1001_1
(BETA-LACTAMASE
CTX-M-9)		 4c75 BETA-LACTAMASE
(synthetic
construct) 		10 / 12 SER A  70
LYS A  73
SER A 130
ASN A 132
GLU A 166
ASN A 170
THR A 216
LYS A 234
GLY A 236
GLY A 238
 NA  A 294 ( 2.5A)
SO4  A 291 ( 4.6A)
SO4  A 291 (-2.8A)
None
None
None
SO4  A 291 ( 4.1A)
SO4  A 291 (-3.4A)
NA  A 294 ( 3.2A)
None
 0.41A 1ymxA-4c75A:
42.7		 1ymxA-4c75A:
57.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YMX_A_CFXA1001_2
(BETA-LACTAMASE
CTX-M-9)		 4c75 BETA-LACTAMASE
(synthetic
construct) 		4 / 5 CYH A  69
TYR A 105
PRO A 167
THR A 235
 None
None
None
SO4  A 291 (-3.8A)
 0.54A 1ymxA-4c75A:
42.7		 1ymxA-4c75A:
57.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YMX_B_CFXB1002_1
(BETA-LACTAMASE
CTX-M-9)		 4c75 BETA-LACTAMASE
(synthetic
construct) 		9 / 12 SER A  70
LYS A  73
SER A 130
ASN A 132
GLU A 166
ASN A 170
LYS A 234
GLY A 236
GLY A 238
 NA  A 294 ( 2.5A)
SO4  A 291 ( 4.6A)
SO4  A 291 (-2.8A)
None
None
None
SO4  A 291 (-3.4A)
NA  A 294 ( 3.2A)
None
 0.35A 1ymxB-4c75A:
42.8		 1ymxB-4c75A:
57.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YMX_B_CFXB1002_2
(BETA-LACTAMASE
CTX-M-9)		 4c75 BETA-LACTAMASE
(synthetic
construct) 		5 / 5 CYH A  69
TYR A 105
PRO A 167
THR A 216
THR A 235
 None
None
None
SO4  A 291 ( 4.1A)
SO4  A 291 (-3.8A)
 0.52A 1ymxB-4c75A:
42.8		 1ymxB-4c75A:
57.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA6_B_STRB402_1
(MINERALOCORTICOID
RECEPTOR)		 4c75 BETA-LACTAMASE
(synthetic
construct) 		5 / 12 ALA A 198
LEU A 207
MET A 211
LEU A 190
THR A 160
 None
 1.38A 2aa6B-4c75A:
undetectable		 2aa6B-4c75A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_B_SAMB500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 4c75 BETA-LACTAMASE
(synthetic
construct) 		5 / 11 GLU A 281
ALA A 280
ILE A 221
ALA A 287
ASP A 246
 PEG  A 295 ( 4.9A)
None
None
None
None
 1.21A 2admB-4c75A:
undetectable		 2admB-4c75A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B7Z_B_MK1B200_2
(HIV-1 PROTEASE)		 4c75 BETA-LACTAMASE
(synthetic
construct) 		5 / 12 ALA A  48
ILE A 250
ILE A 247
ALA A 282
VAL A 286
 None
 0.98A 2b7zB-4c75A:
undetectable		 2b7zB-4c75A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMA_A_SAMA375_0
(PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE)		 4c75 BETA-LACTAMASE
(synthetic
construct) 		5 / 11 SER A 130
SER A  70
ASN A 276
THR A 237
GLY A 236
 SO4  A 291 (-2.8A)
NA  A 294 ( 2.5A)
None
SO4  A 291 ( 3.4A)
NA  A 294 ( 3.2A)
 1.37A 2hmaA-4c75A:
undetectable		 2hmaA-4c75A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_D_ASDD1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 4c75 BETA-LACTAMASE
(synthetic
construct) 		5 / 9 PRO A 145
LEU A 162
LEU A 139
ALA A 135
PHE A  72
 None
 1.13A 2vcvD-4c75A:
undetectable		 2vcvD-4c75A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZGW_A_ADNA1301_1
(BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 4c75 BETA-LACTAMASE
(synthetic
construct) 		4 / 7 ARG A  65
GLU A  64
ALA A 185
ALA A 184
 None
 0.93A 2zgwA-4c75A:
undetectable		 2zgwA-4c75A:
21.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HLW_A_CE3A301_1
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 4c75 BETA-LACTAMASE
(synthetic
construct) 		9 / 12 LYS A  73
TYR A 105
SER A 130
ASN A 132
ASN A 170
THR A 216
LYS A 234
GLY A 236
GLY A 238
 SO4  A 291 ( 4.6A)
None
SO4  A 291 (-2.8A)
None
None
SO4  A 291 ( 4.1A)
SO4  A 291 (-3.4A)
NA  A 294 ( 3.2A)
None
 0.45A 3hlwA-4c75A:
42.7		 3hlwA-4c75A:
56.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HLW_B_CE3B302_1
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 4c75 BETA-LACTAMASE
(synthetic
construct) 		9 / 12 TYR A 105
SER A 130
ASN A 132
ASN A 170
THR A 216
LYS A 234
THR A 235
GLY A 236
GLY A 238
 None
SO4  A 291 (-2.8A)
None
None
SO4  A 291 ( 4.1A)
SO4  A 291 (-3.4A)
SO4  A 291 (-3.8A)
NA  A 294 ( 3.2A)
None
 0.41A 3hlwB-4c75A:
42.9		 3hlwB-4c75A:
56.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HUO_A_PNNA300_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 4c75 BETA-LACTAMASE
(synthetic
construct) 		8 / 12 CYH A  69
LYS A  73
ASN A 132
ASN A 170
LYS A 234
THR A 235
GLY A 236
GLY A 238
 None
SO4  A 291 ( 4.6A)
None
None
SO4  A 291 (-3.4A)
SO4  A 291 (-3.8A)
NA  A 294 ( 3.2A)
None
 0.27A 3huoA-4c75A:
42.6		 3huoA-4c75A:
56.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HUO_A_PNNA302_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 4c75 BETA-LACTAMASE
(synthetic
construct) 		6 / 6 THR A  51
ARG A 191
LEU A 195
GLY A 196
ALA A 257
PRO A 258
 None
 0.42A 3huoA-4c75A:
42.6		 3huoA-4c75A:
56.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HUO_B_PNNB301_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 4c75 BETA-LACTAMASE
(synthetic
construct) 		7 / 12 CYH A  69
LYS A  73
ASN A 132
ASN A 170
LYS A 234
GLY A 236
GLY A 238
 None
SO4  A 291 ( 4.6A)
None
None
SO4  A 291 (-3.4A)
NA  A 294 ( 3.2A)
None
 0.23A 3huoB-4c75A:
42.7		 3huoB-4c75A:
56.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		 4c75 BETA-LACTAMASE
(synthetic
construct) 		6 / 12 SER A  70
LYS A  73
ASN A 132
THR A 235
GLY A 236
ARG A 244
 NA  A 294 ( 2.5A)
SO4  A 291 ( 4.6A)
None
SO4  A 291 (-3.8A)
NA  A 294 ( 3.2A)
SO4  A 291 (-4.1A)
 1.09A 3mzeA-4c75A:
21.2		 3mzeA-4c75A:
20.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NY4_A_SMXA308_1
(BETA-LACTAMASE)		 4c75 BETA-LACTAMASE
(synthetic
construct) 		9 / 12 SER A  70
SER A 130
ASN A 170
THR A 216
LYS A 234
THR A 235
GLY A 236
THR A 237
GLY A 238
 NA  A 294 ( 2.5A)
SO4  A 291 (-2.8A)
None
SO4  A 291 ( 4.1A)
SO4  A 291 (-3.4A)
SO4  A 291 (-3.8A)
NA  A 294 ( 3.2A)
SO4  A 291 ( 3.4A)
None
 0.44A 3ny4A-4c75A:
39.7		 3ny4A-4c75A:
58.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3Q07_A_WPPA300_1
(BETA-LACTAMASE)		 4c75 BETA-LACTAMASE
(synthetic
construct) 		7 / 12 LYS A  73
SER A 130
ASN A 132
ASN A 170
LYS A 234
GLY A 236
GLY A 238
 SO4  A 291 ( 4.6A)
SO4  A 291 (-2.8A)
None
None
SO4  A 291 (-3.4A)
NA  A 294 ( 3.2A)
None
 0.27A 3q07A-4c75A:
42.7		 3q07A-4c75A:
56.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3Q07_A_WPPA300_2
(BETA-LACTAMASE)		 4c75 BETA-LACTAMASE
(synthetic
construct) 		4 / 5 CYH A  69
TYR A 105
PRO A 167
THR A 235
 None
None
None
SO4  A 291 (-3.8A)
 0.49A 3q07A-4c75A:
42.7		 3q07A-4c75A:
56.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3Q07_B_WPPB400_1
(BETA-LACTAMASE)		 4c75 BETA-LACTAMASE
(synthetic
construct) 		7 / 12 LYS A  73
SER A 130
ASN A 132
ASN A 170
LYS A 234
GLY A 236
GLY A 238
 SO4  A 291 ( 4.6A)
SO4  A 291 (-2.8A)
None
None
SO4  A 291 (-3.4A)
NA  A 294 ( 3.2A)
None
 0.35A 3q07B-4c75A:
42.7		 3q07B-4c75A:
56.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3Q07_B_WPPB400_2
(BETA-LACTAMASE)		 4c75 BETA-LACTAMASE
(synthetic
construct) 		4 / 5 CYH A  69
TYR A 105
PRO A 167
THR A 235
 None
None
None
SO4  A 291 (-3.8A)
 0.48A 3q07B-4c75A:
42.7		 3q07B-4c75A:
56.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SH8_A_CEDA1_1
(BETA-LACTAMASE)		 4c75 BETA-LACTAMASE
(synthetic
construct) 		8 / 12 SER A  70
TYR A 105
SER A 130
ASN A 132
LYS A 234
THR A 235
GLY A 236
ARG A 244
 NA  A 294 ( 2.5A)
None
SO4  A 291 (-2.8A)
None
SO4  A 291 (-3.4A)
SO4  A 291 (-3.8A)
NA  A 294 ( 3.2A)
SO4  A 291 (-4.1A)
 0.47A 3sh8A-4c75A:
39.7		 3sh8A-4c75A:
56.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SH8_B_CEDB1_1
(BETA-LACTAMASE)		 4c75 BETA-LACTAMASE
(synthetic
construct) 		7 / 12 SER A  70
LYS A  73
SER A 130
ASN A 132
LYS A 234
GLY A 236
ARG A 244
 NA  A 294 ( 2.5A)
SO4  A 291 ( 4.6A)
SO4  A 291 (-2.8A)
None
SO4  A 291 (-3.4A)
NA  A 294 ( 3.2A)
SO4  A 291 (-4.1A)
 0.31A 3sh8B-4c75A:
39.5		 3sh8B-4c75A:
56.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EUZ_A_MEMA401_1
(CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1)		 4c75 BETA-LACTAMASE
(synthetic
construct) 		9 / 12 LYS A  73
SER A 130
ASN A 132
ASN A 170
THR A 216
LYS A 234
THR A 235
GLY A 236
THR A 237
 SO4  A 291 ( 4.6A)
SO4  A 291 (-2.8A)
None
None
SO4  A 291 ( 4.1A)
SO4  A 291 (-3.4A)
SO4  A 291 (-3.8A)
NA  A 294 ( 3.2A)
SO4  A 291 ( 3.4A)
 0.48A 4euzA-4c75A:
41.4		 4euzA-4c75A:
52.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FH2_A_0RNA303_1
(BETA-LACTAMASE SHV-1)		 4c75 BETA-LACTAMASE
(synthetic
construct) 		7 / 10 TYR A 105
SER A 130
ASN A 132
LYS A 234
THR A 235
GLY A 236
ARG A 244
 None
SO4  A 291 (-2.8A)
None
SO4  A 291 (-3.4A)
SO4  A 291 (-3.8A)
NA  A 294 ( 3.2A)
SO4  A 291 (-4.1A)
 0.58A 4fh2A-4c75A:
38.4		 4fh2A-4c75A:
55.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4c75 BETA-LACTAMASE
(synthetic
construct) 		4 / 6 ARG A 161
ASP A 176
ASP A 163
ARG A 178
 None
 1.34A 4kcnB-4c75A:
undetectable		 4kcnB-4c75A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 4c75 BETA-LACTAMASE
(synthetic
construct) 		4 / 7 VAL A  80
ILE A 142
LEU A 169
LEU A 162
 None
 1.00A 4l1wA-4c75A:
undetectable		 4l1wA-4c75A:
22.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4N9K_A_CEDA301_1
(BETA-LACTAMASE)		 4c75 BETA-LACTAMASE
(synthetic
construct) 		9 / 12 SER A  70
TYR A 105
SER A 130
ASN A 132
ASN A 170
LYS A 234
THR A 235
GLY A 236
ARG A 244
 NA  A 294 ( 2.5A)
None
SO4  A 291 (-2.8A)
None
None
SO4  A 291 (-3.4A)
SO4  A 291 (-3.8A)
NA  A 294 ( 3.2A)
SO4  A 291 (-4.1A)
 0.39A 4n9kA-4c75A:
41.1		 4n9kA-4c75A:
56.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4N9K_B_CEDB301_1
(BETA-LACTAMASE)		 4c75 BETA-LACTAMASE
(synthetic
construct) 		8 / 12 SER A  70
SER A 130
ASN A 132
ASN A 170
LYS A 234
THR A 235
GLY A 236
ARG A 244
 NA  A 294 ( 2.5A)
SO4  A 291 (-2.8A)
None
None
SO4  A 291 (-3.4A)
SO4  A 291 (-3.8A)
NA  A 294 ( 3.2A)
SO4  A 291 (-4.1A)
 0.26A 4n9kB-4c75A:
41.1		 4n9kB-4c75A:
56.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NTX_A_AMRA509_1
(ACID-SENSING ION
CHANNEL 1
BASIC PHOSPHOLIPASE
A2 HOMOLOG TX-BETA)		 4c75 BETA-LACTAMASE
(synthetic
construct) 		4 / 6 ASP A 233
ASP A 246
ASN A 276
ARG A 244
 None
None
None
SO4  A 291 (-4.1A)
 1.25A 4ntxA-4c75A:
undetectable
4ntxC-4c75A:
undetectable		 4ntxA-4c75A:
20.00
4ntxC-4c75A:
18.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PM5_A_CE3A301_1
(BETA-LACTAMASE
CTX-M-14)		 4c75 BETA-LACTAMASE
(synthetic
construct) 		9 / 12 TYR A 105
SER A 130
ASN A 132
ASN A 170
THR A 216
LYS A 234
THR A 235
GLY A 236
GLY A 238
 None
SO4  A 291 (-2.8A)
None
None
SO4  A 291 ( 4.1A)
SO4  A 291 (-3.4A)
SO4  A 291 (-3.8A)
NA  A 294 ( 3.2A)
None
 0.65A 4pm5A-4c75A:
42.7		 4pm5A-4c75A:
57.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PM7_A_CE3A301_1
(BETA-LACTAMASE
CTX-M-14)		 4c75 BETA-LACTAMASE
(synthetic
construct) 		9 / 12 LYS A  73
TYR A 105
SER A 130
ASN A 132
ASN A 170
THR A 216
LYS A 234
GLY A 236
GLY A 238
 SO4  A 291 ( 4.6A)
None
SO4  A 291 (-2.8A)
None
None
SO4  A 291 ( 4.1A)
SO4  A 291 (-3.4A)
NA  A 294 ( 3.2A)
None
 0.68A 4pm7A-4c75A:
42.7		 4pm7A-4c75A:
57.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PM9_A_CE3A301_1
(BETA-LACTAMASE
CTX-M-14)		 4c75 BETA-LACTAMASE
(synthetic
construct) 		9 / 12 TYR A 105
SER A 130
ASN A 132
ASN A 170
THR A 216
LYS A 234
THR A 235
GLY A 236
GLY A 238
 None
SO4  A 291 (-2.8A)
None
None
SO4  A 291 ( 4.1A)
SO4  A 291 (-3.4A)
SO4  A 291 (-3.8A)
NA  A 294 ( 3.2A)
None
 0.62A 4pm9A-4c75A:
42.7		 4pm9A-4c75A:
57.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1X_A_017A101_2
(ASPARTYL PROTEASE)		 4c75 BETA-LACTAMASE
(synthetic
construct) 		6 / 12 ALA A  48
ILE A 250
ILE A 221
ILE A 285
PRO A 226
ILE A 259
 None
 1.45A 4q1xB-4c75A:
undetectable		 4q1xB-4c75A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4c75 BETA-LACTAMASE
(synthetic
construct) 		4 / 8 THR A 189
LEU A 190
LEU A 207
LEU A 194
 None
 0.74A 4z90F-4c75A:
undetectable
4z90G-4c75A:
undetectable
4z90H-4c75A:
undetectable
4z90I-4c75A:
undetectable
4z90J-4c75A:
undetectable		 4z90F-4c75A:
21.95
4z90G-4c75A:
21.95
4z90H-4c75A:
21.95
4z90I-4c75A:
21.95
4z90J-4c75A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_B_0HKB1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 4c75 BETA-LACTAMASE
(synthetic
construct) 		3 / 3 ASP A 233
ASN A 245
PHE A  72
 None
 0.73A 5dsgB-4c75A:
undetectable		 5dsgB-4c75A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB203_0
(HYDROXYNITRILE LYASE)		 4c75 BETA-LACTAMASE
(synthetic
construct) 		4 / 4 VAL A  80
ALA A 120
ILE A  95
THR A 118
 None
 1.16A 5e4dB-4c75A:
undetectable		 5e4dB-4c75A:
20.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5GHY_A_CEDA301_1
(BETA-LACTAMASE)		 4c75 BETA-LACTAMASE
(synthetic
construct) 		7 / 12 SER A  70
SER A 130
ASN A 132
ASN A 170
LYS A 234
GLY A 236
ARG A 244
 NA  A 294 ( 2.5A)
SO4  A 291 (-2.8A)
None
None
SO4  A 291 (-3.4A)
NA  A 294 ( 3.2A)
SO4  A 291 (-4.1A)
 0.33A 5ghyA-4c75A:
41.2		 5ghyA-4c75A:
56.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5GHY_A_CEDA301_1
(BETA-LACTAMASE)		 4c75 BETA-LACTAMASE
(synthetic
construct) 		6 / 12 SER A  70
TYR A 105
ASN A 132
ASN A 170
GLY A 236
ARG A 244
 NA  A 294 ( 2.5A)
None
None
None
NA  A 294 ( 3.2A)
SO4  A 291 (-4.1A)
 1.31A 5ghyA-4c75A:
41.2		 5ghyA-4c75A:
56.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5GHY_B_CEDB301_1
(BETA-LACTAMASE)		 4c75 BETA-LACTAMASE
(synthetic
construct) 		7 / 12 SER A  70
SER A 130
ASN A 132
ASN A 170
LYS A 234
GLY A 236
ARG A 244
 NA  A 294 ( 2.5A)
SO4  A 291 (-2.8A)
None
None
SO4  A 291 (-3.4A)
NA  A 294 ( 3.2A)
SO4  A 291 (-4.1A)
 0.32A 5ghyB-4c75A:
41.2		 5ghyB-4c75A:
56.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5GHY_B_CEDB301_1
(BETA-LACTAMASE)		 4c75 BETA-LACTAMASE
(synthetic
construct) 		6 / 12 SER A  70
TYR A 105
ASN A 132
ASN A 170
GLY A 236
ARG A 244
 NA  A 294 ( 2.5A)
None
None
None
NA  A 294 ( 3.2A)
SO4  A 291 (-4.1A)
 1.26A 5ghyB-4c75A:
41.2		 5ghyB-4c75A:
56.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5GHZ_A_CEDA301_1
(BETA-LACTAMASE)		 4c75 BETA-LACTAMASE
(synthetic
construct) 		9 / 11 SER A  70
TYR A 105
SER A 130
ASN A 132
ASN A 170
LYS A 234
THR A 235
GLY A 236
ARG A 244
 NA  A 294 ( 2.5A)
None
SO4  A 291 (-2.8A)
None
None
SO4  A 291 (-3.4A)
SO4  A 291 (-3.8A)
NA  A 294 ( 3.2A)
SO4  A 291 (-4.1A)
 0.43A 5ghzA-4c75A:
41.2		 5ghzA-4c75A:
56.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5GHZ_B_CEDB301_1
(BETA-LACTAMASE)		 4c75 BETA-LACTAMASE
(synthetic
construct) 		9 / 10 SER A  70
TYR A 105
SER A 130
ASN A 132
ASN A 170
LYS A 234
THR A 235
GLY A 236
ARG A 244
 NA  A 294 ( 2.5A)
None
SO4  A 291 (-2.8A)
None
None
SO4  A 291 (-3.4A)
SO4  A 291 (-3.8A)
NA  A 294 ( 3.2A)
SO4  A 291 (-4.1A)
 0.41A 5ghzB-4c75A:
41.2		 5ghzB-4c75A:
56.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_B_PFLB510_1
(PROTON-GATED ION
CHANNEL)		 4c75 BETA-LACTAMASE
(synthetic
construct) 		4 / 6 ILE A 259
ALA A 287
LEU A 290
ILE A  57
 None
 0.81A 5mvmB-4c75A:
undetectable
5mvmC-4c75A:
undetectable		 5mvmB-4c75A:
17.24
5mvmC-4c75A:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFP_A_8W5A804_2
(GLUCOCORTICOID
RECEPTOR)		 4c75 BETA-LACTAMASE
(synthetic
construct) 		4 / 4 LEU A  81
MET A 211
ILE A 142
LEU A  75
 None
 1.23A 5nfpA-4c75A:
undetectable		 5nfpA-4c75A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 4c75 BETA-LACTAMASE
(synthetic
construct) 		4 / 7 THR A 149
PHE A  72
ASP A 179
LEU A 169
 None
 1.21A 5uxcA-4c75A:
undetectable		 5uxcA-4c75A:
25.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5Y_B_9F2B400_1
(BETA-LACTAMASE)		 4c75 BETA-LACTAMASE
(synthetic
construct) 		10 / 12 CYH A  69
SER A  70
SER A 130
ASN A 170
THR A 216
LYS A 234
THR A 235
GLY A 236
THR A 237
GLY A 238
 None
NA  A 294 ( 2.5A)
SO4  A 291 (-2.8A)
None
SO4  A 291 ( 4.1A)
SO4  A 291 (-3.4A)
SO4  A 291 (-3.8A)
NA  A 294 ( 3.2A)
SO4  A 291 ( 3.4A)
None
 0.48A 6b5yB-4c75A:
40.1		 6b5yB-4c75A:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5Y_D_9F2D400_1
(BETA-LACTAMASE)		 4c75 BETA-LACTAMASE
(synthetic
construct) 		10 / 12 CYH A  69
SER A  70
SER A 130
ASN A 170
THR A 216
LYS A 234
THR A 235
GLY A 236
THR A 237
GLY A 238
 None
NA  A 294 ( 2.5A)
SO4  A 291 (-2.8A)
None
SO4  A 291 ( 4.1A)
SO4  A 291 (-3.4A)
SO4  A 291 (-3.8A)
NA  A 294 ( 3.2A)
SO4  A 291 ( 3.4A)
None
 0.47A 6b5yD-4c75A:
40.2		 6b5yD-4c75A:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B68_B_9F2B301_1
(BETA-LACTAMASE)		 4c75 BETA-LACTAMASE
(synthetic
construct) 		10 / 12 CYH A  69
SER A  70
SER A 130
ASN A 170
THR A 216
LYS A 234
THR A 235
GLY A 236
THR A 237
GLY A 238
 None
NA  A 294 ( 2.5A)
SO4  A 291 (-2.8A)
None
SO4  A 291 ( 4.1A)
SO4  A 291 (-3.4A)
SO4  A 291 (-3.8A)
NA  A 294 ( 3.2A)
SO4  A 291 ( 3.4A)
None
 0.38A 6b68B-4c75A:
40.3		 6b68B-4c75A:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B68_D_9F2D400_1
(BETA-LACTAMASE)		 4c75 BETA-LACTAMASE
(synthetic
construct) 		8 / 12 SER A  70
SER A 130
ASN A 170
THR A 216
LYS A 234
GLY A 236
THR A 237
GLY A 238
 NA  A 294 ( 2.5A)
SO4  A 291 (-2.8A)
None
SO4  A 291 ( 4.1A)
SO4  A 291 (-3.4A)
NA  A 294 ( 3.2A)
SO4  A 291 ( 3.4A)
None
 0.42A 6b68D-4c75A:
40.3		 6b68D-4c75A:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B69_B_9F2B301_1
(BETA-LACTAMASE)		 4c75 BETA-LACTAMASE
(synthetic
construct) 		10 / 12 SER A  70
SER A 130
PRO A 167
ASN A 170
THR A 216
LYS A 234
THR A 235
GLY A 236
THR A 237
GLY A 238
 NA  A 294 ( 2.5A)
SO4  A 291 (-2.8A)
None
None
SO4  A 291 ( 4.1A)
SO4  A 291 (-3.4A)
SO4  A 291 (-3.8A)
NA  A 294 ( 3.2A)
SO4  A 291 ( 3.4A)
None
 0.36A 6b69A-4c75A:
40.2
6b69B-4c75A:
40.3		 6b69A-4c75A:
24.39
6b69B-4c75A:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B69_D_9F2D301_1
(BETA-LACTAMASE)		 4c75 BETA-LACTAMASE
(synthetic
construct) 		10 / 12 CYH A  69
SER A  70
SER A 130
ASN A 170
THR A 216
LYS A 234
THR A 235
GLY A 236
THR A 237
GLY A 238
 None
NA  A 294 ( 2.5A)
SO4  A 291 (-2.8A)
None
SO4  A 291 ( 4.1A)
SO4  A 291 (-3.4A)
SO4  A 291 (-3.8A)
NA  A 294 ( 3.2A)
SO4  A 291 ( 3.4A)
None
 0.35A 6b69D-4c75A:
40.3		 6b69D-4c75A:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B6A_B_9F2B301_1
(BETA-LACTAMASE)		 4c75 BETA-LACTAMASE
(synthetic
construct) 		10 / 12 CYH A  69
SER A  70
SER A 130
ASN A 170
THR A 216
LYS A 234
THR A 235
GLY A 236
THR A 237
GLY A 238
 None
NA  A 294 ( 2.5A)
SO4  A 291 (-2.8A)
None
SO4  A 291 ( 4.1A)
SO4  A 291 (-3.4A)
SO4  A 291 (-3.8A)
NA  A 294 ( 3.2A)
SO4  A 291 ( 3.4A)
None
 0.38A 6b6aB-4c75A:
40.1		 6b6aB-4c75A:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B6A_D_9F2D301_1
(BETA-LACTAMASE)		 4c75 BETA-LACTAMASE
(synthetic
construct) 		8 / 12 SER A  70
SER A 130
ASN A 170
LYS A 234
THR A 235
GLY A 236
THR A 237
GLY A 238
 NA  A 294 ( 2.5A)
SO4  A 291 (-2.8A)
None
SO4  A 291 (-3.4A)
SO4  A 291 (-3.8A)
NA  A 294 ( 3.2A)
SO4  A 291 ( 3.4A)
None
 0.32A 6b6aD-4c75A:
40.1		 6b6aD-4c75A:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B6C_A_9F2A301_1
(BETA-LACTAMASE)		 4c75 BETA-LACTAMASE
(synthetic
construct) 		9 / 12 SER A  70
SER A 130
PRO A 167
ASN A 170
LYS A 234
THR A 235
GLY A 236
THR A 237
GLY A 238
 NA  A 294 ( 2.5A)
SO4  A 291 (-2.8A)
None
None
SO4  A 291 (-3.4A)
SO4  A 291 (-3.8A)
NA  A 294 ( 3.2A)
SO4  A 291 ( 3.4A)
None
 0.44A 6b6cA-4c75A:
39.9		 6b6cA-4c75A:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B6D_A_9F2A302_1
(BETA-LACTAMASE)		 4c75 BETA-LACTAMASE
(synthetic
construct) 		10 / 12 CYH A  69
SER A  70
SER A 130
ASN A 170
THR A 216
LYS A 234
THR A 235
GLY A 236
THR A 237
GLY A 238
 None
NA  A 294 ( 2.5A)
SO4  A 291 (-2.8A)
None
SO4  A 291 ( 4.1A)
SO4  A 291 (-3.4A)
SO4  A 291 (-3.8A)
NA  A 294 ( 3.2A)
SO4  A 291 ( 3.4A)
None
 0.55A 6b6dA-4c75A:
39.9		 6b6dA-4c75A:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B6E_A_9F2A302_1
(BETA-LACTAMASE)		 4c75 BETA-LACTAMASE
(synthetic
construct) 		9 / 12 SER A  70
SER A 130
ASN A 170
THR A 216
LYS A 234
THR A 235
GLY A 236
THR A 237
GLY A 238
 NA  A 294 ( 2.5A)
SO4  A 291 (-2.8A)
None
SO4  A 291 ( 4.1A)
SO4  A 291 (-3.4A)
SO4  A 291 (-3.8A)
NA  A 294 ( 3.2A)
SO4  A 291 ( 3.4A)
None
 0.36A 6b6eA-4c75A:
40.0		 6b6eA-4c75A:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B6F_A_9F2A301_1
(BETA-LACTAMASE)		 4c75 BETA-LACTAMASE
(synthetic
construct) 		10 / 12 CYH A  69
SER A  70
SER A 130
PRO A 167
ASN A 170
LYS A 234
THR A 235
GLY A 236
THR A 237
GLY A 238
 None
NA  A 294 ( 2.5A)
SO4  A 291 (-2.8A)
None
None
SO4  A 291 (-3.4A)
SO4  A 291 (-3.8A)
NA  A 294 ( 3.2A)
SO4  A 291 ( 3.4A)
None
 0.49A 6b6fA-4c75A:
39.5		 6b6fA-4c75A:
24.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6C79_A_CE3A301_1
(BETA-LACTAMASE
TOHO-1)		 4c75 BETA-LACTAMASE
(synthetic
construct) 		8 / 12 TYR A 105
SER A 130
ASN A 132
ASN A 170
THR A 216
LYS A 234
GLY A 236
GLY A 238
 None
SO4  A 291 (-2.8A)
None
None
SO4  A 291 ( 4.1A)
SO4  A 291 (-3.4A)
NA  A 294 ( 3.2A)
None
 0.44A 6c79A-4c75A:
42.4		 6c79A-4c75A:
49.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DHB_A_BEZA202_0
(HEPATITIS A VIRUS
CELLULAR RECEPTOR 2)		 4c75 BETA-LACTAMASE
(synthetic
construct) 		4 / 6 ILE A 127
MET A 211
ASN A 214
ASP A 233
 None
 1.45A 6dhbA-4c75A:
undetectable		 6dhbA-4c75A:
17.69