SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4c76'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_A_STRA1001_2
(MINERALOCORTICOID
RECEPTOR)		 4c76 FMN REDUCTASE
(NADPH)
(Pseudomonas
putida) 		4 / 4 LEU A 100
LEU A  49
SER A  50
LEU A  93
 None
 1.13A 1ya3A-4c76A:
undetectable		 1ya3A-4c76A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZY_A_CHDA237_0
(PHOSPHOLIPASE A2,
MAJOR ISOENZYME)		 4c76 FMN REDUCTASE
(NADPH)
(Pseudomonas
putida) 		5 / 11 ILE A  73
HIS A  96
TYR A  90
GLY A  82
LEU A 133
 None
 1.02A 2azyA-4c76A:
undetectable		 2azyA-4c76A:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_E_TOPE200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4c76 FMN REDUCTASE
(NADPH)
(Pseudomonas
putida) 		5 / 10 LEU A  32
LEU A  80
VAL A 112
ILE A 167
LEU A 146
 None
 1.10A 3fl9E-4c76A:
undetectable		 3fl9E-4c76A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_B_REAB1501_1
(RETINOIC ACID
RECEPTOR BETA)		 4c76 FMN REDUCTASE
(NADPH)
(Pseudomonas
putida) 		5 / 12 ALA A  76
LEU A  80
LEU A  79
SER A 105
LEU A  36
 None
None
None
NA  A 201 (-4.8A)
None
 1.08A 4dm8B-4c76A:
undetectable		 4dm8B-4c76A:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 4c76 FMN REDUCTASE
(NADPH)
(Pseudomonas
putida) 		5 / 12 VAL A  10
PHE A 178
PHE A 177
LEU A 171
VAL A 170
 None
 1.19A 4ib4A-4c76A:
undetectable		 4ib4A-4c76A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4c76 FMN REDUCTASE
(NADPH)
(Pseudomonas
putida) 		4 / 4 GLY A 145
ALA A 114
MET A 125
THR A  21
 PGE  A 206 (-4.7A)
None
None
None
 1.43A 5n0sB-4c76A:
undetectable		 5n0sB-4c76A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_2
(CYTOCHROME P450 2C9)		 4c76 FMN REDUCTASE
(NADPH)
(Pseudomonas
putida) 		4 / 4 PHE A 164
LEU A  80
LEU A  24
VAL A 170
 None
 1.15A 5xxiA-4c76A:
undetectable		 5xxiA-4c76A:
16.59