SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4c7g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQP_A_803A311_1
(ANTIGEN CD11A (P180))		 4c7g BETA-N-ACETYLHEXOSAM
INIDASE
(Streptomyces
coelicolor) 		5 / 10 LEU A 112
VAL A 128
ILE A  25
LEU A  46
VAL A 105
 None
 0.85A 1cqpA-4c7gA:
2.6
1cqpB-4c7gA:
2.7		 1cqpA-4c7gA:
17.68
1cqpB-4c7gA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FO4_A_SALA3005_1
(XANTHINE
DEHYDROGENASE)		 4c7g BETA-N-ACETYLHEXOSAM
INIDASE
(Streptomyces
coelicolor) 		5 / 9 SER A 488
ARG A 487
VAL A 491
LEU A 471
ALA A 475
 None
 1.15A 1fo4A-4c7gA:
undetectable		 1fo4A-4c7gA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GAH_A_ACRA497_2
(GLUCOAMYLASE-471)		 4c7g BETA-N-ACETYLHEXOSAM
INIDASE
(Streptomyces
coelicolor) 		4 / 6 ALA A 114
TRP A 493
ARG A 487
TRP A 478
 None
 1.12A 1gahA-4c7gA:
undetectable		 1gahA-4c7gA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_D_TRPD81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4c7g BETA-N-ACETYLHEXOSAM
INIDASE
(Streptomyces
coelicolor) 		4 / 7 VAL A  91
GLY A  67
THR A  29
ILE A  68
 None
 0.64A 1gtnC-4c7gA:
undetectable
1gtnD-4c7gA:
undetectable		 1gtnC-4c7gA:
9.09
1gtnD-4c7gA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_L_TRPL81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4c7g BETA-N-ACETYLHEXOSAM
INIDASE
(Streptomyces
coelicolor) 		5 / 9 VAL A  91
GLY A  67
THR A  26
THR A  29
ILE A  68
 None
 1.08A 1gtnL-4c7gA:
undetectable
1gtnM-4c7gA:
undetectable		 1gtnL-4c7gA:
9.09
1gtnM-4c7gA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_G_BEZG1162_0
(PEROXIREDOXIN 5)		 4c7g BETA-N-ACETYLHEXOSAM
INIDASE
(Streptomyces
coelicolor) 		4 / 8 THR A 291
PRO A 292
GLY A 293
LEU A 175
 None
 0.73A 1h4oG-4c7gA:
undetectable		 1h4oG-4c7gA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_C_ADNC1503_1
(CLASS B ACID
PHOSPHATASE)		 4c7g BETA-N-ACETYLHEXOSAM
INIDASE
(Streptomyces
coelicolor) 		5 / 8 ASP A 441
PHE A 445
TYR A 168
LEU A 167
ASP A 163
 None
 1.37A 1rmtC-4c7gA:
undetectable		 1rmtC-4c7gA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_D_ADND1504_1
(CLASS B ACID
PHOSPHATASE)		 4c7g BETA-N-ACETYLHEXOSAM
INIDASE
(Streptomyces
coelicolor) 		5 / 8 ASP A 441
PHE A 445
TYR A 168
LEU A 167
ASP A 163
 None
 1.41A 1rmtD-4c7gA:
undetectable		 1rmtD-4c7gA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B8J_A_SPMA653_1
(CLASS B ACID
PHOSPHATASE)		 4c7g BETA-N-ACETYLHEXOSAM
INIDASE
(Streptomyces
coelicolor) 		5 / 9 ASP A 441
PHE A 445
TYR A 168
GLY A 482
TYR A 485
 None
 1.48A 2b8jA-4c7gA:
1.9		 2b8jA-4c7gA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RCT_A_RTLA140_1
(RETINOL-BINDING
PROTEIN II, CELLULAR)		 4c7g BETA-N-ACETYLHEXOSAM
INIDASE
(Streptomyces
coelicolor) 		3 / 3 GLN A 361
THR A 354
TRP A 349
 EDO  A1502 (-4.3A)
EDO  A1500 (-3.0A)
NGO  A1495 ( 3.4A)
 1.13A 2rctA-4c7gA:
undetectable		 2rctA-4c7gA:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_B_REAB1445_1
(PUTATIVE CYTOCHROME
P450 120)		 4c7g BETA-N-ACETYLHEXOSAM
INIDASE
(Streptomyces
coelicolor) 		5 / 12 PHE A 311
ALA A 366
VAL A 346
GLY A 331
PRO A 340
 EDO  A1503 (-3.6A)
None
None
None
None
 1.10A 2ve3B-4c7gA:
undetectable		 2ve3B-4c7gA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VL2_B_BEZB1162_0
(PEROXIREDOXIN-5)		 4c7g BETA-N-ACETYLHEXOSAM
INIDASE
(Streptomyces
coelicolor) 		4 / 7 THR A 291
PRO A 292
GLY A 293
LEU A 175
 None
 0.75A 2vl2B-4c7gA:
undetectable		 2vl2B-4c7gA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX7_A_SALA1336_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4c7g BETA-N-ACETYLHEXOSAM
INIDASE
(Streptomyces
coelicolor) 		4 / 8 SER A 488
ARG A 487
LEU A 471
ALA A 475
 None
 0.88A 3ax7A-4c7gA:
undetectable		 3ax7A-4c7gA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_A_SHHA301_1
(HISTONE DEACETYLASE
7A)		 4c7g BETA-N-ACETYLHEXOSAM
INIDASE
(Streptomyces
coelicolor) 		4 / 5 HIS A 176
ASP A 234
HIS A 238
ASP A 301
 None
None
NGO  A1495 (-4.0A)
NGO  A1495 (-3.8A)
 1.24A 3c0zA-4c7gA:
undetectable		 3c0zA-4c7gA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HAV_A_SRYA403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 4c7g BETA-N-ACETYLHEXOSAM
INIDASE
(Streptomyces
coelicolor) 		4 / 8 ASP A 441
ASP A 484
ASP A 163
ASP A 156
 None
EDO  A1504 (-2.8A)
None
None
 1.19A 3havA-4c7gA:
undetectable		 3havA-4c7gA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LMY_A_CP6A562_1
(BETA-HEXOSAMINIDASE
SUBUNIT BETA)		 4c7g BETA-N-ACETYLHEXOSAM
INIDASE
(Streptomyces
coelicolor) 		11 / 12 ARG A 150
HIS A 176
ASP A 179
ASP A 234
HIS A 238
ASP A 301
TRP A 349
TYR A 381
ASP A 383
TRP A 430
GLU A 432
 NGO  A1495 (-2.8A)
None
None
None
NGO  A1495 (-4.0A)
NGO  A1495 (-3.8A)
NGO  A1495 ( 3.4A)
NGO  A1495 (-4.5A)
NGO  A1495 (-3.0A)
NGO  A1495 (-3.6A)
NGO  A1495 (-2.7A)
 0.36A 3lmyA-4c7gA:
39.3		 3lmyA-4c7gA:
25.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LMY_A_CP6A562_1
(BETA-HEXOSAMINIDASE
SUBUNIT BETA)		 4c7g BETA-N-ACETYLHEXOSAM
INIDASE
(Streptomyces
coelicolor) 		5 / 12 HIS A 174
TRP A 349
TYR A 381
ASP A 383
TRP A 430
 None
NGO  A1495 ( 3.4A)
NGO  A1495 (-4.5A)
NGO  A1495 (-3.0A)
NGO  A1495 (-3.6A)
 1.49A 3lmyA-4c7gA:
39.3		 3lmyA-4c7gA:
25.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LMY_B_CP6B563_1
(BETA-HEXOSAMINIDASE
SUBUNIT BETA)		 4c7g BETA-N-ACETYLHEXOSAM
INIDASE
(Streptomyces
coelicolor) 		11 / 12 ARG A 150
HIS A 176
ASP A 179
ASP A 234
HIS A 238
ASP A 301
TRP A 332
TRP A 349
TYR A 381
TRP A 430
GLU A 432
 NGO  A1495 (-2.8A)
None
None
None
NGO  A1495 (-4.0A)
NGO  A1495 (-3.8A)
NGO  A1495 (-3.6A)
NGO  A1495 ( 3.4A)
NGO  A1495 (-4.5A)
NGO  A1495 (-3.6A)
NGO  A1495 (-2.7A)
 0.34A 3lmyB-4c7gA:
39.4		 3lmyB-4c7gA:
25.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4c7g BETA-N-ACETYLHEXOSAM
INIDASE
(Streptomyces
coelicolor) 		4 / 8 SER A 488
ARG A 487
LEU A 471
ALA A 475
 None
 0.97A 3ns1L-4c7gA:
undetectable		 3ns1L-4c7gA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_0
(YAEB-LIKE PROTEIN
RPA0152)		 4c7g BETA-N-ACETYLHEXOSAM
INIDASE
(Streptomyces
coelicolor) 		3 / 3 LYS A   1
ARG A  24
LYS A 118
 None
 1.17A 3okxA-4c7gA:
undetectable		 3okxA-4c7gA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNA_A_SALA1340_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4c7g BETA-N-ACETYLHEXOSAM
INIDASE
(Streptomyces
coelicolor) 		5 / 9 SER A 488
ARG A 487
VAL A 491
LEU A 471
ALA A 475
 None
 1.16A 3unaA-4c7gA:
undetectable		 3unaA-4c7gA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNA_B_SALB1340_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4c7g BETA-N-ACETYLHEXOSAM
INIDASE
(Streptomyces
coelicolor) 		5 / 9 SER A 488
ARG A 487
VAL A 491
LEU A 471
ALA A 475
 None
 1.17A 3unaB-4c7gA:
undetectable		 3unaB-4c7gA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 4c7g BETA-N-ACETYLHEXOSAM
INIDASE
(Streptomyces
coelicolor) 		3 / 3 TYR A  82
THR A 107
GLU A  80
 None
 0.81A 4df3A-4c7gA:
undetectable		 4df3A-4c7gA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_B_SAMB301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 4c7g BETA-N-ACETYLHEXOSAM
INIDASE
(Streptomyces
coelicolor) 		3 / 3 TYR A  82
THR A 107
GLU A  80
 None
 0.83A 4df3B-4c7gA:
undetectable		 4df3B-4c7gA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_F_ASWF101_1
(DNA TOPOISOMERASE
2-BETA)		 4c7g BETA-N-ACETYLHEXOSAM
INIDASE
(Streptomyces
coelicolor) 		4 / 6 GLY A 450
ALA A  12
GLU A 453
GLN A 490
 None
 1.12A 4g0uA-4c7gA:
undetectable		 4g0uA-4c7gA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTR_B_IZPB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 4c7g BETA-N-ACETYLHEXOSAM
INIDASE
(Streptomyces
coelicolor) 		4 / 6 TYR A 486
VAL A 402
TYR A 386
TRP A 493
 None
 1.42A 4jtrB-4c7gA:
10.2		 4jtrB-4c7gA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KN2_C_LYAC304_2
(FOLATE RECEPTOR BETA)		 4c7g BETA-N-ACETYLHEXOSAM
INIDASE
(Streptomyces
coelicolor) 		3 / 3 TYR A 467
GLN A 490
TRP A 408
 None
 1.11A 4kn2C-4c7gA:
undetectable		 4kn2C-4c7gA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_A_9TPA601_1
(SERUM ALBUMIN)		 4c7g BETA-N-ACETYLHEXOSAM
INIDASE
(Streptomyces
coelicolor) 		5 / 12 LEU A 108
ARG A 109
ALA A  39
TYR A  82
ILE A 133
 None
 1.33A 4l9qA-4c7gA:
undetectable		 4l9qA-4c7gA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_D_FOLD301_1
(FOLATE RECEPTOR
ALPHA)		 4c7g BETA-N-ACETYLHEXOSAM
INIDASE
(Streptomyces
coelicolor) 		3 / 3 HIS A 176
TRP A 349
SER A 149
 None
NGO  A1495 ( 3.4A)
None
 1.17A 4lrhD-4c7gA:
undetectable		 4lrhD-4c7gA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMA_A_CXXA603_1
(TRANSPORTER)		 4c7g BETA-N-ACETYLHEXOSAM
INIDASE
(Streptomyces
coelicolor) 		5 / 11 TYR A 161
PRO A 449
VAL A 451
ALA A 452
THR A 380
 None
 1.19A 4mmaA-4c7gA:
undetectable		 4mmaA-4c7gA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESF_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4c7g BETA-N-ACETYLHEXOSAM
INIDASE
(Streptomyces
coelicolor) 		4 / 8 ILE A 162
TYR A 221
PHE A 102
LEU A  49
 None
None
EDO  A1498 ( 4.7A)
None
 0.90A 5esfA-4c7gA:
undetectable		 5esfA-4c7gA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_B_SAMB601_1
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 4c7g BETA-N-ACETYLHEXOSAM
INIDASE
(Streptomyces
coelicolor) 		4 / 7 GLY A 207
GLY A 198
GLU A 201
THR A 431
 None
 0.77A 5ybbB-4c7gA:
undetectable		 5ybbB-4c7gA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BC9_A_ETSA302_2
(CARBONIC ANHYDRASE 2)		 4c7g BETA-N-ACETYLHEXOSAM
INIDASE
(Streptomyces
coelicolor) 		4 / 5 HIS A 333
GLU A 232
HIS A 174
LEU A 382
 EDO  A1502 ( 4.2A)
None
None
None
 1.17A 6bc9A-4c7gA:
undetectable		 6bc9A-4c7gA:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GQI_A_ACTA604_0
(CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE)		 4c7g BETA-N-ACETYLHEXOSAM
INIDASE
(Streptomyces
coelicolor) 		4 / 6 ILE A  10
GLY A 450
TYR A 168
GLU A 453
 None
 1.08A 6gqiA-4c7gA:
undetectable		 6gqiA-4c7gA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IE8_A_CHDA201_0
(REGULATORY PROTEIN)		 4c7g BETA-N-ACETYLHEXOSAM
INIDASE
(Streptomyces
coelicolor) 		5 / 12 LEU A 146
ILE A 162
TYR A 161
ARG A 142
LEU A 448
 None
 1.28A 6ie8A-4c7gA:
undetectable		 6ie8A-4c7gA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN8_A_GLYA607_0
(UNCHARACTERIZED
PROTEIN)		 4c7g BETA-N-ACETYLHEXOSAM
INIDASE
(Streptomyces
coelicolor) 		4 / 4 GLU A 232
ASP A 147
ARG A 150
TRP A 430
 None
None
NGO  A1495 (-2.8A)
NGO  A1495 (-3.6A)
 1.08A 6mn8A-4c7gA:
undetectable		 6mn8A-4c7gA:
21.28