SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4c7m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1YA4_C_CTXC1383_1 (CES1 PROTEIN)	4c7m	TIR DOMAIN-CONTAINING PROTEIN (Brucella melitensis)	4 / 5	PRO A 224 LEU A 226 GLY A 202 LYS A 229	None	1.49A	1ya4C-4c7mA: 1.7	1ya4C-4c7mA: 14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4P65_E_IPHE101_0 (INSULIN)	4c7m	TIR DOMAIN-CONTAINING PROTEIN (Brucella melitensis)	5 / 11	ILE A 148 LEU A 137 HIS A 247 LEU A 246 ALA A 243	None	1.06A	4p65E-4c7mA: undetectable 4p65F-4c7mA: undetectable 4p65J-4c7mA: undetectable 4p65L-4c7mA: undetectable	4p65E-4c7mA: 14.29 4p65F-4c7mA: 19.51 4p65J-4c7mA: 19.51 4p65L-4c7mA: 19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HFJ_A_SAMA301_0 (ADENINE SPECIFIC DNA METHYLTRANSFERASE (DPNA))	4c7m	TIR DOMAIN-CONTAINING PROTEIN (Brucella melitensis)	5 / 12	ASP A 120 ALA A 119 ASP A 151 PHE A 149 THR A 154	None	1.07A	5hfjA-4c7mA: undetectable	5hfjA-4c7mA: 20.25