SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4c7n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_A_LEIA16_0
(COIL SER L16D-PEN)		 4c7n MICROPHTHALMIA
ASSOCIATED
TRANSCRIPTION FACTOR
SYNTHETIC
ALPHA-HELIX, IM10
(Homo
sapiens;
synthetic
construct) 		4 / 6 GLN A  39
LEU A  41
GLU A  42
LEU B  42
 None
 0.80A 3h5gA-4c7nA:
undetectable
3h5gC-4c7nA:
undetectable		 3h5gA-4c7nA:
26.00
3h5gC-4c7nA:
26.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_A_LEIA16_0
(COIL SER L16D-PEN)		 4c7n MICROPHTHALMIA
ASSOCIATED
TRANSCRIPTION FACTOR
SYNTHETIC
ALPHA-HELIX, IM10
(Homo
sapiens;
synthetic
construct) 		4 / 6 GLN B  40
LEU B  42
GLU B  43
LEU A  41
 None
 0.69A 3h5gA-4c7nB:
undetectable
3h5gC-4c7nB:
undetectable		 3h5gA-4c7nB:
22.64
3h5gC-4c7nB:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_A_ACTA502_0
(RNA-DEPENDENT RNA
POLYMERASE)		 4c7n MICROPHTHALMIA
ASSOCIATED
TRANSCRIPTION FACTOR
SYNTHETIC
ALPHA-HELIX, IM10
(Homo
sapiens;
synthetic
construct) 		4 / 5 LYS A  18
LEU A  20
GLU A  21
LEU B  21
 None
 1.20A 4k4yA-4c7nA:
undetectable		 4k4yA-4c7nA:
6.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_A_ACTA502_0
(RNA-DEPENDENT RNA
POLYMERASE)		 4c7n MICROPHTHALMIA
ASSOCIATED
TRANSCRIPTION FACTOR
SYNTHETIC
ALPHA-HELIX, IM10
(Homo
sapiens;
synthetic
construct) 		4 / 5 LYS B  26
LEU B  25
GLU B  22
LEU A  20
 None
 1.29A 4k4yA-4c7nB:
undetectable		 4k4yA-4c7nB:
7.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_E_ACTE503_0
(RNA-DEPENDENT RNA
POLYMERASE)		 4c7n MICROPHTHALMIA
ASSOCIATED
TRANSCRIPTION FACTOR
SYNTHETIC
ALPHA-HELIX, IM10
(Homo
sapiens;
synthetic
construct) 		4 / 4 LYS A  18
LEU A  20
GLU A  21
LEU B  21
 None
 1.20A 4k4yE-4c7nA:
undetectable		 4k4yE-4c7nA:
6.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_E_ACTE503_0
(RNA-DEPENDENT RNA
POLYMERASE)		 4c7n MICROPHTHALMIA
ASSOCIATED
TRANSCRIPTION FACTOR
SYNTHETIC
ALPHA-HELIX, IM10
(Homo
sapiens;
synthetic
construct) 		4 / 4 LYS B  26
LEU B  25
GLU B  22
LEU A  20
 None
 1.32A 4k4yE-4c7nB:
undetectable		 4k4yE-4c7nB:
7.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_I_ACTI503_0
(RNA-DEPENDENT RNA
POLYMERASE)		 4c7n MICROPHTHALMIA
ASSOCIATED
TRANSCRIPTION FACTOR
SYNTHETIC
ALPHA-HELIX, IM10
(Homo
sapiens;
synthetic
construct) 		4 / 5 LYS A  18
LEU A  20
GLU A  21
LEU B  21
 None
 1.20A 4k4yI-4c7nA:
undetectable		 4k4yI-4c7nA:
6.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_I_ACTI503_0
(RNA-DEPENDENT RNA
POLYMERASE)		 4c7n MICROPHTHALMIA
ASSOCIATED
TRANSCRIPTION FACTOR
SYNTHETIC
ALPHA-HELIX, IM10
(Homo
sapiens;
synthetic
construct) 		4 / 5 LYS B  26
LEU B  25
GLU B  22
LEU A  20
 None
 1.27A 4k4yI-4c7nB:
undetectable		 4k4yI-4c7nB:
7.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L3G_F_ACTF401_0
(METHYLAMINE
DEHYDROGENASE HEAVY
CHAIN)		 4c7n SYNTHETIC
ALPHA-HELIX, IM10
(synthetic
construct) 		3 / 3 ARG B  17
LEU B  21
GLU B  20
 None
None
HG  B1056 (-3.9A)
 0.75A 4l3gF-4c7nB:
undetectable		 4l3gF-4c7nB:
8.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8F_A_ACTA803_0
(UNCHARACTERIZED
PROTEIN)		 4c7n MICROPHTHALMIA
ASSOCIATED
TRANSCRIPTION FACTOR
SYNTHETIC
ALPHA-HELIX, IM10
(Homo
sapiens;
synthetic
construct) 		3 / 3 GLU A  19
LEU A  20
ARG B  17
 None
 0.82A 6d8fA-4c7nA:
undetectable		 6d8fA-4c7nA:
5.91