SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4c7o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_B_SAMB402_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 4c7o SIGNAL RECOGNITION
PARTICLE PROTEIN
(Escherichia
coli) 		5 / 12 THR A 115
GLY A 112
GLY A 110
VAL A 220
GLY A 276
 GDP  A1003 (-3.5A)
GDP  A1003 (-3.2A)
GDP  A1003 ( 3.2A)
None
GDP  A1003 (-3.4A)
 0.95A 1n2xB-4c7oA:
2.6		 1n2xB-4c7oA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITZ_A_IREA2021_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4c7o SIGNAL RECOGNITION
PARTICLE PROTEIN
(Escherichia
coli) 		3 / 3 LEU A 133
LEU A 104
MET A 105
 None
 0.83A 2itzA-4c7oA:
undetectable		 2itzA-4c7oA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIA_B_CL9B401_2
(DEOXYCYTIDINE KINASE)		 4c7o SIGNAL RECOGNITION
PARTICLE PROTEIN
(Escherichia
coli) 		4 / 4 ARG A 255
ASP A  42
LEU A 260
ARG A   8
 None
 1.42A 2ziaB-4c7oA:
6.0		 2ziaB-4c7oA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZLC_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 4c7o SIGNAL RECOGNITION
PARTICLE PROTEIN
(Escherichia
coli) 		5 / 12 LEU A 187
VAL A 102
VAL A 208
HIS A 209
LEU A 240
 None
 1.43A 2zlcA-4c7oA:
undetectable		 2zlcA-4c7oA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZM_A_SAMA401_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 4c7o SIGNAL RECOGNITION
PARTICLE PROTEIN
(Escherichia
coli) 		5 / 12 ARG A  79
GLY A  71
ILE A  77
VAL A  55
PHE A  51
 None
 1.07A 2zzmA-4c7oA:
undetectable		 2zzmA-4c7oA:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_A_PAUA248_0
(TYPE III
PANTOTHENATE KINASE)		 4c7o SIGNAL RECOGNITION
PARTICLE PROTEIN
(Escherichia
coli) 		5 / 11 GLY A 107
THR A 191
ILE A 205
THR A 217
LEU A 240
 None
 1.35A 3bf1A-4c7oA:
undetectable
3bf1B-4c7oA:
1.9		 3bf1A-4c7oA:
22.91
3bf1B-4c7oA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LS4_H_TCIH220_1
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT)		 4c7o SIGNAL RECOGNITION
PARTICLE PROTEIN
(Escherichia
coli) 		5 / 10 VAL A 132
VAL A 134
LEU A 148
GLY A 121
GLY A 118
 None
 1.20A 3ls4H-4c7oA:
undetectable		 3ls4H-4c7oA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA451_1
(CYTOCHROME P450
164A2)		 4c7o SIGNAL RECOGNITION
PARTICLE PROTEIN
(Escherichia
coli) 		5 / 10 LEU A 240
ALA A 106
THR A 191
VAL A 189
VAL A 102
 None
 1.41A 3r9cA-4c7oA:
undetectable		 3r9cA-4c7oA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V7P_A_BEZA430_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 4c7o SIGNAL RECOGNITION
PARTICLE PROTEIN
(Escherichia
coli) 		4 / 7 ILE A 294
GLY A 256
PHE A 285
LEU A 247
 None
 0.82A 3v7pA-4c7oA:
undetectable		 3v7pA-4c7oA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FWD_A_BO2A801_1
(TTC1975 PEPTIDASE)		 4c7o SIGNAL RECOGNITION
PARTICLE PROTEIN
(Escherichia
coli) 		5 / 9 VAL A 246
VAL A 245
VAL A 103
GLY A 107
ALA A 111
 None
None
None
None
GDP  A1003 (-4.1A)
 0.98A 4fwdA-4c7oA:
1.9		 4fwdA-4c7oA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECO_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4c7o SIGNAL RECOGNITION
PARTICLE PROTEIN
(Escherichia
coli) 		4 / 6 THR A 191
ALA A 137
VAL A 139
TYR A 140
 None
 0.82A 5ecoA-4c7oA:
2.5		 5ecoA-4c7oA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4c7o SIGNAL RECOGNITION
PARTICLE PROTEIN
(Escherichia
coli) 		4 / 4 GLY A 193
ALA A 111
MET A 105
THR A 248
 ALF  A1001 (-3.1A)
GDP  A1003 (-4.1A)
None
GDP  A1003 ( 4.4A)
 1.49A 5n0sB-4c7oA:
5.6		 5n0sB-4c7oA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QXS_D_FOZD403_0
(THYMIDYLATE SYNTHASE)		 4c7o SIGNAL RECOGNITION
PARTICLE PROTEIN
(Escherichia
coli) 		5 / 12 PRO A 214
LEU A 104
LEU A 242
GLY A 244
ALA A 233
 None
 1.01A 6qxsD-4c7oA:
undetectable		 6qxsD-4c7oA:
21.94