SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4c7v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM4_A_DXCA1001_0
(MAJOR POLLEN
ALLERGEN BET V 1-L)		 4c7v TRANSKETOLASE
(Lactobacillus
salivarius) 		5 / 12 PRO A 585
ILE A 354
TYR A 348
ALA A 501
SER A 500
 None
 0.97A 1fm4A-4c7vA:
undetectable		 1fm4A-4c7vA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_A_BEZA1162_0
(PEROXIREDOXIN 5)		 4c7v TRANSKETOLASE
(Lactobacillus
salivarius) 		5 / 10 PRO A 101
THR A 109
GLY A 107
CYH A 108
LEU A  74
 None
 1.41A 1h4oA-4c7vA:
undetectable
1h4oB-4c7vA:
undetectable		 1h4oA-4c7vA:
14.01
1h4oB-4c7vA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_G_BEZG1162_0
(PEROXIREDOXIN 5)		 4c7v TRANSKETOLASE
(Lactobacillus
salivarius) 		5 / 8 PRO A 101
THR A 109
GLY A 107
CYH A 108
LEU A  74
 None
 1.39A 1h4oG-4c7vA:
undetectable		 1h4oG-4c7vA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_1
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 4c7v TRANSKETOLASE
(Lactobacillus
salivarius) 		4 / 7 LEU A 178
ILE A 216
THR A 242
GLN A 233
 None
 1.10A 1kglA-4c7vA:
undetectable		 1kglA-4c7vA:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_B_SAMB1293_1
(GLYCINE
N-METHYLTRANSFERASE)		 4c7v TRANSKETOLASE
(Lactobacillus
salivarius) 		4 / 5 ASP A 331
SER A 330
ASN A 335
SER A 372
 None
 1.31A 1kiaB-4c7vA:
2.8		 1kiaB-4c7vA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_C_SAMC2293_1
(GLYCINE
N-METHYLTRANSFERASE)		 4c7v TRANSKETOLASE
(Lactobacillus
salivarius) 		4 / 6 ASP A 331
SER A 330
ASN A 335
SER A 372
 None
 1.32A 1kiaC-4c7vA:
2.7		 1kiaC-4c7vA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 4c7v TRANSKETOLASE
(Lactobacillus
salivarius) 		4 / 5 ILE A 528
LEU A 526
VAL A 562
ALA A 614
 None
 0.98A 1mz9C-4c7vA:
undetectable		 1mz9C-4c7vA:
5.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 4c7v TRANSKETOLASE
(Lactobacillus
salivarius) 		4 / 6 ARG A 207
ILE A 156
PHE A 208
GLU A 245
 None
 1.41A 1nsiA-4c7vA:
undetectable
1nsiB-4c7vA:
undetectable		 1nsiA-4c7vA:
22.69
1nsiB-4c7vA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 4c7v TRANSKETOLASE
(Lactobacillus
salivarius) 		4 / 6 PHE A 208
GLU A 245
ARG A 207
ILE A 156
 None
 1.41A 1nsiA-4c7vA:
undetectable
1nsiB-4c7vA:
undetectable		 1nsiA-4c7vA:
22.69
1nsiB-4c7vA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_C_H4BC602_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 4c7v TRANSKETOLASE
(Lactobacillus
salivarius) 		4 / 6 ARG A 207
ILE A 156
PHE A 208
GLU A 245
 None
 1.44A 1nsiC-4c7vA:
undetectable
1nsiD-4c7vA:
undetectable		 1nsiC-4c7vA:
22.69
1nsiD-4c7vA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_D_H4BD603_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 4c7v TRANSKETOLASE
(Lactobacillus
salivarius) 		4 / 6 PHE A 208
GLU A 245
ARG A 207
ILE A 156
 None
 1.44A 1nsiC-4c7vA:
undetectable
1nsiD-4c7vA:
undetectable		 1nsiC-4c7vA:
22.69
1nsiD-4c7vA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OLT_A_SAMA501_0
(OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE)		 4c7v TRANSKETOLASE
(Lactobacillus
salivarius) 		5 / 12 THR A 248
GLU A 245
ASP A 186
GLY A 157
ALA A 198
 None
 1.31A 1oltA-4c7vA:
undetectable		 1oltA-4c7vA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OLT_A_SAMA501_0
(OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE)		 4c7v TRANSKETOLASE
(Lactobacillus
salivarius) 		5 / 12 THR A 248
GLU A 245
GLY A 157
PHE A 200
ALA A 198
 None
 1.15A 1oltA-4c7vA:
undetectable		 1oltA-4c7vA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA502_1
(YKOF)		 4c7v TRANSKETOLASE
(Lactobacillus
salivarius) 		4 / 6 ALA A 173
LEU A 176
SER A 171
CYH A 416
 None
 0.97A 1sbrA-4c7vA:
undetectable
1sbrB-4c7vA:
undetectable		 1sbrA-4c7vA:
15.84
1sbrB-4c7vA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_C_SAMC303_0
(HEMK PROTEIN)		 4c7v TRANSKETOLASE
(Lactobacillus
salivarius) 		5 / 12 ILE A 421
GLY A 413
ALA A 379
SER A 124
ALA A 444
 None
 1.17A 1sg9C-4c7vA:
3.0		 1sg9C-4c7vA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_B_DESB128_1
(TRANSTHYRETIN)		 4c7v TRANSKETOLASE
(Lactobacillus
salivarius) 		5 / 11 LEU A 479
SER A 463
LEU A 518
SER A 560
THR A 558
 None
 1.25A 1tz8A-4c7vA:
undetectable
1tz8B-4c7vA:
undetectable		 1tz8A-4c7vA:
13.64
1tz8B-4c7vA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_A_ACTA294_0
(GLYCINE
N-METHYLTRANSFERASE)		 4c7v TRANSKETOLASE
(Lactobacillus
salivarius) 		4 / 5 ILE A 633
LEU A 646
ALA A 465
GLU A 474
 None
 1.27A 1xvaA-4c7vA:
3.1
1xvaB-4c7vA:
2.8		 1xvaA-4c7vA:
19.31
1xvaB-4c7vA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 4c7v TRANSKETOLASE
(Lactobacillus
salivarius) 		4 / 7 ARG A 207
ILE A 156
PHE A 208
GLU A 245
 None
 1.37A 2nsiA-4c7vA:
undetectable
2nsiB-4c7vA:
undetectable		 2nsiA-4c7vA:
22.69
2nsiB-4c7vA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 4c7v TRANSKETOLASE
(Lactobacillus
salivarius) 		4 / 7 PHE A 208
GLU A 245
ARG A 207
ILE A 156
 None
 1.39A 2nsiA-4c7vA:
undetectable
2nsiB-4c7vA:
undetectable		 2nsiA-4c7vA:
22.69
2nsiB-4c7vA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_C_H4BC602_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 4c7v TRANSKETOLASE
(Lactobacillus
salivarius) 		4 / 7 ARG A 207
ILE A 156
PHE A 208
GLU A 245
 None
 1.40A 2nsiC-4c7vA:
undetectable
2nsiD-4c7vA:
undetectable		 2nsiC-4c7vA:
22.69
2nsiD-4c7vA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_D_H4BD603_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 4c7v TRANSKETOLASE
(Lactobacillus
salivarius) 		4 / 7 PHE A 208
GLU A 245
ARG A 207
ILE A 156
 None
 1.41A 2nsiC-4c7vA:
undetectable
2nsiD-4c7vA:
undetectable		 2nsiC-4c7vA:
22.69
2nsiD-4c7vA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A35_B_RBFB191_1
(LUMAZINE PROTEIN)		 4c7v TRANSKETOLASE
(Lactobacillus
salivarius) 		5 / 12 SER A 519
LEU A 518
THR A 460
ALA A 359
ASN A 522
 None
 1.20A 3a35B-4c7vA:
undetectable		 3a35B-4c7vA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A35_B_RBFB191_1
(LUMAZINE PROTEIN)		 4c7v TRANSKETOLASE
(Lactobacillus
salivarius) 		5 / 12 THR A 152
ALA A 114
THR A 115
THR A 116
ASN A 419
 None
 1.22A 3a35B-4c7vA:
undetectable		 3a35B-4c7vA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A3B_A_RBFA191_1
(LUMAZINE PROTEIN)		 4c7v TRANSKETOLASE
(Lactobacillus
salivarius) 		5 / 12 SER A 519
LEU A 518
THR A 460
ALA A 359
ASN A 522
 None
 1.21A 3a3bA-4c7vA:
undetectable		 3a3bA-4c7vA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS8_A_BRLA503_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4c7v TRANSKETOLASE
(Lactobacillus
salivarius) 		5 / 12 GLY A 496
SER A 360
ILE A 364
LEU A 367
LEU A 518
 None
 1.34A 3cs8A-4c7vA:
undetectable		 3cs8A-4c7vA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_3
(HIV-1 PROTEASE)		 4c7v TRANSKETOLASE
(Lactobacillus
salivarius) 		5 / 12 GLY A 615
ALA A 614
GLY A 559
VAL A 517
VAL A 466
 None
 0.96A 3cyxB-4c7vA:
undetectable		 3cyxB-4c7vA:
9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D41_A_FCNA4001_1
(FOMA PROTEIN)		 4c7v TRANSKETOLASE
(Lactobacillus
salivarius) 		5 / 8 GLY A 332
GLY A 426
GLY A 425
ILE A 421
SER A 373
 None
 1.36A 3d41A-4c7vA:
undetectable		 3d41A-4c7vA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZG_B_NCAB302_0
(ADP-RIBOSYL CYCLASE
1)		 4c7v TRANSKETOLASE
(Lactobacillus
salivarius) 		4 / 7 TRP A 587
LEU A 479
GLU A 613
THR A 484
 None
 1.31A 3dzgB-4c7vA:
undetectable		 3dzgB-4c7vA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4c7v TRANSKETOLASE
(Lactobacillus
salivarius) 		4 / 7 ARG A 207
ILE A 156
PHE A 208
GLU A 245
 None
 1.40A 3e7gA-4c7vA:
undetectable
3e7gB-4c7vA:
undetectable		 3e7gA-4c7vA:
20.75
3e7gB-4c7vA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_B_H4BB1902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4c7v TRANSKETOLASE
(Lactobacillus
salivarius) 		4 / 7 PHE A 208
GLU A 245
ARG A 207
ILE A 156
 None
 1.40A 3e7gA-4c7vA:
undetectable
3e7gB-4c7vA:
undetectable		 3e7gA-4c7vA:
20.75
3e7gB-4c7vA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_C_H4BC2902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4c7v TRANSKETOLASE
(Lactobacillus
salivarius) 		4 / 7 ARG A 207
ILE A 156
PHE A 208
GLU A 245
 None
 1.42A 3e7gC-4c7vA:
undetectable
3e7gD-4c7vA:
undetectable		 3e7gC-4c7vA:
20.75
3e7gD-4c7vA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_D_H4BD3902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4c7v TRANSKETOLASE
(Lactobacillus
salivarius) 		4 / 8 PHE A 208
GLU A 245
ARG A 207
ILE A 156
 None
 1.43A 3e7gC-4c7vA:
undetectable
3e7gD-4c7vA:
undetectable		 3e7gC-4c7vA:
20.75
3e7gD-4c7vA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL0_A_1UNA201_2
(PROTEASE)		 4c7v TRANSKETOLASE
(Lactobacillus
salivarius) 		5 / 9 LEU A 441
VAL A 165
GLY A 128
ILE A 421
ALA A 444
 None
 1.01A 3el0B-4c7vA:
undetectable		 3el0B-4c7vA:
9.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_B_ADNB301_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 4c7v TRANSKETOLASE
(Lactobacillus
salivarius) 		5 / 12 GLY A 540
GLU A 498
VAL A 537
GLY A 536
VAL A 601
 None
 1.25A 3f8wB-4c7vA:
undetectable		 3f8wB-4c7vA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_F_TOPF200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4c7v TRANSKETOLASE
(Lactobacillus
salivarius) 		5 / 10 ALA A 173
ALA A 154
ILE A 156
LEU A 161
PHE A 208
 None
 1.23A 3fl9F-4c7vA:
undetectable		 3fl9F-4c7vA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 4c7v TRANSKETOLASE
(Lactobacillus
salivarius) 		5 / 12 GLN A 121
GLY A 120
LEU A 161
GLU A 168
ALA A 169
 None
 1.16A 3kkzA-4c7vA:
undetectable		 3kkzA-4c7vA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXI_B_CAMB423_0
(CYTOCHROME P450)		 4c7v TRANSKETOLASE
(Lactobacillus
salivarius) 		5 / 11 THR A  44
THR A  12
LEU A  80
VAL A   5
ASP A   6
 None
 1.09A 3lxiB-4c7vA:
undetectable		 3lxiB-4c7vA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_E_P77E203_1
(PROTEIN S100-A4)		 4c7v TRANSKETOLASE
(Lactobacillus
salivarius) 		4 / 8 SER A  17
PHE A 222
LEU A 184
ASP A 186
 None
 0.83A 3m0wE-4c7vA:
undetectable
3m0wF-4c7vA:
undetectable
3m0wG-4c7vA:
1.6
3m0wH-4c7vA:
1.8		 3m0wE-4c7vA:
9.22
3m0wF-4c7vA:
9.22
3m0wG-4c7vA:
9.22
3m0wH-4c7vA:
9.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 4c7v TRANSKETOLASE
(Lactobacillus
salivarius) 		3 / 3 PHE A 412
SER A 124
GLN A 121
 None
 0.99A 3smtA-4c7vA:
undetectable		 3smtA-4c7vA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_B_T1CB405_1
(TETX2 PROTEIN)		 4c7v TRANSKETOLASE
(Lactobacillus
salivarius) 		5 / 12 ASN A 256
GLY A 264
PRO A  32
ALA A  35
GLY A  34
 None
 1.27A 3v3oB-4c7vA:
undetectable		 3v3oB-4c7vA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_A_SAMA501_0
(MNMC2)		 4c7v TRANSKETOLASE
(Lactobacillus
salivarius) 		5 / 12 GLY A 251
GLY A 258
ASN A 188
ALA A 275
LEU A 267
 None
 1.13A 3vywA-4c7vA:
2.5		 3vywA-4c7vA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_B_SAMB401_0
(MNMC2)		 4c7v TRANSKETOLASE
(Lactobacillus
salivarius) 		5 / 12 GLY A 251
GLY A 258
ASN A 188
ALA A 275
LEU A 267
 None
 1.15A 3vywB-4c7vA:
2.7		 3vywB-4c7vA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_D_SAMD401_0
(MNMC2)		 4c7v TRANSKETOLASE
(Lactobacillus
salivarius) 		5 / 12 GLY A 251
GLY A 258
ASN A 188
ALA A 275
LEU A 267
 None
 1.15A 3vywD-4c7vA:
2.6		 3vywD-4c7vA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6D_A_SAMA1350_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 4c7v TRANSKETOLASE
(Lactobacillus
salivarius) 		5 / 12 LEU A 224
GLY A 221
ILE A 244
VAL A 218
ALA A  36
 None
 1.16A 4a6dA-4c7vA:
3.2		 4a6dA-4c7vA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 4c7v TRANSKETOLASE
(Lactobacillus
salivarius) 		5 / 12 LEU A 224
GLY A 221
ILE A 244
VAL A 218
ALA A  36
 None
 1.14A 4a6eA-4c7vA:
3.5		 4a6eA-4c7vA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_A_T1CA392_1
(TETX2 PROTEIN)		 4c7v TRANSKETOLASE
(Lactobacillus
salivarius) 		5 / 11 ASN A 256
GLY A 264
PRO A  32
ALA A  35
GLY A  34
 None
 1.31A 4a6nA-4c7vA:
undetectable		 4a6nA-4c7vA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1476_0
(MJ0495-LIKE PROTEIN)		 4c7v TRANSKETOLASE
(Lactobacillus
salivarius) 		4 / 5 ILE A 405
ALA A 417
HIS A 135
MET A 131
 None
 1.06A 4ac9B-4c7vA:
undetectable
4ac9C-4c7vA:
undetectable		 4ac9B-4c7vA:
24.06
4ac9C-4c7vA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1476_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4c7v TRANSKETOLASE
(Lactobacillus
salivarius) 		4 / 5 ILE A 405
ALA A 417
HIS A 135
MET A 131
 None
 1.06A 4acaB-4c7vA:
2.1
4acaC-4c7vA:
undetectable		 4acaB-4c7vA:
24.06
4acaC-4c7vA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_B_CAMB1420_0
(CYTOCHROME P450)		 4c7v TRANSKETOLASE
(Lactobacillus
salivarius) 		5 / 10 THR A  44
THR A  12
LEU A  80
VAL A   5
ASP A   6
 None
 1.16A 4c9nB-4c7vA:
undetectable		 4c9nB-4c7vA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4c7v TRANSKETOLASE
(Lactobacillus
salivarius) 		4 / 8 PHE A 208
GLU A 245
ARG A 207
ILE A 156
 None
 1.36A 4cx7A-4c7vA:
undetectable
4cx7B-4c7vA:
undetectable		 4cx7A-4c7vA:
22.69
4cx7B-4c7vA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_D_H4BD600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4c7v TRANSKETOLASE
(Lactobacillus
salivarius) 		4 / 7 PHE A 208
GLU A 245
ARG A 207
ILE A 156
 None
 1.31A 4cx7C-4c7vA:
undetectable
4cx7D-4c7vA:
undetectable		 4cx7C-4c7vA:
22.69
4cx7D-4c7vA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7H_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 4c7v TRANSKETOLASE
(Lactobacillus
salivarius) 		3 / 3 ARG A 492
THR A 617
TRP A 620
 None
 1.16A 4d7hA-4c7vA:
undetectable		 4d7hA-4c7vA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DA7_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4c7v TRANSKETOLASE
(Lactobacillus
salivarius) 		5 / 10 GLY A 221
ALA A 230
VAL A 218
GLU A 226
GLU A 225
 None
 1.26A 4da7A-4c7vA:
2.4		 4da7A-4c7vA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3A_B_ADNB500_1
(SUGAR KINASE PROTEIN)		 4c7v TRANSKETOLASE
(Lactobacillus
salivarius) 		6 / 12 ILE A 123
ASP A 160
GLY A 120
GLY A 122
LEU A 181
GLY A  68
 None
 1.14A 4e3aB-4c7vA:
undetectable		 4e3aB-4c7vA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_A_NCTA501_1
(CYTOCHROME P450 2A6)		 4c7v TRANSKETOLASE
(Lactobacillus
salivarius) 		4 / 7 ASN A 419
GLY A 128
ILE A 405
PHE A 407
 None
 0.92A 4ejjA-4c7vA:
undetectable		 4ejjA-4c7vA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4c7v TRANSKETOLASE
(Lactobacillus
salivarius) 		4 / 7 GLY A 268
GLY A 271
ASN A 256
GLU A 269
 None
 1.10A 4fgkB-4c7vA:
3.9		 4fgkB-4c7vA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FN9_B_STRB301_1
(STEROID RECEPTOR 2)		 4c7v TRANSKETOLASE
(Lactobacillus
salivarius) 		5 / 12 LEU A  65
LEU A 155
LEU A 184
ALA A 183
THR A 116
 None
 1.13A 4fn9B-4c7vA:
undetectable		 4fn9B-4c7vA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		 4c7v TRANSKETOLASE
(Lactobacillus
salivarius) 		3 / 3 PRO A 104
TYR A  75
GLY A  70
 None
 0.72A 4g2zA-4c7vA:
undetectable		 4g2zA-4c7vA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I00_A_ZMRA509_2
(NEURAMINIDASE)		 4c7v TRANSKETOLASE
(Lactobacillus
salivarius) 		4 / 5 LEU A 345
TRP A 503
ILE A 456
ASN A 335
 None
 1.02A 4i00A-4c7vA:
undetectable		 4i00A-4c7vA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_B_H4BB1011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 4c7v TRANSKETOLASE
(Lactobacillus
salivarius) 		4 / 7 PHE A 208
GLU A 245
ARG A 207
ILE A 156
 None
 1.44A 4nosA-4c7vA:
undetectable
4nosB-4c7vA:
undetectable		 4nosA-4c7vA:
20.61
4nosB-4c7vA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_C_H4BC2011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 4c7v TRANSKETOLASE
(Lactobacillus
salivarius) 		4 / 7 ARG A 207
ILE A 156
PHE A 208
GLU A 245
 None
 1.38A 4nosC-4c7vA:
undetectable
4nosD-4c7vA:
undetectable		 4nosC-4c7vA:
20.61
4nosD-4c7vA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_C_377C402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4c7v TRANSKETOLASE
(Lactobacillus
salivarius) 		4 / 5 ASN A 599
GLU A 591
TYR A 623
PHE A 590
 None
 1.31A 4twdC-4c7vA:
0.3
4twdD-4c7vA:
0.1		 4twdC-4c7vA:
17.60
4twdD-4c7vA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_E_377E401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4c7v TRANSKETOLASE
(Lactobacillus
salivarius) 		4 / 6 ASN A 599
GLU A 591
TYR A 623
PHE A 590
 None
 1.30A 4twdD-4c7vA:
undetectable
4twdE-4c7vA:
undetectable		 4twdD-4c7vA:
17.60
4twdE-4c7vA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_H_377H401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4c7v TRANSKETOLASE
(Lactobacillus
salivarius) 		4 / 6 ASN A 599
GLU A 591
TYR A 623
PHE A 590
 None
 1.30A 4twdG-4c7vA:
undetectable
4twdH-4c7vA:
undetectable		 4twdG-4c7vA:
17.60
4twdH-4c7vA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_A_SAMA2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 4c7v TRANSKETOLASE
(Lactobacillus
salivarius) 		6 / 12 THR A 427
GLY A 128
GLY A 420
TRP A 375
ALA A 173
ALA A 130
 None
 1.36A 4uciA-4c7vA:
2.8		 4uciA-4c7vA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_A_SAMA2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 4c7v TRANSKETOLASE
(Lactobacillus
salivarius) 		6 / 12 THR A 427
GLY A 128
GLY A 420
TRP A 375
ALA A 173
ALA A 130
 None
 1.35A 4uckA-4c7vA:
undetectable		 4uckA-4c7vA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UG5_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 4c7v TRANSKETOLASE
(Lactobacillus
salivarius) 		3 / 3 ARG A 492
THR A 617
TRP A 620
 None
 1.12A 4ug5A-4c7vA:
0.6		 4ug5A-4c7vA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UGL_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE)		 4c7v TRANSKETOLASE
(Lactobacillus
salivarius) 		3 / 3 ARG A 492
THR A 617
TRP A 620
 None
 1.09A 4uglA-4c7vA:
undetectable		 4uglA-4c7vA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_D_ACTD403_0
(D-ALANINE--D-ALANINE
LIGASE)		 4c7v TRANSKETOLASE
(Lactobacillus
salivarius) 		4 / 6 TYR A 623
GLY A 540
SER A 586
LEU A 584
 None
 1.24A 5bphD-4c7vA:
5.3		 5bphD-4c7vA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6C_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 4c7v TRANSKETOLASE
(Lactobacillus
salivarius) 		3 / 3 ARG A 492
THR A 617
TRP A 620
 None
 1.14A 5g6cA-4c7vA:
undetectable		 5g6cA-4c7vA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFP_A_8W5A804_2
(GLUCOCORTICOID
RECEPTOR)		 4c7v TRANSKETOLASE
(Lactobacillus
salivarius) 		4 / 4 LEU A  13
MET A  38
ILE A  18
LEU A  31
 None
 1.20A 5nfpA-4c7vA:
undetectable		 5nfpA-4c7vA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OJ0_A_9WTA801_0
(PENICILLIN-BINDING
PROTEIN 2X)		 4c7v TRANSKETOLASE
(Lactobacillus
salivarius) 		5 / 12 ARG A 589
THR A 356
SER A 560
GLY A 559
THR A 558
 None
 1.16A 5oj0A-4c7vA:
undetectable		 5oj0A-4c7vA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIX_B_OQRB302_0
(SULFOTRANSFERASE)		 4c7v TRANSKETOLASE
(Lactobacillus
salivarius) 		5 / 10 MET A  33
ILE A  18
VAL A 278
SER A 254
GLU A 255
 None
 1.35A 5tixB-4c7vA:
undetectable		 5tixB-4c7vA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_B_ESTB601_1
(ESTROGEN RECEPTOR
BETA)		 4c7v TRANSKETOLASE
(Lactobacillus
salivarius) 		5 / 12 LEU A 155
LEU A  74
LEU A  73
LEU A  13
LEU A  47
 None
 1.26A 5toaB-4c7vA:
undetectable		 5toaB-4c7vA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_B_SAMB601_0
(NS5
METHYLTRANSFERASE)		 4c7v TRANSKETOLASE
(Lactobacillus
salivarius) 		6 / 12 GLY A 212
GLY A 179
GLY A 174
TRP A 213
ASP A  61
ILE A 182
 None
 1.38A 5wz1B-4c7vA:
undetectable		 5wz1B-4c7vA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_A_SALA201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 4c7v TRANSKETOLASE
(Lactobacillus
salivarius) 		4 / 5 VAL A  10
ARG A  14
GLY A  34
TYR A 252
 None
 1.11A 5x80A-4c7vA:
undetectable
5x80B-4c7vA:
undetectable		 5x80A-4c7vA:
13.80
5x80B-4c7vA:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_D_SALD201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 4c7v TRANSKETOLASE
(Lactobacillus
salivarius) 		4 / 5 GLY A  34
TYR A 252
VAL A  10
ARG A  14
 None
 1.11A 5x80C-4c7vA:
undetectable
5x80D-4c7vA:
undetectable		 5x80C-4c7vA:
13.80
5x80D-4c7vA:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_E_GBME2001_1
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 4c7v TRANSKETOLASE
(Lactobacillus
salivarius) 		5 / 12 ILE A 515
ASN A 419
MET A 125
THR A 115
LEU A 447
 None
 1.43A 6baaE-4c7vA:
1.3		 6baaE-4c7vA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_F_GBMF2001_1
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 4c7v TRANSKETOLASE
(Lactobacillus
salivarius) 		5 / 12 ILE A 515
ASN A 419
MET A 125
THR A 115
LEU A 447
 None
 1.43A 6baaF-4c7vA:
1.1		 6baaF-4c7vA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_G_GBMG2001_1
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 4c7v TRANSKETOLASE
(Lactobacillus
salivarius) 		5 / 12 ILE A 515
ASN A 419
MET A 125
THR A 115
LEU A 447
 None
 1.43A 6baaG-4c7vA:
1.8		 6baaG-4c7vA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_H_GBMH2001_1
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 4c7v TRANSKETOLASE
(Lactobacillus
salivarius) 		5 / 12 ILE A 515
ASN A 419
MET A 125
THR A 115
LEU A 447
 None
 1.43A 6baaH-4c7vA:
1.5		 6baaH-4c7vA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BTX_A_EDTA503_0
(SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER))		 4c7v TRANSKETOLASE
(Lactobacillus
salivarius) 		4 / 7 SER A 463
SER A 560
GLY A 559
LEU A 646
 None
 1.11A 6btxA-4c7vA:
undetectable		 6btxA-4c7vA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 4c7v TRANSKETOLASE
(Lactobacillus
salivarius) 		5 / 12 SER A 373
THR A 427
VAL A 505
GLY A 425
VAL A 337
 None
 1.15A 6drzA-4c7vA:
undetectable		 6drzA-4c7vA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_D_AM2D301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4c7v TRANSKETOLASE
(Lactobacillus
salivarius) 		4 / 8 ASP A 228
ARG A  45
HIS A  46
ASP A   6
 None
 1.21A 6mn4D-4c7vA:
undetectable		 6mn4D-4c7vA:
18.62