SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4c7w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		 4c7w HEMAGGLUTININ-ESTERA
SE
(Murine
coronavirus) 		5 / 10 LEU A 269
VAL A 241
TYR A 243
TYR A 234
LEU A 199
 None
 1.35A 1fkoA-4c7wA:
undetectable		 1fkoA-4c7wA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HO5_A_ADNA1604_1
(5'-NUCLEOTIDASE)		 4c7w HEMAGGLUTININ-ESTERA
SE
(Murine
coronavirus) 		5 / 11 ASN A 373
ARG A 330
GLY A 368
PHE A 370
ASN A  26
 None
 1.44A 1ho5A-4c7wA:
undetectable		 1ho5A-4c7wA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_2
(NEURAMINIDASE A)		 4c7w HEMAGGLUTININ-ESTERA
SE
(Murine
coronavirus) 		4 / 6 ARG A 265
ILE A 206
LEU A 292
GLU A 140
 None
 1.06A 2ya7A-4c7wA:
undetectable		 2ya7A-4c7wA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_2
(NEURAMINIDASE A)		 4c7w HEMAGGLUTININ-ESTERA
SE
(Murine
coronavirus) 		4 / 6 ARG A 265
ILE A 206
LEU A 292
GLU A 140
 None
 1.04A 2ya7B-4c7wA:
undetectable		 2ya7B-4c7wA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_2
(NEURAMINIDASE A)		 4c7w HEMAGGLUTININ-ESTERA
SE
(Murine
coronavirus) 		4 / 6 ARG A 265
ILE A 206
LEU A 292
GLU A 140
 None
 1.05A 2ya7D-4c7wA:
undetectable		 2ya7D-4c7wA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 4c7w HEMAGGLUTININ-ESTERA
SE
(Murine
coronavirus) 		4 / 8 PHE A  42
GLY A  43
LEU A 353
TRP A  39
 None
 1.04A 3bgdB-4c7wA:
undetectable		 3bgdB-4c7wA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA802_0
(GLUTAMATE RECEPTOR 2)		 4c7w HEMAGGLUTININ-ESTERA
SE
(Murine
coronavirus) 		3 / 3 ASP A 100
ASN A  36
SER A 297
 None
 0.99A 3lslA-4c7wA:
undetectable
3lslD-4c7wA:
undetectable		 3lslA-4c7wA:
20.48
3lslD-4c7wA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTR_A_LQZA90_1
(LACTOTRANSFERRIN)		 4c7w HEMAGGLUTININ-ESTERA
SE
(Murine
coronavirus) 		3 / 3 PRO A 163
THR A 164
LEU A 282
 None
 0.54A 3ttrA-4c7wA:
undetectable		 3ttrA-4c7wA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW7_A_VPXA2001_2
(PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME)		 4c7w HEMAGGLUTININ-ESTERA
SE
(Murine
coronavirus) 		4 / 4 PRO A  67
LEU A 358
HIS A  34
LEU A  35
 None
 1.45A 3vw7A-4c7wA:
undetectable		 3vw7A-4c7wA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_A_377A401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4c7w HEMAGGLUTININ-ESTERA
SE
(Murine
coronavirus) 		4 / 5 GLU A 106
TYR A 135
PHE A 104
TYR A  95
 None
 1.38A 4twdA-4c7wA:
0.0
4twdE-4c7wA:
0.0		 4twdA-4c7wA:
20.26
4twdE-4c7wA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_H_377H401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4c7w HEMAGGLUTININ-ESTERA
SE
(Murine
coronavirus) 		4 / 6 TYR A  95
GLU A 106
TYR A 135
PHE A 104
 None
 1.49A 4twdG-4c7wA:
undetectable
4twdH-4c7wA:
undetectable		 4twdG-4c7wA:
20.26
4twdH-4c7wA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_H_377H402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4c7w HEMAGGLUTININ-ESTERA
SE
(Murine
coronavirus) 		4 / 5 TYR A  95
GLU A 106
TYR A 135
PHE A 104
 None
 1.42A 4twdH-4c7wA:
0.0
4twdI-4c7wA:
undetectable		 4twdH-4c7wA:
20.26
4twdI-4c7wA:
20.26