SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4c84'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1EPB_A_9CRA165_1 (EPIDIDYMAL RETINOIC ACID-BINDING PROTEIN)	4c84	E3 UBIQUITIN-PROTEIN LIGASE ZNRF3 (Danio rerio)	5 / 12	ILE A 128 VAL A 35 VAL A 168 ALA A 174 ILE A 167	None	1.00A	1epbA-4c84A: undetectable	1epbA-4c84A: 20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1EPB_B_9CRB165_1 (EPIDIDYMAL RETINOIC ACID-BINDING PROTEIN)	4c84	E3 UBIQUITIN-PROTEIN LIGASE ZNRF3 (Danio rerio)	5 / 12	ILE A 128 VAL A 35 VAL A 168 ALA A 174 ILE A 167	None	0.96A	1epbB-4c84A: undetectable	1epbB-4c84A: 20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ME6_D_CGED501_1 (CYTOCHROME P450 2B4)	4c84	E3 UBIQUITIN-PROTEIN LIGASE ZNRF3 (Danio rerio)	5 / 9	VAL A 97 ILE A 72 ALA A 68 VAL A 35 VAL A 37	None	1.24A	3me6D-4c84A: undetectable	3me6D-4c84A: 15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FWD_A_BO2A801_1 (TTC1975 PEPTIDASE)	4c84	E3 UBIQUITIN-PROTEIN LIGASE ZNRF3 (Danio rerio)	5 / 9	VAL A 153 VAL A 154 VAL A 112 GLY A 96 ALA A 124	None	1.09A	4fwdA-4c84A: undetectable	4fwdA-4c84A: 14.15

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1EPB_A_9CRA165_1","EPIDIDYMAL RETINOIC ACID-BINDING PROTEIN","4c84","E3 UBIQUITIN-PROTEIN LIGASE ZNRF3","Danio rerio",5,"ILE A 128;VAL A  35;VAL A 168;ALA A 174;ILE A 167","None","1.00A","1epbA-4c84A:undetectable","1epbA-4c84A:20.57"],["1EPB_B_9CRB165_1","EPIDIDYMAL RETINOIC ACID-BINDING PROTEIN","4c84","E3 UBIQUITIN-PROTEIN LIGASE ZNRF3","Danio rerio",5,"ILE A 128;VAL A  35;VAL A 168;ALA A 174;ILE A 167","None","0.96A","1epbB-4c84A:undetectable","1epbB-4c84A:20.57"],["3ME6_D_CGED501_1","CYTOCHROME P450 2B4","4c84","E3 UBIQUITIN-PROTEIN LIGASE ZNRF3","Danio rerio",5,"VAL A  97;ILE A  72;ALA A  68;VAL A  35;VAL A  37","None","1.24A","3me6D-4c84A:undetectable","3me6D-4c84A:15.09"],["4FWD_A_BO2A801_1","TTC1975 PEPTIDASE","4c84","E3 UBIQUITIN-PROTEIN LIGASE ZNRF3","Danio rerio",5,"VAL A 153;VAL A 154;VAL A 112;GLY A  96;ALA A 124","None","1.09A","4fwdA-4c84A:undetectable","4fwdA-4c84A:14.15"]]