SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4c8d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_A_ADNA601_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 4c8d LYSINE-SPECIFIC
DEMETHYLASE 3B
(Homo
sapiens) 		4 / 5 THR A1657
GLU A1592
THR A1589
HIS A1615
 None
 1.44A 1d4fA-4c8dA:
undetectable		 1d4fA-4c8dA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KCX_A_CQLA1_0
(HYPOXIA-INDUCIBLE
FACTOR 1-ALPHA
INHIBITOR)		 4c8d LYSINE-SPECIFIC
DEMETHYLASE 3B
(Homo
sapiens) 		5 / 10 THR A1557
HIS A1560
ASP A1562
ILE A1683
HIS A1689
 OGA  A2722 (-3.3A)
MN  A2721 ( 3.3A)
MN  A2721 ( 3.0A)
None
MN  A2721 ( 3.2A)
 0.50A 3kcxA-4c8dA:
14.3		 3kcxA-4c8dA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE502_1
(HEMOLYTIC LECTIN
CEL-III)		 4c8d LYSINE-SPECIFIC
DEMETHYLASE 3B
(Homo
sapiens) 		4 / 6 ASP A1679
GLY A1419
LEU A1416
GLU A1608
 None
 1.15A 3w9tE-4c8dA:
undetectable		 3w9tE-4c8dA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF503_1
(HEMOLYTIC LECTIN
CEL-III)		 4c8d LYSINE-SPECIFIC
DEMETHYLASE 3B
(Homo
sapiens) 		4 / 6 ASP A1679
GLY A1419
LEU A1416
GLU A1608
 None
 1.16A 3w9tF-4c8dA:
undetectable		 3w9tF-4c8dA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_1
(DIHYDROPTEROATE
SYNTHASE DHPS)		 4c8d LYSINE-SPECIFIC
DEMETHYLASE 3B
(Homo
sapiens) 		3 / 3 LYS A1458
ASN A1542
ASP A1442
 None
 0.71A 4o1eA-4c8dA:
undetectable		 4o1eA-4c8dA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ELI_A_T27A701_1
(REVERSE
TRANSCRIPTASE)		 4c8d LYSINE-SPECIFIC
DEMETHYLASE 3B
(Homo
sapiens) 		5 / 12 LEU A1505
VAL A1420
VAL A1571
PRO A1396
LEU A1509
 None
 1.07A 6eliA-4c8dA:
undetectable		 6eliA-4c8dA:
12.89