SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4c8g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XP0_A_VDNA201_1 (CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE)	4c8g	2-C-METHYL-D-ERYTHRI TOL 2,4-CYCLODIPHOSPHATE SYNTHASE (Burkholderia cenocepacia)	5 / 10	LEU A 43 ALA A 45 ILE A 46 VAL A 100 ALA A 133	None None None None C5P A1163 (-3.6A)	1.04A	1xp0A-4c8gA: undetectable	1xp0A-4c8gA: 21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2H42_B_VIAB902_1 (CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE)	4c8g	2-C-METHYL-D-ERYTHRI TOL 2,4-CYCLODIPHOSPHATE SYNTHASE (Burkholderia cenocepacia)	5 / 12	ALA A 152 ILE A 46 VAL A 100 ALA A 133 ILE A 111	None None None C5P A1163 (-3.6A) None	1.16A	2h42B-4c8gA: undetectable	2h42B-4c8gA: 18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2H42_C_VIAC903_1 (CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE)	4c8g	2-C-METHYL-D-ERYTHRI TOL 2,4-CYCLODIPHOSPHATE SYNTHASE (Burkholderia cenocepacia)	5 / 12	LEU A 43 ALA A 45 ILE A 46 VAL A 100 ALA A 133	None None None None C5P A1163 (-3.6A)	1.09A	2h42C-4c8gA: undetectable	2h42C-4c8gA: 18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BXO_A_SAMA238_0 (N,N-DIMETHYLTRANSFER ASE)	4c8g	2-C-METHYL-D-ERYTHRI TOL 2,4-CYCLODIPHOSPHATE SYNTHASE (Burkholderia cenocepacia)	5 / 12	ALA A 154 GLY A 6 ARG A 128 PHE A 51 LEU A 124	None	1.28A	3bxoA-4c8gA: undetectable	3bxoA-4c8gA: 25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3LN1_D_CELD682_1 (PROSTAGLANDIN G/H SYNTHASE 2)	4c8g	2-C-METHYL-D-ERYTHRI TOL 2,4-CYCLODIPHOSPHATE SYNTHASE (Burkholderia cenocepacia)	5 / 12	VAL A 96 SER A 98 GLY A 6 ALA A 49 LEU A 50	None	1.08A	3ln1D-4c8gA: undetectable	3ln1D-4c8gA: 14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3N8Y_A_DIFA701_1 (PROSTAGLANDIN G/H SYNTHASE 1)	4c8g	2-C-METHYL-D-ERYTHRI TOL 2,4-CYCLODIPHOSPHATE SYNTHASE (Burkholderia cenocepacia)	5 / 11	VAL A 96 SER A 98 GLY A 6 ALA A 49 LEU A 50	None	1.14A	3n8yA-4c8gA: undetectable	3n8yA-4c8gA: 15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3WEM_A_ACRA1001_1 (ALPHA-GLUCOSIDASE)	4c8g	2-C-METHYL-D-ERYTHRI TOL 2,4-CYCLODIPHOSPHATE SYNTHASE (Burkholderia cenocepacia)	5 / 12	ALA A 120 ASP A 40 ILE A 21 ASP A 74 ASP A 121	None	1.46A	3wemA-4c8gA: undetectable	3wemA-4c8gA: 11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3WEN_A_ACRA1001_1 (ALPHA-GLUCOSIDASE)	4c8g	2-C-METHYL-D-ERYTHRI TOL 2,4-CYCLODIPHOSPHATE SYNTHASE (Burkholderia cenocepacia)	5 / 12	ALA A 120 ASP A 40 ILE A 21 ASP A 74 ASP A 121	None	1.44A	3wenA-4c8gA: undetectable	3wenA-4c8gA: 11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4COX_A_IMNA701_1 (CYCLOOXYGENASE-2)	4c8g	2-C-METHYL-D-ERYTHRI TOL 2,4-CYCLODIPHOSPHATE SYNTHASE (Burkholderia cenocepacia)	5 / 12	VAL A 96 SER A 98 GLY A 6 ALA A 49 LEU A 50	None	1.07A	4coxA-4c8gA: undetectable	4coxA-4c8gA: 16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4COX_B_IMNB701_1 (CYCLOOXYGENASE-2)	4c8g	2-C-METHYL-D-ERYTHRI TOL 2,4-CYCLODIPHOSPHATE SYNTHASE (Burkholderia cenocepacia)	5 / 12	VAL A 96 SER A 98 GLY A 6 ALA A 49 LEU A 50	None	1.08A	4coxB-4c8gA: undetectable	4coxB-4c8gA: 16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4COX_C_IMNC701_1 (CYCLOOXYGENASE-2)	4c8g	2-C-METHYL-D-ERYTHRI TOL 2,4-CYCLODIPHOSPHATE SYNTHASE (Burkholderia cenocepacia)	5 / 12	VAL A 96 SER A 98 GLY A 6 ALA A 49 LEU A 50	None	1.08A	4coxC-4c8gA: undetectable	4coxC-4c8gA: 16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4COX_D_IMND701_1 (CYCLOOXYGENASE-2)	4c8g	2-C-METHYL-D-ERYTHRI TOL 2,4-CYCLODIPHOSPHATE SYNTHASE (Burkholderia cenocepacia)	5 / 12	VAL A 96 SER A 98 GLY A 6 ALA A 49 LEU A 50	None	1.07A	4coxD-4c8gA: undetectable	4coxD-4c8gA: 16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RRW_A_LURA705_1 (PROSTAGLANDIN G/H SYNTHASE 2)	4c8g	2-C-METHYL-D-ERYTHRI TOL 2,4-CYCLODIPHOSPHATE SYNTHASE (Burkholderia cenocepacia)	5 / 12	VAL A 96 SER A 98 GLY A 6 ALA A 49 LEU A 50	None	1.09A	4rrwA-4c8gA: undetectable	4rrwA-4c8gA: 14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RRW_B_LURB705_1 (PROSTAGLANDIN G/H SYNTHASE 2)	4c8g	2-C-METHYL-D-ERYTHRI TOL 2,4-CYCLODIPHOSPHATE SYNTHASE (Burkholderia cenocepacia)	5 / 12	VAL A 96 SER A 98 GLY A 6 ALA A 49 LEU A 50	None	1.10A	4rrwB-4c8gA: undetectable	4rrwB-4c8gA: 14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RRZ_A_LURA705_1 (PROSTAGLANDIN G/H SYNTHASE 2)	4c8g	2-C-METHYL-D-ERYTHRI TOL 2,4-CYCLODIPHOSPHATE SYNTHASE (Burkholderia cenocepacia)	5 / 12	VAL A 96 SER A 98 GLY A 6 ALA A 49 LEU A 50	None	1.09A	4rrzA-4c8gA: undetectable	4rrzA-4c8gA: 14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RRZ_B_LURB705_1 (PROSTAGLANDIN G/H SYNTHASE 2)	4c8g	2-C-METHYL-D-ERYTHRI TOL 2,4-CYCLODIPHOSPHATE SYNTHASE (Burkholderia cenocepacia)	5 / 12	VAL A 96 SER A 98 GLY A 6 ALA A 49 LEU A 50	None	1.10A	4rrzB-4c8gA: undetectable	4rrzB-4c8gA: 14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RS0_A_IBPA706_1 (PROSTAGLANDIN G/H SYNTHASE 2)	4c8g	2-C-METHYL-D-ERYTHRI TOL 2,4-CYCLODIPHOSPHATE SYNTHASE (Burkholderia cenocepacia)	5 / 9	VAL A 96 SER A 98 GLY A 6 ALA A 49 LEU A 50	None	1.09A	4rs0A-4c8gA: undetectable	4rs0A-4c8gA: 14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5FHZ_B_REAB602_1 (ALDEHYDE DEHYDROGENASE FAMILY 1 MEMBER A3)	4c8g	2-C-METHYL-D-ERYTHRI TOL 2,4-CYCLODIPHOSPHATE SYNTHASE (Burkholderia cenocepacia)	5 / 9	ILE A 118 GLY A 23 LEU A 42 ASN A 130 LEU A 107	None None None None C5P A1163 (-4.1A)	1.37A	5fhzB-4c8gA: undetectable	5fhzB-4c8gA: 17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IKR_A_ID8A601_1 (PROSTAGLANDIN G/H SYNTHASE 2)	4c8g	2-C-METHYL-D-ERYTHRI TOL 2,4-CYCLODIPHOSPHATE SYNTHASE (Burkholderia cenocepacia)	5 / 12	VAL A 96 SER A 98 GLY A 6 ALA A 49 LEU A 50	None	1.11A	5ikrA-4c8gA: undetectable	5ikrA-4c8gA: 15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5JVZ_B_FLPB601_1 (PROSTAGLANDIN G/H SYNTHASE 2)	4c8g	2-C-METHYL-D-ERYTHRI TOL 2,4-CYCLODIPHOSPHATE SYNTHASE (Burkholderia cenocepacia)	5 / 12	VAL A 96 SER A 98 GLY A 6 ALA A 49 LEU A 50	None	1.06A	5jvzB-4c8gA: undetectable	5jvzB-4c8gA: 15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5OV9_A_CVIA609_0 (ACETYLCHOLINESTERASE)	4c8g	2-C-METHYL-D-ERYTHRI TOL 2,4-CYCLODIPHOSPHATE SYNTHASE (Burkholderia cenocepacia)	4 / 6	TYR A 9 ASP A 48 HIS A 44 TYR A 141	None None ZN A1162 (-3.1A) None	1.30A	5ov9A-4c8gA: undetectable	5ov9A-4c8gA: 16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5OV9_B_CVIB603_0 (ACETYLCHOLINESTERASE)	4c8g	2-C-METHYL-D-ERYTHRI TOL 2,4-CYCLODIPHOSPHATE SYNTHASE (Burkholderia cenocepacia)	4 / 7	TYR A 9 ASP A 48 HIS A 44 TYR A 141	None None ZN A1162 (-3.1A) None	1.35A	5ov9B-4c8gA: undetectable	5ov9B-4c8gA: 16.45

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1XP0_A_VDNA201_1","CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE","4c8g","2-C-METHYL-D-ERYTHRITOL 2,4-CYCLODIPHOSPHATE SYNTHASE","Burkholderia cenocepacia",5,"LEU A  43;ALA A  45;ILE A  46;VAL A 100;ALA A 133","None;None;None;None;C5P A1163 (-3.6A)","1.04A","1xp0A-4c8gA:undetectable","1xp0A-4c8gA:21.61"],["2H42_B_VIAB902_1","CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE","4c8g","2-C-METHYL-D-ERYTHRITOL 2,4-CYCLODIPHOSPHATE SYNTHASE","Burkholderia cenocepacia",5,"ALA A 152;ILE A  46;VAL A 100;ALA A 133;ILE A 111","None;None;None;C5P A1163 (-3.6A);None","1.16A","2h42B-4c8gA:undetectable","2h42B-4c8gA:18.13"],["2H42_C_VIAC903_1","CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE","4c8g","2-C-METHYL-D-ERYTHRITOL 2,4-CYCLODIPHOSPHATE SYNTHASE","Burkholderia cenocepacia",5,"LEU A  43;ALA A  45;ILE A  46;VAL A 100;ALA A 133","None;None;None;None;C5P A1163 (-3.6A)","1.09A","2h42C-4c8gA:undetectable","2h42C-4c8gA:18.13"],["3BXO_A_SAMA238_0","N,N-DIMETHYLTRANSFERASE","4c8g","2-C-METHYL-D-ERYTHRITOL 2,4-CYCLODIPHOSPHATE SYNTHASE","Burkholderia cenocepacia",5,"ALA A 154;GLY A   6;ARG A 128;PHE A  51;LEU A 124","None","1.28A","3bxoA-4c8gA:undetectable","3bxoA-4c8gA:25.00"],["3LN1_D_CELD682_1","PROSTAGLANDIN G\/H SYNTHASE 2","4c8g","2-C-METHYL-D-ERYTHRITOL 2,4-CYCLODIPHOSPHATE SYNTHASE","Burkholderia cenocepacia",5,"VAL A  96;SER A  98;GLY A   6;ALA A  49;LEU A  50","None","1.08A","3ln1D-4c8gA:undetectable","3ln1D-4c8gA:14.97"],["3N8Y_A_DIFA701_1","PROSTAGLANDIN G\/H SYNTHASE 1","4c8g","2-C-METHYL-D-ERYTHRITOL 2,4-CYCLODIPHOSPHATE SYNTHASE","Burkholderia cenocepacia",5,"VAL A  96;SER A  98;GLY A   6;ALA A  49;LEU A  50","None","1.14A","3n8yA-4c8gA:undetectable","3n8yA-4c8gA:15.93"],["3WEM_A_ACRA1001_1","ALPHA-GLUCOSIDASE","4c8g","2-C-METHYL-D-ERYTHRITOL 2,4-CYCLODIPHOSPHATE SYNTHASE","Burkholderia cenocepacia",5,"ALA A 120;ASP A  40;ILE A  21;ASP A  74;ASP A 121","None","1.46A","3wemA-4c8gA:undetectable","3wemA-4c8gA:11.98"],["3WEN_A_ACRA1001_1","ALPHA-GLUCOSIDASE","4c8g","2-C-METHYL-D-ERYTHRITOL 2,4-CYCLODIPHOSPHATE SYNTHASE","Burkholderia cenocepacia",5,"ALA A 120;ASP A  40;ILE A  21;ASP A  74;ASP A 121","None","1.44A","3wenA-4c8gA:undetectable","3wenA-4c8gA:11.98"],["4COX_A_IMNA701_1","CYCLOOXYGENASE-2","4c8g","2-C-METHYL-D-ERYTHRITOL 2,4-CYCLODIPHOSPHATE SYNTHASE","Burkholderia cenocepacia",5,"VAL A  96;SER A  98;GLY A   6;ALA A  49;LEU A  50","None","1.07A","4coxA-4c8gA:undetectable","4coxA-4c8gA:16.51"],["4COX_B_IMNB701_1","CYCLOOXYGENASE-2","4c8g","2-C-METHYL-D-ERYTHRITOL 2,4-CYCLODIPHOSPHATE SYNTHASE","Burkholderia cenocepacia",5,"VAL A  96;SER A  98;GLY A   6;ALA A  49;LEU A  50","None","1.08A","4coxB-4c8gA:undetectable","4coxB-4c8gA:16.51"],["4COX_C_IMNC701_1","CYCLOOXYGENASE-2","4c8g","2-C-METHYL-D-ERYTHRITOL 2,4-CYCLODIPHOSPHATE SYNTHASE","Burkholderia cenocepacia",5,"VAL A  96;SER A  98;GLY A   6;ALA A  49;LEU A  50","None","1.08A","4coxC-4c8gA:undetectable","4coxC-4c8gA:16.51"],["4COX_D_IMND701_1","CYCLOOXYGENASE-2","4c8g","2-C-METHYL-D-ERYTHRITOL 2,4-CYCLODIPHOSPHATE SYNTHASE","Burkholderia cenocepacia",5,"VAL A  96;SER A  98;GLY A   6;ALA A  49;LEU A  50","None","1.07A","4coxD-4c8gA:undetectable","4coxD-4c8gA:16.51"],["4RRW_A_LURA705_1","PROSTAGLANDIN G\/H SYNTHASE 2","4c8g","2-C-METHYL-D-ERYTHRITOL 2,4-CYCLODIPHOSPHATE SYNTHASE","Burkholderia cenocepacia",5,"VAL A  96;SER A  98;GLY A   6;ALA A  49;LEU A  50","None","1.09A","4rrwA-4c8gA:undetectable","4rrwA-4c8gA:14.97"],["4RRW_B_LURB705_1","PROSTAGLANDIN G\/H SYNTHASE 2","4c8g","2-C-METHYL-D-ERYTHRITOL 2,4-CYCLODIPHOSPHATE SYNTHASE","Burkholderia cenocepacia",5,"VAL A  96;SER A  98;GLY A   6;ALA A  49;LEU A  50","None","1.10A","4rrwB-4c8gA:undetectable","4rrwB-4c8gA:14.97"],["4RRZ_A_LURA705_1","PROSTAGLANDIN G\/H SYNTHASE 2","4c8g","2-C-METHYL-D-ERYTHRITOL 2,4-CYCLODIPHOSPHATE SYNTHASE","Burkholderia cenocepacia",5,"VAL A  96;SER A  98;GLY A   6;ALA A  49;LEU A  50","None","1.09A","4rrzA-4c8gA:undetectable","4rrzA-4c8gA:14.97"],["4RRZ_B_LURB705_1","PROSTAGLANDIN G\/H SYNTHASE 2","4c8g","2-C-METHYL-D-ERYTHRITOL 2,4-CYCLODIPHOSPHATE SYNTHASE","Burkholderia cenocepacia",5,"VAL A  96;SER A  98;GLY A   6;ALA A  49;LEU A  50","None","1.10A","4rrzB-4c8gA:undetectable","4rrzB-4c8gA:14.97"],["4RS0_A_IBPA706_1","PROSTAGLANDIN G\/H SYNTHASE 2","4c8g","2-C-METHYL-D-ERYTHRITOL 2,4-CYCLODIPHOSPHATE SYNTHASE","Burkholderia cenocepacia",5,"VAL A  96;SER A  98;GLY A   6;ALA A  49;LEU A  50","None","1.09A","4rs0A-4c8gA:undetectable","4rs0A-4c8gA:14.97"],["5FHZ_B_REAB602_1","ALDEHYDE DEHYDROGENASE FAMILY 1 MEMBER A3","4c8g","2-C-METHYL-D-ERYTHRITOL 2,4-CYCLODIPHOSPHATE SYNTHASE","Burkholderia cenocepacia",5,"ILE A 118;GLY A  23;LEU A  42;ASN A 130;LEU A 107","None;None;None;None;C5P A1163 (-4.1A)","1.37A","5fhzB-4c8gA:undetectable","5fhzB-4c8gA:17.51"],["5IKR_A_ID8A601_1","PROSTAGLANDIN G\/H SYNTHASE 2","4c8g","2-C-METHYL-D-ERYTHRITOL 2,4-CYCLODIPHOSPHATE SYNTHASE","Burkholderia cenocepacia",5,"VAL A  96;SER A  98;GLY A   6;ALA A  49;LEU A  50","None","1.11A","5ikrA-4c8gA:undetectable","5ikrA-4c8gA:15.90"],["5JVZ_B_FLPB601_1","PROSTAGLANDIN G\/H SYNTHASE 2","4c8g","2-C-METHYL-D-ERYTHRITOL 2,4-CYCLODIPHOSPHATE SYNTHASE","Burkholderia cenocepacia",5,"VAL A  96;SER A  98;GLY A   6;ALA A  49;LEU A  50","None","1.06A","5jvzB-4c8gA:undetectable","5jvzB-4c8gA:15.55"],["5OV9_A_CVIA609_0","ACETYLCHOLINESTERASE","4c8g","2-C-METHYL-D-ERYTHRITOL 2,4-CYCLODIPHOSPHATE SYNTHASE","Burkholderia cenocepacia",4,"TYR A   9;ASP A  48;HIS A  44;TYR A 141","None;None; ZN A1162 (-3.1A);None","1.30A","5ov9A-4c8gA:undetectable","5ov9A-4c8gA:16.45"],["5OV9_B_CVIB603_0","ACETYLCHOLINESTERASE","4c8g","2-C-METHYL-D-ERYTHRITOL 2,4-CYCLODIPHOSPHATE SYNTHASE","Burkholderia cenocepacia",4,"TYR A   9;ASP A  48;HIS A  44;TYR A 141","None;None; ZN A1162 (-3.1A);None","1.35A","5ov9B-4c8gA:undetectable","5ov9B-4c8gA:16.45"]]