SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4c8q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 4c8q DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1
(Saccharomyces
cerevisiae) 		5 / 12 ILE H 555
LEU H 549
PHE H 556
LEU H 637
ILE H 595
 None
 1.09A 1cd2A-4c8qH:
undetectable		 1cd2A-4c8qH:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_C_CHDC3271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 4c8q DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1
(Saccharomyces
cerevisiae) 		4 / 8 LEU H 562
PHE H 587
LEU H 527
PHE H 523
 None
 0.72A 1v54C-4c8qH:
undetectable
1v54J-4c8qH:
undetectable		 1v54C-4c8qH:
19.40
1v54J-4c8qH:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_P_CHDP4271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 4c8q DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1
(Saccharomyces
cerevisiae) 		4 / 8 LEU H 562
PHE H 587
LEU H 527
PHE H 523
 None
 0.70A 1v54P-4c8qH:
undetectable
1v54W-4c8qH:
undetectable		 1v54P-4c8qH:
19.40
1v54W-4c8qH:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_A_8MOA501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 4c8q DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1
(Saccharomyces
cerevisiae) 		5 / 11 PHE H 556
ILE H 595
ILE H 533
LEU H 527
PHE H 587
 None
 1.04A 1z11A-4c8qH:
undetectable		 1z11A-4c8qH:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_B_8MOB501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 4c8q DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1
(Saccharomyces
cerevisiae) 		5 / 11 PHE H 556
ILE H 595
ILE H 533
LEU H 527
PHE H 587
 None
 0.97A 1z11B-4c8qH:
undetectable		 1z11B-4c8qH:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_C_8MOC501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 4c8q DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1
(Saccharomyces
cerevisiae) 		5 / 10 PHE H 556
ILE H 595
ILE H 533
LEU H 527
PHE H 587
 None
 1.02A 1z11C-4c8qH:
undetectable		 1z11C-4c8qH:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_D_8MOD501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 4c8q DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1
(Saccharomyces
cerevisiae) 		5 / 10 PHE H 556
ILE H 595
ILE H 533
LEU H 527
PHE H 587
 None
 1.07A 1z11D-4c8qH:
undetectable		 1z11D-4c8qH:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4c8q DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1
(Saccharomyces
cerevisiae) 		4 / 8 LEU H 562
PHE H 587
LEU H 527
PHE H 523
 None
 0.72A 2dyrC-4c8qH:
undetectable
2dyrJ-4c8qH:
undetectable		 2dyrC-4c8qH:
19.40
2dyrJ-4c8qH:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4c8q DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1
(Saccharomyces
cerevisiae) 		4 / 8 LEU H 562
PHE H 587
LEU H 527
PHE H 523
 None
 0.73A 2dyrP-4c8qH:
undetectable
2dyrW-4c8qH:
undetectable		 2dyrP-4c8qH:
19.40
2dyrW-4c8qH:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4c8q DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1
(Saccharomyces
cerevisiae) 		4 / 7 LEU H 562
PHE H 587
LEU H 527
PHE H 523
 None
 0.71A 2eikC-4c8qH:
undetectable
2eikJ-4c8qH:
undetectable		 2eikC-4c8qH:
19.40
2eikJ-4c8qH:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4c8q DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1
(Saccharomyces
cerevisiae) 		4 / 8 LEU H 562
PHE H 587
LEU H 527
PHE H 523
 None
 0.73A 2eikP-4c8qH:
undetectable
2eikW-4c8qH:
undetectable		 2eikP-4c8qH:
19.40
2eikW-4c8qH:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4c8q DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1
(Saccharomyces
cerevisiae) 		4 / 8 LEU H 562
PHE H 587
LEU H 527
PHE H 523
 None
 0.69A 2eilC-4c8qH:
undetectable
2eilJ-4c8qH:
undetectable		 2eilC-4c8qH:
19.40
2eilJ-4c8qH:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_W_CHDW1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4c8q DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1
(Saccharomyces
cerevisiae) 		4 / 7 LEU H 562
PHE H 587
LEU H 527
PHE H 523
 None
 0.76A 2eimP-4c8qH:
undetectable
2eimW-4c8qH:
undetectable		 2eimP-4c8qH:
19.40
2eimW-4c8qH:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4c8q DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1
(Saccharomyces
cerevisiae) 		4 / 6 LEU H 562
PHE H 587
LEU H 527
PHE H 523
 None
 0.74A 3abkP-4c8qH:
undetectable
3abkW-4c8qH:
undetectable		 3abkP-4c8qH:
19.40
3abkW-4c8qH:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4c8q DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1
(Saccharomyces
cerevisiae) 		5 / 12 ILE H 594
ILE H 608
LEU H 637
LEU H 615
ILE H 555
 None
 1.33A 3adsB-4c8qH:
undetectable		 3adsB-4c8qH:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4c8q DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1
(Saccharomyces
cerevisiae) 		4 / 7 LEU H 562
PHE H 587
LEU H 527
PHE H 523
 None
 0.82A 3ag2P-4c8qH:
undetectable
3ag2W-4c8qH:
undetectable		 3ag2P-4c8qH:
19.40
3ag2W-4c8qH:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4c8q DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1
(Saccharomyces
cerevisiae) 		4 / 8 LEU H 562
PHE H 587
LEU H 527
PHE H 523
 None
 0.73A 3ag4C-4c8qH:
undetectable
3ag4J-4c8qH:
undetectable		 3ag4C-4c8qH:
19.40
3ag4J-4c8qH:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4c8q DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1
(Saccharomyces
cerevisiae) 		4 / 7 LEU H 562
PHE H 587
LEU H 527
PHE H 523
 None
 0.75A 3ag4P-4c8qH:
undetectable
3ag4W-4c8qH:
undetectable		 3ag4P-4c8qH:
19.40
3ag4W-4c8qH:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 4c8q DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1
(Saccharomyces
cerevisiae) 		4 / 7 LEU H 562
PHE H 587
LEU H 527
PHE H 523
 None
 0.74A 3asnC-4c8qH:
undetectable
3asnJ-4c8qH:
undetectable		 3asnC-4c8qH:
19.40
3asnJ-4c8qH:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_P_CHDP1271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 4c8q DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1
(Saccharomyces
cerevisiae) 		4 / 7 LEU H 562
PHE H 587
LEU H 527
PHE H 523
 None
 0.71A 3asnP-4c8qH:
undetectable
3asnW-4c8qH:
undetectable		 3asnP-4c8qH:
19.40
3asnW-4c8qH:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_P_CHDP1271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 4c8q DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1
(Saccharomyces
cerevisiae) 		4 / 7 LEU H 562
PHE H 587
LEU H 527
PHE H 523
 None
 0.75A 3asoP-4c8qH:
undetectable
3asoW-4c8qH:
undetectable		 3asoP-4c8qH:
19.40
3asoW-4c8qH:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_2
(CYTOCHROME P450 2R1)		 4c8q DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1
(Saccharomyces
cerevisiae) 		3 / 3 LEU H 511
GLU H 488
ILE H 489
 None
 0.59A 3czhA-4c8qH:
undetectable		 3czhA-4c8qH:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_B_H3PB552_1
(GLUTAMATE
DEHYDROGENASE)		 4c8q DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1
(Saccharomyces
cerevisiae) 		3 / 3 TYR H 570
TYR H 703
ILE H 704
 None
 0.80A 3eteA-4c8qH:
undetectable
3eteB-4c8qH:
undetectable		 3eteA-4c8qH:
20.99
3eteB-4c8qH:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3006_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4c8q DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1
(Saccharomyces
cerevisiae) 		4 / 6 ASN H 687
MET H 691
ILE H 690
GLU H 701
 None
None
None
CO  H1080 (-3.8A)
 1.26A 3kp6A-4c8qH:
undetectable
3kp6B-4c8qH:
undetectable		 3kp6A-4c8qH:
19.21
3kp6B-4c8qH:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZU_A_X89A411_1
(FLAVOHEMOPROTEIN)		 4c8q DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1
(Saccharomyces
cerevisiae) 		5 / 12 ILE H 513
LEU H 511
VAL H 485
LEU H 543
LEU H 492
 None
 1.28A 3ozuA-4c8qH:
undetectable		 3ozuA-4c8qH:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGZ_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 4c8q DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1
(Saccharomyces
cerevisiae) 		5 / 10 ILE H 564
ILE H 533
ILE H 555
LEU H 592
SER H 627
 None
 1.17A 3qgzA-4c8qH:
undetectable		 3qgzA-4c8qH:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB323_0
(INVASIN IPAD)		 4c8q DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1
(Saccharomyces
cerevisiae) 		4 / 7 ILE H 636
VAL H 596
LEU H 599
SER H 600
 None
 0.70A 3r9vA-4c8qH:
undetectable
3r9vB-4c8qH:
undetectable		 3r9vA-4c8qH:
23.23
3r9vB-4c8qH:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQ8_A_TOPA2001_1
(DIHYDROFOLATE
REDUCTASE)		 4c8q DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1
(Saccharomyces
cerevisiae) 		5 / 9 ILE H 513
LEU H 562
PHE H 523
ILE H 591
ILE H 551
 None
 1.02A 3tq8A-4c8qH:
undetectable		 3tq8A-4c8qH:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4c8q DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1
(Saccharomyces
cerevisiae) 		4 / 6 LEU H 562
PHE H 587
LEU H 527
PHE H 523
 None
 0.71A 3wg7C-4c8qH:
undetectable
3wg7J-4c8qH:
undetectable		 3wg7C-4c8qH:
19.40
3wg7J-4c8qH:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4c8q DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1
(Saccharomyces
cerevisiae) 		4 / 6 LEU H 562
PHE H 587
LEU H 527
PHE H 523
 None
 0.84A 3wg7P-4c8qH:
undetectable
3wg7W-4c8qH:
undetectable		 3wg7P-4c8qH:
19.40
3wg7W-4c8qH:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4c8q DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1
(Saccharomyces
cerevisiae) 		4 / 7 LEU H 562
PHE H 587
LEU H 527
PHE H 523
 None
 0.74A 3x2qC-4c8qH:
undetectable
3x2qJ-4c8qH:
undetectable		 3x2qC-4c8qH:
19.40
3x2qJ-4c8qH:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4c8q DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1
(Saccharomyces
cerevisiae) 		4 / 7 LEU H 562
PHE H 587
LEU H 527
PHE H 523
 None
 0.81A 3x2qP-4c8qH:
undetectable
3x2qW-4c8qH:
undetectable		 3x2qP-4c8qH:
19.40
3x2qW-4c8qH:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4c8q DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1
(Saccharomyces
cerevisiae) 		4 / 7 PHE H 681
VAL H 727
ILE H 724
GLU H 701
 None
None
None
CO  H1080 (-3.8A)
 1.06A 4a97E-4c8qH:
undetectable		 4a97E-4c8qH:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4c8q DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1
(Saccharomyces
cerevisiae) 		4 / 8 PHE H 681
VAL H 727
ILE H 724
GLU H 701
 None
None
None
CO  H1080 (-3.8A)
 1.08A 4a97C-4c8qH:
1.5		 4a97C-4c8qH:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4c8q DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1
(Saccharomyces
cerevisiae) 		4 / 8 PHE H 681
VAL H 727
ILE H 724
GLU H 701
 None
None
None
CO  H1080 (-3.8A)
 1.05A 4a97D-4c8qH:
undetectable		 4a97D-4c8qH:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4c8q DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1
(Saccharomyces
cerevisiae) 		4 / 8 PHE H 681
VAL H 727
ILE H 724
GLU H 701
 None
None
None
CO  H1080 (-3.8A)
 1.09A 4a97G-4c8qH:
undetectable		 4a97G-4c8qH:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4c8q DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1
(Saccharomyces
cerevisiae) 		4 / 7 PHE H 681
VAL H 727
ILE H 724
GLU H 701
 None
None
None
CO  H1080 (-3.8A)
 1.00A 4a97H-4c8qH:
undetectable		 4a97H-4c8qH:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_0
(METHYLTRANSFERASE
NSUN4)		 4c8q DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1
(Saccharomyces
cerevisiae) 		5 / 12 GLY H 473
GLY H 474
ASN H 521
SER H 517
ASP H 514
 None
 1.07A 4fp9D-4c8qH:
undetectable		 4fp9D-4c8qH:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_0
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 4c8q DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1
(Saccharomyces
cerevisiae) 		5 / 12 GLY H 473
GLY H 474
ASN H 521
SER H 517
ASP H 514
 None
 1.06A 4fzvA-4c8qH:
undetectable		 4fzvA-4c8qH:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODR_B_FK5B201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA)		 4c8q DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1
(Saccharomyces
cerevisiae) 		5 / 11 LEU H 552
LEU H 559
ILE H 636
LEU H 637
ILE H 594
 None
 1.09A 4odrA-4c8qH:
undetectable
4odrB-4c8qH:
undetectable		 4odrA-4c8qH:
13.11
4odrB-4c8qH:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RMJ_A_NCAA402_0
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2)		 4c8q DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1
(Saccharomyces
cerevisiae) 		4 / 7 ILE H 608
PHE H 556
LEU H 552
ILE H 636
 None
 0.84A 4rmjA-4c8qH:
undetectable		 4rmjA-4c8qH:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4c8q DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1
(Saccharomyces
cerevisiae) 		4 / 7 LEU H 562
PHE H 587
LEU H 527
PHE H 523
 None
 0.82A 5b1bP-4c8qH:
undetectable
5b1bW-4c8qH:
undetectable		 5b1bP-4c8qH:
19.40
5b1bW-4c8qH:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_E_PFLE406_1
(PROTON-GATED ION
CHANNEL)		 4c8q DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1
(Saccharomyces
cerevisiae) 		5 / 10 ILE H 535
ILE H 539
ILE H 594
ILE H 590
ILE H 591
 None
 1.10A 5murE-4c8qH:
undetectable		 5murE-4c8qH:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4c8q DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1
(Saccharomyces
cerevisiae) 		4 / 5 LEU H 562
PHE H 587
LEU H 527
PHE H 523
 None
 0.73A 5x19C-4c8qH:
undetectable
5x19J-4c8qH:
undetectable		 5x19C-4c8qH:
19.40
5x19J-4c8qH:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_P_CHDP304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4c8q DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1
(Saccharomyces
cerevisiae) 		4 / 7 LEU H 562
PHE H 587
LEU H 527
PHE H 523
 None
 0.74A 5x1fP-4c8qH:
undetectable
5x1fW-4c8qH:
undetectable		 5x1fP-4c8qH:
19.40
5x1fW-4c8qH:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4c8q DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1
(Saccharomyces
cerevisiae) 		4 / 7 LEU H 562
PHE H 587
LEU H 527
PHE H 523
 None
 0.82A 5zcoC-4c8qH:
undetectable
5zcoJ-4c8qH:
undetectable		 5zcoC-4c8qH:
19.40
5zcoJ-4c8qH:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4c8q DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1
(Saccharomyces
cerevisiae) 		4 / 7 LEU H 562
PHE H 587
LEU H 527
PHE H 523
 None
 0.81A 5zcqC-4c8qH:
undetectable
5zcqJ-4c8qH:
undetectable		 5zcqC-4c8qH:
19.40
5zcqJ-4c8qH:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_1
(NS3 PROTEASE)		 4c8q SM-LIKE PROTEIN LSM1
U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM2
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 9 VAL A 109
LEU B  40
ARG B  63
VAL B  32
SER B  31
 None
 1.10A 6c2mB-4c8qA:
undetectable		 6c2mB-4c8qA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_A_SAMA501_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 4c8q DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1
(Saccharomyces
cerevisiae) 		5 / 12 ILE H 533
GLY H 532
ILE H 535
ILE H 555
ILE H 591
 None
 0.96A 6emuA-4c8qH:
undetectable		 6emuA-4c8qH:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_B_SAMB301_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 4c8q DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1
(Saccharomyces
cerevisiae) 		5 / 12 ILE H 533
GLY H 532
ILE H 535
ILE H 555
ILE H 591
 None
 0.94A 6emuB-4c8qH:
undetectable		 6emuB-4c8qH:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_C_SAMC301_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 4c8q DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1
(Saccharomyces
cerevisiae) 		5 / 12 ILE H 533
GLY H 532
ILE H 535
ILE H 555
ILE H 591
 None
 0.97A 6emuC-4c8qH:
undetectable		 6emuC-4c8qH:
20.31