SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4c8t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 4c8t E3 UBIQUITIN-PROTEIN
LIGASE ZNRF3
(Xenopus
tropicalis) 		5 / 12 ILE A 128
VAL A  34
VAL A 168
ALA A 174
ILE A 167
 None
 0.89A 1epbA-4c8tA:
undetectable		 1epbA-4c8tA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 4c8t E3 UBIQUITIN-PROTEIN
LIGASE ZNRF3
(Xenopus
tropicalis) 		5 / 12 ILE A 128
VAL A  34
VAL A 168
ALA A 174
ILE A 167
 None
 0.86A 1epbB-4c8tA:
undetectable		 1epbB-4c8tA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_D_CGED501_1
(CYTOCHROME P450 2B4)		 4c8t E3 UBIQUITIN-PROTEIN
LIGASE ZNRF3
(Xenopus
tropicalis) 		5 / 9 VAL A  96
ILE A  71
ALA A  67
VAL A  34
VAL A  36
 None
 1.23A 3me6D-4c8tA:
undetectable		 3me6D-4c8tA:
15.59