SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4c8y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_A_T44A128_1
(TRANSTHYRETIN)		 4c8y CAS6A
(Thermus
thermophilus) 		5 / 10 LEU A 151
LEU A 148
LEU A 118
ALA A 213
LEU A 211
 None
 1.36A 1ie4A-4c8yA:
undetectable
1ie4C-4c8yA:
undetectable		 1ie4A-4c8yA:
20.59
1ie4C-4c8yA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W1B_A_DXCA2034_0
(ACRIFLAVIN
RESISTANCE PROTEIN B)		 4c8y CAS6A
(Thermus
thermophilus) 		3 / 3 PHE A 122
SER A 146
LEU A 142
 None
G  C  26 ( 3.8A)
G  C  25 ( 4.5A)
 0.69A 2w1bA-4c8yA:
3.2		 2w1bA-4c8yA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ERD_A_DESA600_1
(ESTROGEN RECEPTOR
ALPHA)		 4c8y CAS6A
(Thermus
thermophilus) 		5 / 12 ALA A 213
LEU A 148
LEU A 151
LEU A 157
LEU A 167
 None
 1.15A 3erdA-4c8yA:
undetectable		 3erdA-4c8yA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_A_NIMA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4c8y CAS6A
(Thermus
thermophilus) 		3 / 3 VAL A 223
SER A 221
LEU A 147
 None
 0.66A 3n8xA-4c8yA:
undetectable		 3n8xA-4c8yA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_B_SAMB500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 4c8y CAS6A
(Thermus
thermophilus) 		5 / 12 TYR A 231
SER A 124
GLY A 191
ALA A 190
PHE A  48
 None
 1.19A 4bupB-4c8yA:
undetectable		 4bupB-4c8yA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_D_LOCD502_1
(TUBULIN BETA CHAIN)		 4c8y CAS6A
(Thermus
thermophilus) 		5 / 12 LEU A 118
LEU A 147
THR A 126
ALA A 234
ALA A 236
 None
 1.11A 4x1iD-4c8yA:
undetectable		 4x1iD-4c8yA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_B_REAB602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 4c8y CAS6A
(Thermus
thermophilus) 		5 / 9 GLY A  47
LEU A  46
GLN A  95
LEU A   8
LEU A  84
 None
 1.39A 5fhzB-4c8yA:
undetectable		 5fhzB-4c8yA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_A_SAMA402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 4c8y CAS6A
(Thermus
thermophilus) 		5 / 12 TYR A 231
SER A 124
GLY A 191
ALA A 190
PHE A  48
 None
 1.04A 5wbvA-4c8yA:
undetectable		 5wbvA-4c8yA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 4c8y CAS6A
(Thermus
thermophilus) 		5 / 12 TYR A 231
SER A 124
GLY A 191
ALA A 190
PHE A  48
 None
 1.03A 5wbvB-4c8yA:
undetectable		 5wbvB-4c8yA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_B_SAMB901_0
(MRNA CAPPING ENZYME
P5)		 4c8y CAS6A
(Thermus
thermophilus) 		5 / 10 VAL A 223
GLY A 224
ALA A 218
SER A 146
LEU A 147
 None
G  C  26 ( 3.5A)
None
G  C  26 ( 3.8A)
None
 1.20A 5x6yB-4c8yA:
undetectable		 5x6yB-4c8yA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA821_0
(GEPHYRIN)		 4c8y CAS6A
(Thermus
thermophilus) 		3 / 3 ARG A 121
PHE A 122
GLY A 194
 None
 0.81A 6fgdA-4c8yA:
undetectable		 6fgdA-4c8yA:
20.86