SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4c90'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_C_DVAC6_0
(GRAMICIDIN A)		 4c90 ALPHA-GLUCURONIDASE
GH115
(Bacteroides
ovatus) 		3 / 3 ALA A 230
VAL A 232
TRP A 172
 None
 0.85A 1av2C-4c90A:
undetectable
1av2D-4c90A:
undetectable		 1av2C-4c90A:
3.20
1av2D-4c90A:
3.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5Q_B_CFFB1864_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4c90 ALPHA-GLUCURONIDASE
GH115
(Bacteroides
ovatus) 		3 / 3 TRP A 370
HIS A 413
MET A 392
 None
 1.49A 1l5qB-4c90A:
undetectable		 1l5qB-4c90A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXF_B_MTXB2278_1
(PTERIDINE REDUCTASE
2)		 4c90 ALPHA-GLUCURONIDASE
GH115
(Bacteroides
ovatus) 		5 / 11 SER A 562
TYR A 571
PHE A 503
LEU A 552
TYR A 518
 None
 1.43A 1mxfB-4c90A:
undetectable		 1mxfB-4c90A:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXF_C_MTXC3278_1
(PTERIDINE REDUCTASE
2)		 4c90 ALPHA-GLUCURONIDASE
GH115
(Bacteroides
ovatus) 		5 / 11 SER A 562
TYR A 571
PHE A 503
LEU A 552
TYR A 518
 None
 1.41A 1mxfC-4c90A:
undetectable		 1mxfC-4c90A:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXF_D_MTXD4278_1
(PTERIDINE REDUCTASE
2)		 4c90 ALPHA-GLUCURONIDASE
GH115
(Bacteroides
ovatus) 		5 / 11 SER A 562
TYR A 571
PHE A 503
LEU A 552
TYR A 518
 None
 1.42A 1mxfD-4c90A:
undetectable		 1mxfD-4c90A:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 4c90 ALPHA-GLUCURONIDASE
GH115
(Bacteroides
ovatus) 		4 / 5 LEU A 466
VAL A 232
CYH A 233
ALA A 264
 None
 1.14A 1mz9D-4c90A:
undetectable		 1mz9D-4c90A:
4.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 4c90 ALPHA-GLUCURONIDASE
GH115
(Bacteroides
ovatus) 		4 / 4 LEU A 466
VAL A 232
CYH A 233
ALA A 264
 None
 1.25A 1mz9E-4c90A:
undetectable		 1mz9E-4c90A:
4.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT6_A_DVAA6_0
(GRAMICIDIN C)		 4c90 ALPHA-GLUCURONIDASE
GH115
(Bacteroides
ovatus) 		3 / 3 ALA A 230
VAL A 232
TRP A 172
 None
 0.89A 1nt6A-4c90A:
undetectable		 1nt6A-4c90A:
3.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT6_B_DVAB6_0
(GRAMICIDIN C)		 4c90 ALPHA-GLUCURONIDASE
GH115
(Bacteroides
ovatus) 		3 / 3 ALA A 230
VAL A 232
TRP A 172
 None
 0.89A 1nt6B-4c90A:
undetectable		 1nt6B-4c90A:
3.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_C_DVAC6_0
(GRAMICIDIN D)		 4c90 ALPHA-GLUCURONIDASE
GH115
(Bacteroides
ovatus) 		3 / 3 ALA A 230
VAL A 232
TRP A 172
 None
 0.82A 1w5uC-4c90A:
undetectable
1w5uD-4c90A:
undetectable		 1w5uC-4c90A:
3.20
1w5uD-4c90A:
3.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X1A_A_SAMA4264_0
(CRTF-RELATED PROTEIN)		 4c90 ALPHA-GLUCURONIDASE
GH115
(Bacteroides
ovatus) 		6 / 12 GLU A  61
ALA A  68
GLY A 147
GLY A  99
ILE A 157
ASP A 121
 None
 1.17A 1x1aA-4c90A:
undetectable		 1x1aA-4c90A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 4c90 ALPHA-GLUCURONIDASE
GH115
(Bacteroides
ovatus) 		5 / 12 ILE A 185
MET A 164
LEU A  72
ILE A  76
PHE A  34
 None
 1.37A 1y0xX-4c90A:
undetectable		 1y0xX-4c90A:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1434_1
(CHITINASE)		 4c90 ALPHA-GLUCURONIDASE
GH115
(Bacteroides
ovatus) 		3 / 3 TRP A 172
THR A 218
TYR A 219
 None
 0.98A 2a3aA-4c90A:
9.4		 2a3aA-4c90A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_B_TEPB2434_1
(CHITINASE)		 4c90 ALPHA-GLUCURONIDASE
GH115
(Bacteroides
ovatus) 		3 / 3 TRP A 172
THR A 218
TYR A 219
 None
 1.07A 2a3aB-4c90A:
9.7		 2a3aB-4c90A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_A_CFFA1434_1
(CHITINASE)		 4c90 ALPHA-GLUCURONIDASE
GH115
(Bacteroides
ovatus) 		3 / 3 TRP A 172
THR A 218
TYR A 219
 None
 1.02A 2a3bA-4c90A:
9.8		 2a3bA-4c90A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXP_A_P1ZA3001_1
(SERUM ALBUMIN)		 4c90 ALPHA-GLUCURONIDASE
GH115
(Bacteroides
ovatus) 		5 / 12 PHE A  34
LEU A  46
LEU A 160
LEU A  72
ALA A  69
 None
 1.12A 2bxpA-4c90A:
undetectable		 2bxpA-4c90A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_B_DVAB6_0
(GRAMICIDIN D)		 4c90 ALPHA-GLUCURONIDASE
GH115
(Bacteroides
ovatus) 		3 / 3 TRP A 172
ALA A 230
VAL A 232
 None
 0.79A 2izqA-4c90A:
undetectable
2izqB-4c90A:
undetectable		 2izqA-4c90A:
3.20
2izqB-4c90A:
3.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q83_B_ADNB2_1
(YTAA PROTEIN)		 4c90 ALPHA-GLUCURONIDASE
GH115
(Bacteroides
ovatus) 		4 / 6 ILE A 157
PRO A  84
LEU A  46
ILE A  76
 None
 1.00A 2q83B-4c90A:
undetectable		 2q83B-4c90A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QK8_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 4c90 ALPHA-GLUCURONIDASE
GH115
(Bacteroides
ovatus) 		5 / 12 ALA A 804
ILE A 733
LEU A 735
PRO A 736
PHE A 766
 None
 1.23A 2qk8A-4c90A:
undetectable		 2qk8A-4c90A:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VL2_B_BEZB1162_0
(PEROXIREDOXIN-5)		 4c90 ALPHA-GLUCURONIDASE
GH115
(Bacteroides
ovatus) 		4 / 7 THR A  90
GLY A 138
LEU A 109
PHE A 105
 None
 0.99A 2vl2B-4c90A:
undetectable		 2vl2B-4c90A:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_H_CPFH1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 4c90 ALPHA-GLUCURONIDASE
GH115
(Bacteroides
ovatus) 		3 / 3 ARG A 238
GLU A 234
SER A 632
 None
 0.81A 2xctD-4c90A:
2.4		 2xctD-4c90A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM9_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4c90 ALPHA-GLUCURONIDASE
GH115
(Bacteroides
ovatus) 		4 / 8 MET A 279
ALA A 280
GLY A 312
ILE A 313
 None
 0.58A 2zm9A-4c90A:
undetectable		 2zm9A-4c90A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_B_VD3B2001_1
(VITAMIN D
HYDROXYLASE)		 4c90 ALPHA-GLUCURONIDASE
GH115
(Bacteroides
ovatus) 		5 / 11 ILE A  76
LEU A  86
LEU A  72
ILE A  55
PRO A  52
 None
 1.40A 3a50B-4c90A:
undetectable		 3a50B-4c90A:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_C_VD3C2001_1
(VITAMIN D
HYDROXYLASE)		 4c90 ALPHA-GLUCURONIDASE
GH115
(Bacteroides
ovatus) 		5 / 11 MET A 477
ILE A 473
LEU A 239
ILE A 236
LEU A 204
 None
 0.95A 3a50C-4c90A:
1.8		 3a50C-4c90A:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_D_VDYD6178_1
(VITAMIN D
HYDROXYLASE)		 4c90 ALPHA-GLUCURONIDASE
GH115
(Bacteroides
ovatus) 		5 / 12 MET A 477
ILE A 473
LEU A 239
ILE A 236
LEU A 204
 None
 0.99A 3a51D-4c90A:
undetectable		 3a51D-4c90A:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_A_ACRA5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4c90 ALPHA-GLUCURONIDASE
GH115
(Bacteroides
ovatus) 		3 / 3 LEU A 447
TRP A 481
TYR A 451
 None
 0.97A 3aicA-4c90A:
5.9		 3aicA-4c90A:
22.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_B_ACRB5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4c90 ALPHA-GLUCURONIDASE
GH115
(Bacteroides
ovatus) 		3 / 3 LEU A 447
TRP A 481
TYR A 451
 None
 0.94A 3aicB-4c90A:
2.8		 3aicB-4c90A:
22.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_E_ACRE5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4c90 ALPHA-GLUCURONIDASE
GH115
(Bacteroides
ovatus) 		3 / 3 LEU A 447
TRP A 481
TYR A 451
 None
 0.94A 3aicE-4c90A:
3.1		 3aicE-4c90A:
22.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_F_ACRF5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4c90 ALPHA-GLUCURONIDASE
GH115
(Bacteroides
ovatus) 		3 / 3 LEU A 447
TRP A 481
TYR A 451
 None
 0.94A 3aicF-4c90A:
3.0		 3aicF-4c90A:
22.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_G_ACRG5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4c90 ALPHA-GLUCURONIDASE
GH115
(Bacteroides
ovatus) 		3 / 3 LEU A 447
TRP A 481
TYR A 451
 None
 0.97A 3aicG-4c90A:
3.3		 3aicG-4c90A:
22.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_H_ACRH5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4c90 ALPHA-GLUCURONIDASE
GH115
(Bacteroides
ovatus) 		3 / 3 LEU A 447
TRP A 481
TYR A 451
 None
 0.92A 3aicH-4c90A:
2.8		 3aicH-4c90A:
22.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_1
(N,N-DIMETHYLTRANSFER
ASE)		 4c90 ALPHA-GLUCURONIDASE
GH115
(Bacteroides
ovatus) 		3 / 3 TYR A 586
GLU A 528
ASP A 206
 None
 0.80A 3bxoA-4c90A:
undetectable		 3bxoA-4c90A:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		 4c90 ALPHA-GLUCURONIDASE
GH115
(Bacteroides
ovatus) 		4 / 5 TYR A 379
ALA A 333
ALA A 371
TYR A 420
 None
 1.19A 3d91A-4c90A:
undetectable		 3d91A-4c90A:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 4c90 ALPHA-GLUCURONIDASE
GH115
(Bacteroides
ovatus) 		4 / 8 LYS A 240
TYR A 451
ASP A 478
GLU A 159
 None
 1.43A 3dh0A-4c90A:
undetectable		 3dh0A-4c90A:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_B_SAMB270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 4c90 ALPHA-GLUCURONIDASE
GH115
(Bacteroides
ovatus) 		5 / 11 LEU A 717
GLY A 826
ILE A 729
LEU A 829
VAL A 828
 None
 1.15A 3gyqB-4c90A:
2.1		 3gyqB-4c90A:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HVT_A_NVPA557_1
(HIV-1 REVERSE
TRANSCRIPTASE
(SUBUNIT P66))		 4c90 ALPHA-GLUCURONIDASE
GH115
(Bacteroides
ovatus) 		5 / 9 LEU A 832
TYR A 762
GLY A 765
LEU A 829
TYR A 731
 None
 1.47A 3hvtA-4c90A:
undetectable		 3hvtA-4c90A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_A_DVAA6_0
(GRAMICIDIN D)		 4c90 ALPHA-GLUCURONIDASE
GH115
(Bacteroides
ovatus) 		3 / 3 ALA A 230
VAL A 232
TRP A 172
 None
 0.78A 3l8lA-4c90A:
undetectable
3l8lB-4c90A:
undetectable		 3l8lA-4c90A:
3.20
3l8lB-4c90A:
3.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_C_DVAC6_0
(GRAMICIDIN D)		 4c90 ALPHA-GLUCURONIDASE
GH115
(Bacteroides
ovatus) 		3 / 3 ALA A 230
VAL A 232
TRP A 172
 None
 0.81A 3l8lC-4c90A:
undetectable
3l8lD-4c90A:
undetectable		 3l8lC-4c90A:
3.20
3l8lD-4c90A:
3.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_1
(YAEB-LIKE PROTEIN
RPA0152)		 4c90 ALPHA-GLUCURONIDASE
GH115
(Bacteroides
ovatus) 		5 / 12 LEU A 623
LEU A 585
ARG A 619
GLY A 527
THR A 526
 None
 1.30A 3okxB-4c90A:
undetectable		 3okxB-4c90A:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4c90 ALPHA-GLUCURONIDASE
GH115
(Bacteroides
ovatus) 		3 / 3 TYR A 155
ASP A 149
ASP A  62
 None
 0.88A 3ou7B-4c90A:
undetectable		 3ou7B-4c90A:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_B_DSFB319_1
(GLR4197 PROTEIN)		 4c90 ALPHA-GLUCURONIDASE
GH115
(Bacteroides
ovatus) 		5 / 9 ILE A  57
VAL A  65
THR A 153
ILE A 145
ILE A 157
 None
 1.16A 3p4wB-4c90A:
4.8		 3p4wB-4c90A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_D_DSFD319_1
(GLR4197 PROTEIN)		 4c90 ALPHA-GLUCURONIDASE
GH115
(Bacteroides
ovatus) 		5 / 10 ILE A  57
VAL A  65
THR A 153
ILE A 145
ILE A 157
 None
 1.19A 3p4wD-4c90A:
4.5		 3p4wD-4c90A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_E_DSFE319_1
(GLR4197 PROTEIN)		 4c90 ALPHA-GLUCURONIDASE
GH115
(Bacteroides
ovatus) 		5 / 10 ILE A  57
VAL A  65
THR A 153
ILE A 145
ILE A 157
 None
 1.18A 3p4wE-4c90A:
4.5		 3p4wE-4c90A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QJ7_A_SPMA264_1
(THYMIDYLATE SYNTHASE)		 4c90 ALPHA-GLUCURONIDASE
GH115
(Bacteroides
ovatus) 		4 / 8 ALA A 556
GLN A 559
LEU A 576
TYR A 571
 None
 1.01A 3qj7A-4c90A:
undetectable
3qj7D-4c90A:
undetectable		 3qj7A-4c90A:
15.82
3qj7D-4c90A:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRM_A_VD3A502_1
(VITAMIN D(3)
25-HYDROXYLASE)		 4c90 ALPHA-GLUCURONIDASE
GH115
(Bacteroides
ovatus) 		5 / 12 MET A 477
ILE A 473
LEU A 239
ILE A 236
LEU A 204
 None
 0.96A 3vrmA-4c90A:
undetectable		 3vrmA-4c90A:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_B_TYLB1187_1
(BROMODOMAIN
CONTAINING 2)		 4c90 ALPHA-GLUCURONIDASE
GH115
(Bacteroides
ovatus) 		4 / 5 VAL A 463
LEU A 466
LEU A 204
ILE A 236
 None
 0.93A 4a9jB-4c90A:
3.1		 4a9jB-4c90A:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		 4c90 ALPHA-GLUCURONIDASE
GH115
(Bacteroides
ovatus) 		3 / 3 LEU A 447
MET A 479
ASP A 424
 None
None
NA  A1855 ( 4.5A)
 0.82A 4j7xB-4c90A:
undetectable		 4j7xB-4c90A:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_B_MRVB1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 4c90 ALPHA-GLUCURONIDASE
GH115
(Bacteroides
ovatus) 		4 / 5 TYR A 155
THR A 450
LEU A 447
THR A 474
 None
 1.40A 4mbsB-4c90A:
1.7		 4mbsB-4c90A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_2
(TUBULIN BETA-2B
CHAIN)		 4c90 ALPHA-GLUCURONIDASE
GH115
(Bacteroides
ovatus) 		5 / 12 LEU A  86
THR A 100
ALA A  98
ILE A  96
ILE A 145
 None
 0.92A 4o2bB-4c90A:
undetectable		 4o2bB-4c90A:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_2
(TUBULIN BETA-2B
CHAIN)		 4c90 ALPHA-GLUCURONIDASE
GH115
(Bacteroides
ovatus) 		5 / 12 LEU A  86
THR A 100
ALA A  98
ILE A  96
ILE A 145
 None
 0.89A 4o2bD-4c90A:
undetectable		 4o2bD-4c90A:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZP0_A_DXCA500_0
(MULTIDRUG
TRANSPORTER MDFA)		 4c90 ALPHA-GLUCURONIDASE
GH115
(Bacteroides
ovatus) 		5 / 10 MET A 582
LEU A 585
LEU A 530
GLN A 592
MET A 588
 None
 1.50A 4zp0A-4c90A:
1.4		 4zp0A-4c90A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4c90 ALPHA-GLUCURONIDASE
GH115
(Bacteroides
ovatus) 		4 / 5 GLU A 320
THR A 319
THR A 324
HIS A 275
 None
 0.94A 5axaA-4c90A:
undetectable		 5axaA-4c90A:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_C_ADNC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4c90 ALPHA-GLUCURONIDASE
GH115
(Bacteroides
ovatus) 		4 / 5 GLU A 320
THR A 319
THR A 324
HIS A 275
 None
 0.89A 5axaC-4c90A:
undetectable		 5axaC-4c90A:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH612_0
(NADH DEHYDROGENASE,
PUTATIVE)		 4c90 ALPHA-GLUCURONIDASE
GH115
(Bacteroides
ovatus) 		3 / 3 ARG A 200
PRO A 195
ASN A 124
 None
 0.93A 5jwaA-4c90A:
undetectable
5jwaH-4c90A:
undetectable		 5jwaA-4c90A:
20.00
5jwaH-4c90A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_B_LOCB504_2
(TUBULIN BETA CHAIN)		 4c90 ALPHA-GLUCURONIDASE
GH115
(Bacteroides
ovatus) 		5 / 12 LEU A  86
THR A 100
ALA A  98
ILE A  96
ILE A 145
 None
 0.98A 5xiwB-4c90A:
undetectable		 5xiwB-4c90A:
6.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YN6_A_SAMA401_0
(NSP16 PROTEIN)		 4c90 ALPHA-GLUCURONIDASE
GH115
(Bacteroides
ovatus) 		5 / 12 GLY A 224
GLY A 220
LEU A 204
ASP A 225
PHE A 253
 None
 1.32A 5yn6A-4c90A:
undetectable		 5yn6A-4c90A:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJ8_A_9DCA303_0
(METALLO-BETA-LACTAMA
SE TYPE 2)		 4c90 ALPHA-GLUCURONIDASE
GH115
(Bacteroides
ovatus) 		4 / 8 MET A 248
ASP A 332
HIS A 422
HIS A 275
 None
 1.04A 5zj8A-4c90A:
undetectable		 5zj8A-4c90A:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_I_PACI1_0
(SERINE PROTEASE NS3
SERINE PROTEASE
SUBUNIT NS2B
PEPTIDE
PAC-DLY-DLY-DAR)		 4c90 ALPHA-GLUCURONIDASE
GH115
(Bacteroides
ovatus) 		3 / 3 VAL A 833
TYR A 683
GLU A 801
 None
 0.96A 5zmqD-4c90A:
undetectable
5zmqE-4c90A:
undetectable		 5zmqD-4c90A:
12.61
5zmqE-4c90A:
5.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_B_TRPB403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 4c90 ALPHA-GLUCURONIDASE
GH115
(Bacteroides
ovatus) 		4 / 7 GLU A 456
TRP A 459
THR A 450
PRO A 483
 None
 1.39A 6a4iB-4c90A:
2.0		 6a4iB-4c90A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CNJ_A_NCTA402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 4c90 ALPHA-GLUCURONIDASE
GH115
(Bacteroides
ovatus) 		4 / 7 TYR A 219
TYR A 229
TRP A 214
LEU A 211
 None
 1.30A 6cnjA-4c90A:
4.3
6cnjB-4c90A:
4.6		 6cnjA-4c90A:
6.01
6cnjB-4c90A:
7.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CNJ_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 4c90 ALPHA-GLUCURONIDASE
GH115
(Bacteroides
ovatus) 		4 / 8 TYR A 219
TYR A 229
TRP A 214
LEU A 211
 None
 1.32A 6cnjD-4c90A:
4.0
6cnjE-4c90A:
4.4		 6cnjD-4c90A:
6.01
6cnjE-4c90A:
7.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CNK_B_NCTB402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 4c90 ALPHA-GLUCURONIDASE
GH115
(Bacteroides
ovatus) 		4 / 7 TYR A 219
TYR A 229
TRP A 214
LEU A 211
 None
 1.29A 6cnkB-4c90A:
4.8
6cnkC-4c90A:
5.3		 6cnkB-4c90A:
6.01
6cnkC-4c90A:
7.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EUQ_A_DXCA502_0
(MULTIDRUG
TRANSPORTER MDFA)		 4c90 ALPHA-GLUCURONIDASE
GH115
(Bacteroides
ovatus) 		5 / 11 MET A 582
LEU A 585
LEU A 530
GLN A 592
MET A 588
 None
 1.45A 6euqA-4c90A:
1.5		 6euqA-4c90A:
19.51